Instruct: Given a question, retrieve documents that answer the question.
Query: What is the average volume of blood in an adult human?
A typical adult has a blood volume of approximately 5 liters, with females and males having approximately the same blood volume.[1] Blood volume is regulated by the kidneys.
Blood accounts for 7% of the human body weight,[3][4] with an average density around 1060kg/m3, very close to pure water's density of 1000kg/m3.[5] The average adult has a blood volume of roughly 5 litres (11USpt),[4] which is composed of plasma and several kinds of cells. These blood cells (which are also called corpuscles or "formed elements") consist of erythrocytes (red blood cells, RBCs), leukocytes (white blood cells), and thrombocytes (platelets). By volume, the red blood cells constitute about 45% of whole blood, the plasma about 54.3%, and white cells about 0.7%.
On average, about 8.1% of plasma proteins attached to doripenem; it is separate from drug concentrations of plasma. Doripenem’s distribution volume is close to that of extracellular fluid volume in humans (18.2 L). When doripenem is essentially stable, the average volume of distribution is approximately 16.8 L. Within the few of the body’s fluids and tissues, Doripenem is filtered successfully as well as reaching concentration levels that are able to restrain from more vulnerable bacteria than what is required.
The table at right shows circulating blood volumes, given as volume per kilogram, for healthy adults and some animals.[6] However, it can be 15% less in obese and old animals.[6]
An average adult human contains about 0.7 kg of phosphorus, about 85–90% in bones and teeth in the form of apatite, and the remainder in soft tissues and extracellular fluids (~1%). The phosphorus content increases from about 0.5 weight% in infancy to 0.65–1.1 weight% in adults. Average phosphorus concentration in the blood is about 0.4 g/L, about 70% of that is organic and 30% inorganic phosphates. An adult with healthy diet consumes and excretes about 1–3 grams of phosphorus per day, with consumption in the form of inorganic phosphate and phosphorus-containing biomolecules such as nucleic acids and phospholipids; and excretion almost exclusively in the form of phosphate ions such as and . Only about 0.1% of body phosphate circulates in the blood, paralleling the amount of phosphate available to soft tissue cells.
In terms of surface area, the skin is the second largest organ in the human body (the inside of the small intestine is 15 to 20 times larger). For the average adult human, the skin has a surface area of between 1.5-2.0 square meters (16.1-21.5 sq ft.). The thickness of the skin varies considerably over all parts of the body, and between men and women and the young and the old. An example is the skin on the forearm which is on average 1.3 mm in the male and 1.26 mm in the female. The average square inch (6.5 cm²) of skin holds 650 sweat glands, 20 blood vessels, 60,000 melanocytes, and more than 1,000 nerve endings. The average human skin cell is about 30 micrometers in diameter, but there are variants. A skin cell usually ranges from 25-40 micrometers (squared), depending on a variety of factors.
The average human respiratory rate is 30-60 breaths per minute at birth, decreasing to 12-20 breaths per minute in adults.
Xenotransfusion uses non-human animals to aid in the shortage of blood for blood transfusion in humans. Although there needs to be more study on the topic some scientists are already considering the idea to use Sus scrofa domesticus (pigs) for blood transfusion. To come up with this answer they tested many animals to see which one was the best candidate for blood donation. As a result, pig red blood cells (pRBCs) showed more characteristics similar to that of a human. Starting with RBC diameters (pig 6 μm: human 7.2 μm) and RBC counts (pig 5.7 to 6.9 million/ll; human 4.2 to 6.2 million/ll) and, RBC average lifespan (86 vs. 120 days). Current evidence shows that pRBCs will function normally in humans due to a relation between porcine blood groups and human ABO group system. In addition, it is possible to produce pigs with type O blood and it is also possible to genetically modify the pig to make its blood more compatible with humans. Sus scrofa domesticus’s blood will be used to save lives and to increase blood quantity. The organism will be kept alive and no serious harm will be involved in XTF. It will be similar to how blood is removed from humans. Only 10% of the animal’s blood volume will be used each time, therefore, it is ethically acceptable to raise pigs for periodical blood collection as it does not damage the health of the animal. It will also be ethical to use pRBCs on humans since it will not cause a severe harm on human’s health. At the moment XTF is not a real necessity because a lot of people are willing to donate their blood and there is not a significant shortage on blood. However, it represents a great opportunity for new science as well as an unlimited blood bank for blood transfusions.
