Location, Location, Location
For the price tag don't expect anything more than the average Hampton Inn... but LOCATION... that's what makes the difference... walking distance to the heart of Manhattan... Times Square, Rockefeller Center (and its Top of the Rock attraction), Radio City Hall (now showing wonderful, spectacular Cirque du Soleil Zarkana.. highly recommended), 5th Ave and its wonderful shops (window shopping or not...), Broadway... and many more!!! 
There are restaurants, cafes, diners... all prices, all cuisines... Convenience stores, specialty stores... You name it!
What you overpay in the hotel rate you will save on transportation, that's for sure... and valuable time, of course... BUT, for the price you may expect a little more than a Concierge desk in the lobby... The included breakfast is surely a PLUS ....BUT ...will it kill Hampton Inn to extend the breakfast until 11:00am... at least here ... ?? Breakfast was the average Hampton Inn's hot breakfast...nothing out of the ordinary. 
BEDS ARE GREAT... very comfy, so are the pillows. Bathroom shower is very good...massage type, our bathroom sink cabinet was in the need of a renovation...but it served its purpose. Overall, I would certainly recommend this hotel to families with children and teenagers. 
We stayed in NYC for 3 nights and Hampton Inn TSQ North was a good choice overall.