If you want to be close to the bay - RESERVE!
I was here recently for a conference. I had no idea what to expect and felt like the totally transplanted East-Coaster that I am. However, the staff are very nice, the hotel is fine; it's not fancy - but my room was spacious and clean, modern, and comfortable. It's a very short walk to the wharf. I didn't eat in the restaurant but I felt very comfortable and safe here. When you're visiting San Francisco, there's so much to do and see - you won't be in your room much and you'll be happy for the comfort and convenience at the end of the day.