Instruct: Given a question, retrieve relevant passages that can help answer the question.
Query: When did the Human Genome Project begin?
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the sequence of nucleotide base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional standpoint.[1] It remains the world's largest collaborative biological project.[2] After the idea was picked up in 1984 by the US government when the planning started, the project formally launched in 1990 and was declared complete on April 14, 2003.[3] Funding came from the US government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside government by the Celera Corporation, or Celera Genomics, which was formally launched in 1998. Most of the government-sponsored sequencing was performed in twenty universities and research centers in the United States, the United Kingdom, Japan, France, Germany and China.[4]
The Human Genome Project originally aimed to map the nucleotides contained in a human haploid reference genome (more than three billion). The "genome" of any given individual is unique; mapping the "human genome" involved sequencing a small number of individuals and then assembling these together to get a complete sequence for each chromosome. Therefore, the finished human genome is a mosaic, not representing any one individual.
The study of human populations has been at the forefront of genomic and clinical research since the Human Genome Project (HGP) was completed. Projects similar to HGDP are the 1000 Genomes Project and the HapMap Project. Each has its own specificities and each has been used by scientists to a large extent for overlapping purposes.
Its predecessor was Human Genome Research Center of Institute of Genetics and Developmental Biology (CAS) which was founded on August 1998. The predecessor center participated in the International Human Genome Project (HGP) on behalf of China, and China became the sixth member states which took part in the Human Genome Project.
Birney is one of the founders of the Ensembl genome browser and other databases, and has played a key role in many large-scale genomics projects, notably the sequencing of the Human Genome in 2000 and the analysis of genome function in the ENCODE project. He has played a role in annotating the genome sequences of the human, mouse, chicken and several other organisms. His research group focuses on genomic algorithms and inter-individual differences in human and other animal species.
Besides the International Human Genome Project, other achievements of BIG included the participation of the HapMap Project; the completion of the Chinese Superhybrid Rice ("Oryza sativa" L. ssp. indica) Genome Project; the collaborations of the Silkworm Genome Project and the Chicken Genome Diversity Project. 
While the 1000 Genomes Project has been initially estimated to cost up to $50 million USD,[3] the 1000 Plant Genomes Project will likely not be as expensive; the difference in cost comes from the target sequence in the genomes.[1] Since the 1000 Plant Genomes Project will only be sequencing the transcriptome, whereas the human project will sequence as much of the genome as is decided feasible,[3] there is a much lower amount of sequencing effort needed in this more specific approach. While this means that there will be less overall sequence output relative to the 1000 Genomes Project, the non-coding portions of the genomes excluded in the 1000 Plant Genomes Project are not important to its goals like they are to the human project. So then the more focused approach of the 1000 Plant Genomes Project minimizes cost while still achieving its goals.
. NHGRI led the National Institutes of Health's contribution to the International Human Genome Project. This project, which had as its primary goal the sequencing of the three thousand million base pairs that make up human genome, was successfully completed in April 2003. . Published from 1989 to 2002 by the US Department of Energy, this newsletter was a major communications method for coordination of the Human Genome Project. Complete online archives are available. Department of Energy's portal to the international Human Genome Project, Microbial Genome Program, and Genomics:GTL systems biology for energy and environment has general and detailed primers on DNA, genes and genomes, the Human Genome Project and science spotlights. , an automated annotation system and browser for the human genome , This site contains the reference sequence and working draft assemblies for a large collection of genomes. It also provides a portal to the ENCODE project. , including the HGP's paper on the draft genome sequence A free resource allowing you to explore the human genome, your health and your future. Venter discusses Celera's progress in deciphering the human genome sequence and its relationship to healthcare and to the federally funded Human Genome Project. Companion website to 2-hour NOVA program documenting the race to decode the genome, including the entire program hosted in 16 parts in either QuickTime or RealPlayer format. Numerous original documents at Georgetown University.
The Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC) was established by Richard A. Gibbs in 1996 when Baylor College of Medicine was chosen as one of six worldwide sites to complete the final phase of the international Human Genome Project. Gibbs is the current director of the BCM-HGSC.
The Human Genome Project (HGP) was declared complete in April 2003. An initial rough draft of the human genome was available in June 2000 and by February 2001 a working draft had been completed and published followed by the final sequencing mapping of the human genome on April 14, 2003. Although this was reported to cover 99% of the euchromatic human genome with 99.99% accuracy, a major quality assessment of the human genome sequence was published on May 27, 2004 indicating over 92% of sampling exceeded 99.99% accuracy which was within the intended goal.[27] Further analyses and papers on the HGP continue to occur.[28]
The Human Genome Organisation (HUGO) is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world. The HUGO Gene Nomenclature Committee (HGNC), sometimes referred to as "HUGO", is one of HUGO's most active committees and aims to assign a unique gene name and symbol to each human gene.
As a collaborator on the international Human Genome Project, his team posted the first publicly available computational assembly of the human genome sequence on the Internet on July 7, 2000. Following this, his team developed the UCSC Genome Browser, a web-based tool that is used extensively in biomedical research and serves as the platform for several large-scale genomics projects. These include NHGRI’s ENCODE project to use omics methods to explore the function of every base in the human genome (for which UCSC serves as the Data Coordination Center), NIH’s Mammalian Gene Collection, NHGRI’s 1000 genomes project to explore human genetic variation, and NCI’s Cancer Genome Atlas project to explore the genomic changes in cancer.
