Space age but personable
My husband and I and another couple spent the recent holiday weekend at the Yotel, using a Groupon deal that made this both an enjoyable and economical stay. The hotel is a superbly designed concept (using the theme of aircraft/cabins) that creates a truly efficient and comfortable use of space. While highly automated (self check in, self-baggage storage ROBOT!!) there was *always* a highly solicitous human to help out with check in, check out, hailing cabs, etc. 
Each room is truly small: bed, desk, shower bath/toilet, smallish spaces for hanging clothes, under-bed suitcase stowage. However, every surface is cleverly and thoughtfully designed to serve and remove any claustrophobic feel. The bath amenities include a hair dryer and two kinds of liquid soap. You will need your own extras. I found the futon-style bed a little firm, my husband did not. The place is gleamingly clean and sparkling white -- which helps with the small spaces. Every floor has a free LAVAZZA coffee galley (with teas and cocoa, too) that was a godsend during our cold-weather stay.
 The free breakfast was decent coffee and passable muffins: what is better are the ultra-mod green lounging pods next to the huge windows on the city. If it had been warmer, there is an outside patio that looks inviting. There are plenty of nearby delis/diners, and a CVS across the street.
The clientele runs to people who are much younger and cooler than my group, but we nonetheless felt quite happy here.