Decent Union Square Hotel
We were quite pleased with our stay at this hotel. After reading the reviews about the protests across the street, I called and requested a quiet room in the back of the hotel. We were placed in 429 and were not disappointed! The room was about twice the size as the room given to our travel companions even though we paid the same rate so if space is an issue, I would request one of the larger room layouts. It was tucked away down a side hallway so it was completely silent and the bed was very comfortable leaving us well rested in the mornings. Getting ready for a night out was easy because the room has plenty of outlets and the bathroom even has an extra vanity area (something our companions’ room lacked). The staff was very helpful and friendly. 
The location is decent because the hotel is 2 blocks from the Powell Bart station and half a block from Union Square with all its great restaurant and shopping areas. Because this is a very touristy area, the crowds are horrific, but we were willing to overlook this since it was so easy to walk to China town, The Wharf, and everywhere else we wanted to visit. Be aware that the homeless people and street performers are extremely aggressive. I lived in Midtown Manhattan for 3 years and currently live in downtown Chicago and even I was appalled by how abrasive they are towards tourists. 
Try the Oriental Pearl at Clay and Grant in China town for exceptional Peking Duck. And check out The Tonga Room & Hurricane Bar at the Fairmont for a neat dining experience.