<p>What things should be kept most in mind when writing cross-platform applications in C? Targeted platforms: 32-bit Intel based PC, Mac, and Linux. I'm especially looking for the type of versatility that Jungle Disk has in their USB desktop edition ( <a href="http://www.jungledisk.com/desktop/download.aspx" rel="noreferrer">http://www.jungledisk.com/desktop/download.aspx</a> )</p>

<p>What are tips and "gotchas" for this type of development?</p>

Try to write as much as you can with POSIX. Mac and Linux support POSIX natively and Windows has a system that can run it (as far as I know - I've never actually used it). If your app is graphical, both Mac and Linux support X11 libraries (Linux natively, Mac through X11.app)  and there are numerous ways of getting X11 apps to run on Windows.
However, if you're looking for true multi-platform deployment, you should probably switch to a language like Java or Python that's capable of running the same program on multiple systems with little or no change.
Edit: I just downloaded the application and looked at the files. It does appear to have binaries for all 3 platforms in one directory. If your concern is in how to write apps that can be moved from machine to machine without losing settings, you should probably write all your configuration to a file in the same directory as the executable and not touch the Windows registry or create any dot directories in the home folder of the user that's running the program on Linux or Mac. And as far as creating a cross-distribution Linux binary, 32-bit POSIX/X11 would probably be the safest bet. I'm not sure what JungleDisk uses as I'm currently on a Mac.