The blood's red color is due to the spectral properties of the hemic iron ions in hemoglobin. Each human red blood cell contains approximately 270 million of these hemoglobin molecules. Each hemoglobin molecule carries four heme groups; hemoglobin constitutes about a third of the total cell volume. Hemoglobin is responsible for the transport of more than 98% of the oxygen in the body (the remaining oxygen is carried dissolved in the blood plasma). The red blood cells of an average adult human male store collectively about 2.5 grams of iron, representing about 65% of the total iron contained in the body.[20][21]
About 55% of blood is blood plasma, a fluid that is the blood's liquid medium, which by itself is straw-yellow in color. The blood plasma volume totals of 2.7–3.0 liters (2.8–3.2 quarts) in an average human. It is essentially an aqueous solution containing 92% water, 8% blood plasma proteins, and trace amounts of other materials. Plasma circulates dissolved nutrients, such as glucose, amino acids, and fatty acids (dissolved in the blood or bound to plasma proteins), and removes waste products, such as carbon dioxide, urea, and lactic acid.
The term macrocytic is from Greek words meaning "large cell". A macrocytic class of anemia is an "anemia" (defined as blood with an insufficient concentration of hemoglobin) in which the red blood cells (erythrocytes) are larger than their normal volume. The normal erythrocyte volume in humans is about 80 to 100 femtoliters (fL= 10 L). In metric terms the size is given in equivalent cubic micrometers (1 μm = 1 fL). The condition of having erythrocytes which (on average) are too large, is called macrocytosis. In contrast, in microcytic anemia, the erythrocytes are smaller than normal.
The normal concentration of 3-methylhistidine in the urine of healthy adult humans has been detected and quantified in a range of  micromoles per millimole (μmol/mmol) of creatinine, with most studies reporting the average urinary concentration between 15–20 μmol/mmol of creatinine. The average concentration of 3-methylhistidine in human blood plasma has been detected and quantified at 2.85 micromolar (μM) with a range of  μM. The average concentration of 3-methylhistidine in human cerebrospinal fluid (CSF) has been detected and quantified at 3.82 μM with a range of  μM.
In the physiology of the kidney, renal blood flow (RBF) is the volume of blood delivered to the kidneys per unit time. In humans, the kidneys together receive roughly 25% of cardiac output, amounting to 1.1 L/min in a 70-kg adult male. RBF is closely related to renal plasma flow (RPF), which is the volume of blood plasma delivered to the kidneys per unit time.
The average total lung capacity of an adult human male is about 6 litres of air.
The female lays about three eggs a day. The eggs take 6–8 days to hatch, and there are three nymphal stages which together take 10–17 days before the adult develops, making a total life cycle from egg to adult of 16–25 days. Adults live for up to 30 days. Crab lice feed exclusively on blood, and take a blood meal 4–5 times daily. Adults are 1.5–2.0 mm long and flattened. They are much broader in comparison to head and body lice. Adults are found only on the human host and require human blood to survive. If adults are forced off the host, they will die within 24–48 hours without a blood feeding. Pubic lice are transmitted from person to person most-commonly via sexual contact, although fomites (bedding, clothing) may play a minor role in their transmission.
The essential components of the human cardiovascular system are the heart, blood and blood vessels. It includes the pulmonary circulation, a "loop" through the lungs where blood is oxygenated; and the systemic circulation, a "loop" through the rest of the body to provide oxygenated blood. The systemic circulation can also be seen to function in two parts – a "macrocirculation" and a microcirculation. An average adult contains five to six quarts (roughly 4.7 to 5.7 liters) of blood, accounting for approximately 7% of their total body weight. Blood consists of plasma, red blood cells, white blood cells, and platelets. Also, the digestive system works with the circulatory system to provide the nutrients the system needs to keep the heart pumping.
Inuit adaptation to high-fat diet and cold climate has been traced to a mutation dated the Last Glacial Maximum (20,000 years ago). Average cranial capacity in modern human populations varies in the range of 1,200 to 1,450 cm (adult male averages). Larger cranial volume is associated with climatic region, the largest averages being found in populations of Siberia and the Arctic.
Both Neanderthal and EEMH had somewhat larger cranial volumes on average than modern Europeans, suggesting the relaxation of selection pressures for larger brain volume after the end of the LGM.
