The best place, The Ace!
I stayed in the Ace Hotel for 3 nights during a recent business trip to NY. Such a cool hotel with a great atmosphere and some of the friendliest, helpful staff I've ever come across who were full of really on the mark restaurant recommendations...especially Cannibal a few streets down. 
The room decor is really unique and raw, especially the cool bed throws and lighting. 
Love the fact that Stumptown coffee is just downstairs adjoining the hotel, best way to start a busy work day in NY. Overall, I really rate this place and it's atmosphere and will definitley be making a return trip...
 It's really well positioned if you have meetings both uptown and downtown.