Great location, great service, great rooms.
The Oxford Hotel reminds me of something you would expect to see in a movie from the 50's - grand, elegant and charming. The staff are fantastic, providing a level of service many other establishments could learn from. The rooms some of the most comfortable i have stayed in - the beds are hugely comfortable, and shower and bathroom ameneties are brilliant. The locations is great for the Denver nightlife (downtown is pretty easy to navigate), and all of the best bars are within a 10 minute walk - unless you wish to use the complimentary car.
Can be a tad expensive at times (USD 370 a night when i last stayed due to the Denver Beer Festival), but generally this hotel is worth it.