great hotel
We stayed 4 nights in Hotel Tomo for our vacations and we enjoyed it. Nosiy neighborhood and a little pricey (I travelled many places and it is the first time I see hotels that pricey... but you are in SF so it was expected).
Staff is very friendly and helpful. You are near the center so it is a great location (in the middle of Japantown) and less expensive than hotels in Fishermanwharf's or union square (about half price).
One negative point : if you want a shuttle to the airport make sure it will come on time. We waited 30 minutes for it. At least, the reception saw us still waiting and called the shuttle to make sure they did not forget us... really appreciated. 
I recommend this hotel.