Too many things went wrong
I stayed at this hotel for a conference. 
Pros:
- next to conference center
- 5-10 minute walk to Gaslamp district
- Not bad hotel restaurant (called Sally's) 
- if you get a room with a view the views are lovely
- lovely lobby
Cons:
- completely unreliable wireless internet connection
- service was spotty 
- breakfast prices were outrageous and no a la carte
- rooms were somewhat run down
Our experience here was negative for several reasons.
First, we arrived at midnight due to a delayed flight, and despite having checked in using their on-line check-in service, they didn't have a room for us on arrival. They ended up finding a shoddy room for the first night that had a shower that sprayed all over the bathroom. They moved us the next night to an equally shoddy room (bathrooms especially need renovating), but with a working shower. In fairness, they did give us free breakfast the first day by way of apology (no small thing since the breakfasts are way overpriced).
Second, the internet didn't work at all in the conference rooms or main areas outside the conference rooms. Many of the conference goers complained about the awful internet connections. In the rooms, the internet worked about 30% of the time, but was incredibly slow.
Third, the blow dryers didn't work in either of the rooms. Each time I had to call down for a new blow dryer (not ideal when you are rushing to make a conference session on time).
Fourth, one night our neighbors threw a loud party that woke us up at 2am. We called down and complained, and they sent someone up. The music stopped but the yelling continued. We had to call again before they sent someone up to shut it down completely (which they did).
Fifth, the breakfast is broken down into three types of buffets and you had to keep track of what was included in what buffet (e.g., cheese and salmon was not included in one of them but was in the other two). They kept the food all in the same area so you just had to work out what you could eat depending on which exorbitant price you wanted to spend.
Sixth, we asked the concierge to book a restaurant for us and they talked us out of the restaurant we had researched on-line, and promised a better experience somewhere else. They gave us a card promising a free appetizer at this other restaurant. The food at the restaurant they sent us to was terrible, and it was likely that the hotel had some sort of deal with restaurant to send over customers.
There are lots of hotels along the waterfront. I'd recommend considering another one instead of this one.