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gen_e0913fc28a64c40867d0ee7ee0b2ffa7
|
Additive Manufacturing Initiative for Transnational Innovation in Europe
|
European Commission
|
INSTITUT STRAUMANN AG
|
CORDIS-734342
|
Additive manufacturing (AM) technologies and overall numerical fabrication methods have been recognized by stakeholders as the next industrial revolution bringing customers’ needs and suppliers’ offers closer. It cannot be dissociated to the present trends in increased virtualization, cloud approaches and collaborative developments (i.e. sharing of resources). AM is likely to be one good option paving the way to Europe re-industrialization and increased competitiveness. AMITIE will reinforce European capacities in the AM field applied to ceramic-based products. Through its extensive programme of transnational and intersectoral secondments, AMITIE will promote fast technology transfer and enable as well training of AM experts from upstream research down to more technical issues. This will provide Europe with specialists of generic skills having a great potential of knowledge-based careers considering present growing needs for AM industry development. To do that, AMITIE brings together leading academic and industrial European players in the fields of materials science/processes, materials characterizations, AM technologies and associated numerical simulations, applied to the fabrication of functional and/or structural ceramic-based materials for energy/transport, and ICTs applications, as well as biomaterials. Those players will develop a new concept of smart factory for the future based on 3D AM technologies (i.e. powder bed methods, robocasting, inkjet printing, stereolithography, etc.) and their possible hybridization together or with subtractive technologies (e.g. laser machining). It will allow for the production of parts whose dimensions, shapes, functionality and assembly strategies may be tailored to address today’s key technological issues of the fabrication of high added value objects following a fully-combinatorial route. This is expected to lead to a new paradigm for production of multiscale, multimaterial and multifunctional components and systems
|
H2020-EU.1.3. / 1.3 Marie Skłodowska-Curie Actions (MSCA)
| 6project_grants_public
|
gen_a07c6dd830906043d5f87eacd36e8b2a
|
Pan-European system with an efficient coordinated use of flexibilities for the integration of a large share of RES
|
European Commission
|
INNOGY SE; WRD WOBBEN RESEARCH AND DEVELOPMENT GMBH
|
CORDIS-773505
|
The overall objective is to ensure an efficient and sufficient level of system services are provided to facilitate meeting world leading levels of RES-E while maintaining the level of resilience that consumers and society have come to expect from the European electricity system. This requires defining the right amount of flexibility and system services to support transmission system operators using a threefold approach. Firstly, the technical needs of the pan-European system will be defined for scenarios with more than 50% RES-E in will be identified and translated to services and products to be delivered in an enhanced market design. Secondly, the electricity market design and regulation needs to be augmented to efficiently and effectively procure the appropriate combination of these system services. Thirdly, implicit and explicit barriers to competitive forces being applied need to be removed. This requires an in-depth understanding of all stakeholders’ roles (Generation and flexibility providers, Transmission system operators (TSO) and Distribution System Operators (DSO) and regulators) at all system levels (interconnected system, national transmission and distribution sub-systems and consumers). For doing so, EU-SysFlex joins a multidisciplinary team of 34 partners from 14 European countries, led by the (Transmission System Operators) TSOs representing four different synchronous systems that integrate the pan-European interconnected electricity system: EirGrid & SONI (Ireland), PSE (Poland), AST (Latvia), Elering (Estonia), supported by the necessary (Distribution System Operators) DSOs, technology providers, and research & experienced entities. In addition, a group of three other European TSOs: Fingrid (Finland), LitGrid (Lithuania) and Ceps (Czech Republic), will join the advisory board of the project, in addition to EDSO for Smart Grids and USEF, in order to help the project maximising its impact.
|
H2020-EU.3.3. / 3.3 Societal Challenges - Energy
| 6project_grants_public
|
gen_54887b470bd33d2b38b6ddd8bc49a533
|
productive Green Infrastructure for post-industrial urban regeneration
|
European Commission
|
ASOCIATIA DE DEZVOLTARE INTERCOMUNITARA ZONA METROPOLITANA - CLUJ
|
CORDIS-776528
|
For proGIreg three front-runner cities (Dortmund (DE); Turin (IT); Zagreb (HR))will create Living Labs in urban areas which face the challenge of post-industrial regeneration. These areas suffer from social and economic disadvantages, inequality and related crime and security problems. They lack quality greenspaces, have a negative impact on human health and wellbeing and are more vulnerable to the effects of climate change. Going beyond the current state-of-the-art with Green Infrastructure as a one-off state intervention, the proGIreg Living Labs will develop NBS which are citizen owned and co-developed by state, market and civil society stakeholders. Innovation will take place on the technical level through the NBS deployments, on the social level through co-designing, co-creating and co-implementing NBS with local communities and on the economic level through combining NBS with market-ready business models. Four follower cities in Eastern and Southern Europe (Cascais PT, Cluj-Napoca RO, Piraeus GR, Zenica BA) will be co-steering the research process to assure replicability and adaptability to their local context resulting in urban plans for NBS deployment. The NBS to be tested i.a. include: regenerating industrial soils biotic compounds, creating community-based urban agriculture and aquaponics and making renatured river corridors accessible for local residents. Scientific assessment and monitoring results from the Living Labs will be made available on the EU NBS platforms OPPLA and THINKNATURE and will contribute to the European reference framework for NBS. Global impact will be achieved by a training programme for cooperative planning, implementation and management of NBS. It will be provided by partners from the cities, SMEs and universities involved. Training events will be organised in cooperation with the partner ICLEI. Massive Open Online Courses (MOOCs) will be distributed via EdX, the most renowned MOOCs platform worldwide.
|
H2020-EU.3.5. / 3.5 Societal Challenges - Climate
| 6project_grants_public
|
gen_f01956431452841c2a2f2ba3f1d21d73
|
Gates Foundatoin
|
Wits Health Consortium (Pty) Ltd
|
INV-030975
|
to plan for a demonstration of PrEP delivery in private pharmacies in South Africa
|
Family Planning / Global Health
| 5out_of_scope
|
|
gen_de1dde3e52cd2cf9f0bbe71bc099a2c6
|
Gates Foundatoin
|
Wits Health Consortium (Pty) Ltd
|
INV-032725
|
to establish the presence of long-term complications in COVID-19 survivors and guide the rehabilitation of COVID-19 survivors
|
K-12 Education / Global Health
| 6project_grants_public
|
|
gen_417df97233d9a55fa24a05a663b1604d
|
Farmer clusters for Realising Agrobiodiversity Management across Ecosystems
|
European Commission
|
University of Natural Resources and Life Sciences
|
CORDIS-862731
|
FRAMEwork is constructed based on the Farmer Cluster approach successfully implemented in the UK. FRAMEWORK will enrich and innovate existing Farmer Clusters by liaising with local and (inter)national stakeholder groups, and set up new, multi-actor, Farmer Clusters in different cropping systems in Europe, based on existing collaborations. The Farmer Clusters will be united in a European-wide self-sustaining network and linked with the Citizen Observatory and Information Hub that will facilitate farmer and citizen-based collection and sharing of harmonised, high-quality information on biodiversity and farming, and develop engaging online and offline activities to amplify awareness and understanding of biodiversity and Biodiversity Sensitive Farming across different stakeholders in Europe. The scientific contribution to these citizen-based activities will deliver the following outcomes: 1) Advanced ecological understanding of the drivers of biodiversity change in agricultural landscapes; 2) a selection of best-practice biodiversity-sensitive management by farmers based on their local requirement; 3) validated methods for biodiversity targeting, monitoring and evaluation and 4) private and public incentives to foster biodiversity-sensitive farming as a public good. Furthermore, FRAMEwork will assess the effectiveness of the Farmer Cluster approach to develop and implement place and system-specific biodiversity-sensitive farming practices and evaluate the economic and environmental performance, delivering a permanent on-line evaluation tool on the Citizen Observatory and Information Hub. The TRL of the Decision Support Tools ranges from 3-5, where improvements are foreseen for the TRL5 Decision Support Tool, while the ones at TRL3 will be brought to TRL4-5 through testing and improvements in the Farmers Clusters. FRAMEwork will be innovative in the way in which it will implement EU ethics, data protection and gender regulations.
|
H2020-EU.3.2. / 3.2 Societal Challenges - Food
| 6project_grants_public
|
gen_380234b321cc09681102a4f8c9764de7
|
A POsitive Energy CITY Transformation Framework
|
European Commission
|
UBIWHERE Lda
|
CORDIS-864400
|
POCITYF supports the Lighthouse cities of Evora (PT) and Alkmaar (NL) and their Fellow cities Granada (ES), Bari (ΙΤ), Celje (SI), Ujpest (HU), Ioannina (GR) and Hvidovre (DK) to address their urgent need to deliver positive energy blocks and districts in their cities, towards rendering their mixed urban environment (also including the case of cultural protected buildings) into cheaper, better accessible, healthier and more reliable. By demonstrating in overall 10 integrated solutions (ISs), comprising 73 individual innovative elements (technologies, tools, methods), rooted under existing City Information Platforms (CIPs), POCITYF quantifies their value, and connects interests of many different stakeholders in innovative business models, allowing for upscale and replication of those solutions in a form of a validated roadmap for sustainable cities across Europe and world-wide. To achieve this, POCITYF works along 4 Energy Transition Tracks (ETTs), encompassing the ISs according to the role each one serves for. ETT#1 focuses on the examination and application of ISs transforming existing and new building stock into Energy Positive, while ETT#2 focuses on the application of a) grid flexibility strategies and b) storage systems, supported by DSM platforms for optimizing energy flows to maximize self-consumption and reduce grid stress. ETT#3 with its merit of innovation offers the integration of e-Mobility to as well promote the decarbonisation of the mobility sector. The 3 ETTs under the coordination of ETT#4, which links existing CIPs with innovative apps and other instruments, offers inclusive and holistic services for interdisciplinary citizen engagement and co-creation of them with the city stakeholders and industry, towards the development of each city’s own bold city-vision up to 2050. Through POCITYF the two LHs will achieve a local RES penetration of 16.2 GWh/y, energy savings of 2.32 GWh/y and an emission reduction of 9,743 tons CO2eq/y within their districts.
|
H2020-EU.3.3. / 3.3 Societal Challenges - Energy
| 6project_grants_public
|
gen_7d224695c51b346eba8cce3f6b78a556
|
REsilient WAter Innovation for Smart Economy
|
European Commission
|
ASOCIACION DE INDUSTRIAS DE LAS TECNOLOGIAS ELECTRONICAS Y DE LA INFORMACION DEL PAIS VASCO GAIA
|
CORDIS-869496
|
REWAISE will create a new “smart water ecosystem”, mobilising all relevant stakeholders to make society embrace the true value of water, reducing freshwater and energy use, resulting in a carbon free, sustainable hydrological cycle, to transition into a resilient circular economy. A network of nine living labs, involving 5 major water utilities, demonstrates real-life, large-scale operational environments for technological innovations and new governance methods to secure a resource-efficient water supply for the EU. New business niches will be created, incentivizing water-related investments, and accelerating SME growth, by linking users with specific water needs, incorporating life cycle and cost assessments, and collective action in new governance frameworks for smart value creation and high social returns. By incorporating paradigm shifts from a linear Roman heritage to a new circular, water-smart economy, REWAISE reveals the full Value of Water for Europe, considering 3 key components of the economic and societal value generated by integral water cycles: • Value in Water: is accomplished by extracting and putting to beneficial use dissolved substances such as nutrients, minerals, chemicals and metals, as well as organic matter and energy, embedded in raw and used water streams. • Value from Water: encompasses the economic activities inherent to the water cycle, related products and services that generate benefits and jobs, directly or in other sectors that depend on water, such as energy and transportation, • Value through Water: the societal, health and well-being functions of water, which will be enhanced by inter-linking users, regulators, water operators and other stakeholders in electricity and chemicals markets through a digital platform that optimizes decision making and business opportunities through socio-economics-based coordination between them, while minimizing emissions , risks and vulnerability.
|
H2020-EU.3.5. / 3.5 Societal Challenges - Climate
| 6project_grants_public
|
gen_6bc818ea77762eec402d2c680f9030a0
|
Digital Platform for Circular Economy in Cross-sectorial Sustainable Value Networks
|
European Commission
|
INDRA SAS; SAUBERMACHER DIENSTLEISTUNGS AG; HOLONIX SRL-SPIN OFF DEL POLITECNICO DI MILANO; KNORR-BREMSE SYSTEME FUR NUTZFAHRZEUGE GMBH
|
CORDIS-873111
|
DigiPrime has the mission to develop a new concept of Circular Economy digital platform overcoming current information asymmetry among value-chain stakeholders, in order to unlock new circular business models based on the data-enhanced recovery and re-use of functions and materials from high value-added post-use products with a cross-sectorial approach. DigiPrime will create and operate a federated model of digital platforms for cross-sector business in the Circular Economy. Nodes of the federation will offer interoperable functions and data, that can be accessed by other nodes, combined with local data and services, that are not exposed outside; connectors and open interfaces enable easy integration of new services, provided by third parties, that are not made accessible outside. Specific attention will be devoted to create trustable data sharing mechanisms, preserving the confidentiality of business-critical data. Security and sovereignity of information are guaranteed by IDSA (Industrial Data Space Association)-based solutions for on-demand and controlled sharing of data among organisations, regulated by smart contracts and tracked by block-chain. The services covers: i) the cross-sector value-Chains dimension (De- and remanufacturing oriented product information management, product co-creation, LCA-LCC for eco-design, demand-supply matching, sustainable value network and reverse logistics barriers identification and legislation support, etc.), ii) the operational dimension (rediction of product conditions, de-and remanufacturing decision support system, demand and supply forecasting, circular production planning and control, material testing and certificationetc). DigiPrime, will be thoroughly validated through 6 cross-sectorial pilots, further detailed in 20 use-cases covering 5 different European industrial sectors (automotive, renewable energy, electronics, textile, construction), and by additional pilots in new sectors, funded through an Open Call mechanism.
