Good hotel with some drawbacks, topnotch staff, but not centrally located
I stayed about a week at Town and Country resort for a convention I attended. The prices were very reasonable, and the staff exceeded the bounds of hospitality. It is a great place for a conference, because it is so self-contained. Further, for shoppers, a mall is a five-minute walk, and a golf course is next door. 
While the resort is not downtown, one can easily catch San Diego’s famed trolleys for five bucks and ride to one’s heart’s content. Taxi rides are a bit more costly, though, so be warned.
The resort boasts two nice pools, beautiful grounds, a bar and grill, steakhouse, a breakfast/ coffee bar with outdoor seating and yet another good restaurant, the trellis.
Try to get a room in the Royal Palm Tower, which has more updated rooms than some of the other parts. 
The rooms are the one problem with the resort. Some are rather dated, and they are not really set up for business use. None has a safe, for instance, that I am aware of. Some are oddly decorated. One woman I know actually had a Murphy bed in her room.
Overall, we had a great stay and an excellent conference. But if you want to be able to walk to a variety of restaurants, bars and nightlife, there are doubtless more strategically located hotels.