Datasets:
row_id string | series_id string | treatment_day int64 | host_model string | drug string | duration_exposure_index float64 | wbc_k_uL float64 | expected_wbc_k_uL float64 | wbc_drop_vs_expected float64 | anc_k_uL float64 | expected_anc_k_uL float64 | anc_drop_vs_expected float64 | platelets_k_uL int64 | expected_platelets_k_uL int64 | plt_drop_vs_expected int64 | heme_coherence_index float64 | host_stress_index float64 | later_severe_cytopenia_flag int64 | assay_method string | source_type string | heme_tox_signal int64 | earliest_heme_tox int64 | notes string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ABXHT009-TR-0001 | S1 | 0 | human_sim | linezolid | 0.1 | 6.8 | 6.8 | 0 | 3.8 | 3.8 | 0 | 240 | 240 | 0 | 0.9 | 0.1 | 0 | cbc_panel | simulated | 0 | 0 | baseline |
ABXHT009-TR-0002 | S1 | 7 | human_sim | linezolid | 0.85 | 6.6 | 6.6 | 0 | 3.7 | 3.7 | 0 | 235 | 235 | 0 | 0.88 | 0.9 | 0 | cbc_panel | simulated | 0 | 0 | tracks expected |
ABXHT009-TR-0003 | S1 | 10 | human_sim | linezolid | 0.9 | 4.8 | 6.4 | 1.6 | 2.2 | 3.6 | 1.4 | 210 | 232 | 22 | 0.35 | 0.9 | 0 | cbc_panel | simulated | 0 | 0 | first suppression drift |
ABXHT009-TR-0004 | S1 | 12 | human_sim | linezolid | 0.9 | 4.5 | 6.3 | 1.8 | 2 | 3.6 | 1.6 | 200 | 230 | 30 | 0.3 | 0.9 | 0 | cbc_panel | simulated | 1 | 1 | onset |
ABXHT009-TR-0005 | S1 | 21 | human_sim | linezolid | 0.9 | 2.5 | 6 | 3.5 | 0.6 | 3.3 | 2.7 | 120 | 220 | 100 | 0.2 | 0.9 | 1 | cbc_panel | simulated | 1 | 0 | severe later |
ABXHT009-TR-0006 | S2 | 0 | human_sim | amoxicillin | 0.1 | 6.9 | 6.9 | 0 | 3.9 | 3.9 | 0 | 245 | 245 | 0 | 0.9 | 0.1 | 0 | cbc_panel | simulated | 0 | 0 | baseline |
ABXHT009-TR-0007 | S2 | 10 | human_sim | amoxicillin | 0.9 | 6.5 | 6.5 | 0 | 3.6 | 3.6 | 0 | 240 | 240 | 0 | 0.86 | 0.9 | 0 | cbc_panel | simulated | 0 | 0 | stable |
ABXHT009-TR-0008 | S2 | 20 | human_sim | amoxicillin | 0.9 | 6.6 | 6.4 | -0.2 | 3.7 | 3.5 | -0.2 | 238 | 238 | 0 | 0.84 | 0.9 | 0 | cbc_panel | simulated | 0 | 0 | stable |
ABXHT009-TR-0009 | S3 | 0 | human_sim | linezolid | 0.9 | 5 | 5 | 0 | 0.9 | 0.9 | 0 | 200 | 200 | 0 | 0.9 | 0.9 | 1 | cbc_panel | simulated | 0 | 0 | baseline ANC low |
ABXHT009-TR-0010 | S4 | 12 | human_sim | linezolid | 0.9 | 4.5 | 6.3 | 1.8 | 2 | 3.6 | 1.6 | 200 | 230 | 30 | 0.3 | 0.3 | 1 | cbc_panel | simulated | 0 | 0 | stress low |
ABX-HT-009 Hematological Toxicity Warning
Purpose
Detect early bone marrow suppression when CBC markers stop tracking expected course before severe cytopenia events.
Core pattern
- host_stress_index high
- duration_exposure_index high
- heme_coherence_index drops
- anc_drop_vs_expected stays high
- later_severe_cytopenia_flag appears
Files
- data/train.csv
- data/test.csv
- scorer.py
Schema
Each row is one timepoint in a within series treatment course.
Required columns
- row_id
- series_id
- treatment_day
- host_model
- drug
- duration_exposure_index
- wbc_k_uL
- expected_wbc_k_uL
- wbc_drop_vs_expected
- anc_k_uL
- expected_anc_k_uL
- anc_drop_vs_expected
- platelets_k_uL
- expected_platelets_k_uL
- plt_drop_vs_expected
- heme_coherence_index
- host_stress_index
- later_severe_cytopenia_flag
- assay_method
- source_type
- heme_tox_signal
- earliest_heme_tox
Labels
heme_tox_signal
- 1 for rows at or after first confirmed suppression onset
earliest_heme_tox
- 1 only for the first onset row in that series
Scorer logic in v1
- exclude series with low baseline ANC
- candidate onset point
- host_stress_index at least 0.80
- duration_exposure_index at least 0.80
- heme_coherence_index at most 0.40
- anc_drop_vs_expected at least 1.2 for two consecutive points
- ignore one point lab error then rebound artifacts
- confirmation
- later_severe_cytopenia_flag equals 1 later in series
Evaluation
Run
- python scorer.py --path data/test.csv
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