|
H2020-EU.2.1.1. / 2.1.1 LEIT - ICT
| 0business_rnd_innovation
|
gen_72c8d6ae85f892d97d1b6f62cac65e3d
|
The CALIPER project: Linking research and innovation for gender equality
|
European Commission
|
VILABS OE
|
CORDIS-873134
|
The CALIPER project aims at driving a structural change process and implementing Gender Equality Plans in 7 Research Performing and 2 Research Funding organizations, involving the highest and middle management levels since the beginning to impact the whole institution. The project goal is to make research organizations more gender equal by increasing the number of female researchers in STEM, improving their careers prospects and integrating a gender dimension in research. CALIPER is featured by a broad geographic focus and an innovative approach based on engaging national and regional innovation ecosystems in the partners’ countries with a quadruple helix approach: the project will trigger and make internal changes and gender equality policies sustainable by orchestrating the core inward auditing/internal assessment and GEPs design with outward actions engaging external stakeholders to activate synergies at all different junctions of the ‘education-research- transfer to market of STEM research results’ chain. CALIPER will adopt an intersectional approach to gender equality issues, paying attention to the ways gender inequalities are linked to and intersected with other discriminations. CALIPER will ensure its successful implementation by adopting a holistic methodology featured by capacity building support to build and sustain internal gender knowledge and expertise, mutual learning among partners, a participatory co-design of GEPs as well as 2 iteration levels for implementing and refining GEPs and a thorough monitoring and evaluation mechanism, leading to durable institutional changes. Thanks to the presence of α pan- European Professional association in the consortium and further dissemination actions such as the Caliper Charter and Code and awareness raising sessions on gender in research open to external stakeholders and other RPOs/RFOs , Caliper results have strong potentials to be multiplied both nationally and in other EU28 countries.
|
H2020-EU.5. / 5.0 Science with and for Society
| 6project_grants_public
|
gen_80415a606190d47acdf25c51867ae9f2
|
Human Brain Project Specific Grant Agreement 3
|
European Commission
|
INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES; Universitätsklinikum Aachen; Barcelona Supercomputing Center - Centre Nacional de Supercomputació (BSC-CNS); KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW; POLYTECHNEIO KRITIS; KUNGLIGA TEKNISKA HOEGSKOLAN; AI2LIFE SRL; Universidad Autónoma de Madrid
|
CORDIS-945539
|
The last of four multi-year work plans will take the HBP to the end of its original incarnation as an EU Future and Emerging Technology Flagship. The plan is that the end of the Flagship will see the start of a new, enduring European scientific research infrastructure, EBRAINS, hopefully on the European Strategy Forum on Research Infrastructures (ESFRI) roadmap. The SGA3 work plan builds on the strong scientific foundations laid in the preceding phases, makes structural adaptations to profit from lessons learned along the way (e.g. transforming the previous Subprojects and Co-Design Projects into fewer, stronger, well-integrated Work Packages) and introduces new participants, with additional capabilities. The SGA3 work plan is built around improved integration and a sharpening of focus, to ensure a strong HBP legacy at the end of this last SGA. In previous phases, the HBP laid the foundation for empowering empirical and theoretical neuroscience to approaching the different spatial and temporal scales using state-of-the-art neuroinformatics, simulation, neuromorphic computing, neurorobotics, as well as high-performance analytics and computing. While these disciplines have been evolving for some years, we now see a convergence in this field and a dramatic speeding-up of progress. Data is driving a scientific revolution that relies heavily on computing to analyse data and to provide the results to the research community. Only with strong computer support, is it possible to translate information into knowledge, into a deeper understanding of brain organisation and diseases, and into technological innovation. In this respect, the underlying Fenix HPC and data e-infrastructure, co-designed with the HBP, will be key. The services offered by EBRAINS will be grouped in six Service Categories: SC1: Curated and shared data: EBRAINS FAIR data services - neuroscience data publishing SC2: Brain atlas services: navigate the brain in 3D - find, contribute and analyse brain data, based on location SC3: Brain modelling and simulation workflows: integrated tools to create and investigate models of the brain SC4: Closed loop AI and robotics workflows: design, test and implement robotic and AI solutions SC5: Medical Data Analytics SC6: Interactive workflows on HPC or NMC: Europe-wide access to scalable and interactive compute services Their users are to be supported with High-Level Support Teams and Vouchers, as well as Engagement and Facility Hubs located around Europe, at which additional services, unique equipment and compute infrastructure will be offered by local HBP Partners. Significant outcomes in relevant scientific communities are expected to materialise rapidly. Association with new Partnering Projects is still sought, along with wider international cooperation. The SGA3 objectives can be summarised as: 1)_x0001_Establish a sustainable European scientific research infrastructure, EBRAINS, leading to an increased use and adoption of FAIR data, web-based analyses, model building, simulation, atlasing, and virtual experiments for brain research and brain-inspired sciences. 2)_x0001_Provide a multi-level atlas of the human brain - the first of its kind that links microstructural detail and inter-subject variability. 3)_x0001_Increase the capacity of neuroscientists for multiscale neural activity modelling of the human brain network. 4)_x0001_Increase the availability of integrated multiscale data and computational models supporting brain states transitions, network complexity and cognitive functions. 5)_x0001_Enhance real-world task performance through biologically plausible adaptive cognitive architectures running on neuromorphic hardware and a closed-loop Neurorobotics Platform. 6)_x0001_Ensure that neuroscientific insights at the interface of neuro-inspired computing and technology are being translated into a benefit for patients with brain diseases. 7)_x0001_Ensure an ethically and legally compliant infrastructure and promote embedding of Responsible Research and Innovation, a
|
H2020-EU.1.2. / 1.2 Future and Emerging Technologies (FET)
| 6project_grants_public
|
gen_ddc2f381b18a6e0aa092cf4e10358f22
|
OPEN INNOVATION TEST BED FOR DEVELOPING SAFE NANO-ENABLED BIO-BASED MATERIALS AND POLYMER BIONANOCOMPOSITES FOR MULTIFUNCTIONAL AND NEW ADVANCED APPLICATIONS
|
European Commission
|
Wrocław University of Technology
|
CORDIS-953206
|
To succeed in the ambitious objective of achieving a climate-neutral EU by 2050 the nano-enabled bio-based materials sector shall respond to some specific risks in the short term. BIONANOPOLYS will address the following risks and challenges in order to strengthen the circularity of nano-enabled bio-based materials in the economy: ›_x0001_Acceptance of new technology by the market. ›_x0001_Seasonal sustainability of feedstocks. ›_x0001_Price competition and market. ›_x0001_Other risks: The existing legislation is costly in particular for small companies. For example, nano-ecotoxicology related to the use of nano-enabled materials in industry and/or food contact. Considering these challenges, BIONONAPOLYS Open Innovation Test Bed will improve technologies, processes, considering different feedstock. BIONANOPOLYS offers: ›_x0001_PILOT LINES: Cutting edge technology upgraded at TRL 7 with the objetive to produce nanoenabled biobased materials with multifunctional properties to be dispersed in cellulose and polymeric matrices assuring the best dispersion and the robustness of the final properties. Developed materials will be validated in application such as packaging, cosmetic, medical, foam, nonwoven, coating, 3D printing, textiles and cellulose-paper. ›_x0001_PRIMARY RAW MATERIALS FROM DIFFERENT FEEDSTOCKS: BIONANOPOLYS will use the most relevant feedstock in Europe to obtain bio-based nano-enabled composites. ›_x0001_HIGH VOLUME APPLICATIONS: BIONANOPOLYS offer solutions for more than the 50% of the applications that are currently using bio-based materials. ›_x0001_COMPLEMENTARY SERVICES: BIONANOPOLYS will offer to the industry a wide variety of services for the market uptake of a new bio-based nano-enabled products, such as safety protocols for bio-based nano-enabled materials, training for staff specialization, standardisation, business modelling, access to follow-on finance or IPR protection as a crucial mean of ensuring the capitalisation on the investments made by our stakeholders and other investors.
|
H2020-EU.2.1.3. / 2.1.3 LEIT - Advanced materials
| 4other_research_funding
|
gen_52f286fb34ebbffc92672fb1374454f2
|
Prototype system for a Copernicus CO2 service
|
European Commission
|
Cyprus Institute; KAMINSKI THOMAS HERBERT
|
CORDIS-958927
|
To support EU countries in assessing their progress for reaching their targets agreed in the Paris Agreement, the European Commission has clearly stated that a way to monitor anthropogenic CO2 emissions is needed. Such a capacity would deliver consistent and reliable information to support policy- and decision-making processes. To maintain Europe’s independence in this domain, it is imperative that the EU establishes an observation-based operational anthropogenic CO2 emissions Monitoring and Verification Support (MVS) capacity as part of its Copernicus programme. The CoCO2 Coordination and Support Action is intended as a continuation of the CO2 Human Emissions (CHE) project, led by ECMWF. In the Work Programme, ECMWF is identified as the predefined beneficiary tasked to further develop the prototype system for the foreseen MVS capacity together with partners principally based on the CHE consortium. In addition, ECMWF will continue some of the work initiated in the VERIFY project as well. The main objective of CoCO2 is to perform R&D activities identified as a need in the CHE project and strongly recommended by the European Commission's CO2 monitoring Task Force. The activities shall sustain the development of a European capacity for monitoring anthropogenic CO2 emissions. The activities will address all components of the system, such as atmospheric transport models, re-analysis, data assimilation techniques, bottom-up estimation, in-situ networks and ancillary measurements needed to address the attribution of CO2 emissions. The aim is to have prototype systems at the required spatial scales ready by the end of the project as input for the foreseen Copernicus CO2 service element.
|
H2020-EU.2.1.6. / 2.1.6 LEIT - Space
| 6project_grants_public
|
gen_4b07c8893d6634e6bf614e3e346a13b5
|
Interventions that Address Structural Racism to Reduce Kidney Health Disparities Research Coordinating Center
|
NIH
|
DUKE UNIVERSITY
|
5U24DK137631-02
|
PROJECT ABSTRACT Recognizing the significant impact of structural racism on kidney health in minority populations, the NIH is creating a new Consortium focused on Interventions that Address Structural Racism to Reduce Kidney Health Disparities. The Consortium will bring together research teams from six Intervention Sites to conduct community-engaged intervention studies to address structural racism and reduce disparities across the spectrum of kidney health and disease. We propose to serve as the Research Coordinating Center (RCC) for the Consortium. The Duke RCC will leverage extensive institutional resources and expertise at Duke University to provide administrative leadership and research coordination to ensure seamless operations of the Consortium and successful conduct of Consortium studies; support rigorous data collection, data management, and data analysis for Consortium studies; and foster research collaboration, capacity-building, and workforce diversification in kidney health equity research. Three closely integrated cores will lead the core activities of the RCC. The Administrative and Coordination Core will provide administrative, operational, and logistical support to the Consortium, including coordinating meetings, developing a secure web-based communications and collaboration platform, supporting program management and regulatory submissions, administering an opportunity pool for ancillary studies, and continually evaluating and enhancing Consortium operations. The Data Management and Analysis Core will contribute to the final design of Consortium studies, provide data monitoring for multi-site Consortium studies, and support statistical analysis for multi-site Consortium studies and pooled analyses of common data elements across the Consortium. The Collaboration and Community Engagement Core will foster a vibrant and collaborative research community within and beyond the Consortium by facilitating discussion at Consortium meetings and workshops, supporting dissemination of Consortium results to the broader research and lay communities, integrating selected NIH career development awardees in relevant Consortium activities, and exposing early-career trainees from underrepresented groups to kidney- focused structural racism scholarly work in order to successfully implement health equity research and interventions. Together, the multidisciplinary RCC team will ensure the successful completion of multiple intervention trials targeting disparities in kidney health and build a diverse and sustainable community of researchers and community partners focused on improving kidney health in marginalized populations. PROJECT NARRATIVE Structural racism is an important contributor to disparities in kidney disease. The proposed research coordinating center will support a research network and multiple clinical trials focused on addressing structural racism to reduce disparities in kidney health and disease.
