Once bitten
Before you decide which hotel to stay at in Venice, think twice about whether you want to stay in Venice at all. If you don't have at least five body piercings, four tattoos and a crystal meth habit you will feel out of place here. It's a very grubby resort.
The suites here are quite well appointed and the first impression of the rooms is that they are much nicer than the common parts of the hotel would suggest.
However, there are a number of drawbacks that become evident!
1. The standard of the housekeeping is very poor. Don't be surprised if a few of your predecessors hairs remain in the basin and shower to greet you on your arrival. I recommend re-washing up any cup or utensile before you use it.
2. The bedding is old and grubby, don't look under the sheets at the matress if you want to sleep soundly. I was bitten by bedbugs on my first night and retreived two large blood swollen creatures from the bed the next morning. Manangement were very apologetic and offered to refund my remaining stay. It was President's Day weekend and I was very jet-lagged so I took up their offer to clean de-louse the room and I stayed. I was bitten again on my third and last night so the proceedure was clearly ineffective.
3. The walls are paper thin and the amourous activities of your neighbours across the corridor are clearly audible as are the fights down below between the homeless drug addicts who live on the streets of Venice. Although the hotel has a no smoking policy don't be surprised if the coridoors are perfumed with smell of residents enjoying the prescriptions of the many 'Medical Marajuana Doctors' who have set up shop along the broadwalk. 
I don't know if there is better to be had in Venice, but I would recommend moving up to Marina del Rey and finding something slightly cleaner and more conventional unless you have a strong need to be here, especially as this hotel is not that cheap given the drawbacks listed above.