Good location but nothing special.
I got the Grand Hyatt through a Priceline bid for $60 + tax (Sat. night). So, not too shabby.
If you're looking for proximity to Downtown, this is it. It's one block from the 16th St. area. But because it's Downtown, there is only valet parking and it costs $28. I did find street parking in front of the hotel -- be mindful of the parking signs though and pay attention or you'll get ticket. Street allows for overnight parking but only on certain nights and you have to move it by 8 a.m. 
A few days before our trip, I called the hotel to make sure I was getting a king-sized bed. The receptionist said because it was a Priceline deal, I automatically get reserved for a king, so I said "great, I guess I didn't have to call to confirm then." Lo and behold, when we showed up to check-in, they didn't have anymore king beds and gave us two fulls. Not a huge deal, but I definitely let them know that they were in the wrong because I called about it beforehand. Minor annoyance.
The room itself was clean and everything that I needed a room to be. Beds were comfortable and shower had good water pressure. 
The hotel is undergoing a major renovation but I didn't notice any major construction when we were there last week - but I'm sure it'll get busy after the holidays. 
Overall, a decent stay if you can get it at a good price. Pretty sterile but I'm OK with that.