|
Other Research-Related
| 6project_grants_public
|
gen_4f2db9b0e3b7f50c316fdd879b28a156
|
Investigating the Critical Role of Glia In Peripheral Organ Development and Physiology
|
NIH
|
UNIVERSITY OF NOTRE DAME
|
1F32HL165966-01A1
|
Project Summary Organs of the human body rely on complex integration of multiple neuronal circuits in order to maintain homeostasis. For example, the heart must respond to internal and external stimuli and produce sufficient blood flow to meet environmental demands. Glia play critical roles to support nervous system function but are also indispensable for establishment of appropriate circuit structure and physiology. Our lab recently identified a cell type in the heart with many similarities to astroglia populations found elsewhere in the body. This cell type, which we termed cardiac nexus glia, is present as the heart is being formed and is critical for establishment of heart rhythm. Ablation of these glia causes cardiac arrhythmia and ventricular fibrillation, both serious physiological conditions. This project uses the zebrafish animal model to investigate the developmental ontogeny and morphological characteristics of cardiac nexus glia in the developing hearts of living animals (Aim 1). Additionally, it probes the functional relationship between these glia and cardiomyocytes and their roles in modulating heart rate and rhythm (Aim 2). The results of these experiments will contribute crucial detail to our understanding of the multi-faceted roles of glia in the peripheral nervous system and provide important and specific insight about cardiac nexus glia function in heart development and disease. This research will be undertaken in a supportive and collaborative laboratory environment within the Biological Sciences Department at Notre Dame University. It will rely on expertise from staff of the Center for Zebrafish Research and the Integrated Imaging Facility. In addition to the development of bench skills and technical expertise inherent to this project, the applicant will also hone teaching, mentoring, and management skills that will be critical for her future success as a PI running her own research group at a primarily undergraduate institution. Project Narrative Current understanding of the development and function of the peripheral nervous system is almost entirely neuron-centric and little attention has been given to the important contributions of glial cell types. This proposal aims to rectify this gap in knowledge by investigating a glial population in the developing heart that actively modulates cardiac function. A better understanding of glia supports a more complete model of neural control over peripheral physiology and pathology.
|
Training, Individual
| 6project_grants_public
|
gen_6107a38dc0bc4b789417340faceb688e
|
Polyamine Dysregulation in the Gastric Epithelium during Helicobacter pylori Infection and its Impact on Gastric Carcinogenesis
|
NIH
|
VANDERBILT UNIVERSITY
|
5F31CA278330-02
|
PROJECT SUMMARY Helicobacter pylori colonizes the stomach of about 50% of the world’s population and is the strongest known risk factor for developing gastric cancer, the fourth most common cause of cancer related deaths. Failure of the host response to control the infection leads to persistent inflammation, which initiates disease progression from chronic gastritis through a histological “Correa Cascade” that results in gastric carcinoma in 1-3% of all those infected. Due to antibiotic resistance, and the fact that antibiotic treatment may not be effective in reducing cancer risk once precancerous lesions are present, we need to develop new therapeutic strategies to limit progression to dysplasia and carcinoma. Our lab investigates the role of the polyamines, putrescine, spermidine, and spermine in gastric inflammation and carcinogenesis. Putrescine is sequentially converted to spermidine and spermine, which is back-converted to spermidine by spermine oxidase (SMOX). We have shown that SMOX expression is elevated in human and mouse gastric tissues infected with H. pylori. Furthermore, infected C57BL/6 Smox–/– mice exhibit depleted spermidine levels, and a decrease in gastritis and carcinogenic signaling compared to wild-type mice. Using FVB/N INS-GAS mice prone to developing gastric dysplasia and intramucosal carcinoma with H. pylori infection, we have seen that Smox–/– mice infected with H. pylori exhibit a significant reduction in gastric intramucosal carcinoma and extent of dysplasia. Spermine catabolism by SMOX generates 3-aminopropanol, which can spontaneously form acrolein, a reactive electrophilic aldehyde that has the potential to damage DNA and proteins. Our preliminary findings demonstrate that acrolein is produced in gastric tissues of H. pylori-infected FVB/N INS-GAS mice and is significantly reduced in Smox–/– FVB/N INS-GAS mice. Additionally, spermidine is an essential substrate for the synthesis of hypusine, a unique amino acid that is only found in the protein eukaryotic translation initiation factor 5A (EIF5A) by the action of the enzyme deoxyhypusine synthase (DHPS). Our recent work with human gastric organoids has revealed induction of hypusinated EIF5A levels with H. pylori infection, which was ablated with the chemical inhibitor of the pathway. Proteomic analysis on these organoids implicated hypusination as a critical pathway for oncogenesis. Taken together, we hypothesize that polyamine dysregulation due to SMOX activity in H. pylori-infected gastric epithelial cells leads to the generation of spermidine and acrolein, and upregulation of the hypusination pathway resulting in increased risk for gastric cancer development. Our specific aims are to determine: 1) the role of SMOX activity in gastric carcinogenesis, including effects of spermidine, spermine and acrolein in FVB/N INS-GAS mice. 2) if spermidine generated by SMOX contributes to gastric cancer development through hypusination using studies in human gastric organoids and mice with an epithelial-specific deletion of Dhps. This proposal seeks to elucidate the mechanisms by which SMOX induces gastric disease progression, thus identifying novel pathways to be targeted for therapeutic benefit, while providing the ideal training for my future career as a principal investigator. PROJECT NARRATIVE Helicobacter pylori infects half of the world’s population and is the strongest known risk factor for gastric cancer; however, traditional treatment with antibiotics is often ineffective, especially once precancerous lesions are present. We have previously shown that polyamines are involved in gastric inflammation and carcinogenesis, and our data indicate that the enzyme spermidine oxidase (SMOX) regulates key pathways involved in the progression to cancer. This project will investigate the mechanisms by which SMOX contributes to gastric carcinogenesis by examining its metabolic products, spermidine and the toxic metabolite acrolein, and the enhancement of a pathway involved in translation, hypusination, all of which could contribute to carcinogenetic signaling, with the ultimate goal of discovering novel pathways to be therapeutically targeted.
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Training, Individual
| 6project_grants_public
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gen_c8399bffa4c34295571724788ed5098e
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Translational Pathology Core
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NIH
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UNIVERSITY OF MICHIGAN AT ANN ARBOR
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1P50CA269022-01A1
|
PROJECT SUMMARY-ABSTRACT (Translational Pathology Core) The overarching mission of the Translational Pathology Core is to collect human tissues associated with clinical information and distribute to SPORE investigators to facilitate translational research. The Translational Pathology Core will be housed and administered within the Department of Pathology to ensure uncompromised patient care, optimal use of limited tissue resources, and patient confidentiality. The specific goals of the core include: (1) Uncompromised patient care and proper surgical pathology diagnosis. All tissues will be collected under IRB-approved protocols. (2) Prospective procurement of appropriate brain, breast, pancreas and other future tissues as dictated by the needs of the SPORE projects. The core will work closely with and enhance the existing Tissue Procurement Service of the Tissue and Molecular Pathology Shared Resource of the University of Michigan Rogel Cancer Center. Dr. Thomas Giordano has been a director of this shared resource continuously since 1996. (3) Expert pathology review of human tissues from surgical pathology specimens. Dr. Sriram Venneti, a neuropathologist and accomplished glioma investigator, will review all brain tissues, Dr. Jiaqi Shi, a GI pathologist with special expertise in pancreas cancer, will review all pancreas tissues, and Dr. Thomas Giordano, a surgical pathologist with decades of experience in breast pathology, will review all breast tissues. As needed, other expert pathologists from the Department of Pathology will be recruited to support the core. (4) Tissue-based gene expression and biomarker validation studies, such as immunohistochemistry, as indicated by the needs of the SPORE projects. Dr. Dafydd Thomas, an expert in tissue-based investigation, will lead these efforts. Collectively, the services of the Translational Pathology Core will support the projects by facilitating translational research and also enhance the resources of other NCI-supported networks.
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Research Centers
| 6project_grants_public
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gen_f9f57c6ce6c7c81873bc955f74df451e
|
Biosynthesis of Several Oxyvinylglycine Nonproteinogenic Amino Acids Bearing Unusual Alkoxyamine Bonds
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NIH
|
UNIV OF NORTH CAROLINA CHAPEL HILL
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1F32GM151822-01
|
Project Summary Natural products serve crucial roles in the pharmaceutical industry as drugs or leads for drug compounds. Generated through secondary metabolism, these molecules impact the virulence, symbiosis, and survival of microorganisms. The nonproteinogenic oxyvinylglycine amino acids are an interesting class of secondary metabolites characterized by the presence of a vinyl oxygen moiety. Members of this class, such as 4-(2’- aminoethoxy)vinylglycine (AVG), are known to arrest germination in plants by inhibiting the pyridoxal 5’- phosphate (PLP)-dependent enzyme 1-aminocyclopropane-1-carboxylate (ACC) synthase.2 While the biosynthesis of vinyl ether-bearing oxyvinylglycine nonproteinogenic amino acids including AVG has been explored, the formation of other members of the family with alternative functional groups remains undetermined. 4-Formylaminooxyvinylglycine (FVG), an oxyvinylglycine containing an N–O bond, was reported to have duel herbicidal and bactericidal activity.3,4 The gvg biosynthetic gene cluster in Pseudomonas fluorescens strain WH6 is responsible for the biosynthesis of FVG and the related compounds guanidinooxyvinylglycine (GOVG) and aminooxyvinylglycine (AOVG) though the exact biosynthetic mechanism remains unclear.5,6 In this proposal I will determine the biosynthetic pathways responsible for the formation of FVG, GOVG, and AOVG. I will use a combination of feeding experiments and in vitro biochemical assays to determine the substrate and product of each enzyme along the biosynthetic pathway of these three nonproteinogenic amino acids. The vinyl alkoxyamine is unusual in amino acids, therefore I will characterize the enzyme responsible for N–O bond construction and determine its chemical mechanism. These studies will facilitate the bioinformatic discovery of similar oxyvinylglycine nonproteinogenic amino acids. Moreover, characterization of the iron-dependent enzyme responsible for N–O bond formation will facilitate its use in a synthetic context to expand the repertoire of oxidative biocatalysts. PROJECT NARRATIVE Natural products are an invaluable source of and inspiration for pharmaceuticals and agrochemicals. This project proposes to study the biosynthetic pathways of bioactive nonproteinogenic amino acid secondary metabolites that contain unusual vinyl N–O bonds. Understanding the synthesis of these small molecules and the biochemical mechanisms underlying their formation will enable our search for similar bioactive compounds and expand the toolbox of biocatalytic oxidative enzymes.
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Training, Individual
| 6project_grants_public
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gen_d0089c2894fe005d030390fef08a30a0
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Ethics Core (FABRIC)
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NIH
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YALE UNIVERSITY
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5U54HG012510-04
|
Bridge2AI: a FAIR AI BRIDGE Center (FABRIC) Ethics Core Summary The use of artificial intelligence (AI), and particularly machine learning (ML), in healthcare opens up many opportunities to improve healthcare and biomedical research. However, AI/ML also raise important issues that implicate ethics and trust, including defining parameters for consent and re-use of personal data, protecting privacy, ensuring transparency and engagement with stakeholders about this research, and developing and deploying tools that are useful and valid for all people. Without an ethically robust set of principles and practices that are generalizable and reusable in a wide range of biomedical environments, AI/ML could violate personal rights, widen the gap between fairness and equality, and fan the flames of mistrust, as exemplified by recent work showing how racial bias can influence clinical decision algorithms. Our vision for the FAIR AI Bridge Center - Ethics Core (FABRIC-Ethics) is to ensure that AI/ML is developed and applied in an ethical and trustworthy manner. FABRIC-Ethics will support the Bridge2AI program to become sustainable by making it more ethical and trustworthy by the end of the four-year project period. To realize this vision, we will use an iterative and reflective four-step cycle: 1) Scaffold, 2) Assess, 3) Facilitate and 4) Evaluate and educate, or SAFE, to provide a platform for convening, analyzing and curating, public relations and original research in a multidisciplinary manner. We will work with the Bridge2AI program to formulate ethical and trustworthy principles for AI/ML (ETAI) to address existing and future practices in biomedical AI research and applications. These include the collection and management of data, the development and deployment of AI/ML technologies and AI/ML applications. In close collaboration with the Bridge2AI program and its Data Generation Projects (DGPs), we will conduct a closed- and open-ended survey, discuss priorities and experiences with Bridge2AI DGPs, and develop an open, curated catalog of relevant literature. These efforts will run in parallel with multiple mechanisms for building a learning ETAI community, convening Bridge2AI data generation projects to distill best practices, and organizing studio sessions to support contact with the other core areas of the Bridge2AI Center and the broader community. Our core will further develop a digital health checklist and framework that prepares Bridge2AI DGPs to evaluate: 1) access and usability, 2) risks and benefits, 3) privacy and 4) data management. We will work with the Bridge2AI DGPs to share knowledge about ETAI, inform the development of principles and best practices, and to set up conferences for sustainable development of ETAI culture beyond Bridge2AI. The team assembled for the core has expertise in a wide range of areas, including bioethics, digital health research ethics, law, public policy, AI/ML, data protection, informatics, medicine, human- centered design, implementation science, and community engagement. To ensure success, FABRIC-Ethics will be led by four PIs with a proven track record in multidisciplinary approaches to the study of ethical issues in technology, center management, and core support.
