Excellent!
We stayed in this hotel as part of our honeymoon in July for 3 nights. It had gained points before we even got there as we had emailed to confirm booking and received an email back from Brandon the concierge recommeding restaurants for dinner on our first night and asking if we Wanted him to book one. On arrival we were checked in by Hughes who was very professional and friendly. We were then shown to our room which was small but very plush! We had a card on the bed comgratulating us on our wedding and offering us a bottle of Prosecco. We had a minor problem with the safe in the room which was promptly fixed by the manager (at 8pm!). We then headed out to dinner to the restaurant recommended by the hotel and were shocked and impressed at how close the hotel is to Times Square! The restaurant the hotel sent us to was excellent and offered us champagne and free dessert as Brandon had told them we were on honeymoon. For the rest of the week we dined at restaurants recommended by the concierge Jake. On approaching him for advice he was very helpful and sent us to some excellent places. 
Lots of reviews complained about the continental breakfast. We thought it was perfectly good and made use of it every day.
We drank at the roof-top bar on one occasion which was a great experience (if a little expensive). We can't stress enough how good this hotel is. Its decor is very modern and the service from all staff is excellent. We would particularly like to thank Brandon and Jake for assisting in making our first visit to New York so memorable. When we return to NYC we will definitely be trying to book the Sanctuary again and have already recommended it to friends who are going to NYC to get married in October!