Centrally located hotel in New York City
My boyfriend and I stayed in the Affinia Manhattan for 3 nights at the beginning of January 2012. It is located right across the road from Penn Station so we took a train directly from Newark to the hotel ($12.50, 15 minutes). This was really convenient and meant that there was no stress of lugging suitcases around the city. 
The room was small enough but we knew this in advance. The room was clean and the bed was comfortable. It was surprisingly quiet for such a central location. 
The gym is well equipped with 3 or 4 treadmills, a couple of cross trainers (elipticals), 4 bikes and some weight machines. There were no free weights. We ate in the hotel restaurant one night, the food was good, I can't remember how much we paid. There is a discount for residents eating in the restaurant. 
The Empire State Building is 3 or 4 blocks away, Times Square is also very close. The subway is two blocks away so it's very easy to get to anywhere in the city from the Affinia. 
I would definitely stay in this hotel again and I have recommended it to friends since our trip.