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Research Centers
| 6project_grants_public
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gen_66ad22898cb557cbfb362c34c79210ce
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Thick and Thin Filament Dysfunction in Obese Heart Failure with Preserved Ejection Fraction
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NIH
|
JOHNS HOPKINS UNIVERSITY
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1F31HL168850-01
|
PROJECT SUMMARY Heart Failure with Preserved Ejection (HFpEF) is one of the largest unmet needs of all cardiovascular disease. Although it now is the most common form of heart failure, to date, it has little to no specific effective therapy. An obesity pandemic has now changed its phenotype, with obesity and metabolic syndrome now significant drivers of the disease. We recently reported that an obese-HFpEF phenotype exhibits striking depression of right ventricular myocyte tension generation at higher (contraction-related) levels of calcium. Critically, the mechanism by which this occurs is unknown. Myocyte tension is regulated by both the thick filament, consisting of myosin, and the thin filament, consisting of actin, tropomyosin, and cardiac troponins. In the thick filament, approximately half of all myosin heads are in a conformation known as the super-relaxed (SRX) state, and the proportion of myosin in this state is an important regulator of tension. The thin filament regulates tension by altering calcium sensitivity, and one regulator is phosphorylation of cardiac troponin I (cTnI). In exciting new preliminary data, I find that thick filament structure and phosphorylation of myofilament proteins are altered in obese-HFpEF. This proposal derives from these data and aims to elucidate how obesity alters the thick and thin filament in human HFpEF. In Aim 1, I will test the hypothesis that structural inactivation of the thick filament in obese-HFpEF results from an excess of SRX myosin. To assess thick filament structure, I use small angle x-ray diffraction, a technique that leverages the ordered structure of cardiac muscle to quantify distances between sarcomere proteins. This technique is performed at the synchrotron at Argonne National Laboratory, one of few locations globally that can perform the assay, and this proposal describes the first application of this technique to endomyocardial biopsies from human HFpEF patients. While informative, X-ray diffraction on its own cannot prove the presence of excess SRX myosin. For this, I will measure the myosin ATP turnover from single cardiomyocytes from HFpEF patients. I will then explore whether obesity is a driver of excess SRX myosin by measuring both assays in HFpEF patients with both obesity and hypertension/hypertrophy. In Aim 2, I explore the mechanism underlying how hyperphosphorylation alters calcium activated tension. My preliminary data finds that the exposure to enzymatically active protein phosphatase 2A (PP2A) partially reverses the deficit observed in calcium activated tension in obese HFpEF, but the mechanism is unknown. I will test if this is from thick filament activation by measuring x-ray diffraction patterns and myosin ATP turnover after PP2A exposure. I also test if this results from thin filament hyperphosphorylation, specifically at cTnI, in HFpEF. We have identified a novel threonine 181 residue of cTnI to be hyperphosphorylated in HFpEF, but its function is unknown. Phospho-null/mimetic transgenic cTnI Thr181 will be swapped into skinned myocytes from HFpEF patients, and myocyte tension measured. These studies will advance our understanding of the thick and thin filament in HFpEF and could pave the way for new therapies with small molecule sarcomere enhancers that target these mechanisms. PROJECT NARRATIVE Recently, we have demonstrated that patients with heart failure and preserved ejection fraction (HFpEF) with comorbid obesity have striking depression of right ventricular myocyte calcium activated force, with force negatively correlating with BMI. This finding has clinical implications, suggesting that the selective use of small molecule sarcomere enhancers might benefit patients with obese HFpEF. In this proposal, I aim to elucidate the mechanism of obesity mediated myocyte dysfunction, specifically exploring the impact of obesity on both the thick and thin filament in HFpEF.
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Training, Individual
| 6project_grants_public
|
gen_58ed133c5022779e30eb49f666f6c9c2
|
Cancer-associated fibroblasts promote thyroid cancer malignancy through Wnt signaling
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NIH
|
VANDERBILT UNIVERSITY
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5F30CA281125-02
|
PROJECT SUMMARY Many aggressive cancers have a robust tumor microenvironment composed of heterogenous stromal and immune cells. Although the advent of immune checkpoint inhibitors has shifted therapeutic targets of cancer research to include tumor-cell extrinsic targets, the therapeutic potential of targeting the tumor stroma remains underexploited. Recently, cancer-associated fibroblasts (CAFs) have been implicated as drivers of disease progression. From preliminary attempts to harness the therapeutic potential of targeting CAFs, it has become clear that targeting CAFs as a bulk population of cells will not be sufficient. As such, there have been efforts in breast and pancreatic cancer to define the heterogeneity of CAFs. These efforts have yielded diverse subtypes commonly described by two overarching groups: myofibroblast CAFs (myCAFs) and inflammatory CAFs (iCAFs). In pancreatic cancer, myCAFs are observed to be tumor-adjacent and iCAFs are more distant from tumor cells. While defining subtypes of CAFs is a necessary first step, the development of novel therapeutic approaches will likely require the identification of specific functions of CAF subtypes. To this end, Wnt2 has been identified as upregulated in CAFs from pancreatic, breast, and colorectal cancer, yet the role of CAF-driven Wnt signaling on tumor progression remains largely unknown. Anaplastic thyroid carcinoma (ATC) is a lethal disease (~3-5 month median survival) with an abundant tumor stroma and no efficacious treatment options. The composition of the tumor stroma in ATC has been largely unexplored. My preliminary work identifies a prominent fibroblast population in ATC that expresses WNT2. As ATC is known to have upregulated Wnt signaling relative to other thyroid neoplasms, this provides a unique opportunity to study the dynamics of CAF-driven Wnt signaling. The goal of this proposal is to define the CAF subtypes present in thyroid carcinoma and determine the functional role of CAF-derived Wnt2 on tumor growth. I hypothesize that distinct CAF populations promote tumor growth and invasion in thyroid carcinoma through Wnt signaling and have unique spatial relationships. To test my hypothesis, I will perform experiments in ATC models and papillary thyroid carcinoma (PTC) models. PTC is a predominantly indolent thyroid carcinoma that can transform to ATC in vivo, making it ideal for examining the ability of CAFs to promote disease progression. In aim 1, I will elucidate subtypes of CAFs present in ATC and PTC and probe Wnt ligand-receptor interactions. Further, I will determine spatial resolution of myCAF and iCAF fibroblast populations in thyroid carcinoma. In aim 2, I will utilize >40 primary patient thyroid carcinoma CAF cultures that our lab has collected to demonstrate the role of CAF-derived Wnt2 signaling both paracrine on PTC and ATC tumor cells and autocrine to shape the phenotype of CAFs. In completing these studies, I will for the first time define the heterogeneity of CAFs in thyroid carcinoma and characterize a potential novel therapeutic target applicable to CAFs in multiple cancer types. PROJECT NARRATIVE Cancer-associated fibroblasts (CAFs) are a heterogeneous stromal cell population that influence disease course and treatment responses in aggressive cancers. Anaplastic thyroid carcinoma has a substantial stromal component, yet the composition of the stroma and its role in promoting malignancy remain unclear. In this proposal, I will elucidate the subtypes of CAFs in thyroid carcinoma and investigate the tumor-promoting effects of CAF-driven Wnt signaling, providing a novel therapeutic target for a disease with an urgent need for new treatment options.
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Training, Individual
| 6project_grants_public
|
gen_f81a1428a2e9554d25a7773fa27d01c1
|
Southwest Center on Resilience for Climate Change and Health (SCORCH)
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NIH
|
UNIVERSITY OF ARIZONA
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1P20ES036112-01
|
PROJECT ABSTRACT – Component: Overall Arid lands are home to one in three people, totaling a population of more than 2 billion spanning the globe. Arid land communities are facing multiple climate change-exacerbated threats impacting health including extreme heat events, wildfires, dust storms, biodiversity loss, emerging pathogens, poor air quality, and drought. The Southwest Center on Resilience for Climate Change and Health (SCORCH) brings together transdisciplinary research groups to conduct team-science projects addressing the health needs of arid lands communities adapting to climate change. The Center's overarching mission is to improve health equity across the lifespan by enhancing community partnerships and supporting adaptation efforts by Indigenous, Latinx, low-resource urban, and rural communities in the Southwestern United States and globally. Based at the University of Arizona (UArizona), home of internationally recognized climate science and adaptation researchers and Centers, SCORCH will serve as a foundation for expanding UArizona campus initiatives aiming to increase health research at the intersection of climate change science. The three-year planning phase will be used to identify researchers whose expertise align with climate change and health across UArizona and the region, build transdisciplinary teams, identify priority research areas for community adaptation planning, and implement two research projects to develop our initial Research Focus Group (RFG) themes. Our initial three RFGs build on the expertise of the current SCORCH team members and are purposefully broad to encompass evolving research priorities. These three themes include: 1) Health impacts of extreme weather events; 2) Forecasting and early warning of climate change health outcomes; and 3) Adaptive responses in the built environment. Research Project 1 aligns with RFG 2 and 3, to develop an assessment tool that can predict potential health outcomes of greenspace designs. Research Project 2 aligns with RFG 1 to examine the role of maternal exposure to extreme heat and long-term child health outcomes. Through community engaged activities founded on respect and trust, led by the Community Engagement Core, and novel data visualization services, led by the Integrated Data Visualization Core, we will deepen existing and develop new partnerships with academic and community entities with diverse lived experiences and knowledge frameworks. The geographic location of SCORCH in the Southwestern United States provides unique research opportunities to support adaptation and resilience efforts of Indigenous, Latinx, low-resource urban, and rural communities in the region as well as addressing the unique circumstances found in borderland areas. The potential international reach of SCORCH enables high-impact climate change and health initiatives that will translate globally. PROJECT NARRATIVE – Component: Overall The Southwest Center for Resilience in Climate Change and Health (SCORCH) will bring together transdisciplinary research groups to conduct solutions-oriented team-science projects responsive to the human health needs of Arid Lands communities adapting to climate change. The Center’s overarching mission is to improve health equity across the lifespan by enhancing existing community partnerships and supporting adaptation efforts by Indigenous, Latinx, low resource urban and rural communities in the southwestern United States and globally. Research will span several areas including: Research Focus Groups; 1) Health effects of extreme weather events, 2) Forecasting and Early Warning, and 3) Adaptive Responses to the Built Environment.
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Research Centers
| 6project_grants_public
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gen_a475163d8f71bcc387196ffc232a4e2a
|
Molecular MR-PET to characterize malignant transformation and identify therapeutic vulnerabilities in human IDH-mutant gliomas
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NIH
|
UNIVERSITY OF CALIFORNIA LOS ANGELES
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1F30CA284809-01
|
PROJECT SUMMARY/ABSTRACT The World Health Organization (WHO) classification of gliomas has been steadily shifting from a histological classification towards a molecular classification. For example, isocitrate dehydrogenase (IDH) mutational status is a critical feature of the recent 2021 WHO classification. Compared to IDH-wild-type (IDH-wt) gliomas, IDH- mutant (IDH-m) gliomas have distinct clinical characteristics such as accounting for most low-grade gliomas (LGGs; grade 2), having better prognosis, growing slower, and affecting a younger patient population compared to IDH-wt gliomas. However, all WHO grade 2 IDHm gliomas are expected to eventually become malignant higher-grade (WHO grades 3-4) gliomas in a process known as malignant transformation. Upon malignant transformation, patients with IDHm gliomas have a significantly worse prognosis. Thus, early, non-invasive imaging biomarkers of IDHm glioma malignant transformation may allow for earlier identification of treatment failure and appropriate therapeutic interventions. Magnetic resonance imaging (MRI) is critical for the management of patients with IDHm gliomas. Currently, identification of malignant transformation in patients with IDHm gliomas involves the emergence of contrast- enhancing areas on T1-post-contrast MRI in previously non-enhancing grade 2 gliomas. However, advanced MRI biomarkers sensitive to acidity, perfusion, and cellular density may provide earlier identification of the tumor microenvironment changes associated with malignant transformation and earlier identification of treatment failure. Furthermore, combining our lab’s pH-sensitive MRI with metabolic positron emission tomography (PET) imaging may yield deeper insights into the tumor microenvironment, particularly for metabolic shifts associated with malignant transformation and new IDH inhibitor targeted therapies that inhibit the mutant IDH enzyme. As a result, this proposal seeks to identify molecular MR-PET biomarkers associated with malignant transformation and successful IDH inhibition of IDHm gliomas. In Specific Aim 1, we will establish a sequential order of advanced MRI biomarkers in IDHm gliomas undergoing malignant transformation using pH-sensitive, perfusion, diffusion, and anatomical MRI and then validate MR-PET biomarkers of IDHm gliomas with histopathological markers from targeted surgical biopsies. In Specific Aim 2, we will utilize pH-sensitive MRI and PET to evaluate metabolic perturbations in IDHm gliomas following successful IDH inhibitor therapy. The proposed studies may improve IDHm glioma management by establishing imaging biomarkers of malignant transformation and successful IDH inhibitor treatment response. PROJECT NARRATIVE Isocitrate dehydrogenase (IDH)-mutant gliomas have distinct metabolic characteristics and therapeutic vulnerabilities. However, advanced imaging biomarkers of IDH-mutant glioma remain limited for malignant transformation and new IDH inhibition therapy. Our proposed studies will utilize molecular MR-PET imaging to identify imaging biomarkers that could improve the clinical management of IDH-mutant gliomas.
