Instruct: Given a question, retrieve passages that answer the question.
Query: Who invented MRI technology?
Raymond Vahan Damadian (born March 16, 1936) is an American physician, medical practitioner, and inventor of the first MR (Magnetic Resonance) Scanning Machine.[1]
Magnetic resonance imaging (MRI) is used for scanning the brain for topological and landmark structure in the brain, but can also be used for imaging activation in the brain. While detail about how MRI works is reserved for the actual MRI article, the uses of MRI are far reaching in the study of neuroscience. It is a cornerstone technology in studying the mind, especially with the advent of functional MRI (fMRI). Functional MRI measures the oxygen levels in the brain upon activation (higher oxygen content = neural activation) and allows researchers to understand what loci are responsible for activation under a given stimulus. This technology is a large improvement to single cell or loci activation by means of exposing the brain and contact stimulation. Functional MRI allows researchers to draw associative relationships between different loci and regions of the brain and provides a large amount of knowledge in establishing new landmarks and loci in the brain.
Strengths: Researchers can use standalone PET or MRI operation, or use multi-modality imaging. PET and MRI techniques can be carried out either independently (using either the PET or MRI systems as standalone devices), or in sequence (with a clip-on PET) in front of the bore of the MRI system, or simultaneously (with the PET inserted inside the MRI magnet). This provides a much more accurate picture far more quickly. By operating the PET and MRI systems simultaneously workflow within a laboratory can be increased. The MR-PET system from MR Solutions incorporates the latest technology in Silicon Photomultipliers (SiPM), which significantly reduces the size of the system and avoids the problems of using photomultipliers or other legacy detector types within the magnetic field of the MRI. The performance characteristics of SiPM are similar to a conventional PMT, but with the practical advantages of solid-state technology.
The Varian brothers and their associates individually left Sperry and returned to the West Coast between 1945 and 1948. After the war, the klystron became an important component in the further development of radar and the microwave industry. It was used in broadcast television and in the development of various telecommunications technologies. In 1950, the Varians were awarded the John Price Wetherill Medal of the Franklin Institute "in recognition of their foresight ... energy and technical insight in developing ... the klystron". Klystron technology was still being used in 1993 in UHF television, the free-electron laser, and the Stanford Linear Accelerator.
Each brother developed other inventions. Russell gained patents for technology related to nuclear magnetic resonance (NMR), as used in magnetic resonance imaging (MRI), thermionic tubes, and various radar technologies. Sigurd's inventions, some of which he patented, included a system of pumps, filters, and heaters for his swimming pool, as well as a high-speed drill press. Sigurd also led projects that built models and prototypes to develop Russell's concepts into usable products. Russell was awarded an honorary Doctor of Engineering degree by the Polytechnic Institute of Brooklyn. He was also named alumnus of the year by California State Polytechnic College for inventing the Klystron.
In a similar fashion, Siemens launched the Biograph mMR in 2010, the first scanner to completely combine MRI and PET technologies. . Like PET-CT, PET-MR hybrid systems combine multiple technologies to provide a better image of the body, enabling for better diagnoses, research and treatment plans for patients. It combines precise images of the body's organs from MRI with metabolic cell activity from PET.
The primary aim of the projects was a more sophisticated development of the rather modest MRI techniques available in the early eighties - mainly with respect to speed and specificity. Already in 1985 the group presented a major breakthrough for the future development of MRI in both science and medicine. The invention of a rapid imaging principle, the FLASH MRI (fast low angle shot) technique, allowed for a 100-fold reduction of the measuring times of cross-sectional and three-dimensional images. The FLASH acquisition technique led the ground for many modern MRI applications in diagnostic imaging. Examples include breathhold imaging of the abdomen, electrocardiogram-synchronized quasi-real time movies of the beating heart, dynamic scanning of contrast media uptake, 3D imaging of complex anatomic structures such as the brain that allow for unprecedented high spatial resolution and arbitrary view angles, and magnetic resonance angiography (MRA) of the vasculature. Other achievements extended to MRI and localized magnetic resonance spectroscopy (MRS) techniques based on stimulated echoes - another invention from 1984.
According to a UCSD website, the work of Dale's laboratory at UCSD has yield several other technological developments, including “a method for tracking and correcting for head motion, in real time, during MRI scans; a fully automated method for identifying white matter tracts from MRI scans; and a method for quantifying longitudinal anatomical change from serial MRI scans.” In addition, the laboratory has produced “a free software program that aids in the study of anatomical changes associated with early stages of Alzheimer’s disease and Mild Cognitive Impairment (MCI). This technology, developed for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), involves longitudinal MRI and PET scans as well as CSF biomarkers in a large number of patients.” Dale has also initiated a number of “collaborative efforts using neuroimaging methods to study the genetic and environmental influences on brain structure and development” and that an “FDA-approved version of his automated segmentation technology is now in routine use for quantitative assessment of regional atrophy in patients under clinical evaluation for AD/MCI at UCSD.”
