Would stay here again if needing access to Indianapolis
Stayed recently at this Hilton property mostly based on the generally positive reviews here on Trip Advisor in order to attend the Indiana State Fair. This property is clean, well kept, very accessible to the freeway, and in a decent area. Located just off I-65 at the Southport exit, the HIIS is about a 15 minute drive from downtown and/or the fairgrounds. The hotel is not in any kind of neighborhood with the only things in the vicinity being other hotels, fast food places, and restaurants like the Steak & Bake.
The front desk staff were friendly and efficient. My room had no issues though I am a little worried about the layout of the bathroom for any patrons with less flexibility than a monkey. I believe the hotel to be smoke-free and I did not notice any stink around the outside of the hotel as is so often the case with so-called "smoke-free" properties.
My room was clean, fresh-smelling, and quiet. I did not hear anything from my neighbors (rooms free of my neighbors’ noise are important to me). When I was there, most of the other guests appeared to be business travelers. I appreciated the small microwave and refrigerator as I had stopped by the Kroger’s on Madison a few miles away for snacks. No problems with the wi-fi or the business center. They offered basic cable on an LCD television. I was looking for a guest laundry but did not see one. The breakfast area offered coffee, tea, fruit, pastries, several hot choices, and cereal. 
In summary, I recommend this property for anybody with a vehicle wanting access to Indianapolis but not wanting to stay in the downtown area.