Clean, modern hotel in the Financial District
This is my second stay at Le Meridien. It's 4-5 blocks from the Bart, so overall pretty convenient though it did feel like a longer trek in the rain than it did when I stayed here during the summer. Overall rooms are clean and spacious with modern decor.
NOTE: They're currently undergoing construction, it's supposed to be done soon, but call and ask about the drilling schedule, I woke up to it at 11 am on a Sunday.
Last time I was here, I had a room that a slight view of the water, this time I was facing inwards towards the city. Apparently there's a venue across the street called Bentley Hall that can be rented for parties, there was a party Sat night. Luckily I was awake past when they were, but HIGHLY RECOMMEND getting a room not facing it. Between that and the drilling in the morning, the lady at the front desk compensated me with free breakfast, and the restaurant staff was accomodating as well in my food adjustments since I was only 1 person and the certificate was for 2.
Concierge can be a little frosty, but they get you the information you need. Ask for the bus map. Overall, quite comfortable, the deal I had this time had free wifi in the room (normally not) and also free parking. Best part of the financial district is that it's away from the tourist clogged streets and walking up to the Italian district is a cinch. 
Also highly recommend Cafe Me around the corner for breakfast on weekdays. Super friendly, super cheap!