Damadian received a National Medal of Technology in 1988 and was inducted into the National Inventors Hall of Fame[15] in 1989. His original MRI full-body scanner was given to the Smithsonian Institution in the 1980s and is now on loan and on display at the National Inventors Hall of Fame in Ohio.[32] In 2001, the Lemelson-MIT Prize Program bestowed its $100,000 Lifetime Achievement Award on Damadian as "the man who invented the MRI scanner."[3]
While MRI is used normally for diagnosis and follow up, it has limitations. New MRI technologies like pulse sequences and post-processing are under study.
Diffusion tensor MRI or Magnetic Transfer MRI are two options to enhance MRI-hidden abnormalities discovery. This is currently an active field of research with no definitive results, but it seems that these two technologies are complementary.
The United States spends more on technology than Canada. In a 2004 study on medical imaging in Canada, it was found that Canada had 4.6 MRI scanners per million population while the U.S. had 19.5 per million. Canada's 10.3 CT scanners per million also ranked behind the U.S., which had 29.5 per million. The study did not attempt to assess whether the difference in the number of MRI and CT scanners had any effect on the medical outcomes or were a result of overcapacity but did observe that MRI scanners are used more intensively in Canada than either the U.S. or Great Britain. This disparity in the availability of technology, some believe, results in longer wait times. In 1984 wait times of up to 22 months for an MRI were alleged in Saskatchewan. However, according to more recent official statistics (2007), all emergency patients receive MRIs within 24 hours, those classified as urgent receive them in under 3 weeks and the maximum elective wait time is 19 weeks in Regina and 26 weeks in Saskatoon, the province's two largest metropolitan areas.
ACMT offered courses in the use of medical technology such as MRI scanners. Former students reported a number of problems with the courses offered, including a lack of hands-on training with appropriate machinery, incorrect or out-of-date textbooks, and instructors who were not familiar with the material.
The university offers associate, bachelor, master, doctoral and higher doctorate degrees through a college, a graduate school and six faculties. UQ incorporates over one hundred research institutes and centres, such as the Boeing Research and Technology Australia Centre, the Australian Institute for Bioengineering and Nanotechnology and the UQ Dow Centre. Recent research achievements of the university include pioneering the invention of the HPV vaccine that prevents cervical cancer and the development of high-performance superconducting MRI magnets for portable scanning of human limbs.
The European group MAGNIMS periodically publishes guidelines for using MRI in the diagnosis of MS that are updated as MRI technology evolves. Moreover, new MRI techniques, such as double inversion recovery imaging or phase sensitive inversion recovery, can be used to identify more lesions in MS which, if further validated, could be included in future criteria. Another promising MRI technique is magnetic transfer imaging, which will allow the detection of damage in normal-appearing brain tissue away from focal lesions. Finally, high resolution spectral domain optical coherence tomography could prove to be a very promising and sensitive way of identifying optic neuritis in the future.
Damadian is the company's largest shareholder, with 8% of stock worth $6.5 million.[7] Despite owning only 8% of the stock, he maintains almost 100% control of the company through a separate class of shares (Class C) that only Damadian controls 2007.[28] Damadian later collaborated with Wilson Greatbatch, one early developer of the implantable pacemaker, to develop an MRI-compatible pacemaker. He invented a stand-up MRI system and has 15 MRI scanning centers across the United States. There are a number of independent MRI centers that use this technology both in the U.S. and around the world. The company conceived and built the world's first Upright Multi-Positional MRI, which was recognized as The Invention of the Year in 2007 by the Intellectual Properties Owners Association Education Foundation.[29]
The Microwave Research Institute (MRI) was founded in 1945 by Ernst Weber at the Polytechnic Institute of Brooklyn (which later became the Polytechnic Institute of New York University). Research conducted at the institute included work in the areas of "electromagnetic theory, antennas and radiation, network theory and microwave networks, microwave components and devices." MRI was internationally regarded as one of the foremost centers of research on microwave field theory in the world. In 1985 it was renamed the Weber Research Institute in honor of its founder.Among its most prominent members were Nathan Marcuvitz, Leo B. Felsen, Dante C. Youla and Arthur A. Oliner, all fellows of IEEE and members of the National Academy of Engineering. The institute has attracted researchers from all over the world, including Alexander Graham Bell Medal winner Tsuneo Nakahara, who in 1961 was a visiting research associate of the institute, and who went on to be vice chairman of the Sumitomo Electric Company, and Dr. Oguchi, who became chief engineer of Nippon Telegraph and Telephone. Another faculty member closely associated with MRI was KunMo Chung, Director of the Plasma Physics Laboratory from 1967 to 1975, who served as Minister of Science and Technology of South Korea two times and who was associated with numerous international science and technology agencies.
