A winning combination
Unless you have limitless resources, and where getting from point A to point B isn't part of the equation, choosing a NYC hotel can involve a lot of tradeoffs. Hotel Indigo met our needs and exceeded expectations on a long weekend (3 nights) trip to visit relatives and do NY things -- wander around, go to a play, and see a museum. We live in the DC area and rode the Vamoose bus, and one big plus is that the Indigo is a quick walk from the Penn Station drop-off point, yet still removed from the noise and chaos of the Penn Station/Madison Square Garden area. Visiting the relatives meant a return to Penn Station the next day to catch the Long Island RR to Queens -- easy. The lndigo's location on 28th St. between 6th and 7th Aves. was convenient for other purposes -- walking down to the West Village and up to the theater district.
I got a good rate from the hotel's site (similar to what was offered on the travel sites); staying over on Sunday night brought the average cost/night down significantly. Our room was comfortable, clean, bright, well-maintained, and cheerful -- 17th floor, front of the hotel. No noise at all except one or two emergency vehicle sirens from a nearby street and came and went quickly. Super bed, reliable free WiFi, and the first hotel room I've stayed in for a while that wasn't either freezing or too hot. The thermostat can be set to a specific temperature, and the vent is located so that the a/c doesn't blow on your head. Also, the windows can be opened. Nice chair by the window, with a rolling stand for papers or a laptop or tablet; also a separate desk. Bathroom modern and very clean. Yes, the design makes it easy for some water from the shower to splash onto the floor, but it wasn't a big deal, and there was an ample supply of towels. A long mirror on the inside of each of the two closet doors. Keurig coffee maker. In other words, even though you don't go to NYC to linger in a hotel room, the room at the Indigo was just the ticket to recharge or rest. We'd certainly go back, assuming the room prices don't escalate.
As other reviewers have mentioned, the hotel is in the Flower (and "Fashion") District, and the sidewalks are full of potted trees and plants awaiting pick up. Maybe not for those who want the Upper East Side scenery, but I loved looking into the windows. Each flower supplier seems to have its resident friendly cat/rodent control expert in the window, on the counter inside, or at the door. 
We didn't eat at the Indigo, but there are plenty of options nearby. We liked The Dish, a few blocks down 8th Ave. for breakfast. Also, check out Eataly, the huge and busy Italian food hall, on 5th Ave. near 19th St; all kinds of offerings there. 
Staff members at the desk were friendly. We arrived an hour or more before check-in time and were able to get into our room early.