A BIG NOOOOO! YIKES!
I booked my trip for my two daughter's and I and stayed there in August 2012. It wasn't my first choice, but even booking a month or more in advance, it was hard to find availability within our price range of no more than $350 a night. It looked interesting since I figured as a chain, there have to have been some sort of standards... (did I not learn from Embassy Suites, Tampa? lol) 
When I made the reservation, there were a few options and different pricing. I needed the space and so I reserved a King room for more money and specifically noted that my infant with her port-a-crib would also be in the room. Although I requested an early check in, I do realize that it's not always available.
The actual location is great, just a couple of blocks to Times Square, but good luck finding this place without circling a few blocks a million times, as the La Quinta sign is about as big as a brick and is hardly visible while walking by it, let alone driving! The entrance has roughly 5 or 6 stairs, and is NOT handicapped accessible, nor is having a stroller a great idea. Wouldn't have been so bad, but upon pulling up with my car, it took forever for the one bellman they have to even help me. He asked if I was checking in and then seemed disinterested even as he saw me unpacking a suitcase, the portacrib, stroller, baby bags etc etc, and having a hard time doing so on my own. Finally he half heartedly carried up the suitcase into the entrance. But I was on my own with the rest! Thank goodness for my oldest daughter's help. I valet parked the car, as their self parking is off premises and only around a $2 per night difference. The cost shown on the website for the Valet parking shows $28 a day. But beware, that is subject to change, as when I had to pay it upon check out, there was an issue to where it became $33 a day. It also has to be paid separately from your hotel bill, and in cash only. Thank God I had it, otherwise that would've been another issue on top of many at this cut rate dive.
Because a room was not readily available, the receptionist suggested we leave our stuff in the lobby and go do whatever. The problem, was that there was no security and only one bell man who was not always present. I saw other people too a little cautious about leaving their belongings. So I insisted we would stay with them until a room was available. At that time, she said she actually DID have one, so up we went carrying half of our luggage since only the portacrib, suitcase and other stuff fit on the one rack it seemed was all that they had.. Now, small doesn't even begin to describe the room. It was a glorified broom closet in between two fire escapes with sketchy window locks at best. The real issue though was that 1) it was a full size bed, 2) There was no space to move freely or put luggage down without blocking the entrance to either the room door or the bathroom. Needless to say, there was nowhere to even try to open the portacrib. So I immediately called down to the front desk and thanked them for getting us into a room early, but that my reservation explicitly stated I needed a KING room with room for the crib. After an hour at the front desk waiting for the elusive bell man that works at a snails crawl to show us a possible room on the 8th floor, we went up and agreed it was better. The catch though, was that just like the valet, even this price was now changing, even though I showed her my reservation and quoted price!! I think it should be illegal to advertise a price, get there, and they change it. So I could have this room, but it was going to be $10 she said, earlier to 'upgrade'. Best part is once I agreed, it became $15 extra a night. Are you kidding me??? So I was robbed in broad daylight. I had no choice, with two kids in tow, one being 14 months old, I couldn't exactly just go window shopping for another hotel at this late hour, which, by the way, was already pushing 4pm. Upon entering the bathroom, I see ONE BATH TOWEL, ONE HAND TOWEL AND TWO WASHCLOTHS... I kid you not. So I was lucky that their happened to be a housekeeper on the floor whom I was able to get more towels from. The shower was disgusting. I mean as a whole, the building should be demolished and rebuilt. There's no security as far as I can see, and anyone can freely walk in and out of the hotel from the street. The hallways are NOT air conditioned, so in the heat of an enclosed hotel in the summer at 95 degrees can get VERRRRY uncomfortable, especially in the elevator. The one redeeming thing I will say, is that the receptionist who checked us in, although she was changing the prices on everything, she did at least give decent directions and provided us with a street map. Again though, upon returning to our hotel at around 9:30 that night, we were on our own getting the stroller up the 5 or so steep steps into the hotel, if not for the help of a passerby. Next catastrophe? BREAKFAST. They advertise a hot continental breakfast, but what you get, is a few stale individually wrapped pastries, coffee and diluted juice and a very angry Indian man in a turban running it. Breakfast the next morning didn't change, so it wasn't as if they had just run out of stuff. On our last morning there, my older daughter came out from the breakfast room almost in tears, since as a diabetic who was low and needed juice, went into the breakfast room 10 mins after they closed to go pour herself some, only to be YELLED at by this rude man and cursed at!! Imagine? My 17 year old daughter who's all of 5 feet and a hundred pounds who looks 14! I was ready to go in there and rip him a new one, but I kept my composure and of course always like to keep a clear head. That was insane. Although housekeeping came each day, the linens were visibly not changed due to the fact that my daughter had spilled juice from her baby bottle on it, and upon going to bed the 2nd night, was still there. The floors weren't vacuumed either, as there were also bits of lint etc that were visible to the eye and in the same place. I'm wondering what exactly they did, besides make the bed and replace the towels.
Upon checking out, we waited about 20 minutes for our car to come and were notified that it had to be paid separately with cash only and that the charge was now $33 a day instead of the originally quoted price of $28. Upon waiting for our car, they just so happened to have work being done in the front vestibule that day. FLOOR work I guess to replace the tiles. The problem, is that there is only one entrance and all guests had to wait and take turns to come in or leave, because the workers were bringing in stacks of tiles and using the entrance as a holding spot for them. SERIOUSLY? There is no service entrance? It made it so difficult to carry my stuff out to my car, and not one employee offered to help. So 15 trips later back and forth and getting dirty looks from the workers (INCREDULOUS) we got in the car and vowed never again to stay there, or any other La Quinta for that matter, as if that's what $320 a night gets you, what on earth will an average $70-$120 get? A bedbug infested roach motel? NO thanks!