Great Location, Small Beds, Quiet Room, Expensive Room Service
In brief.... too many Aussies, Quiet room (if you are NOT on the street), double beds a bit small, pillows not good, great location, expensive room service, not a ' stuck-up' hotel.
Aussie, Aussie, Aussie....oi, oi, oi.
Were we in San Francisco or Australia? It was hard to tell sometimes when walking around the hotel. The Handlery has obviously done an excellent sell job to Aussie travel agents as there appeared to be more Aussie's in the place than any other nationality. 
Apart from our toilet overflowing one morning over the bathroom floor and onto the carpet (nice way to wake up) and then having 3 cleaners in our little room with machines and plungers, it was a pretty good stay.
Although the room was on the small side, the beds were really too small for us. 2 double beds are just not enough for us with 2 kids in tow. Queen is good, double is really not that comfortable. I had tried to pre-book the Queen Queen room but the travel agent said that because we had children we could only upgrade when we got there. When we got there....no Queen Queen rooms available. The pillows were DREADFUL as well, but we were so tired and jet lagged we just put up with it.
The location of this hotel is in an excellent position. Right near the Cable Car, Union Square (where a lot of the tourist buses leave from), shops and restaurants.
We could never get the air-conditioning low enough either. That was a pain.
The highlight of our San Francisco trip was taking the open top bus over the Golden Gate bridge, wandering around Sausalito, catching a ferry back across the Bay past Alcatraz, wandering around the city looking at architecture, the Nordstroms building, riding the cable car, shopping at Levi, The Golden Gate park - Californian Academy of Sciences and the de Young gallery. What we didn't really like was Fisherman's Wharf - way to touristy and full of trashy shops.