Instruct: Given a question, retrieve passages that can help answer the question.
Query: What is the recommended amount of iodine for humans?
The U.S. Institute of Medicine (IOM) updated Estimated Average Requirements (EARs) and Recommended Dietary Allowances (RDAs) for iodine in 2000. For people age 14 and up, the iodine RDA is 150 μg/day; the RDA for pregnant women is 220 μg/day and the RDA during lactation is 290 μg/day. For children 1–8 years, the RDA is 90 μg/day; for children 8–13 years, 130 μg/day.[16] As a safety consideration, the IOM sets tolerable upper intake levels (ULs) for vitamins and minerals when evidence is sufficient. The UL for iodine for adults is 1,100μg/day. This UL was assessed by analyzing the effect of supplementation on thyroid-stimulating hormone.[5] Collectively, the EARs, RDAs, AIs and ULs are referred to as Dietary Reference Intakes (DRIs).[16]
With iodine supplementation, goiters caused by iodine deficiency decrease in size in very young children and pregnant women. Generally, however, long-standing goiters caused by iodine deficiency respond with only small amounts of shrinkage after iodine supplementation, and patients are at risk for developing hyperthyroidism. Following the adoption of iodised salt in the United States in 1924, there was a gradual increase in average intelligence of 1 standard deviation, 15 points in iodine-deficient areas, 3.5 points nationally, but also an increase in deaths of older people in iodine-deficient areas due to hyperthyroidism.
Povidone-iodine (PVP-I), also known as iodopovidone, is an antiseptic used for skin disinfection before and after surgery. It may be used both to disinfect the skin of the patient and the hands of the healthcare providers. It may also be used for minor wounds. It may be applied to the skin as a liquid or a powder.
Side effects include skin irritation. If used on large wounds kidney problems, high blood sodium, and metabolic acidosis may occur. It is not recommended in people who are less than 32 weeks pregnant or are taking lithium. Frequent use is not recommended in people with thyroid problems. Povidone-iodine is a chemical complex of povidone, hydrogen iodide, and elemental iodine. It contains from 9% to 12% available iodine. It works by releasing iodine which results in the death of a range of microorganisms.
Povidone-iodine came into commercial use in 1955. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Povidone-iodine is available over the counter. The wholesale cost in the developing world is about 3.30 to 11.40 per liter of 10% solution. This amount in the United Kingdom cost the NHS about £10.86. It is sold under a number of brand names including Betadine.
Iodine tincture is not a recommended source of solely-nutritional iodine. Nutritional iodine is better supplied in the form of the less toxic iodide (see SSKI) or iodate salts, which the body can easily convert to thyroid hormone.
Iodine is used to treat and prevent iodine deficiency and as an antiseptic. For iodine deficiency it can be given by mouth or injection into a muscle. As an antiseptic it may be used on wounds that are wet or to disinfect the skin before surgery.
Common side effects when applied to the skin include irritation and discoloration. When taken by mouth or injection side effects may include allergic reactions, goitre, and thyroid dysfunction. Use during pregnancy is recommended in regions where deficiency is common, otherwise it is not recommended. Iodine is an essential trace element.
In 1811, Bernard Courtois isolated iodine from seaweed while in 1820 Jean-Francois Coindet linked iodine intake to goiter size. It initially came into use as a disinfectant and for goiter. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Table salt with iodine, known as iodized salt, is available in more than 110 countries. In areas with low dietary iodine one dose of iodine a year at 0.32 USD per dose may be recommended.
Humans typically consume less than 100 micrograms of iodine per day. Iodine deficiency can cause intellectual disability. Organoiodine compounds occur in humans in some of the glands, especially the thyroid gland, as well as the stomach, epidermis, and immune system. Foods containing iodine include cod, oysters, shrimp, herring, lobsters, sunflower seeds, seaweed, and mushrooms. However, iodine is not known to have a biological role in plants. There are typically 0.06 milligrams per liter of iodine in human blood, 300 parts per billion of iodine in human bones, and 50 to 700 parts per billion of iodine in human tissue. There are 10 to 20 milligrams of iodine in a typical 70-kilogram human.
In 1953, the AEC ran several studies at the University of Iowa on the health effects of radioactive iodine in newborns and pregnant women. In one study, researchers gave pregnant women from of iodine-131, in order to study the women's aborted embryos in an attempt to discover at what stage, and to what extent, radioactive iodine crosses the placental barrier. In another study, they gave 25 newborn babies (who were under 36 hours old and weighed from ) iodine-131, either by oral administration or through an injection, so that they could measure the amount of iodine in their thyroid glands, as iodine would go to that gland.
