Good location, friendly and professional service
I stayed at the Hyatt 48 Lex. It's a small more boutique type hotel with very personal service.
Rooms are modern, ideal for someone working while traveling. I enjoyed my small outside balcony and the expresso maker in the room.
The hotel has a comfortable lounge serving coffee, soft drinks and pastries all day. I used the lounge for my business meetings - and it worked great,
The gym in the basement is small, but had cardio equipment and a combined weight machine. I always feel hotels should emphasis more on outstanding fitness facilities - but I guess this is hardly ever the case at US city hotels.
The restaurant was good, but a bit expensive. Perhaps prices are normal for being in the center of Manhattan.
It was easy to explore Manhattan from this location.
Overall my three night stay was pleasant, I got my work done and got some rest. 
Talking about rest: my room was next to the staff door on my floor. There were only 4 rooms on one floor, and I was woken up several times by staff slamming doors and having their radio on. After I complaint the additional two nights were quiet and I was able to sleep very well.