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Training, Individual
| 6project_grants_public
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gen_9095655c8f382e87af126ecc5e067777
|
Senescent hepatocytes mediate reprogramming of immune cells in acute liver failure
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NIH
|
UNIVERSITY OF KANSAS MEDICAL CENTER
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5F31DK134197-02
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PROJECT SUMMARY Acute liver failure (ALF) is characterized by coagulopathy, hepatic encephalopathy, jaundice and multi-organ failure. Fifty percent of all ALF cases in the United States and UK are due to acetaminophen (APAP) overdose. Supraphysiological doses of APAP overwhelm safe detoxification pathways in the liver leading to excessive bioactivation of APAP by Cyp2e1 into the highly reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI). This initiates a cascade of intracellular events driving hepatocyte death. An extensive body of work has elucidated the molecular mechanisms of hepatocyte necrosis during APAP overdose, but detailed mechanisms involved in the development of ALF have been largely unexplored. The innate immune response after liver injury plays a critical role in liver recovery in the human relevant mouse model of APAP overdose. However, immune cell dysfunction has been implicated in the development of ALF. Though crosstalk between stressed hepatocytes and immune cells actively supports liver recovery, persistent and prolonged hepatocyte stress may alter this communication network, resulting in immune cell reprogramming towards detrimental phenotypes which facilitate ALF. Excessive cell stress can elicit temporary or permanent cell cycle arrest, a cell fate decision called senescence. Some cells acquire a senescent associated secretory phenotype (SASP) which can elicit pleotropic effects on nearby cells and the tissue microenvironment. Our preliminary data demonstrate that Klf6 and p21 induce hepatocyte senescence after a severe APAP overdose and that these hepatocytes have an active SASP, enriched in the cytokine Cxcl14 which persists in circulation. These key findings lead us to hypothesize that upon severe APAP-induced liver injury, prolonged hepatocyte senescence results in a sustained secretome exposure enriched in Cxcl14 causing immune cell reprogramming impeding tissue repair and injury resolution. This hypothesis will be tested by pursuit of two specific aims. Experiments in Aim 1 are designed to evaluate how Klf6 induces p21 and Cxcl14 and the influence of in vivo silencing of Klf6 on APAP-induced senescence and liver recovery after injury. Aim 2 will use single-cell RNA sequencing in combination with wet-lab approaches to define how the critical SASP component Cxcl14 alters the global communication network between senescent hepatocytes and immune cells after a severe APAP overdose. Collectively, these data will define the molecular mechanisms responsible for sustained induction of hepatocyte senescence, its relationship to the induction of a senescent associated secretory phenotype, and the signaling interactions between senescent hepatocytes and the innate immune response. This proposed work will provide valuable insights into why ALF develops after severe APAP overdose and will assist in addressing this unmet clinical need. PROJECT NARRATIVE Acute liver failure (ALF) is associated with a dysfunctional immune response, but the reason for this is unclear. My proposal will investigate if senescent hepatocytes reprogram infiltrating immune cells interfering with their capacity to promote liver regeneration after injury. This work will elucidate the role of hepatocyte senescence in influencing the liver microenvironment to facilitate ALF and will support the identification of novel therapeutic approaches to address this unmet clinical need.
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Training, Individual
| 6project_grants_public
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gen_7d5be766c3e477103a3213c5c1b61a36
|
Johns Hopkins Retinal Degenerations and Visual Electrophysiology Conference 2023.
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NIH
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JOHNS HOPKINS UNIVERSITY
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1R13EY035562-01
|
Project Summary/Abstract This application seeks to support three biennial editions of the Johns Hopkins Retinal Degenerations and Visual Electrophysiology Conference. These meetings will continuously update early-stage investigators, trainees, clinicians, and scientists on the latest translational and clinical research on Inherited retinal diseases (IRDs). In addition, the conference will address multiple identified gaps in knowledge in interpreting visual function tests, including electrophysiology and microperimetry. The meetings will be held biannually in September in Baltimore, Maryland. The specific aims covered by this conference include 1) understanding the cellular and molecular basis of selected IRDs, 2) reviewing the recommendations from the Society of Clinical Electrophysiology of Vision (ISCEV) regarding visual neurophysiology testing, 3) reviewing the structural and functional outcome measures of IRDs, including those relevant to research subjects with ultra-low vision, 4) analyzing data and results from current treatments in development, especially those in Phase I, II, and III clinical trials and large animal studies, with an emphasis on retinal stem cells and gene therapy, and other treatment modalities, and 5) reviewing aspects relating to equitable access to clinical care and research for IRD patients, and ethical considerations unique to people with vision loss due to IRDs. The requested funds will support the attendance of trainees and early-career investigators, travel awards, and diversity awards to support women, under- represented minorities (URMs), and international participants, including those from developing countries. These meetings will be an ideal opportunity for trainees of diverse backgrounds, early-stage investigators, under- represented minorities, and international trainees to network and learn from leaders in the field of retinal degeneration. In addition, we hope this meeting will encourage multidisciplinary and international collaboration between clinicians and investigators to develop novel therapies and clinical trials end points. Project narrative Considering the current rapid development of novel treatments for inherited retinal diseases (IRDs), we propose to organize a scientific conference focusing primarily on translational and clinical IRD research, to complement other basic science conferences. The proposed conference will emphasize latest developments in cell therapy, gene therapy, genome editing, pharmacotherapy and nanomedicine, artificial intelligence for case detection and progression analysis, structural and functional IRD outcome measures, Phase I–III clinical trial data, ethics and equity, and surgical delivery in humans. We have prioritized avenues to promote the participation of trainees, women, and under-represented minorities while fostering international ideas exchange.
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Other Research-Related
| 6project_grants_public
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gen_5744875a40c6e2e7c5741c5cc1417f99
|
Rocky Mountain REACH (RMT-REACH)
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NIH
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UNIVERSITY OF MONTANA
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5U01GM152530-02
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PROJECT SUMMARY/ABSTRACT The L.S. Skaggs Institute for Health Innovation (SIHI)-Research Evaluation and Commercialization Hub (SIHI- REACH) at the University of Montana (UM) will catalyze the emerging biomedical industry corridor in Montana and the surrounding states by establishing a hub to accelerate translation of academic discoveries into products that impact human health. Untapped opportunities exist in IDeA states to turn biomedical research discoveries into technologies that address unmet medical needs, disease burden, and health disparities for populations across the United States (US). We have partnered with 10 academic institutions across the IDeA states in the Washington, Wyoming, Alaska, Montana, and Idaho (WWAMI) region—including a community, a technological, and a tribal college—as well as the Washington Entrepreneurial-REACH (WE-REACH) at the University of Washington to gain invaluable guidance from their leadership team. Academic discovery is indispensable for ensuring a pipeline of research for novel diagnostics, devices, and therapies, yet sustainable infrastructure to support academic innovators in resource-limited regions has yet to be fully realized. Geographically remote regions have unique challenges in developing and promoting commercialization and entrepreneurship, including lack of infrastructure, less access to innovators and subject matters experts, and lower levels of funding. Gaps in resource allocation contribute to higher rates of mortality and disease burden, and health systems in these areas have traditionally been late to implement health innovation when compared to their metropolitan counterparts. In order for health innovation to reach clinical usefulness for all people, efforts are needed to ensure the inclusion of minority, geographically-isolated, and historically medically underserved populations at every stage of the biomedical research life cycle. We will accomplish our ultimate goals through the following aims: 1) Identify emerging biomedical discoveries with commercial viability in academic institutions within the four regional IDeA states supported by SIHI-REACH, emphasizing discoveries that address disease burden and health disparities for underserved communities; 2) Develop an innovative implementation system to enable access to gap funding, key subject matter experts in areas of product development, regulatory, reimbursement, legal, business development, and overall commercial strategy for academic researchers in resource-limited areas; 3) Provide funding and project management support for promising technologies and development teams to accelerate product definition studies; and 4) Elevate a WWAMI region-wide pro-entrepreneurial culture among academic investigators by engaging and mentoring biomedical innovators in rural and tribal institutions. With a strong leadership team providing diverse and complementary expertise and proven experience in entrepreneurial startups, SIHI-REACH will train the next generation of biomedical innovators in entrepreneurship and product development, positively impact the regional economy, and bring products that address health disparities to market. 1 PROJECT NARRATIVE The L.S. Skaggs Institute for Health Innovation (SIHI) Research Evaluation and Commercialization Hub (SIHI- REACH) at the University of Montana will accelerate translation of academic discoveries into products that impact human health in states that have largely not benefitted from investment in commercialization. We have partnered with 10 academic institutions in the Washington, Wyoming, Alaska, Montana, Idaho (WWAMI) region—including a community, a technological, and a tribal college—and are building upon the success of the Washington Entrepreneurial REACH (WE-REACH) at the University of Washington. Participating institutions and innovators will gain access to funding, training, and resources to guide the research and development of new medical products, ultimately fostering a pro-entrepreneurial culture across the region, creating new small businesses, and bringing products to market that address disease burden and health disparities. 1
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Non-SBIR/STTR
| 6project_grants_public
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gen_b711f9c749a5a2394ee333feecc5f60b
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San Diego State University Advancing Cancer Careers for ExceLlence (ACCEL)
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NIH
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SAN DIEGO STATE UNIVERSITY
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1R25CA285813-01
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PROJECT SUMMARY / ABSTRACT San Diego State University’s Advancing Cancer Careers for ExceLlence (ACCEL) Program, in partnership with University of California San Diego (UCSD) Moores Cancer Center, will provide 70 SDSU postdoctoral fellows and graduate students each year with a coordinated and innovative array of resources to support excellence, inclusion and transformation of the cancer research science force. ACCEL will leverage existing infrastructure and develop new programming to a) expand and strengthen the pipeline of underrepresented (UR) scholars pursuing cancer research; and b) broaden SDSU’s capacity to support and advance UR pre- and postdoctoral cancer research scholars. Three distinct and complimentary aims have been developed to meet these larger objectives. Led by a Training Champion (TC) team with diverse areas of expertise, the ACCEL program will a) implement mentoring activities and community-building engagement that reduce feelings of isolation and increase sense of belonging to increase doctoral student and postdoctoral scholar participation and retention in cancer research; b) provide structured support services including skills development courses for doctoral students and postdoctoral scholars to broaden advancement in cancer research and promote diversity in the scientific workforce; and c) build tailored and sustainable linkages for SDSU students and scholars to existing support and resources through the National Cancer Institute and other partners. While ACCEL program development and implementation will benefit greatly from strong integration with existing partners and programs including the UC San Diego Moores Cancer Center, SDSU-UCSD CREATE Cancer Partnership, and the NCI Center to Reduce Cancer Health Disparities (CRCHD) training navigation, ACCEL will also introduce innovative methodologies to address isolation and build community and belonging in tandem with skills building. PROJECT NARRATIVE San Diego State University’s Advancing Cancer Careers for ExceLlence (ACCEL) Program, in partnership with University of California San Diego (UCSD) Moores Cancer Center, will provide 70 SDSU postdoctoral fellows and graduate students each year with a coordinated and innovative array of resources to support excellence, inclusion and transformation of the cancer research science force. ACCEL will leverage existing infrastructure and develop new programming to a) expand and strengthen the pipeline of underrepresented (UR) scholars pursuing cancer research; and b) broaden SDSU’s capacity to support and advance UR pre- and postdoctoral cancer research scholars.
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Other Research-Related
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gen_13935d821d6d9f175ff042831c07895b
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FEDER - UNICAEN (LABO GREYC) - ONE4YOU PROJECT
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Kohesio
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UNIVERSITE DE CAEN NORMANDIE
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https://linkedopendata.eu/entity/Q3680141
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SOGET, leader of this project, is a world-class player in the development and implementation of multimodal one-stop shops. Its vision is to serve the fluidity of port operations, by organizing for the various public and private operators, intelligent, shared and instantaneous management of information relating to logistics chains. GREYC, ISEL and SOGET wish to join forces in order to respond to the major structural challenges of international flows: The logistics ecosystem is changing with flow operators who are constantly looking for productivity gains and fluidity of trade. Conversely, sovereign actors (customs authorities, port authorities and other administrations) seek to control and secure the flow of goods. To respond to these two movements which can oppose each other, multimodal port and airport one-stop shops must reinvent themselves and combine facilitation and security of trade. On the other hand, the one-stop shop market is experiencing unprecedented development. As part of the WTO BALI agreements, an agreement on trade facilitation was ratified and came into force on February 22, 2017. The latter aims to accelerate the movement, release and customs clearance of goods at borders. Its entry into force marks the start of a new phase of reforms intended to facilitate trade around the world and creates important momentum for trade and the multilateral trading system as a whole. At the same time, new technologies are emerging, such as artificial intelligence which opens up new fields of application in logistics. These systems are capable of learning, making decisions, automating tasks, and carrying out global flow monitoring tasks based on exchange histories. Innovation being the pillar of research and development of any software publisher, SOGET launched in 2014 the reflection of the e-maritime 2 project "Artificial Intelligence at the service of logistics which was included in the CPER 2014-2020 as a priority digital project in transport. The e-maritime 2 project is part of the dynamic of the trade facilitation agreement of the World Trade Organization, the massification of one-stop shops has across the world, and the emergence of national operators of vital importance. This new complex environment requires the contribution of artificial intelligence to the service of tomorrow's logistics in a context of globalization at the level of operators and sovereign authorities. Artificial intelligence will be the true digital revolution in the service of trade facilitation. The e-maritime 2 project will consist of the development of new information systems for management, control, targeting and monitoring of international supply chains based on artificial intelligence technologies, the digital intensities of the Internet of Things and cyber-security linked to the dematerialized power of the Cloud. Already, a prospective study has been carried out with a certain number of companies following an internal reflection between SOGET, GREYC and ISEL which made it possible to determine various concrete expectations complementary to the S)ONE one-stop shop. These new services are grouped under the title ONE4YOU and represent one of the first components of e-maritime2. ONE4YOU thus aims to determine the research and development roadmap to address the global market for port single windows.
