Good location to see the sites
My husband and I recently stayed for 4 nights at this lovely hotel. Our room was surprisingly spacious and we were tucked away at the end of the hall, which made it ultra quite. The bar was cozy, but on the expensive side. The front desk and doormen were extremely helpful with information about the area. Across the street is a French bakery, La Boulange, where we had breakfast one morning. Make sure you grab some delicious coconut macarons while you are there as the ones we purchased stay fresh for our entire trip. 
I would definitely stay at the Omni again if my travels have me in San Fran.