Perfect locations and nice rooms
We stayed at Hampton Inn Manhattan-SoHo in december (4-10) and had a great experience :) 
The room was clean everyday with new beddings at towels etc. The breakfast was very nice, and had everything from waffles to eggs and fruit, juices and coffee etc. And there is a fine fitness room with the basic equipment you need.
The Hotel's location is perfect if you wish to around NY. It is located between two subways and the hotel will help you with the directions and maps. 
I give it 4 stars instead of 5 because one of the receptionists was not so helpful when we arrived and the same person had the same attitude the rest of the stay. But the manager J, was so helpful and fixed everything. So this could of course just be an unfortunate experience. 
I would recommend the hotel at any time and we already have family who will go there in the spring!