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Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking
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gen_2f5ed02f02e253dff7389d0f725e8816
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FEDER - UNICAEN - Design, synthesis and biological evaluation of MT5-MMP inhibitors Investment
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Kohesio
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UNIVERSITE DE CAEN NORMANDIE
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https://linkedopendata.eu/entity/Q3673587
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Not available
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Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking
| 6project_grants_public
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gen_513b44c289829e04e98a259d2f6ad47a
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FEDER - UNIROUEN (LMSM) - Production of Actives and Cosmetic Products Modulating the Hair MICrobiota (MICCA)
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Kohesio
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UNIVERSITE DE ROUEN-NORMANDIE
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https://linkedopendata.eu/entity/Q3681808
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The MICCA project aims to develop a hair cosmetic product acting on the communication between the cells of the hair follicle and the microbiota, through the use of raw materials of natural or peptide origin. This project is led by the LMSM (EA4312 of the University of Rouen Normandy) and the companies SEDERMA, SISLEY and GENOSKIN (PME). Activities of the consortium members: • SISLEY specializes in the creation and manufacturing of cosmetic products (skincare, makeup, hair and perfumes). • GENOSKIN provides a unique platform of ex vivo models of human skin to validate the development of cosmetic active ingredients, chemicals, drugs, or administered medical devices.•SEDERMA designs, produces, analyzes and markets cosmetic raw materials.•LMSM works to study the role of communication and environmental and host factors on bacterial adaptation and virulence.
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Smarter Europe / Research and innovation / Technology transfer and university-enterprise cooperation primarily benefiting SMEs
| 6project_grants_public
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gen_cc4cf182d3c914f73092d15d4dd5a225
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FEDER - URN - MOTHER OF PEARL - SPRINGBOARD
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Kohesio
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UNIVERSITE DE ROUEN-NORMANDIE
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https://linkedopendata.eu/entity/Q3681630
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Currently, and more particularly in the pharmaceutical field, many substances discovered or in development are composed of chiral molecules. They can therefore exist in the form of two isomers with identical physicochemical properties but with different, or even opposing, biological activities and often only one of the two enantiomers has the required therapeutic activity. The development of processes allowing access to pure enantiomers (chiral resolution processes) therefore constitutes a major economic and scientific challenge. The SMS laboratory has extensive experience in the development of chiral resolution methods by crystallization (Pasteurian resolution, preferential crystallization, deracemization, preferential enrichment). It benefits from significant recognition from the scientific and industrial community in this field which results in different types of partnerships (university collaborations, research contracts, CIFRE Theses, patent filings, ANR, etc.). It is also thanks to this experience that the SMS laboratory is one of the beneficiary partners of the European ITN Marie-Curie CoRe project, (Continuous Resolution and Deracemization of Chiral Compounds by Crystallization) which started in October 2016 and will end in October 2020. The research carried out as part of the CoRe project has made it possible to highlight the need for the development of optimized processes of increased understanding and control. of the very first step of the crystallization process: nucleation. The idea that the theme of the nucleation of chiral phases should be the subject of a European request for a new ITN which would thus follow up on the research carried out within the framework of the CoRe project is now a consensus among our European partners. It is in this context that the SMS laboratory wishes to benefit from the support of the Normandy region. (see the description of the attached file)
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Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 6project_grants_public
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gen_c015356060ae0efa29abf8257b0973bd
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FEDER - ESIGELEC - ANDECE - INVEST/FONCT
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Kohesio
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ESIGELEC
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https://linkedopendata.eu/entity/Q3680972
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In recent years, the growing penetration of the electrical energy vector in a large number of products and industrial sectors through the multiplication of electrical devices (machines-converters-storage) leads to complex systems with restrictive requirements in terms of operational safety and availability and which can be very critical for certain applications. For example, the automotive sector saw the implementation of the ISO 26262:2011 standard in 2011, which would guarantee the functional safety of a system embedded in the vehicle. Likewise, the ED-12C and DO-178C standards concern the analysis of safety for avionics. It should be noted that this expansion of the electrification of machines and objects in different sectors of human activity has been accompanied by a dazzling increase in the production of electrical machines and static converters throughout the world. This new situation accentuates the need for systems (devices and components) for the conversion and transformation of energy which, while not being totally immune, have qualities of intrinsic availability despite the occurrence of a fault. Thus, these increasingly strong requirements for availability and safety of systems, imply new requirements in the research effort on the methods and methodology of diagnosis/prognosis of electrical devices accompanied by a review of their design in order to structurally integrate availability through their capacity to be tolerant of certain defects. Indeed, diagnosis consists of detecting, locating and identifying faults allowing supervision systems to act effectively by applying one of fault tolerance scenarios, namely accommodation, reconfiguration or restructuring depending on the degree of severity of the fault. The prognosis for its part predicts the future operating state of the equipment concerned which is the subject of an international standard (ISO, 2004). Thus, prognosis is considered a key process in maintenance strategies. It is in this context that GREAH and IRSEEM combine their forces by constituting a multidisciplinary project team capable of dealing with many of the multiple aspects of the issue of safety and availability of electrical energy conversion and transformation devices.
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Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking
| 6project_grants_public
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gen_56e12d121ba66b53b7fb9a3ed030065d
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FEDER - UNICAEN - CPER INNOVONS - INNOVARET translational research - fct
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Kohesio
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UNIVERSITE DE CAEN NORMANDIE
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https://linkedopendata.eu/entity/Q3673557
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Cerebral, cancer and cardiovascular pathologies represent the leading causes of mortality in all developed countries. They cause physical and cognitive disabilities and more or less severe disabilities that directly impact the quality of life of patients and their loved ones. The aging of the population in developed countries makes the burden of these pathologies increasingly heavy on public health. Improving the care of people suffering from these conditions depends directly on the emergence and diffusion of biomedical innovations from screening to treatment. The interest of these innovations can only be scientifically demonstrated by the implementation of rigorous experimental and/or clinical research protocols. The real impact of recent pre-clinical and clinical innovations on improving patient care in real life is very poorly understood and their impact on the organization of care is poorly evaluated. The rare studies conducted in the general population show how the practice of care and the integration of innovations often escape biomedical logic and depend on social, economic or geographical determinants. The development of supportive care, ambulatory care, therapeutic education as well as the establishment of a care network and the growing involvement of patients in their care have revealed and reinforced the close links between the occurrence and evolution of illnesses and the environment of individuals in its family, social, economic and geographical. Psychological and sociological approaches, facilitated by the growing involvement of user committees, have highlighted the need to take into consideration, around the role of the "carer", the patient's family environment to optimize their care. Geographic and sociological approaches have shown how taking into account the characteristics of the place of residence and the socio-economic environment of patients is a major criterion in the successful development of ambulatory medicine and care networks. Recent examples of health planning, the cancer plan, the Alzheimer's plan show how an integrative approach to the evaluation of innovations, from proof of concept to the measurement of efficiency, is essential to the optimization of care practices, the good management of financial resources in an ever more constrained context and the guarantee of social equity. On the North Caen plateau there is recognized expertise in the fields of neuroscience and oncology through international level research teams, approved by major national organizations (CNRS, INSERM, CEA), supported by cutting-edge regional infrastructures (CYCERON - IBISA platform in in vivo imaging -, CURB - IBISA platform in research on strokes (ESRP) -, SFR ICORE technical platforms), on remarkable coverage of the territory by morbidity registers; all in close relations with health centers (Caen University Hospital and Center François Baclesse). Innov@ReT is part of the more global INNOVONS project which will allow the consolidation of a coherent whole promoting pre-clinical and clinical investigations in the field of screening and functional explorations in neurology, oncology and cardiology. Innov@ReT focuses on the translational aspect of research ranging from cell biology to imaging in humans. This new tool will benefit existing and future EPST structures and the University's reception teams. In addition to providing these research units with the tools for their development and their interface with the clinic, it would be the place for common methodological developments.
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Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking
| 6project_grants_public
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gen_08b2f3c727ce3158f4d974ce95eba28d
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FEDER - UNICAEN (EVA LAB) - ALGOEVA PROJECT
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Kohesio
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UNIVERSITE DE CAEN NORMANDIE
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https://linkedopendata.eu/entity/Q3680074
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Over the past fifteen years, it has been established that anthropogenic activities combined with natural climatic factors lead to an acceleration of changes in agricultural crop conditions. As a result of these disturbances, plants undergo higher intensity abiotic stress. However, abiotic stresses (extreme temperatures, high salinity, drought, flooding, excess heavy metals, oxidative stress) are the leading cause of loss of agricultural production yields worldwide. In a global context where the challenge of tomorrow is to produce enough to feed an exponential world population, it is a question of innovating in techniques and products intended for agriculture while regulating and legislating effectively to ensure healthy and sustainable development of agricultural production throughout the world. The use of biostimulants is one of the innovative methods allowing sustainable production by limiting the supply of inputs (fertilizers, phytosanitary products). By definition, biostimulants are organic compounds that improve the growth and development of plants. Companies developing in this field need to have precise and rapid tools (bioassays) to test new molecules or extracts and understand their mechanisms of action to guarantee their effectiveness for producers while meeting the requirements of legislators. At the European level, a special council made up of biostimulant producers (EBIC) was created in 2011 to respond to this demand at the legislative and commercial level. Several companies producing algae extracts, including ALGAIA, collaborate within the EBIC on analytical and formulation aspects. Indeed, algae have been used for several generations to improve the performance and quality of plants. Among the molecules isolated from distinct algae sources, some (polysaccharides, mannitol, hormones, antioxidant compounds, etc.) have biostimulating properties. Algae also represent a source of molecules (dextran sulfate, heparin, sulfoevernan, fucoidans, etc.) with antiviral and antibacterial activities. Viral and bacterial infections constitute a major health risk for equines and cause significant economic losses for the equine industry. Thus, the Equine Viral Arteritis (AVE) virus persists in 30 to 70% of infected stallions in the accessory glands of the reproductive system. The virus is excreted in semen. These excretory standards constitute the reservoir of the virus, but no specific treatment allowing the elimination of the virus is currently available. Likewise, no effective vaccine or treatment is available to combat the Equine Infectious Anemia (EIA) retrovirus, which remains a major health concern since infected horses must be euthanized. In the equine industry, bacterial infections are frequent and serious, particularly in young animals. Depending on the age class, they are responsible for 20 to 50% of mortality cases in Normandy equines. In recent years, the intensive use of antibiotics has led to a sharp increase in resistant bacterial populations, with consequences both economic (costly treatments) and public health (possible transmission of multi-resistant strains from animals to humans). Resistance has already been described in certain pathogenic or commensal bacteria in horses such as enterobacteria, enterococci and staphylococci. Certain bacteria could ultimately become resistant to all molecules in the veterinary therapeutic arsenal. This prospect is all the more worrying as innovation in antibiotic molecules is now very limited, hence the need to develop alternative treatments.
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Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking
| 6project_grants_public
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gen_f997b7b8403531e5fac631765f74fb51
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FEDER FCT GMN PRA CHIROPTERES DE NORMANDIE 2021
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Kohesio
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ASS GROUPE MAMMALOGIQUE NORMAND
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https://linkedopendata.eu/entity/Q3681854
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The 3rd National Action Plan for Bats 2016-2025 and its Norman version (Regional Bat Action Plan 2017-2025) aim to restore and then maintain the populations of the most threatened bat species. In Normandy, a network of actors has been strongly mobilized since 2009 and the interregional version of the 2nd PNA led by the Norman Mammalogical Group (Interregional Chiroptera Action Plan 2009-2013).
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Greener, carbon-free Europe / Environment protection and resource efficiency / Protection and enhancement of biodiversity, nature protection and green infrastructure
| 6project_grants_public
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gen_534d748190232136bc4539583e65f47c
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FEDER - ESPRIMED - EM.SIM.BASICS PROJECT
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Kohesio
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ESPRIMED
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https://linkedopendata.eu/entity/Q3673410
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Interventional radiology (IR) consists of using imaging, particularly X-rays, to guide devices in the human body for diagnostic or therapeutic purposes. The rate of increase in interventional procedures is of the order of 10 to 20% per year and this discipline is a major focus of the new 2014-2020 Cancer Plan. For example, the CAEN University Hospital carried out 2,023 IR procedures related to oncology in 2013. Due to the duration and complexity of the procedures, the radiation doses delivered to patients and received by practitioners can be very high. IR is definitely the practice to which the institutions responsible for preventing ionizing risks are paying the most attention today. The Nuclear Safety Authority is thus maintaining IR as an inspection priority for the coming years and the High Authority for Health (HAS) published in May 2014 a guide intended to support health professionals in the prevention of deterministic risk in IR. Prevention of radiological risk and the application of the principle of dose optimization mainly depend on the level of training and qualification of the healthcare teams. However, according to articles R.4451-47 and 50 of the labor code, any worker likely to work in a supervised or controlled zone must benefit from training in the radiation protection of the patient (renewed every 10 years) and training in the radiation protection of the worker (renewed every 3 years). This training obligation falls on the employer. Most often, the main obstacles to training mentioned by healthcare structures are the cost, the lack of time of healthcare staff but also the lack of attractiveness of theoretical lessons. The development of simulation for the initial and continuing training of health professionals stands out as an essential innovation which allows one to immerse oneself in reality, to mobilize one's knowledge without taking any risk for the patient and for oneself. This mode of simulation training is supported by the HAS. The objective of the project is therefore to create “serious game” type training software in which the learner will be placed at the center of the action in a very realistic 3D virtual environment reconstituting an IR or operating theater room. In this environment, the learner will be able to choose their operating protocol, their individual and collective protective equipment, freely place the patient and the position of their team in the room in order to identify the right gestures, good radioprotection practices, by illustrating in an interactive and visual manner the influence of their gesture on the dose they receive and on the dose delivered to the patient's skin. The project brings together 4 partners with complementary expertise, essential for the development of a digital training tool for radiation protection in a medical environment: OREKA INGENIERIE, CHU CAEN, esprimed and CEA/INSTN.
