iAluRil is a medical device presented in a prefilled syringe. The solution within the syringe is instilled directly into the bladder to help rebuild the damaged bladder lining.
It contains three active ingredients:
iAluRil can be used in the treatment of:
Bladder pain syndrome (BPS)
Recurrent urinary tract infections (rUTIs)*
Chemical/radiation-induced cystitis
(including BCG)
*iAluRil offers relief and prevention of rUTIs
As a healthy GAG layer is made of more than one component, it follows that an effective therapy will contain a combination. iAluRil is the only GAG therapy to contain both HA and CS; a combination which allows a more effective replenishment of the GAG layer.
Not only is iAluRil the only combination GAG therapy, it is also the only one to contain 3 components. The addition of calcium chloride (CaCl):
iAluRil has the most evidence of any GAG therapy, with the most clinical studies and high quality data from a range of different types of trials.⁶
These GAG components attach together and have the ability to bind water; forming a gel-like layer to protect inside of the bladder.
The addition of calcium chloride is what makes iAluRil different.
Calcium chloride stabilises the iAluRil solution and provides superior adhesive and protective properties.
The lining of the bladder is known as the glycosaminoglycan, or GAG layer. This layer protects the inside of the bladder from bacteria and the irritants found in urine. There are four components that make up the GAG layer, but the two present in iAluRil are hyaluronic acid and chondroitin sulphate.
In certain bladder conditions, like BPS/IC and rUTIs, the GAG layer becomes damaged which means the bladder lining is unprotected. This can cause irritation and damage; resulting in pain.
Nerve endings which are usually protected by the GAG layer may also become exposed; changing the signals sent to the brain about when to urinate; even a very small amount of urine in the bladder can feel like you’re about to burst.
The risk of infection is also higher.
Because iAluRil contains two GAG components; HA and CS, it is able to effectively replenish the damaged GAG layer. In doing so, the symptoms associated with bladder conditions; pain, urgency and frequency, may be alleviated and the risk of bacterial infection is significantly reduced .
iAluRil is available for patients to purchase following training either by a nurse
or by watching our self-administration videos.
We provide a range of useful information for patients;
from videos on self-administration to printable patient information.
A nurse advice line is also available for if you have any questions
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