Didn't live up to expectations (especially for the price!)
My wife and I stayed at ZaZa for 4 nights to have some medical screenings at MD Anderson Cancer Clinic in the TMC. We decided to stay here because we wanted an upscale stay before she began cancer treatment. The hotel has a GREAT location, convenient to the Museum district's parks and museums. Not much in the way of restaurants or shops around, butt still very scenic.
Overall appearance of the hotel is quite good, modern and eccentric. The common areas were "fun" but quite dark, didn't really enjoy that. The rooms were OK as far as amenities, we were disappointed by the lack of a tub in the bath. Also, there was a small room between the bed and bath that was completely useless with nothing but a single light and no power outlets, a waste of space. A wine-opener/bottle opener in the room would have been a nice touch as well with the wine already there.
Parking was a disappointment, $27 a night for valet seems quite steep with no option for self-parking. As my trip was on the government's dime, I did my best to save them a few dollars and used the street (inconvenient but doable).
Pool was nice, but disappointed to figure out there was no hot-tub as well, only the fountain behind. 
Biggest disappointment of our stay was the spotting of a very large cockroach in the hall our last night there (a good 2"). I killed it and immediately called down to the front desk to have it cleaned up, but it took at least an hour to have someone show up. My wife thinks she saw one in our room as well, which we kept free of food and trash. I'm not sure if it's the dark hallways or perhaps the room service dishes that may attract them, but it worries me regardless. One that big on the tenth floor points to more of an endemic problem than a chance coincidence. The fact that it took so long to have it cleaned up (45 minutes after my first call I actually went down to the front desk instead of calling) I find very disappointing for a hotel of this nature. Service otherwise was very good, but it's hard for us to get over this particular incident. I don't know if we'll stay again when we have to visit Houston.