name says it all
The name says it all. This hotel is indeed a Sanctuary. The dim lighting, music, and ambience in the lobby felt like you are in a spa.
Moved hotels after 3 nights to try this one out due to the great reviews I have read and I"m glad that I did. Stayed one night on March 29th and I wished that I stayed here for my entire stay. The hotel is located half a block away from Time Square. There is a Fedex across the street which came in handy as I had to ship a package back to the office. All of the staff were very friendly and greeted me by name. 
The hotel has a great lounge and the lobby/guestroms looked newly renovated. The bed was comfortable and it nice having a view. The bathroom, especially the shower stall was one of the best ones I've seen. I was in room 513 and it was facing out onto 47th street. The tiles in the bathroom were neat. (It felt like leather). It had a stocked minibar and the prices were decent. The restaurant and rooftop bar was not yet open, but there was complimentary breakfast in the morning. They do not have a fitness centre but they offer passes to a private gym.
There are steps at the entrance and I didn't see a ramp, but the doorman will assist with luggage. They also have a STAR Manager (concierge) who helped with restaurant recommendations.
 I will definetly use this hotel again if the next time I am in NYC