<p>It seems like there should be a simpler way than:</p>

<pre><code>import string
s = "string. With. Punctuation?" # Sample string 
out = s.translate(string.maketrans("",""), string.punctuation)
</code></pre>

<p>Is there?</p>

Not necessarily simpler, but a different way, if you are more familiar with the re family.
```
```
import re, string
s = "string. With. Punctuation?" # Sample string 
out = re.sub('[%s]' % re.escape(string.punctuation), '', s)
```
```