Best Location, great room layout, view from 26th floor, great employees
For our first visit to NY, we chose Doubletree Guest Suites right on Times Square, putting us in the middle of the action. We were steps away from the subway (bought the MTA $29 7 day unlimited passes), close to theaters (saw Spiderman show!), and restaurants (sampled lots of NY food items unique to the area). What I noticed about this Hilton property was the room layout contained a mini-fridge, microwave, 2 large modern flatscreen TVs, and separate bedroom, making it stand out among other hotels in the area. We were able to use a Britta water filtration unit and a special blow up airbed to make the trip even more comfortable with our family of 4.
I wanted to commend 2 people at the front desk that really exhibited professionalism and care, making hotel operations easy. Manny at the front desk was very helpful when we checked in. He even responded to our request for a room with a Times Square view, noticing we made it when we made the original reservations, but it was inadvertently left off our move in paperwork. We were able to move into a great room on the 26th floor with a killer view of Times Square the next night. Make sure you also chose a higher floor as we did, because Time Square can be really noisy if you stay on the lower levels of any hotel in the area! Ami, also at the front desk, was very professional and nice, offering to let us have late checkout at the end of our trip so we didn't have to wander around like nomads with our luggage bound for JFK. I talked to her a few other times with requests, and she was always very willing to help - the mark of a quality establishment. 
The people operating the front desk at this hotel care about their guests, in our two experiences with Manny and Ami. I was also very pleased to find most New Yorker's a very friendly bunch everywhere we encountered them. I brought my Southern California impressions of NY and left with great impressions of the people and rich culture of NY. 
The maids cleaning the rooms also listen to requests and try their best to do this quickly and efficiently. I am used to staying in rented timeshares, and the Doubletree Hilton here is the closest thing you get to that so close to Times Square. 
So, I would like to recommend Doubletree Guest Suites Times Square to anyone planning to take a vacation to Manhattan. Also, Scottevest and Craighoppers make great security clothing if you are concerned about how crowded NY streets are and want to keep your credit cards, MTA passes, and money safe - a problem in any big tourist city. Amazon sometimes has deals on the Craighoppers Kiwi Long shorts and Scottevest has a discount for new customers and daily deals. Both clothes are not cheap, but give you extra piece of mind when traveling.