Very quaint
Small rooms, but nicely appointed with some eclectic furnishings, which only adds to the charm. The bed was comfortable, which is always a plus. The bathrooms are very small by todays standards, but keep in mind it is an old hotel so spa-ing it in the bathroom wasn't a thought when the place was built. A very nice lobby bar downstairs to unwind in before making it up to your room. I found the staff to be courteous, from the front desk, the maid service all the way to the beefeater doormen out front. Everyone had exceptional customer service skills. For a late night drink and dancing, you can't beat the Starlight lounge on the top floor, what a cool place.
As with all San Francisco hotels, smoking is only allowed out front at designated areas. I have stayed at the Hilton on O'farrell several times and the aggresive homeless were non-stop This is probably due to their location next to the tenderloin area. I didn't experience this once at the Drake and I suspect their location on Powell Street may have someting to do with that. 
Within walking distance to Union Square and Chinatown. Another benefit is that the cable cars run up and down the street, so getting to Gairadelli Square and elsewhere is a breeze. OH, and did I mention, there is a Starbucks on the corner and a drugstore directly across the street, very convienent. All in all, a nice little place.