Bedbugs
The stay at the St. James Ramada started out well enough, but after a few nights I realized something was wrong. Each morning I would wake up with one or two or three bites on my body that had not been there the night before. At first I thought it might be a spider bite, but after successive nights of more and more bites, I thought that it had to be something else. I did some research and found that I was encountering bed bugs. I searched the room for evidence and found the feces smeared signature of the bedbugs on a few spots around the room. 
After finding definitive proof, I left the hotel as quickly as I could, cancelling my stay for that evening. The front desk staff was mostly sympathetic, and did not charge me for the night that I cancelled. I was also able to get a refund on one of the other nights that I stayed there, so that was helpful. 
If the bedbug issue hadn't happened, the hotel would have been fine, though I think it is pricey for the actual amenities and quality of the rooms.