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Query: When was the term biochemistry first used?
The history of biochemistry can be said to have started with the ancient Greeks who were interested in the composition and processes of life, although biochemistry as a specific scientific discipline has its beginning around the early 19th century.[1] Some argued that the beginning of biochemistry may have been the discovery of the first enzyme, diastase (today called amylase), in 1833 by Anselme Payen,[2] while others considered Eduard Buchner's first demonstration of a complex biochemical process alcoholic fermentation in cell-free extracts to be the birth of biochemistry.[3][4] Some might also point to the influential work of Justus von Liebig from 1842, Animal chemistry, or, Organic chemistry in its applications to physiology and pathology, which presented a chemical theory of metabolism,[1] or even earlier to the 18th century studies on fermentation and respiration by Antoine Lavoisier.[5][6]
A Commonwealth Fund Exchange Fellowship of the Harkness Foundation enabled him to travel to the USA and work in several biochemistry laboratories. He then returned to the UK where his mentor Hans Krebs had moved to Oxford University and offered him a post there. This partnership produced a paper in "Nature", concerning their discovery of the Glyoxylate cycle, and also a joint book which was the first major publication on biological thermodynamics. 
In 1960 he was appointed to the first Chair in Biochemistry at the University of Leicester, which he held until 1975 when he was elected to the Sir William Dunn Chair of Biochemistry at the University of Cambridge. In 1963 he was awarded the Colworth Medal, the first person to receive it.
Researchers in biochemistry use specific techniques native to biochemistry, but increasingly combine these with techniques and ideas developed in the fields of genetics, molecular biology and biophysics. There has never been a hard-line among these disciplines in terms of content and technique. Today, the terms "molecular biology" and "biochemistry" are nearly interchangeable. The following figure is a schematic that depicts one possible view of the relationship between the fields:a. Fructose is not the only sugar found in fruits. Glucose and sucrose are also found in varying quantities in various fruits, and indeed sometimes exceed the fructose present. For example, 32% of the edible portion of date is glucose, compared with 24% fructose and 8% sucrose. However, peaches contain more sucrose (6.66%) than they do fructose (0.93%) or glucose (1.47%).Poirot, Marc; Soules, Regis; Mallinger, Arnaud; Dalenc, Florence; Silvente-Poirot, Sandrine. Biochimie. Oct2018, Vol. 153, pp. 139–149
Afify, Heba M. American Journal of Biomedical Sciences. 2016, Vol. 8 Issue 3, pp. 200–207
Educated at Queen's College, Belfast and the Royal University of Ireland, Moore's early positions were in the field of physiology at Yale University, Connecticut, United States and Charing Cross Hospital, London. When the first British department of biochemistry was founded at the University of Liverpool in 1902, after a donation from Liverpool shipowner William Johnston, Moore took up the Johnston Chair, the first chair of biochemistry in the UK.
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell. When such chemical signals bind to a receptor, they cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. There are three main ways the action of the receptor can be classified: relay of signal, amplification, or integration. Relaying sends the signal onward, amplification increases the effect of a single ligand, and integration allows the signal to be incorporated into another biochemical pathway. In this sense, a receptor is a protein-molecule that recognizes and responds to endogenous chemical signals, e.g. an acetylcholine receptor recognizes and responds to its endogenous ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug targets, such as enzymes, transporters, and ion channels.
The effect of electric field on equilibrium has been studied by Manfred Eigen among others.In these applications, terms such as stability constant, formation constant, binding constant, affinity constant, association/dissociation constant are used. In biochemistry, it is common to give units for binding constants, which serve to define the concentration units used when the constant's value was determined.
Terminology about epistasis can vary between scientific fields. Geneticists often refer to wild type and mutant alleles where the mutation is implicitly deleterious and may talk in terms of genetic enhancement, synthetic lethality and genetic suppressors. Conversely, a biochemist may more frequently focus on beneficial mutations and so explicitly state the effect of a mutation and use terms such as reciprocal sign epistasis and compensatory mutation. Additionally, there are differences when looking at epistasis within a single gene (biochemistry) and epistasis within a haploid or diploid genome (genetics). In general, epistasis is used to denote the departure from 'independence' of the effects of different genetic loci. Confusion often arises due to the varied interpretation of 'independence' among different branches of biology. The classifications below attempt to cover the various terms and how they relate to one another.
The Department of Biochemistry at Oxford University began as the physiological chemistry section of the Physiology Department, and acquired its own separate department and building in the 1920s. In 1920, Benjamin Moore was elected to the position of the Whitley Professor of Biochemistry, the newly established Chair of Biochemistry at Oxford University. He was followed by Rudolph Peters in 1923, and an endowment of £75,000 was soon granted by the Rockefeller Foundation for the construction of a new building for the Department of Biochemistry, purchase of its equipment, and its maintenance. The Biochemistry Department building opened in 1927.
