In this paper, we will follow the route of a European slave trade voyage, considering how, at every stage, European traders faced resistance to enslavement on the part of captives taken from Madagascar. On the island itself, there was already a form of opposition from enslaved domestic workers, who were fearful of being sold to the Europeans and fled, as did enslaved people who had been purchased inland. We will then focus on the desertion of enslaved people after they had been purchased by the Europeans, both on land and at sea. Finally, we will describe the various forms of resistance to the slavery system following the arrival of enslaved people at their destination in a European colony.