<p>I have seen many people saying on this site and many other 3D printing websites that 24 V systems are safer, compared to 12 V systems. By safer, I am talking in terms of fires or other electrical and component failures. </p>

<p>Why would a 24 V system cause less danger? I would think that 12 V would be safer because it is very common (automotive) and many parts have been around for a while that use it. Although there are an increasingly amount of boards that support 24 V, many don't or need fuses or other parts that do support 24 V. </p>

<p>Also, many parts that I have used are rated for 12 - 24 V. A 12 V power supply can go a bit over fairly comfortably. A 24 V power supply can't without partially going over the rating.</p>

<p>If I had to build a printer designed with safety as a main priority, what voltage would be best?</p>

From a pure safety standpoint there is nothing about a 24v system that is distrinctly more safe than a 12v system. I see you added comments about something involving wire sizes. This is not really a factor.. I would say not knowing what wire size to use is a whole other issue. There is nothing stopping you from putting on larger wires.
The following websites verify the fact that a 24v needs smaller wires. Though again the system it self is not safer because the wires required are smaller.
JamesTown
SDC minimum wire gauge to distance chart
I will also note the size difference is negligible anyways. It is not a major difference.
Now one exception to this. If you had a 24v and a 12v compatible board. I would pick a 24v. The reason is not that the wire sizes needed are different. But for the reduced danger of the CONNECTOR that the wires attach to. I see quite often in the flashforge owner group boards that have caught fire due to a cheap connector that can not handle the load for the printer.