The first neuroimaging technique ever is the so-called ‘human circulation balance’ invented by Angelo Mosso in the 1880s and able to non-invasively measure the redistribution of blood during emotional and intellectual activity. 
Then, in the early 1900s, a technique called pneumoencephalography was set. This process involved draining the cerebrospinal fluid from around the brain and replacing it with air, altering the relative density of the brain and its surroundings, to cause it to show up better on an x-ray, and it was considered to be incredibly unsafe for patients (Beaumont 8). A form of magnetic resonance imaging (MRI) and computed tomography (CT) were developed in the 1970s and 1980s. The new MRI and CT technologies were considerably less harmful and are explained in greater detail below. Next came SPECT and PET scans, which allowed scientists to map brain function because, unlike MRI and CT, these scans could create more than just static images of the brain's structure. Learning from MRI, PET and SPECT scanning, scientists were able to develop functional MRI (fMRI) with abilities that opened the door to direct observation of cognitive activities.
Raymond Damadian, a recipient of the National Medal of Technology, had a significant contribution to the invention of the MRI.
FLASH MRI was invented in 1985 by Jens Frahm, Axel Haase, W Hänicke, KD Merboldt, and D Matthaei (German Patent Application P 35 04 734.8, February 12, 1985) at the Max-Planck-Institut für biophysikalische Chemie in Göttingen, Germany. The technique is revolutionary in shortening MRI measuring times by up to two orders of magnitude.
GEC also funded some of the development of Magnetic Resonance Imaging (MRI) using resistive magnet technology. At the same time, EMI Medical who had introduced the CT Scanner some time before using the principle of Godfrey Hounsfield, for which he won the 1979 Nobel Prize for Physiology or Medicine, were developing MRI using cryogenic magnets - which gave a higher field strength. At the time the maximum field strength with a resistive magnet was about 0.1T. With a cryogenic magnet, 1.0 T was easily achieved. EMI Medical went bankrupt at around this time so their interests in MRI were bought by GEC. This was a major impetus for GEC's acquisition of Picker Corporation in 1981. 
Presently, the main clinical fields of PET-MRI are oncology, cardiology and neurology. Research studies are actively conducted at the moment to understand benefits of the new PET-MRI diagnostic method. The technology combines the exquisite structural and functional characterization of tissue provided by MRI with the extreme sensitivity of PET imaging of metabolism and tracking of uniquely labeled cell types or cell receptors.
There is discussion and investigation into utilizing PET-MR with Ion Therapy for the purpose of cancer treatment. with MRI's ability to accurately depict the proton density of tissue is a good match for the benefits and technical challenges of treatment planning utilizing Ion Therapy systems.
Cougar Software worked in partnership with various consulting and technology firms in the real estate management realm, including:Cougar Software was acquired by MRI Software on February 3, 2015 and is now referred to as "MRI Investment Management."
Boots UK is based in Lenton in Nottingham, with 2,500 UK stores, where Stewart Adams developed Ibuprofen in the 1960s on Rutland Road in West Bridgford, and Vision Express are nearby, next to the A52. Boots was the biggest chemist chain in the world; now A.S. Watson Group is the world's biggest health retail company. Crookes Healthcare, formerly Boots and now Reckitt Benckiser, make Strepsils and Optrex on the enormous Boots site, and Boots Contract Manufacturing (BCM) make products for other firms; it makes Benylin for McNeil. On the ng2 business park, Specsavers have their corporate eyecare and contact lens division. Three out of the four main UK opticians are sited in Nottingham. The MRI scanner was developed at the University of Nottingham by Sir Peter Mansfield; MRI scanners were developed mainly by GEC Medical, once invented; MRI harnesses nuclear magnetic resonance (NMR) of the hydrogen nucleus; Raymond Vahan Damadian of USA also claims the MRI invention. 
Damadian has received several prizes. In 2001, the Lemelson-MIT Prize Program bestowed its $100,000 Lifetime Achievement Award on Damadian as "the man who invented the MRI scanner."[3] He went on to collaborate with Wilson Greatbach, one early developer of the implantable pacemaker, to develop an MRI-compatible pacemaker. The Franklin Institute in Philadelphia gave its recognition of Damadian's work on MRI with the Bower Award in Business Leadership.[4] He was also named Knights of Vartan 2003 "Man of the Year".[5] He received a National Medal of Technology in 1988 and was inducted in the National Inventors Hall of Fame in 1989.[6]
Diagnostic technology is another area for continued research. MRI has enabled scientists to see conditions in the spine, including syringomyelia before symptoms appear. A new technology, known as dynamic MRI, allows investigators to view spinal fluid flow within the syrinx. CT scans allow physicians to see abnormalities in the brain, and other diagnostic tests have also improved greatly with the availability of new, non-toxic, contrast dyes.