The volume of the blood sample collection is very important in experimental animals. All nonterminal blood collection without replacement of fluids is limited up to 10% of total circulating blood volume in healthy, normal, adult animals on a single occasion and collection may be repeated after three to four weeks. In case repeated blood samples are required at short intervals, a maximum of 0.6 ml/kg/day or 1.0% of an animal's total blood volume can be removed every 24 hours. The estimated blood volume in adult animals is 55 to 70 ml/kg body weight. Care should be taken for older and obese animals. If blood collection volume exceeds more than 10% of total blood volume, fluid replacement may be required. Lactated Ringer's solution (LRS) is recommended as the best fluid replacement by National Institutes of Health (NIH). If the volume of blood collection exceeds more than 30% of the total circulatory blood volume, adequate care should be taken so that the animal does not suffer from hypovolemia.
Massive aminopterin overdosage in humans (i.e. > 40 mg AMT in an average 70 kg adult), should be approached with an initial leucovorin dose of 100 mg (50 mg/m), given intravenously and continued at 6 hour intervals until the hematological abnormalities are improved (likely 8–12 courses or more). Additionally, to prevent reversible aminopterin-mediated nephrotoxicity manifesting as increases in serum creatinine and which further delays drug elimination, urinary alkalinization with and volume expansion should be considered in cases of massive aminopterin overdosage, particularly those involving greater than 100 mg AMT in an average 70 kg adult human.
The main intravascular fluid in mammals is blood, a complex mixture with elements of a suspension (blood cells), colloid (globulins), and solutes (glucose and ions). The blood represents both the intracellular compartment (the fluid inside the blood cells) and the extracellular compartment (the blood plasma). The other intravascular fluid is lymph. It too represents both the intracellular compartment (the fluid inside its lymphocytes) and the extracellular compartment (the noncellular matrix of the lymph, which is roughly equivalent to serum). The average volume of plasma in the average (70 kg) male is approximately 3.5 liters. The volume of the intravascular compartment is regulated in part by hydrostatic pressure gradients, and by reabsorption by the kidneys.
In humans, mature red blood cells are flexible and oval biconcave disks. They lack a cell nucleus and most organelles, in order to accommodate maximum space for hemoglobin; they can be viewed as sacks of hemoglobin, with a plasma membrane as the sack. Approximately 2.4 million new erythrocytes are produced per second in human adults.[3] The cells develop in the bone marrow and circulate for about 100–120 days in the body before their components are recycled by macrophages. Each circulation takes about 60 seconds (one minute).[4] Approximately a quarter of the cells in the human body are red blood cells.[5][6] Nearly half of the blood's volume (40% to 45%) is red blood cells.
When blood is lost, the greatest immediate need is to stop further blood loss. The second greatest need is replacing the lost volume. This way remaining red blood cells can still oxygenate body tissue. Normal human blood has a significant excess oxygen transport capability, only used in cases of great physical exertion. Provided blood volume is maintained by volume expanders, a rested patient can safely tolerate very low hemoglobin levels, less than 1/3 that of a healthy person.
Human: "B. malayi" undergoes further development in the human as well as sexual reproduction and egg production.
1-2 The infective larvae (L3) actively penetrate the skin through the bite hole and develop into adults in the lymphatic system over a span of 6 months. Adult worms can survive in the lymphatic system for 5–15 years
3. The male and female adult worms mate and the females produce an average of 10,000 sheathed eggs (microfilaria) daily The microfilariae enter the blood stream and exhibit nocturnal periodicity and subperiodicity.
4. Another mosquito takes a blood meal and ingests the microfilariae. Infection depends on the mosquito taking a blood meal during a periodic episode – when microfilariae are present in the bloodstream.
It is estimated that the worldwide average height for an adult human male is about , while the worldwide average height for adult human females is about . Shrinkage of stature may begin in middle age in some individuals, but tends to be typical in the extremely aged. Through history human populations have universally become taller, probably as a consequence of better nutrition, healthcare, and living conditions. The average mass of an adult human is for females and for males. Like many other conditions, body weight and body type is influenced by both genetic susceptibility and environment and varies greatly among individuals. (see obesity)
Mean corpuscular volume (MCV) is the average volume of a red blood cell and is calculated by dividing the hematocrit (Hct) by the concentration of red blood cell count.