Depressing and Underequipped
I am very surprised to see so many people writing "clean" in the reviews. That was not my room. 
I had a room on the 3rd floor, with musty, stained carpets, old paint and fixtures. It was not pleasant. 
No heat in the room - I used the built-in hairdryer to warm up enough so I could fall asleep. 
But the final insult was the gym. When I finally found it, it was a sad "check the box we have a gym" gym - tiny, stuffy, depressing room with 2 treadmills. Then neighborhood is not great for a run, very downtown urban, but that was all I had. I ran up to Knob HIll, and the view from California street was the best part of the stay. 
Come back to Mark Twain after they've renovated.