A consistently solid venue
I have stayed here and recommended this hotel to several people over the years after a good first experience in 1996. 
Location is very good for exploring - you have subway closeby, as well as usually plenty of taxis. The drugstore across the street is 24h (making up for the partial disappearance of delis). 
Yes, the rooms are not huge, but I find them perfectly acceptable - Manhattan being a crowded island with lots of purchasing power you cannot expect Texas-sized hotel rooms unless you're willing to pay extra... Service staff very helpful without exceptions, got a room despite early checkin and the property was always very clean and well kept.