Clean, trendy, a nice stay.
My wife and I stayed at the Liason Hotel for one night for our anniversary. We were fairly happy with our stay, though it wasn't so amazing that we would stay here again if we were given the opportunity to try a different place.
The hotel is located about two blocks from Union Station and Judiciary Square. The location is one of the best things about the hotel. Its close to almost everything. The only downside is that the neighborhood to the west is slightly sketchy, but not so much that it ever worried us.
The hotel room itself was nice. Modern, maybe slightly on the smallish side. The bed was comfy, the bathroom was average. The TV was nice, but the quality of of the signal bordered on awful for some channels (non-HD). We were on the ninth floor and the view from our windows was of another nondescript building. I've heard the pool is nice, but we didn't have an opportunity to check it out.
We did eat at the hotel restaurant, but it looked pretty nice and was packed when we came through in the evening. We did order room service for breakfast. It was excellent, but very very expensive. Hard to justify $48 for some parfait and and bacon and egg sandwich.
The staff was very nice and and helpful. The cleaning staff busted in on us at 10am (checkout is 12pm), which was a little disconcerting. No knock or anything... they were apologetic, but I've never had that happen at a hotel before. 
I don't have much negative to say about the hotel, but it didn't really leave a lasting impression on me either. I would recommend it to friends, but maybe because I'm not familiar with the options in the area. We had a good time, so that's whats important to us.