Great hotel, but rough neighborhood.
My husband and I just spent 3 nights at the US Grant with another couple. It is a beautiful hotel with a great lobby bar and nice wine. The downside was that I walked a block to CVS one morning and felt uncomfortable being out alone as there are many homeless people in the area around the hotel. We did find it was within walking (a good hike at times!) distance to lots of fun restaurants, waterfront, and Petco baseball park. The staff was very helpful and concierge helped us book at a spa around the corner that was wonderful. We had a great weekend! I would rethink this area if I were taking our children with us-it had a Bourbon Street feel to it. It was a fun destination for a couples weekend!