Yo'll love Yotel
I stayed in the Yotel in September 2012 and found it a quirky experience. I was sharing a bunk bed room with my friend for four nights. The location was really handy, and plenty of storage for us both. The only downside is the air conditioning fans are right by your head if you are sleeping in the bunk, so you wake up with ice on your nose! Me and my friend shared the bed in the end, to save us both from hyperthermia! 
The staff were great and hailed you cabs within seconds, and every morning we had free muffins and coffee on the terrace which is a lovely quiet start to your busy day in NYC. 
A good feature is your keycard only works in certain elevators so people visiting the resturant cannot access the rooms without a card. 
The galley with the vending machine, fridge and microwave was extremely handy storing all the cheesecake you cannot manage to eat! (not that ours ended up in the fridge...)
Although I did not enjoy the city as much as I thought I would, I would highly reccomend staying at the Yotel.