Dirty floors, dirty dishes, loud a/c, good location, nice staff, refused to admit we checked out
I stayed at Home2 Suites for 3 nights in October 2012. The concept of the hotel is nice - each room has a kitchenette with a pretty nice setup, including a nice microwave and sink area and a sizeable fridge. It has a great location only 2 short blocks from the main drag of the Riverwalk, which was probably my favorite thing about this hotel. 
The desk and staff were very pleasant, especially Mia at the front desk.
However, be aware, you get (or don't get) what you pay for, and in this case, there were a few pretty significant downsides to this hotel:
-- The floors of our room were so dirty that clean white socks would turn black on the bottom after just walking across the carpet one time. Ewww.
-- My in-laws, who also stayed at this hotel, arrived to their room to find a dishwasher full of unwashed dishes. Ewww.
-- My in-laws also didn't have the proper bedding in their room for the pull-out couch. They were able to find an extra pillow, but no extra sheets or pillowcases.
-- Don't expect more from breakfast than some yogurt and a bagel. Avoid the "sandwiches" at all costs - they are terrible and barely have any egg or sausage on them. They are mostly half an english muffin covered in weird orange sauce.
-- The air conditioners in the room are extremely loud, as noted by most of the reviewers here. It didn't really bother me, since the bed was on the other side of the room, but my 7-month old was terrified and would cry if we took him near the a/c unit. It's that loud. 
-- The valets take forever to get your car. We called them 30 mins ahead on the day we were leaving to ask for our car to be ready at a specific time, and we still stood waiting on the sidewalk for 15 minutes past that time before they finally showed up with it. It wasn't even a particularly busy time - I don't know why it took so long.
-- We checked out one night early and received a receipt / check-out slip before leaving the hotel. When I called Expedia to ask them to refund our final night's stay (as they previously said they would), the hotel REFUSED TO CONFIRM THAT WE HAD CHECKED OUT. I was extremely frustrated by this, since we told the front desk multiple times that we planned to leave early, and, in fact, checked out and received a time-stamped receipt showing that we had departed. I do not understand why the hotel would not tell Expedia that we had left. 
Bottom line -- Only stay here if you want to be close to the Riverwalk at a bargain rate, but don't expect much, and bring flipflops to keep your feet off the disgusting floors. I won't be staying here again.