Great base for a business trip
Stayed for a business trip in October 2012 and had a great time. The location couldn't be better for the Gaslamp District and sea-front and you can pretty much walk anywhere else easily - so many great restaurants and bars right on your doorstep and SD being pretty small, a taxi anywhere else is pretty cheap.
I think us Brits are always pretty impressed with US hotels because they're just so much bigger, but even by the standards of other American hotels I've stayed in, this was great. Lovely big rooms with all mod-cons, good shower and plenty of power points in useful places - always a bug-bear of mine! I was also pleased to find local craft beer in the mini-bar - so much better than the same old stuff you get in every hotel!
Pool area is really nice and although I didn't go for a swim myself, it was certainly big enough for laps by the looks of things and there was a separate jacuzzi area so those that felt like lounging didn't get in the way of pool-swimmers. 
Had breakfast both in the Terrace Bar by the pool and the in-house Starbucks, both of which were great and really well priced. Also had room service one night and the tacos were excellent!
I actually ended up being stranded in SD for a few extra nights because of Sandy-related flight cancellations and the staff couldn't have been any more helpful, even putting me into a bigger and better room for the 'inconvenience' of having me move! Couldn't have been more pleasant in organising my extra nights.
I'd definitely visit again if I was in San Diego on vacation rather than business and would recommend to colleagues if they were in the city too!
Only complaint would be lack of breakfast - I think that's pretty normal in the US, it does make an extra expense.