#
# test/network/bio/db/kegg/test_genes_hsa7422.rb - Unit test for Bio::KEGG::GENES
#
# Copyright::  Copyright (C) 2019 BioRuby Project <staff@bioruby.org>
# License::    The Ruby License
# Contributor:: kojix2 <2xijok@gmail.com>
#

# loading helper routine for testing bioruby
require 'pathname'
load Pathname.new(File.join(File.dirname(__FILE__), ['..'] * 4,
                            'bioruby_test_helper.rb')).cleanpath.to_s

# libraries needed for the tests
require 'test/unit'
require 'bio/db/kegg/genes'
require 'bio/io/togows'

module Bio
  # This test is moved from test/unit/bio/db/kegg/test_genes.rb
  # and modified to get sample data from the internet
  # because of KEGG data license issue.
  #
  # Note that this test may fail due to the data entry updates in KEGG.
  class TestBioKEGGGENES_hsa7422 < Test::Unit::TestCase
    str = Bio::TogoWS::REST.entry('kegg-genes', 'hsa:7422')
    DATA = str.freeze

    def setup
      # filename = File.join(BioRubyTestDataPath, 'KEGG/hsa7422.gene')
      @obj = Bio::KEGG::GENES.new(DATA)
    end

    def test_diseases_as_strings
      expected = ['H01456  Diabetic nephropathy',
                  'H01457  Diabetic retinopathy',
                  'H01459  Diabetic neuropathy',
                  'H01529  Avascular necrosis of femoral head',
                  'H02559  Microvascular complications of diabetes']

      assert_equal(expected, @obj.diseases_as_strings)
    end

    def test_diseases_as_hash
      expected = { 'H01456' => 'Diabetic nephropathy',
                   'H01457' => 'Diabetic retinopathy',
                   'H01459' => 'Diabetic neuropathy',
                   'H01529' => 'Avascular necrosis of femoral head',
                   'H02559' => 'Microvascular complications of diabetes' }
      assert_equal(expected, @obj.diseases_as_hash)
    end

    def test_drug_targets_as_strings
      expected = ['Abicipar pegol: D11517',
                  'Aflibercept: D09574<JP/US>',
                  'Aflibercept beta: D10819<JP>',
                  'Bevacizumab: D06409<JP/US>',
                  'Bevasiranib sodium: D08874',
                  'Brolucizumab: D11083<JP/US>',
                  'Dilpacimab: D11642',
                  'Emvododstat: D11890',
                  'Faricimab: D11516<JP/US>',
                  'Ivonescimab: D12808',
                  'Navicixizumab: D11126',
                  'Pegaptanib: D05386',
                  'Ranibizumab: D05697<JP/US>',
                  'Tarcocimab: D12507',
                  'Tarcocimab tedromer: D12508',
                  'Vanucizumab: D11244']
      assert_equal(expected, @obj.drug_targets_as_strings)
    end

    def test_networks_as_strings
      expected = ['nt06219  JAK-STAT signaling (cancer)',
                  'nt06225  HIF-1 signaling (cancer)',
                  'nt06227  Nuclear receptor signaling (cancer)',
                  'nt06262  Pancreatic cancer',
                  'nt06264  Renal cell carcinoma',
                  'nt06360  Cushing syndrome',
                  'nt06526  MAPK signaling',
                  'nt06528  Calcium signaling',
                  'nt06530  PI3K signaling',
                  'nt06542  HIF signaling',
                  'N00079  HIF-1 signaling pathway',
                  'N00080  Loss of VHL to HIF-1 signaling pathway',
                  'N00081  Mutation-inactivated VHL to HIF-1 signaling pathway',
                  'N00095  ERBB2-overexpression to EGF-Jak-STAT signaling pathway',
                  'N00317  AhR signaling pathway',
                  'N01412  Metals to HTF-1 signaling pathway',
                  'N01592  GF-RTK-RAS-ERK signaling pathway',
                  'N01641  RTK-PLCG-ITPR signaling pathway',
                  'N01656  GF-RTK-PI3K signaling pathway',
                  'N01658  GF-RTK-RAS-PI3K signaling pathway',
                  'N01870  HIF-2A signaling pathway',
                  'N01873  VHL mutation to HIF-2 signaling pathway']
      assert_equal(expected, @obj.networks_as_strings)
    end
  end # class TestBioKEGGGENES_hsa7422
end # module Bio
