Pricey, trendy but in the middle of it all!
The Muse is a Kimpton property and relatively new by NYC standards. On 46th near Broadway. Its small, but very nicely designed. The rooms look more like an HGTV episode than a hotel. Lobby is small but has free coffee/tea in the morning and free wine/beer from 5-6pm. I've stayed twice on business and it was nice. I can't say that I'd spend the $400 if I was there for personal use but everything in NYC is $$. 
The only bad thing I can say is that one of my co-workers got "bumped" from her room. She showed up at 8pm to check in and they were sold out - had overbooked!! They put her up for free in another Kimpton Hotel on 29th, but it was very stressful. We found out later that it was because One Direction was staying there at the same time, but I guess be careful when you check in!