Older hotel, central location
I stayed in a Historic room with Queen Bed at the Handlery Hotel in San Fran in mid-June. I paid the group (conference) rate, which was reasonable considering San Fran's skyhigh hotel prices. The room was slightly on the small side but tastefully-furnished and had several bedside and desk lamps to ensure the room could be brightly lit even if you lower the window blinds. Flatscreen TV was big, in the room were 2 small armchairs and coffee table, and writing desk, both of which were next to large windows which overlooked an airwell and exhaust (no view at all). The bathroom was about average sized, but was long and narrow with lots of unusable space in the back (see pic) possibly because it was near the edge of the building. Hotel location is a big plus, off of Powell Street (5 mins walk from the Powell Street BART station, 8-10 mins from Moscone Centre, where I was attending a conference, 15 mins from Chinatown, 20-25 mins from the Ferry terminal). The hotel can be accessed on Geary Street (main entrance) or O'Farrell (covered carpark).
My Historic room appeared to be in the older wing, it showed its age in several places if you look closely, but the hotel did a good job with maintenance and upkeep. I arrived at 10:30am and was surprised my room was available for instant check-in. Check-in was a breeze. Main desk was always helpful. There is a concierge desk in the reception as well. There was a gym, business center (2 computers + printer) and an outdoor pool surrounded on all sides by 3-4 storeys of the older and newer wings. My only gripe about the pool is smoking permitted near the pool area. A guest it up a cigar while i was swimming, with the poor air circulation, I kept breathing in cigar smoke. 
I asked reception about the premium rooms, which cost $40-60 more and was told they are bigger and enjoy better views of the city. I'd stay at the Handlery Hotel in future and will likely stay in the bigger premium rooms in future.