Genomics refers to the field of genetics concerned with structural and functional studies of the genome. A genome is all the DNA contained within an organism or a cell including nuclear and mitochondrial DNA. The human genome is the total collection of genes in a human being contained in the human chromosome, composed of over three billion nucleotides. In April 2003, the Human Genome Project was able to sequence all the DNA in the human genome, and to discover that the human genome was composed of around 20,000 protein coding genes.
21st century begins with the first complete sequences of individual human genomes by Human Genome Project, on February 12, 2001, this allowed a switch in drug development and research from the traditional way of drug discovery that was isolating molecules from plants or animals or create new molecules and see if they could be useful in treatment of illness in humans, to pharmacogenomics, that is the study and knowledge of how genes respond to drugs. Another field beneficed by Human Genome Project is pharmacogenetics, that is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.
The establishment of Human Mutation lead Cotton and his colleagues globally to begin efforts to unify the field and make the collection of genetic variation information systematic, standardized and complete across all genes. In 1996, to further stimulate activity in this area, Cotton originally set up the Human Genome Organization Mutation Database Initiative. In 2001 this became the Human Genome Variation Society. Then in the early 2000s, closely following the widely acclaimed completion of the Human Genome Project, it became clear that a more active and more internationally focused effort was needed to enable the systematic collection, curation, interpretation and sharing of genetic variation information. From this realization, Cotton founded and launched the Human Variome Project.
The DNA sequencer was a critical technology for the Human Genome Project.
Hood was involved with the Human Genome Project from its first meeting, held at the University of California, Santa Cruz, in 1985. Hood became an enthusiastic advocate for The Human Genome Project and its potential. Hood directed the Human Genome Center’s sequencing of portions of human chromosomes 14 and 15.
1000 Genomes Project– International research project to catalog human genetic variation 100,000 Genomes Project– A UK Government project that is sequencing whole genomes from National Health Service patients Chimpanzee genome project ENCODE Physiome HUGO Gene Nomenclature Committee Human Brain Project Human Connectome Project Human Cytome Project Human Microbiome Project Human proteome project Human Variome Project List of biological databases Neanderthal genome project– An effort to sequence the Neanderthal genome Wellcome Sanger Institute– British genomics research institute Genographic Project
In 1989 the Howard Hughes Medical Institute provided funding to establish a central repository for human genetic mapping data. This project ultimately resulted in the creation of the GDB Human Genome DataBase in 1990. It was a key database in the Human Genome Project.
In 1989, one of the first Human Genome Project grants went to Waterston and Sulston to begin the sequencing of the worm genome. They were so successful that at the same time that the Wellcome Trust established the Sanger Centre with Sulston at its head, Waterston received funding from the National Human Genome Research Institute to undertake large-scale human sequencing at his Washington University lab. The partnership became the first to complete the sequence of a multicellular organism when the worm genome was published in December 1998, and both labs played key roles in the sequencing of the human genome, with Waterston’s lab contributing more of the finished sequence than any other US lab. The partnership went on have leading roles in the sequencing of both the mouse and chimpanzee genomes.
Human genomics and population genetics are the study of the human genome and variome, respectively. Studies in these areas may concern the patterns and trends in human DNA. The Human Genome Project and The Human Variome Project are examples of large scale studies of the entire human population to collect data which can be analyzed to understand genomic and genetic variation in individuals, respectively.
The Cancer Genome Project is part of the cancer, aging, and somatic mutation research based at the Wellcome Trust Sanger Institute in The United Kingdom. It aims to identify sequence variants/mutations critical in the development of human cancers. Like The Cancer Genome Atlas project within the United States, the Cancer Genome Project represents an effort in the War on Cancer to improve cancer diagnosis, treatment, and prevention through a better understanding of the molecular basis of the disease. The Cancer Genome Project was launched by Michael Stratton in 2000, and Peter Campbell is now the group leader of the project. The project works to combine knowledge of the human genome sequence with high throughput mutation detection techniques.
In 2003, the Human Genome Project produced the first complete human genome. Despite the project’s success, very little is known about cognitive gene expression. Prior to 2003, any evidence concerning human brain connectivity was based on post-mortem observations. Due to ethical concerns, no invasive in vivo genomics studies have been performed on live humans.
Whereas a genome sequence lists the order of every DNA base in a genome, a genome map identifies the landmarks. A genome map is less detailed than a genome sequence and aids in navigating around the genome. The Human Genome Project was organized to map and to sequence the human genome. A fundamental step in the project was the release of a detailed genomic map by Jean Weissenbach and his team at the Genoscope in Paris.
Since the completion of the Human Genome Project, advances in human population genetics and comparative genomics have made it possible to gain increasing insight into the nature of genetic diversity. However, we are just beginning to understand how processes like the random sampling of gametes, structural variations (insertions/deletions (indels), copy number variations (CNV), and retroelements), single-nucleotide polymorphisms (SNPs), and natural selection have shaped the level and pattern of variation within species and also between species.
The project was not able to sequence all the DNA found in human cells. It sequenced only euchromatic regions of the genome, which make up 92% of the human genome. The other regions, called heterochromatic, are found in centromeres and telomeres, and were not sequenced under the project.[26]