Great Hotel, Great Location
My wife and I have just returned from a 4-night stay at the Hotel Chandler and were very pleased with our choice. We, like most people, look at reviews when choosing a hotel and often wonder if what we are reading gives a totally true picture, but having stayed at this hotel we can now readily endorse everything that people have said.
The hotel is in a great location on E31St., equi-distant between Fifth Avenue and Madison, so if you want a cab to go up town it's just a moments walk to the corner of E31St & Madison, and returning, the cab can drop you on the corner of E31St & Fifth which again is just a few moments walk from the hotel. Perfect! 
If you want to walk rather than take a cab then again the hotel is within easy walking distance of many attractions.
Our room was smallish, (not unusual in NYC), but had all that we needed, quietness, (apart from a nosiy air-conditioning unit), a very comfortable bed, and was nicely furnished. We've stayed in NYC on many occasions and this was certainly one of the quietess rooms we've stayed in. The room was situated on the 4th floor in the middle of the hotel so there was no view but our priority was a quiet room and that's what we got.
Important point: there is some extension work being carried out next door so there is a possibility that some rooms could be affected by noise - best ask when booking/checking in.
The staff at the front desk and the bell boys were all very friendly and helpful, which is important in any hotel and made our stay more enjoyable - nothing was too much trouble for them.
The hotel had some nice little touches such as internet access in the lobby so we were able to check-in online and print our boarding passes for our flight home. There is also free tea/coffee and iced water available 24/7 in the lobby.
One slight negative, but of no real importance to us, is that we found the small cocktail bar dark and univiting. We thought we'd give it a try one night but only stayed for one quick drink before going off into town. The bar has no atmosphere and didn't appear to attract many customers.