Nascent Iodine sometimes known by the generic term atomic iodine or generic trademark name Atomidine or by the detoxified iodine, is a liquid orally administered supplemental form of iodine, claimed to be in a and monatomic state, originating from a 1931 Edgar Cayce formula. The concept of nascent state has been debunked. Thus, nascent iodine does not exist and medicines purporting to contain this substance are misrepresentations.The preparation was first conceived in 1931 by American Christian mystic Edgar Cayce in two channelled "readings" for an Indian inventor by the name of Shankar Bhise who inquired about how to improve an iodine medicine. Cayce regarded this specially formulated "atomic" iodine as far easier to assimilate than other forms. Cayce recommended this atomic iodine or "Atomidine" as a therapeutic measure, in over 600 "readings". Extracts from some of his readings:
Iodised salt (also spelled iodized salt) is table salt mixed with a minute amount of various salts of the element iodine. The ingestion of iodine prevents iodine deficiency. Worldwide, iodine deficiency affects about two billion people and is the leading preventable cause of intellectual and developmental disabilities. Deficiency also causes thyroid gland problems, including "endemic goitre". In many countries, iodine deficiency is a major public health problem that can be cheaply addressed by purposely adding small amounts of iodine to the sodium chloride salt.
Some table salt sold for consumption contains additives which address a variety of health concerns, especially in the developing world. The identities and amounts of additives vary widely from country to country. Iodine is an important micronutrient for humans, and a deficiency of the element can cause lowered production of thyroxine (hypothyroidism) and enlargement of the thyroid gland (endemic goitre) in adults or cretinism in children. Iodized salt has been used to correct these conditions since 1924 and consists of table salt mixed with a minute amount of potassium iodide, sodium iodide or sodium iodate. A small amount of dextrose may also be added to stabilize the iodine. Iodine deficiency affects about two billion people around the world and is the leading preventable cause of mental retardation. Iodized table salt has significantly reduced disorders of iodine deficiency in countries where it is used.
Iodine used for water purification is commonly added to water as a solution, in crystallized form, or in tablets containing tetraglycine hydroperiodide that release 8 mg of iodine per tablet adaptation to chronic tetraglycine hydroperiodide. The iodine kills many, but not all, of the most common pathogens present in natural fresh water sources. Carrying iodine for water purification is an imperfect but lightweight solution for those in need of field purification of drinking water. Kits are available in camping stores that include an iodine pill and a second pill (vitamin C or ascorbic acid) that will remove the iodine taste from the water after it has been disinfected. The addition of vitamin C, in the form of a pill or in flavored drink powders, precipitates much of the iodine out of the solution, so it should not be added until the iodine has had sufficient time to work. This time is 30 minutes in relatively clear, warm water, but is considerably longer if the water is turbid or cold. Iodine treated drinking water, treated with tablets containing tetraglycine hydroperiodide, also reduces the uptake of radioactive iodine in human subjects to only 2% of the value it would otherwise be. This could be an important factor worthy of consideration for treating water in a recent post nuclear event survival situation, where radioactive iodine ingestion is a concern for internal radiotoxicity. If the iodine has precipitated out of the solution, then the drinking water has less available iodine in the solution. Also the amount of iodine in one tablet is not sufficient to block uptake. Tetraglycine hydroperiodide maintains its effectiveness indefinitely before the container is opened; although some manufacturers suggest not using the tablets more than three months after the container has initially been opened, the shelf life is in fact very long provided that the container is resealed immediately after each time it is opened.
Guidelines recommend the administration of inorganic iodide (potassium iodide or Lugol's iodine) to reduce the synthesis and release of thyroid hormone. Iodine reduces the synthesis of thyroid hormone via the Wolf-Chaikoff effect. Some guidelines recommend that iodine be administered after antithyroid medications are started, because iodine is also a substrate for the synthesis of thyroid hormone, and may worsen hyperthyroidism if administered without antithyroid medications.
The amount of iodine and the specific iodine compound added to salt varies from country to country. In the United States, the Food and Drug Administration (FDA) recommends [21 CFR 101.9 (c)(8)(iv)] 150 micrograms of iodine per day for both men and women. US iodized salt contains 46–77 ppm (parts per million), whereas in the UK the iodine content of iodized salt is recommended to be 10–22 ppm.
Iodine-131 (I) is the most common RNT worldwide and uses the simple compound sodium iodide with a radioactive isotope of iodine. The patient (human or animal) may ingest an oral solid or liquid amount or receive an intravenous injection of a solution of the compound. The iodide ion is selectively taken up by the thyroid gland. Both benign conditions like thyrotoxicosis and certain malignant conditions like papillary thyroid cancer can be treated with the radiation emitted by radioiodine. Iodine-131 produces beta and gamma radiation. The beta radiation released damages both normal thyroid tissue and any thyroid cancer that behaves like normal thyroid in taking up iodine, so providing the therapeutic effect, whilst most of the gamma radiation escapes the patient's body.