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Smarter Europe / Research and innovation / Research and innovation activities in private research centres including networking
| 6project_grants_public
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gen_94b552dc480c310c8efbee3b685155fe
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FEDER - UNICAEN (LCMT LAB) - FOVETH PROJECT
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Kohesio
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UNIVERSITE DE CAEN NORMANDIE
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https://linkedopendata.eu/entity/Q3680127
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The research project “FOrmulation and development of a Thermogravable VErnis (FOVETH), carried out by the company Mulann Industries and the LCMT laboratory, is a collaborative project aimed at formulating innovative polymer coatings for lacquers. Lacquers are aluminum discs covered with a polymer varnish, used for the manufacture of molds or “stampers” intended to press vinyl records. These lacquers are engraved from a sound recording, then undergo an electroforming (or electroplating) step to obtain a “master” or “original” which will then allow the manufacture of “positives” then “stampers”. The lacquer market (200 to 250,000 pieces per year) is shared on a global scale between two manufacturers: Transco in the USA and MDC in Japan. The FOVETH project should enable the Mulann company, an SME located in Avranches (40 people, €5.5 million turnover) and specialized in the design, manufacturing and distribution of magnetic tapes (analog audio and bank cards), to become the only producer of lacquers in Europe. Taking advantage of the rebound in the vinyl industry since 2017 and the dynamism of the European pressing market (75% of the global market, including the leaders GZ records, MPO, Optimal Media and Record Industries), the capture of 30% of the market for a turnover of 1 to 1.5 M€/year is envisaged based on the need to secure lacquer supplies from European manufacturers and the development of competitive and innovative products. The formulas used to produce lacquer varnishes were developed in the 1950s during the emergence of the vinyl record market. These varnishes are nitrocellulose resins, the use of which was very widespread at the time due to their rigidity and the ease of their implementation (by simple evaporation of solvent). The final properties of the coating are adjusted using solvents or various additives which may be plasticizers, polymers or mineral fillers. Due to the slowdown in the market at the end of the twentieth century, caused by the appearance of new digital media, there is very little recent research devoted to the formulation of this type of varnish. Societal concerns linked to the flammability of solvents used to apply nitrocellulose varnishes (acetates) have led to their substitution in certain applications (furniture), but they remain widely used, particularly in cosmetics (nail varnish). The durability of nitrocellulose varnishes remains limited (UV resistance, sensitivity to humidity) compared to “modern varnishes developed on a polyurethane base for example. In addition, their implementation by solvent evaporation involves application constraints. For example, the time required for drying varnishes (several months) does not allow lacquer producers to be able to respond to urgent demand without maintaining a large stock. In conclusion, there are therefore multiple potential avenues for formulating an innovative and competitive lacquer varnish in a market that has been neglected for several decades. The need to secure the supply of European vinyl manufacturers, the low competition on an international scale, the opportunity to develop innovative and modern formulas, and the adequacy of the skills of the Mulann company and the LCMT laboratory justify the establishment of this research project.
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Smarter Europe / Research and innovation / Research and innovation infrastructure (public)
| 6project_grants_public
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gen_501464355393726da7e58ce2142d70ca
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FED FCT 16E00132 GCS TSBN SI Coordination Secure data sharing and exchange services
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Kohesio
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GROUPEMENT DE COOPERATION SANITAIRE NORMANDE SANTE
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https://linkedopendata.eu/entity/Q3673473
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In 2013, the release of several reports and strategic roadmaps (Pacte Territoire Santé, Cordier Report, National Health Strategy) highlighted the need to decompartmentalize the French health system to enable it to respond to the challenges linked to: - the aging of the French population; - medical desertification, which generates strong territorial inequalities in terms of access to care; - the strong growth in the number of patients suffering from chronic diseases. Faced with these new challenges and the emergence of these new professional practices, e-health constitutes a major lever of transformation. Indeed, information and communication technologies (ICT) applied to health constitute a structuring technological base essential for organizations based on a logic of openness, communication and sharing. The ambulatory component of the SROS determines the regional strategy for organizing ambulatory care by defining action priorities in terms of structuring the provision of primary care. The two major challenges are: maintaining access to local care and decompartmentalizing care. By providing coordination teams and partner health professionals with a professional tool for patient care (diagnosis, PPS creation, needs assessment, advice, expertise), the project aims to provide support for the coordination of professionals serving the decompartmentalization of the patient journey, facilitating collaborative and multi-professional care.
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Smarter Europe / Information and communication technology / ICT solutions addressing the healthy active ageing challenge and e-Health services and applications (including e-Care and ambient assisted living)
| 6project_grants_public
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gen_116cbb462b3b958a739b833d28ace1a5
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18E03435 - CH INTERCOMMUNAL EURE SEINE - DIGITAL PATIENT JOURNEY IN AN EMERGENCY DEPARTMENT
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Kohesio
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CENTRE HOSPITALIER INTERCOMMUNAL EURE SEINE
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https://linkedopendata.eu/entity/Q3681357
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The CH Eure Seine is part of a development and innovation approach, supported by the Normandy Evreux-Vernon Center for Innovation, Clinical Research and Education (CIRCE-NEV). This structure aims to attract practitioners and students to the Hospital Center and the health region by offering them the means to structure and participate in clinical research projects, to engage in the development and deployment of innovative solutions. This diversification of activity makes it possible, while strengthening attractiveness, to fight against medical desertification in the region. With this in mind, the system is open to members of the GHT, private medicine and primary care stakeholders. Above all, this must allow patients in our healthcare region to access research protocols and the most innovative therapies and care techniques. Indeed, recent technological progress, awareness of the issues, as evidenced by the Villani report, and regional dynamism in the field of e-health have led CIRCE-NEV to integrate a digital axis. The conventional partnerships put in place with local authorities, the University of Rouen, the INSA of Rouen and the URML allow this center to respond to the needs of caregivers and the local population while positioning, through its innovative nature, the territory as a precursor in the domain. The actions are divided into 3 axes: teaching, communication, and “pilot digital emergencies”, an innovative global project making it possible to address themes of development of digital tools, exploitation of data, research while being strongly anchored with the socio-economic fabric and the real needs of caregivers and patients. The latter will be able, if they wish, to benefit from digital support for admission to post-emergency follow-up. Particular attention will be paid to supporting the patient throughout their journey. Thus work will be carried out on the ergonomics of the solutions proposed in order to reach the widest population while taking into account particularities and disabilities. The tools will be part of the national e-health strategy by allowing links with the DMP. The emergency department constitutes an interface between hospital care and the ambulatory health network. It also represents an area of tension: with 92,000 passages per year, improving operation with constant human resources represents a real challenge. EMERGENC-e aims to respond to these issues while working to improve patient care. Thus, each step of the journey will be evaluated to measure the quality of the response to these different objectives. Its reproducible nature will make its deployment possible in other services and across the GHT and then in other establishments interested in the solution. Obtaining a significant volume of data will make it possible to address various research issues, whether in terms of improving the quality of care, modeling patient behavior, or controlling health costs. This project will involve strong interdisciplinarity since joint work will have to be carried out with academic mathematics and computer science laboratories. It will have an impact with the training of young graduates who will evolve in an atypical environment by approaching patient care from a new angle at the cutting edge of digital technology. Finally, interactions with the socio-economic fabric will be favored via access to the living-lab, and the entanglement of the device in the digital space of the agglomeration, and inclusion in a global strategy to take into account disabilities in the territory.
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Smarter Europe / Information and communication technology / e-Government services and applications (including e-Procurement, ICT measures supporting the reform of public administration, cyber-security, trust and privacy measures, e-Justice and e-Democracy)
| 6project_grants_public
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gen_9847bcca8b4aeabfefaa6b28be8026b5
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FEDER - UNICAEN - SCHISM - SPRINGBOARD
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Kohesio
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UNIVERSITE DE CAEN NORMANDIE
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https://linkedopendata.eu/entity/Q3680427
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Early research on machine learning (ML) and data mining (DM) tried to fully automate knowledge discovery processes, and reduce human intervention. For good reasons: we have trouble dealing with large amounts of (high-dimensional) data, a tendency to see patterns everywhere, and technical progress has always relieved us of time-consuming tasks. This also motivates current work on automatic parameter tuning [26]. While this can work well in supervised settings where the label to predict gives feedback and a well-working black box model might be all that is needed, this consensus is increasingly being questioned in DM today. users’ assumptions [1], are relatively recent. Also recent is research on interactive data mining methods, which allow the user to give feedback during the mining process – not just before and after – to change exploration strategies, narrow or widen search spaces etc. [3]. The reasons for this shift have been multifold:1. In unsupervised settings such as clustering and pattern mining, labels are by definition absent and automation based on label-information therefore impossible. Yet even in many real-life “supervised” problem settings, a large proportion of data might be unlabeled, and existing labels might be unreliable, so that a user finds herself at best in a semi-supervised setting.2. In an unsupervised or semi-supervised setting, it is almost impossible for users to a priori specify their assumptions, expectations, and goals. If they manage, translating them into, somewhat limited, available constraint languages is difficult. The current framework, where users set parameters before mining, and sift through and interpret output after, wastes time (and money), and is counterintuitive to how we process information. What users can do, however, is react to (partial) results and indicate whether those agree with their intuition, appear interesting etc.3. Often, experts need to understand why algorithms produce the results they do, because large amounts of money or resources are in play, e.g. in drug development or infrastructure deployment, or even lives at stake, e.g. in medicine, disaster preparedness, or military settings. Or they want to understand them because unsupervised DM serves as a hypothesis generator: observing the results of a pattern mining operation or a produced clustering can trigger new insights and inform new research directions - the final step in the “knowledge discovery” process. In the context of SCHISM, we think this process starting from a chemoinformatics setting. Chemoinformatics deals with the description of molecular entities, and both pattern mining and clustering have been used to derive new knowledge: a) Pattern mining, to identify promising substructures for drug development, or shared subpatterns of toxic compounds [19, 13] b) Clustering to identify and select representatives of molecular libraries for virtual or experimental screening, to design novel diverse or focused libraries, and compare libraries from various providers [11], and more generally to actively investigate structural similarity. chemogenomic analysis to pre-clinical studies, cluster-analysis can be used:¿ to get the level of diversity of a molecular dataset,¿ to find molecular structures that share a given structural scaffold,¿ to get a first view of structure-activity relationship by a comparison of chemicals in each cluster,¿ to decide which compounds to prioritize in an acquisition decision, ¿ to guide a lead selection. See application file
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Smarter Europe / Research and innovation / Research and innovation activities in public research centres and centres of competence including networking
| 6project_grants_public
|
gen_815af83d8f863efb0fdcc625743f3bff
|
Auto-Cove 2.0; Greening Europe with support of Clean-tech-vehicle education
|
European Commission (EC)
|
JAKOB-PREH-SCHULE STAATLICHE BERUFSSCHULE BAD NEUSTADT AD SAALE;TARTU LINNAVALITSUS;TECHNISCHE HOCHSCHULE WUERZBURG-SCHWEINFURT;Estonian University of Life Sciences;VOLVO CAR FINLAND OY AB;Kaunas University of Applied Engineering Sciences;VENTSPILS TEHNIKUMS;Teknologian tutkimuskeskus VTT Oy;SOCIETE D'ENSEIGNEMENT PROFESSIONNEL DU RHONE;KAUNO TECHNOLOGIJU MOKYMO CENTRAS;BILIA OY AB;ELECTUDE INTERNATIONAL BV;STICHTING REGIONAAL ONDERWIJS CENTRUM NOORDOOST-BRABANT;ESPOON SEUDUN KOULUTUSKUNTAYHTYMA OMNIA;PREH GMBH;TOYOTA BALTIC AKTSIASELTS
|
Not available
|
Unknown
| 6project_grants_public
|
|
gen_46396fcd879dd8311c19e6cf2cf49771
|
Gates Foundatoin
|
Wits Health Consortium (Pty) Ltd
|
INV-030196
|
to enable African regulators in ensuring the safety of medical products being used by their populations
|
Public Awareness and Analysis / Global Health
| 5out_of_scope
|
|
gen_ca2a73721bfd733e78aef078dd06bd62
|
Teaching History for Disabled Students through Digitilized Gamification Tools
|
European Commission (EC)
|
Stichting International Excellence Reserve;ZDRUZENIE INSTITUT ZA RAZVOJ NA ZAEDNICATA;State Higher Vocational School in Skierniewice;Avrasya Yenilikçi Toplum Derneği;Istituto d'Istruzione Superiore Mandralisca;SCOALA GIMNAZIALA SPECIALA PENTRU DEFICIENTI DE VEDERE
|
Not available
|
Unknown
| 6project_grants_public
|
|
gen_fe2b81803c19fe9b2ed1d4ec3b255620
|
Creative learning for boosting bio-economy within HEIs’ curricula
|
European Commission (EC)
|
University of Foggia;UNIVERSIDADE DE AVEIRO;Warsaw University of Life Sciences;EDEX - EDUCATIONAL EXCELLENCE CORPORATION LIMITED;Valuedo srl
|
Not available
|
Unknown
| 6project_grants_public
|
|
gen_4666bb7d834e3f619fd6aca4ccde2154
|
Excellence in Esport Education
|
European Commission (EC)
|
Teknikum;Arna vidaregåande skule;Svenska Framtidsskolan i Helsingforsregionen Ab
|
Not available
|
Unknown
| 6project_grants_public
|
|
gen_8dfea1b1aeacb5bdcdcc793bbde4c607
|
Non-archimedean methods in geometry and topology
|
Swiss National Science Foundation (SNSF)
|
Chair de géométrie arithmétique EPFL - SB - MATH - ARG
|
Not available
|
Unknown
| 6project_grants_public
|
|
gen_12f40cb526167fa300bce66cf1ca65ca
|
Managing a Just Transition to Net-Zero
|
Swiss National Science Foundation (SNSF)
|
College of Management;PASU Chair Odyssea Station 5 EPFL
|
Not available
|
Unknown
| 6project_grants_public
|
|
gen_b4b376aa202d92e632dab7afd4f4c20d
|
Hyper-Representations: Learning from Populations of Neural Networks
|
Swiss National Science Foundation (SNSF)
|
Chair in Artificial Intelligence & Machine Learning - School of Computer Science;University of St. Gallen
|
Not available
|
Unknown
| 6project_grants_public
|
|
gen_abec02e6588698e695fef37f0b79b367
|
L'exécution forcée en Égypte ptolémaïque et romaine
|
Swiss National Science Foundation (SNSF)
|
Chair of Roman Law and the Law of Antiquity Faculty of Law University of Warsaw
|
Not available
|
Unknown
| 6project_grants_public
|
|
gen_eef7d6bc7b46ed3eee5841ef681d33bc
|
BioExcel Centre of Excellence for ComputationalBiomolecular Research
|
European Commission
|
Nostrum Biodiscovery
|
CORDIS-823830
|
Life Sciences have become increasingly digital and this is accelerating. Computational techniques play key roles in processing, analysis and generating new knowledge from experiments, even in replacing them. This has been enabled due to tremendous advances in techniques such as docking and molecular simulations at both atomistic and quantum levels to which world-leading European research and software are contributing. Pushing computational capabilities towards Exascale will advance the area, enabling researchers to tackle increasingly complex questions related to biomolecules' function, mechanisms, dynamics and interactions. This will impact on our daily life, in health, for the development of new drugs and efficient drug delivery methods, in biotechnology, environment, agriculture, food industry and education. To exploit this great computational power, in academia and industry, significant efforts on software efficiency, scaling, usability and education are needed. This is the mission of the BioExcel Centre of Excellence for Computational Biomolecular Research launched in 2015 with EC support. It has made significant contributions by focusing on highest-impact European codes, workflows and an extensive, international education program. BioExcel-2 will continue and expand this work, with a focus on Exascale impact, improved usability, expanded training and commercial applications, while strengthening its user-driven governance. Specifically it will: * Push performance, efficiency, scalability and usability of the selected software packages towards Exascale in a co-design manner, contributing to the EuroHPC vision * Support convergence of HPC, HTC, and HPDA with workflows combining simulations with data management and analytics * Support and enlarge the user community by providing support, workforce development, continued training, guidance, and best practices * Develop a sustainable and open community centre with user-driven governance and clear KPIs.