In 1954, Hans Krebs was appointed the Whitley Chair of Biochemistry, and his appointment brought greater prominence to the department. He brought with him the Medical Research Council unit established to conduct research on cell metabolism. In 1955, a second professorship in the department, the Iveagh Chair of Microbiology, was established with funding from Guinness and the sub-department of Microbiology created, with Donald Woods its first holder. The eight-storey Hans Krebs Building was constructed in 1964 with funds from the Rockefeller Foundation. Krebs was succeeded by Rodney Porter in 1967. Genetics was brought into the Biochemistry Department when Walter Bodmer was appointed the first Professor of Genetics in 1970. The Laboratory of Molecular Biophysics, first established in the Zoology Department with support from Krebs and also linked to the Physical Chemistry Laboratory of the Chemistry Department, became part of the Biochemistry Department. It moved into the Rex Richards building built in 1984, with David Phillips the Professor in Molecular Biophysics. The Oxford Glycobiology Institute, then headed by Raymond Dwek and housed in the Rodney Porter Building, opened in 1991.
A 1980 letter in "Trends in Biochemistry Sciences" noted the confusion in the literature and the essentially arbitrary distinction made between prosthetic groups and coenzymes group and proposed the following scheme. Here, cofactors were defined as an additional substance apart from protein and substrate that is required for enzyme activity and a prosthetic group as a substance that undergoes its whole catalytic cycle attached to a single enzyme molecule. However, the author could not arrive at a single all-encompassing definition of a "coenzyme" and proposed that this term be dropped from use in the literature.
The department currently has three main buildings:Until 2006, two older buildings housing genetics (the Walter Bodmer building) and biochemistry (the Rudolph Peters building) were also part of the department. However, these were demolished in 2006 to make way for the first phase of the construction of the New Biochemistry building, completed in October 2008. Until 2008 biochemistry also occupied the Donald Woods building and the Hans Krebs Tower, which was demolished in 2014 for the second phase of the construction.
The New Biochemistry building houses interdisciplinary research in the Biosciences including Physiology, Chemistry, Biochemistry, and Clinical Neurosciences. The Department moved into the purpose-built new biochemistry building during the Autumn of 2008 which was designed to promote interaction and collaboration as well as provide facilities for all staff. The New Biochemistry building houses a substantial amount of contemporary art.
At its broadest definition, biochemistry can be seen as a study of the components and composition of living things and how they come together to become life, in this sense the history of biochemistry may therefore go back as far as the ancient Greeks. However, biochemistry as a specific scientific discipline has its beginning sometime in the 19th century, or a little earlier, depending on which aspect of biochemistry is being focused on. Some argued that the beginning of biochemistry may have been the discovery of the first enzyme, diastase (today called amylase), in 1833 by Anselme Payen, while others considered Eduard Buchner's first demonstration of a complex biochemical process alcoholic fermentation in cell-free extracts in 1897 to be the birth of biochemistry. Some might also point as its beginning to the influential 1842 work by Justus von Liebig, "Animal chemistry, or, Organic chemistry in its applications to physiology and pathology", which presented a chemical theory of metabolism, or even earlier to the 18th century studies on fermentation and respiration by Antoine Lavoisier. Many other pioneers in the field who helped to uncover the layers of complexity of biochemistry have been proclaimed founders of modern biochemistry, for example Emil Fischer for his work on the chemistry of proteins, and F. Gowland Hopkins on enzymes and the dynamic nature of biochemistry.
The term “biochemistry” itself is derived from the combining form bio-, meaning "life", and chemistry. The word is first recorded in English in 1848,[7] while in 1877, Felix Hoppe-Seyler used the term (Biochemie in German) in the foreword to the first issue of Zeitschrift für Physiologische Chemie (Journal of Physiological Chemistry) as a synonym for physiological chemistry and argued for the setting up of institutes dedicate to its studies.[8][9] Nevertheless, several sources cite German chemist Carl Neuberg as having coined the term for the new discipline in 1903,[10][11] and some credit it to Franz Hofmeister.[12]
Bioorganic chemistry is a rapidly growing scientific discipline that combines organic chemistry and biochemistry. While biochemistry aims at understanding biological processes using chemistry, bioorganic chemistry attempts to expand organic-chemical researches (that is, structures, synthesis, and kinetics) toward biology. When investigating metalloenzymes and cofactors, bioorganic chemistry overlaps bioinorganic chemistry. Biophysical organic chemistry is a term used when attempting to describe intimate details of molecular recognition by bioorganic chemistry.
The term "in silico" was first used in 1989 at a workshop "Cellular Automata: Theory and Applications" by a mathematician from National Autonomous University of Mexico (UNAM). The term "in silico radiation oncology", a precursor of generic "in silico" medicine was coined and first introduced by G. Stamatakos in Proceedings of the IEEE in 2002. The same researcher coined and introduced the more generic term "in silico oncology". "In silico" medicine is considered an extension of previous work using mathematical models of biological systems. It became apparent that the techniques used to model biological systems has utility to explain and predict dynamics in the medical field. The first fields in medicine to use "in silico" modeling were genetics, physiology and biochemistry. The field saw a dramatic influx of data when the human genome was sequenced in the 1980s and 1990s. Concurrently the increase in available computational power allowed for modeling of complex systems that were previously impractical.
