Reasonable, Clean, Great Location
Echoing other travelers who've said that the Cosmopolitan Hotel Tribeca is a great value, great location with helpful staff. The Chambers Street subway entrance is right in front of the hotel and there are several good eateries, a Starbucks next door and a charming Art Nouveau-decorated French cafe serving a delicious and light breakfast. The first night I had to change rooms b/c it was too cold (quite unexpected since other reviewers complained rooms were too warm!) but the staff was accommodating and the next room was even nicer and larger. The rooms look newly renovated and for the reasonable rate, come with essential toiletries. The room was small but servicable to work at a desk and I loved the bathroom with tub/shower. The bed was divine and after some stressful business, I slept quite well.
All in all, the Comospolitan is a great find if you have some business or pleasure in Manhattan and don't mind being far away from Times Square and the other touristy places. For newbies to New York the location might be daunting to be so far from the well-known spots, but for others who are familiar with New York and the public transit system, the location can't be beat.