Great stay; excellent value
Hotel 91 is located in Chinatown just North of the Manhattan Bridge. It's one block from Canal Street, two blocks from the F Train line, which runs up and down the middle of Manhattan, close to Little Italy and the Village. 
Odd entrance from street level into a long tunnel.... reception desk is on the 2nd floor. The desk clerks were very nice and very helpful. They suggested restaurants, gave directions and stored our luggage on our day of departure until we needed to leave for the airport.
Our room was clean and the beds are super comfortable. As long as you don't mind all night subway train noise (and it really wasn't that bad and the train track was next to our wall), this place is a great option for getting out of the touristy areas.
Biggest con is the elevator. It is VERY slow, especially during check out time. Take the stairs whenever possible. The other con: coffee and tea are served 24 hours; both are instant. :(