The Department of Biochemistry of Oxford University is located in the Science Area in Oxford, England. It is one of the largest biochemistry departments in Europe. The Biochemistry Department is part of the University of Oxford's Medical Sciences Division, the largest of the University's four academic divisions and ranked first in the world for biomedicine.
DNA computing is a branch of computing which uses DNA, biochemistry, and molecular biology hardware, instead of the traditional silicon-based computer technologies. Research and development in this area concerns theory, experiments, and applications of DNA computing. The term "molectronics" has sometimes been used, but this term has already been used for an earlier technology, a then-unsuccessful rival of the first integrated circuits; this term has also been used more generally, for molecular-scale electronic technology.
Victoria Metcalf was born in Christchurch, New Zealand, then moved to Invercargill when she was 4. She graduated in 1996 with BSc(Hons) First Class in Biochemistry, University of Otago. In 2002 she completed her PhD in Biochemistry at Christchurch School of Medicine, University of Otago.
Fletcher was a long-time friend and institutional ally of Frederick Gowland Hopkins, a pioneering biochemist who was trying to establish "general biochemistry" as a field distinct from either medical physiology or organic chemistry, more a part of biology than medicine. Fletcher lobbied for the Dunn estate to fund Hopkins's proposal, among the over 500 funding proposals submitted. By late 1919, Fletcher was negotiating for a considerable endowment that would allow Hopkins to create an institute solely devoted to biochemistry. The approval of this endowment, ultimately about 210,000 pounds, reversed the declining fortunes of Hopkins's research group, which had been suffering from lack of available academic positions, research space, and able students since World War I. With funding in the works, Hopkins group expanded from 10 researchers in 1920 to 59 in 1925; in 1922 they began using endowment funds and in 1924 the Dunn Institute of Biochemistry opened. Hopkins became the first Sir William Dunn Professor of Biochemistry and head of the new University of Cambridge Department of Biochemistry, and he appointed researchers in a range of specialized fields covering the whole of what he considered the proper, broad domain of biochemistry.
The term supermolecule (or supramolecule) was introduced by Karl Lothar Wolf "et al." ("Übermoleküle") in 1937 to describe hydrogen-bonded acetic acid dimers. The study of non-covalent association of complexes of molecules has since developed into the field of supramolecular chemistry. The term supermolecule is sometimes used to describe supramolecular assemblies, which are complexes of two or more molecules (often macromolecules) that are not covalently bonded. The term supermolecule is also used in biochemistry to describe complexes of biomolecules, such as peptides and oligonucleotides composed of multiple strands.
The term was used as early as 1973, when scientist Carl Sagan described it and other human chauvinisms that limit imagination of possible extraterrestrial life. It suggests that human beings, as carbon-based life forms who have never encountered any life that has evolved outside the Earth’s environment, may find it difficult to envision radically different biochemistries.
Biochemistry is a common university textbook used for teaching of biochemistry. It was initially written by Professor Lubert Stryer and published by W. H. Freeman in 1975. It has been published in regular editions since. It is commonly used as an undergraduate teaching textbook or reference work.
Amino acids contain both amino and carboxylic acid functional groups. (In biochemistry, the term amino acid is used when referring to those amino acids in which the amino and carboxylate functionalities are attached to the same carbon, plus proline which is not actually an amino acid).
W. Use of the Terms "Mass" and "Weight." [NOTE 1, See page 6] When used in this handbook, the term "weight" means "mass". The term "weight" appears when inch-pound units are cited, or when both inch-pound and SI units are included in a requirement. The terms "mass" or "masses" are used when only SI units are cited in a requirement. The following note appears where the term "weight" is first used in a law or regulation.
Later he joined the faculty at Rutgers University in the Department of Biochemistry and Microbiology. At Rutgers, Waksman's team discovered several antibiotics, including actinomycin, clavacin, streptothricin, streptomycin, grisein, neomycin, fradicin, candicidin, candidin. Two of these, streptomycin and neomycin, have found extensive application in the treatment of infectious disease. Streptomycin was the first antibiotic that could be used to cure the disease tuberculosis. Waksman is credited with coining the term antibiotics, to describe antibacterials derived from other living organisms, for example penicillin, though the term was used by the French dermatologist François Henri Hallopeau, in 1871 to describe a substance opposed to the development of life.
As a research fellow Young studied diabetes at the University of Aberdeen and the University of Toronto. At the age of 34 he was awarded his first chair when appointed in 1942 as the Professor of Biochemistry at St Thomas's Hospital Medical School, University of London. Thereafter his advancement was rapid, becoming professor of biochemistry at UCL in 1945 and then, in 1949, being elected as the third Sir William Dunn Professor of Biochemistry at Cambridge University, a post he was to hold for the ensuing 26 years. His Cambridge appointment coincided with his election in March 1949 to Fellowship of the Royal Society.