Centrally located
Everytime I have gone to San Diego for work, the company has put us up at the Best Western Plus Bayside Inn. The hotel is resonable, clean and the staff is friendly and other than a few minor occasions with guests, it is fairly quiet. It is centrally located in the downtown area close to the airport, The Gas Lamp District, the Harbor, Little Italy and the MTS Trains. The only issues I have with this hotel is that there is no room service for dinner on the weekends and the attached restaurant is not open after breakfast on Sat or Sun. and dependig on the room, the wireless internet can be spotty. Other than that I would stay there even if I went for pleasure.