<p>I've been looking around for a good MVC framework for Python using PyGTK. I've looked at <a href="http://www.async.com.br/projects/kiwi/" rel="nofollow noreferrer">Kiwi</a> but found it a bit lacking, especially with using the Gazpacho Glade-replacement.</p>

<p>Are there any other nice desktop Python MVC frameworks?  I'm one of the few (it seems) to not want a webapp.</p>

There's
Dabo
, made by some guys moving from FoxPro.  It might work for you if you're writing a data driven business app.
Beyond that, I haven't found anything that you haven't.
GUI stuff is
supposed
to be hard. It builds character.
(
Attributed
to Jim Ahlstrom, at one of the early Python workshops.  Unfortunately, things haven't changed much since then.)