Hotel Good, Location Tainted the Trip
Hotel: Clean, comfy beds, good facilities, recent renovation, very helpful staff, complimentary continental breakfast, free wifi (temperamental), hotel shuttle bus to tourist hot spots, noisy outside.
Location: TENDERLOIN! High homeless population on the hotels door step. OK it's safe to walk down the street during the day, HOWEVER, you will walk past a number of homeless people a long the way, accompanied by a strong smell of cannabis or urine in the air. Most will leave you alone, some will ask you for money, some just want to talk to you. In the evening, it's a no go, not so much because of the homeless, but people hanging around on the streets. 
Due to the location, this limited what we could do in the evening as even our tour bus suggested that tourists should not walk the tenderloin after dark. Taxi is $20 there and back to get you out of the area. Yes the hotel runs a shuttle but you don't want to be clock watching on holiday to keep with the shuttles schedule. Nor do you want to dodge the homeless like a computer game every time you leave the hotel and walk a few blocks.