<p>I want to use Sharepoint with python (C-Python)</p>

<p>Has anyone tried this before ?</p>

SharePoint exposes several web services which you can use to query and update data.
I'm not sure what web service toolkits there are for Python but they should be able to build proxies for these services without any issues.
This article should give you enough information to get started.
http://www.developer.com/tech/article.php/3104621