Cayce gave two separate readings for Shankar Bhise and gave him directions with two different manufacturing methods:Today, Cayce's prescribed "Atomic iodine" is made in different ways by different manufacturers, and is generally named nascent iodine, atomic iodine or detoxified iodine, each with different interpretations of the Edgar Cayce readings in which it was first recommended.
This particular analysis is an example of iodometry. A solution of iodine is yellow/brown in color. When this is added to a solution to be tested, however, any chemical group (usually in this test C=C double bonds) that react with iodine effectively reduce the strength, or magnitude of the colour (by taking iodine out of solution). Thus the amount of iodine required to make a solution retain the characteristic yellow/brown colour can effectively be used to determine the amount of iodine sensitive groups present in the solution.
Small amounts of radioactive iodine were found in the breast milk of women living east of Tokyo. However, the levels were below the safety limits for tap water consumption by infants. Regulatory limits for infants in Japan are several levels of magnitude beneath what is known to potentially affect human health. Radiation protection standards in Japan are currently stricter than international recommendations and the standards of most other states, including those in North America and Europe . By Nov 2012, no radioactivity was detected in Fukushimas mothers breast milk. 100% of samples contained no detectable amount of radioactivity.
Iodine is an essential dietary mineral; the thyroid hormones thyroxine and triiodothyronine contain iodine. In areas where there is little iodine in the diet, typically remote inland
areas where no marine foods are eaten, iodine deficiency is common. It is also common in mountainous regions of the world where food is grown in iodine-poor soil.
Prevention includes adding small amounts of iodine to table salt, a product known as "iodized salt". Iodine compounds have also been added to other foodstuffs, such as flour, water and milk, in areas of deficiency. Seafood is also a well known source of iodine.
Xenetix 300 of Guerbet (Roissy, France) contains Iobitridol in 300 mg iodine/ml concentration. Recommended mean doses are 1.1 to 2.8 ml/kg body mass corresponding to 0,33 to 0,84 g iodine/kg human body mass. Injected into veins it will be filtered out by the kidneys. It is used also to fill joints or the uterus.
Iodine is a micronutrient and dietary mineral that is naturally present in the food supply in some regions, especially near sea coasts, but is generally quite rare in the Earth's crust, since iodine is a so-called heavy element, and abundance of chemical elements generally declines with greater atomic mass. Where natural levels of iodine in the soil are low and the iodine is not taken up by vegetables, iodine added to salt provides the small but essential amount of iodine needed by humans.
Elemental iodine (I2) is poisonous if taken orally in large amounts; 2–3 grams is a lethal dose for an adult human.[38][39] Potassium iodide, on the other hand, has a median lethal dose (LD50) that is relatively high in several other animals: in rabbits, it is 10g/kg; in rats, 14g/kg, and in mice, 22g/kg.[40] The tolerable upper intake level for iodine as established by the Food and Nutrition Board is 1,100µg/day for adults. The safe upper limit of consumption set by the Ministry of Health, Labor and Welfare in Japan is 3,000µg/day.[41]
Iodine, an element essential for human health, is present only in small amounts in sea salt. Iodised salt is table salt mixed with a minute amount of various salts of the element iodine.
To date, there is little information available about minimum requirements of dietary iodine for developing puppies. However, literature suggests that overdosage of iodine in puppies has deleterious effects on the thyroid gland. High dietary iodine may cause both hypothyroidism and changes in bone metabolism, considering that thyroid hormones are key factors in osteogenesis, as they stimulate osteoblasts, and promote collagen synthesis and mineralization of the osteoid. This is particularly important during juvenile development, as these hormones favor the action of growth hormone (GH) and its facilitator, insulin growth factor-1 (IGF-1) at the osteoplastic level. Hypothyroidism acquired at an early age presents a delay in the maturation and development of the ossification sites of newly-developing bone. It is therefore important to closely monitor the amount of iodine in puppy diets in order to prevent overdosage. The NRC states an adequate intake and recommended allowance of 900 μg/kg (DM) which translates into 220μg/1000 kcal. These values have been shown in multiple studies to be the recommended maximum allowance of iodine that would result in no abnormalities.
Lugol's iodine contains potassium iodide and a stoichiometric amount of elemental iodine, so that significant amounts of triiodide ion exist in this solution.
Thyroid hormone is vital during pregnancy. The unborn baby's brain and nervous system need thyroid hormone to develop. During the first trimester, the baby depends on the mother's supply of thyroid hormone. At 10 to 12 weeks of pregnancy, the baby's thyroid begins to work on its own. But the baby still depends on the mother for iodine, which the thyroid uses to make thyroid hormone. Pregnant women need about 250 micrograms (mcg) of iodine a day. Some women might not get all the iodine they need through the foods they eat or prenatal vitamins. Using iodized salt — salt that has had iodine added to it over plain table salt is recommended. Prenatal vitamins that contain iodine are also recommended.