Needs some work to really stand out
Generally, this location is what you would expect from a Hampton Inn. The rooms are clean, albeit somewhat small since this is NYC after all. The staff are friendly. The included breakfast is pretty much what you'd get at any other Hampton inn: edible, but nothing to write home about. The prices are usually pretty good for NYC (weekdays are sometimes on the high side as the hotel is close enough to the financial district to get some business traveler spillover).
They've gone somewhat overboard with the cushiness of the mattresses. I don't recall if that's true of other Hampton Inn locations.
The South Street Seaport area where the hotel is located has a good collection of restaurants, easy access to a TKTS outlet, and an assortment of shops (both major chains and small shops). However, the location is somewhat out-of-the way if you're trying to spend a lot of time in midtown.
The biggest complaint is that the place is fairly noisy - we heard doors slamming shut frequently, especially in the morning when people were going in and out of the rooms a lot. It's not surprising as the doors have absolutely no cushioning between them and the door jamb. It's metal-on-metal for the hallway doors, and wood-on-metal for the bathroom doors (and yes, we could hear bathroom doors in rooms down the hall slamming shut). A little rubber or felt strip on the door jamb would go a long, long way to quieting the place down. We mentioned the problem when we checked out, and hopefully this will get fixed. Until then, we'll be looking for a different place to stay on out next trip to NYC.