Mark Twain is the man!
I stayed here early May and although first slightly wary of the area and put off by the number of homeless people nearby, quickly got used to this and we were never bothered by the people other than being asked for change/food a couple of times. The location is great, five minute walk down to Union Square and from there, there's transport to go wherever you like. 
The room was clean and pretty spacious, the bathroom was a little small but you don't spend that much time there anyway so no bother.
THE FRIDGE! There was a fridge in our room, a stroke of genius. Perfect as we could go shopping before we came back to the hotel and stock up on drinks and snacks which could keep cool in the fridge. Only downside is it was a pretty noisy fridge.
There was a radiator in the room which led a life of it's own, it was pretty warm weather when we were there but during the middle of the night the radiator would come on and make banging noises, and there didn't appear to be an off button for it.
The free wifi is great, we expected this as standard these days but found in other hotels there was either no wifi, shockingly useless free wifi or wifi which you had to pay for. 
The TV was big and has lots of good channels to choose from. 
The room was relatively quiet apart from the fridge and the radiator, but these weren't too bad really.
The staff were helpful and the overall atmosphere is chilled out and not at all hectic.
Would recommend and would stay here again.