A decent stay during a busy week in Chicago
We went to Chicago as a quick last minute girls trip on a whim and although the flights were cheap, the hotels seemed to be ridiculously expensive (I've stayed in NYC for less)
We had had not a whole lot of choices given that we were paying already $300/night for this hotel and if we wanted any of the 4* and up chains, we'd mostly be going $500 and up. (A TIP: Check on whats going on in Chicago before you go because the hotel situation in the city when 40,000 people convene on the city, the choices wont be good unless you stay outside of Chicago center and don't mind the commute, you're looking at some major cash)
OK, so Swissotel... I can tell that they had recently renovated their lobby floor as pictures of the before was more wood and more traditional and upon walking into the Hotel, this lobby was clean, sleek and modern. The staff were as helpful as they could be but because it was a busy night to be checking in, they had my reservation wrong, and had tried to give me a different room. I had to show them the confirmation email that had indicated that I had paid for a Lakeview 2 bed room (3 girls). 
Once we were sorted out the room was adequate but the beds were on the smaller side (doubles) . We had an amazing view of the river, Navy Pier, and the Lake which gave us opportunities to see the ferris wheel at night and fireworks on Wednesdays at Navy Pier.
There was a mini fridge for you to put your own stuff, and keurig coffee for convenience! Unless you are willing to dish out $10 for a bottle of water, bring your own. 
Washrooms were stocked well and clean, with a bathtub, separate glass and tile shower as well. We were supplied with bathrobes to use as well.
My key stopped working 2 days in, and so I had to go to the front desk to reset it... Now the following part, I only observed as I was not affected by this but I feel really bad for the front desk girls that day, as they also appeared to have been over-booked (as I said, we were lucky to even find a room) and the two girls working there were being yelled at by obviously annoyed people who did not have a room for their travels. Again these girls did the best they could, and I overheard that they offered to pay for a nights stay at a neighboring hotel as there were absolutely no rooms to be found. I don't know why they would be overbooked.,... whether it was the hotels fault, a communication thing with travel websites, etc... but they did handle the situation as best as possible and tried to smile through the yelling. After all that, I did get a reset on my key and went about my business.
As for the location... it was not at all close to the loop, don't let the maps trick you... it took us 20 minutes uphill to walk from subway stop to hotel with our luggage the first day!!! It was only about a 3 block walk to Millenium Mile though. It allowed for us to hit shopping, 15 minutes walk to Navy Pier, and also get to the John Hancock Building. We also were about 5 minutes walk to the Chicago theatre, and a Garretts popcorn location so it was sufficient.
I didn't enjoy having to pay $10/day per device to use the wifi and the business centre is run by UPS so everything costs more.
Lastly, I know its not specifically a cleanliness thing, but apparently there is a spider problem in all the highrises in Chicago on the outside of the buildings. We found out because the first day, we saw a spiders that's body were, no joke, at least the size of a quarter (larger when you add the legs) on the outside of the glass with all their friends and babies and webs on the outside of the building so kind of creepy even though they can't come in the thought of them landing on you outside or finding a crevice to sneak in to the room is really gross.
I wouldn't return to this hotel for the price I paid, but if you pay around 175-200/night then I'd say its a go!