My home in NYC.
I have been traveling at least twice a year to Manhattan for the past 4 years and this has become my hotel there. I love the location, the quiteness, the price/quality and their super friendly staff (seriously, friendly and extremely helpful). 
If you like to be close to the west village/soho area this is probably the best option unless you want to go for super expensive hotels like the W in Union Square. 
Great for business or pleasure. Free bottles of water every day, coffee, newspaper and wifi!!