Never again
This place is like a good impressionist painting - looks impressive from a distance, but is a mess when you actually get up close an personal. We actually left this hotel in the middle of the night because we decided we'd rather be at the airport than at this hotel. Not many times I would say that about a hotel...
We stayed here as part of a package from Expedia for a wedding we were in town for. Our room was close to the elevator (read: LOUD) and was handicap accessible (we didn't need/request this, but the room was quite spacious). 
The GOOD: relatively recently remodeled, easy checkin/out process, clean, good location right on the 16th street mall (shopping, restaurants, public transportation, etc.).
The BAD: Walls are paper thin, the place is HUGE (two buildings) and not well-signed, the gym and pool were in the other building (not the main building where you check in) leading to a lot of schlepping, and our room was dark and looked out over the most depressing interior courtyard ever (looked like something out of the Hunger Games or 1984). The shower in our room was also not working very well.
The UGLY: On two occasions during our 3-night stay, an internal alarm system went off with a loud speaker directly inside our room yelling that there was NOT a fire emergency and that the previous issues had been resolved. The first time, it went away after a few repeats of the message. The second time, it was at 4am and went on for at least half an hour. The management couldn't turn it off, but were doing nothing to allay guests' concerns, and were actually *arguing* with guests who came to the front desk to inquire what was going on. I've not seen a hotel situation handled so poorly in a long time. The message was deafeningly loud in the rooms, and was disturbing since it didn't go off until *after* whatever issue set it off had apparently been "resolved" - leads one to wonder what would happen in the event of an actual emergency. Management offered us some extra rewards points for our trouble, but no vouchers for a free night or money back on our $100+ wasted on what was a horrible night's sleep (or lack thereof). We left the hotel at 4:30 that morning and went right to the airport, even though our flight wasn't until 10 that morning. That's how badly we wanted to get out of this hotel...
Also, the pool area, while nice looking in photos, was a complete *SCENE*. It looked like the set of a bad reality show, with people partying (there's a bar next to the pool) and taking up every last inch of space. We'd hoped to spend some relaxing down time by the pool, but felt completely out of place among the drunken revelers. Not exactly family-friendly. The same drunken revelers also took to yelling and running up and down the hotel halls in the wee hours of the morning, which management did nothing to stop, despite our complaints.
I will definitely be avoiding Sheratons in the future, and this one in particular (and I go to Denver several times a year). Horrible experience.