The Affinia Shelburne--a keeper
Recently spent five nights at the Affinia Shelburne during my yearly trip to New York. Overall a very pleasant stay. I had a studio with kitchenette, which works for me in NYC, where coffee and bagels are never more than 100 feet from your door. The room was spacious and, most importantly, well lit. The bathroom, relatively smaller, but also well lit. The room was clean, comfortable and very quiet. I was on the 14th floor, in the back and it was the quietest hotel room I've ever had in NYC. 
There was a large wardrobe to hang clothes and a desk with drawers, but no dresser to unpack completely, so I had to live out of my suitcase. Not a problem for one, but perhaps more so for a couple.
I like the Murray Hill address, a few blocks from the 6 train and Grand Central--easy to go up, down or crosstown. Keep your eyes out for specials, which provide free upgrades and late check-out. 
All my requests were met with efficiency and satisfaction. My one meal at the Rare restaurant was good, the staff attentive. My only complaint is there are no free computers in the lobby. I don't like using my credit card in hotel computers, but there was no choice, as I don't have an Iphone or laptop.
Although it was somewhat more expensive than my usual hotels, it was more comfortable, so I will definitely consider the Affinia Shelburne for my next NYC stay and recommend it without hesitation.