Horrible experience
Had an absolutely horrible stay here for a few days for a conference: 
- The rooms are very noisy - my wife and I were kept awake by sirens that sounded like they were just outside our window even though we were on the 13th floor. We complained about the room and were moved to an interior-facing room on the 16th floor... where we were kept awake by train whistles AND sirens that sitll sounded like they were just outside our room. Being a "trendy" hotel, the neighbors were frequently noisy and easily heard (including the guest next door having "bathroom problems"). 
- The location is a little dangerous, especially while trying to get back from the Gaslamp district at night - numerous homeless people and the like nearby. They have their "Acura Experience" which provides transportation... one way. You're on your own to get back.
- Charging for everything - an insane $35 a day for parking, $15 a day for extremely poor Internet (the wireless was unusable due to signal strength issues - the wired connection was at least workable), and we got charged an extra $7 for no reason at all (Hotel claims we took something from the refrigerator - we moved stuff around to make room for a couple sodas, they had it stuffed pretty full so you can't really store anything in it). An extra $20 a day for a room with a coffee maker - the lowest grade room doesn't have one. The room service is extremely expensive.
- They say they have in-room safes - our room on the 13th did, but not the 16th, so something to definitely make sure of.
- Some pretty bad maintenance problems - lighting problems (a bulb needed to be replaced and even then the fixture hummed pretty badly). One room's bathroom fan didn't work at all, and had mold around the door. This is probably caused by the very poor design of the bathrooms - they have a step-in shower with glass only on the half closest to the shower head, so the spray goes straight out onto the floor and possibly onto the toilet through the hole they leave if you're not really careful. The tile is also really slick when wet. Finally, all the elevators broke down one morning and everyone who wanted to leave had to take stairs down. They apparently got one elevator working by a couple hours later. The TV in the room on the 13th floor didn't work well (all the channels fuzzy, and the in-hotel channels not working).
- The service was varied by department. Valet was usually prompt (but for $35 a day, they should be!). We had to call down for maintenance or other things three times - once for the light bulb, once to get towels which took about a half hour, and once for coffee to actually get restocked since the cleaning staff failed to do so which was just ignored and was never delivered. The front desk people were good and did their best to address our problems. 
- They have removed the in-hotel spa, instead offering in room spa services. My wife opted to go to the (nice) Spa Velia right across the street as opposed to having strangers alone in our hotel room.
- The pool is very tiny and only four feet deep.
- The beds were nice, however all of the furniture looks very Ikea-ish, and the chair for the desk is extremely uncomfortable.