Nice but dated hotel up in Sorrento Mesa
I wouldn't recommend it for you if you needed to hit all of the tourist spots while you're in San Diego, but it's a good choice if you needed to stay at the northerly end of the City. Also there are plenty of choices for food along Mira Mesa Blvd, you wouldn't need to get on a freeway to get your shopping/meals done. 
One item of note, I found the water to be extremely soft. You'll want to stay with bar soap if you're staying here.