Look for bugs!
I stayed at the Red Roof in with my 93 year old dad and 15 year old daughter. We found bed bugs in our room (apparently the Red Roof Inn is famous for bed bugs and everyone knew but my family!). When I trapped the bug on my pillow with a glass and took it to the manager he seemed oh so suprised and said that it was probably brought in from customers from "over seas". He moved us to a different room where I inspected every surface with a book light. I found dirty bedding. It took the manager (the only staff member at work that night) 2 trips and 1 1/2 hours to bring the proper clean bedding. BEWARE!!!!