|
H2020-EU.1.4. / 1.4 Research Infrastructures (RIs)
| 7research_infrastructure
|
gen_cd06e21ad8c4ac4368bf741e056720cf
|
Operations and Infrastructure
|
Medical Research Council
|
London School of Hygiene and Tropical Medicine
|
HRCS22_01343
|
MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine Operations and Infrastructure Support
|
HRCS Research Uncodeable / Unit
| 7research_infrastructure
|
gen_91547d1abc659da7d339253cc59d5576
|
Institutional Translational Partnership Award: Thailand Major Overseas Programme
|
Wellcome Trust
|
University of Oxford
|
HRCS22_20446
|
MORU iTP has successfully demonstrated rapid growth in its research portfolio, which we will be continuing. So far we have been particularly successful with encouraging projects at earlier stages of their translational pathways, therefore we now have a number of projects which are on the middle of translational research pipeline (TRL 4-7). These projects require the final push into the late stages of the translation research pipeline, where further support is needed either in the form of further funding or a cooperates partnership. In order to ensure that the transition of the projects can be run smoothly we are creating a dedicated panel of experts to help develop their implementation strategy (Business model development, partner finding), identify pathways to impact, and customize support based on specific project fields. Thus, the exit strategy is well defined. This will allow for the continuous flow of the projects through the iTP portfolio. With a large number of portfolio projects focusing on diagnostic tests, reflective of MORU’s research landscape more generally, we have singled out this area as one that would benefit from more extensive supportive infrastructure to support diagnostic tools development. These renewal plans reflect the accomplishment of the MORU’s iTP programme as we had set out in our primary aims which is to ensure that the world class global health research being done in MORU and at the Faculty of Tropical Medicine (FTM) in Mahidol University is translated into tangible positive impact. We work towards this overarching goal by identifying and helping develop projects and ideas with high impact potential, by guiding and supporting their progress through translational pipelines.
|
Infrastructure
| 7research_infrastructure
|
gen_bcbb3003172ed3d1cd4906797efa7879
|
Advancing open acces
|
Arcadia Fundation
|
UCLA Library
|
360G-ArcadiaFund-4017
|
To further open access to scholarly and cultural materials
|
Other / Strategic
| 7research_infrastructure
|
gen_48a5950e830ca93fbe0f4ca108a36e61
|
Operating and acquisition costs
|
Arcadia Fundation
|
Wende Museum
|
360G-ArcadiaFund-1297
|
To preserve, catalogue and digitise Cold War era (1945-1991) artefacts, artworks and archives from Eastern Europe and the Soviet Union.
|
Other / Strategic
| 7research_infrastructure
|
gen_995444762b17185e33d70a6696675b20
|
Digitization of manuscripts in Africa and Asia
|
Arcadia Fundation
|
Hill Museum and Manuscript Library
|
360G-ArcadiaFund-4491
|
To continue the Hill Museum & Manuscript Library’s work digitizing endangered manuscripts in Africa and Asia, and to make them available online in an open-access repository.
|
Archives and manuscripts / Strategic
| 7research_infrastructure
|
gen_7957f93062c1f95e65b0c72aa4b24f72
|
Centre for Primary Research
|
Arcadia Fundation
|
University of California Los Angeles
|
360G-ArcadiaFund-2685
|
To increase access to special library collections and train graduate students and scholars in collections management.
|
Other / Strategic
| 7research_infrastructure
|
gen_943cd7eda85ed8b47df965c7f8f78107
|
Core costs
|
Arcadia Fundation
|
Public.Resource.Org
|
360G-ArcadiaFund-3621
|
To digitize and give open access to legal documents, technical standards and safety standards that should be in the public domain.
|
Other / Strategic
| 7research_infrastructure
|
gen_2a3b625cbe6bbb960152dee423e6e06a
|
Endangered Archives Programme
|
Arcadia Fundation
|
British Library
|
360G-ArcadiaFund-4856
|
To continue to support the Endangered Archives Programme, a regranting programme that funds projects to digitize neglected, vulnerable or inaccessible archives older than the mid-twentieth century. The digitized materials are available for free online
|
Archives and manuscripts / Grant programme
| 7research_infrastructure
|
gen_983742250614d92b532e128f4c9c6c65
|
Harvard Library: global fund for open collections
|
Arcadia Fundation
|
Harvard University
|
360G-ArcadiaFund-1292
|
To digitise key collections and make them available for free online.
|
Other / Strategic
| 7research_infrastructure
|
gen_2c910b9a0b71ae8a45ded040cca3258c
|
Advancing Open Access
|
Arcadia Fundation
|
Harvard University
|
360G-ArcadiaFund-4154
|
To support opening Harvard's collections to the world via digitization and open access. Harvard Library has leased a high speed scanner to digitize its holdings in a way that vastly increases the rate of output.
|
Other / Strategic
| 7research_infrastructure
|
gen_d8faf4fb1f304d0fd39e2af415c6bf30
|
To support NYPL's digital work
|
Arcadia Fundation
|
New York Public Library
|
360G-ArcadiaFund-4932
|
To make in-copyright books more widely available online via NYPL’s Digital Research Books platform
|
Other / Strategic
| 7research_infrastructure
|
gen_516440ac34fb76dbeca141e545786f4e
|
Operating and acquisition costs
|
Arcadia Fundation
|
Wende Museum
|
360G-ArcadiaFund-2729
|
To preserve, catalogue and digitise Cold War era (1945-1991) artefacts, artworks and archives from Eastern Europe and the Soviet Union.
|
Other / Strategic
| 7research_infrastructure
|
gen_add46ba40b07a27790c0fc0b7456a135
|
Unlocking University Press Books
|
Arcadia Fundation
|
Internet Archive
|
360G-ArcadiaFund-4081
|
Towards digitizing more than 15,000 volumes of published monographs from university libraries' collections, and making them available via the Internet Archive’s controlled digital lending platform, which protects the university presses’ intellectual property and institutional investments.
|
Books / Strategic
| 7research_infrastructure
|
gen_f0212e8930a2074be44eaa06d01888c5
|
Operating and acquisition costs
|
Arcadia Fundation
|
Wende Museum
|
360G-ArcadiaFund-1754
|
To preserve, catalogue and digitise Cold War era (1945-1991) artefacts, artworks and archives from Eastern Europe and the Soviet Union.
|
Other / Strategic
| 7research_infrastructure
|
gen_4f095c011c41bb45566ef4fe7343cd31
|
Digitizing MIT Press backlist titles
|
Arcadia Fundation
|
Internet Archive
|
360G-ArcadiaFund-3992
|
Digitizing an initial group of 1,500 MIT Press titles at Internet Archive’s Boston Public Library facility to make them more widely available.
|
Other / Strategic
| 7research_infrastructure
|
gen_5b77a7c1f7b2a2c2922593b7cba6e52a
|
DiPiKA - Digitization and Preservation of Kerala Archives
|
Arcadia Fundation
|
University of Hamburg
|
360G-ArcadiaFund-4800
|
To survey and digitize some of the most important collections of palm-leaf manuscripts in the Thrissur and Ernakulam districts, Kerala, India in both institutional and family collections. These will be made available online in an open-access repository
|
Archives and manuscripts / Strategic
| 7research_infrastructure
|
gen_e97d8184c466f19c45af6707508a58a1
|
Sinai Palimpsest Project
|
Arcadia Fundation
|
Early Manuscripts Electronic Library
|
360G-ArcadiaFund-2821
|
To survey, digitize and develop an innovative light source to backlight palimpsest manuscripts in the library of St. Catherine's Monastery.
|
Archives and manuscripts / Strategic
| 7research_infrastructure
|
gen_0cd54f2b867d0eb17dbc1cef02408838
|
Refuseniks & Activists: The Soviet Jewish Emigration Project
|
Arcadia Fundation
|
Blavatnik Archive Foundation
|
360G-ArcadiaFund-5040
|
Towards digitizing primary sources on the Soviet Jewish diaspora from disparate collections, and making them freely accessible online.
|
Archives and manuscripts / Strategic
| 7research_infrastructure
|
gen_e311c3a23fbc417f0bcd6c791166e749
|
Digital library for the study of Africa
|
Arcadia Fundation
|
Aluka
|
360G-ArcadiaFund-2523
|
To build an online library of scholarly resources and make it available for free online to users from African institutions
|
Archives and manuscripts / Strategic
| 7research_infrastructure
|
gen_2b51b626aa7cb50e65836734355da87f
|
Palestinian Museum Digital Archive
|
Arcadia Fundation
|
Palestinian Museum
|
360G-ArcadiaFund-3865
|
To digitize endangered, dispersed and inaccessible collections of documents, photographs, videos and ephemeral materials representing the culture and history of Palestine from 1800 to the present and to make them available in an open-access online archive.
|
Archives and manuscripts / Strategic
| 7research_infrastructure
|
gen_c0d0af42b6e5eab6c791277c00c1737d
|
Endangered Wooden Architecture Programme
|
Arcadia Fundation
|
Oxford Brookes University
|
360G-ArcadiaFund-4382
|
To establish a grant-giving programme for the documentation of endangered wooden architecture. By providing funding to researchers and maintaining an open-access digital repository, its objectives are to document endangered wooden building traditions and preserve the record long term.
|
Heritage sites / Grant programme
| 7research_infrastructure
|
gen_41e4737276e0169b2157ef84c6a11d8d
|
Sinai Palimpsest Project open access online publication
|
Arcadia Fundation
|
University of California Los Angeles
|
360G-ArcadiaFund-3618
|
To provide open access online publication of multispectral images produced by the Sinai Palimpsest Project, which documents the manuscripts in St. Catherine’s Monastery in Sinai
|
Archives and manuscripts / Strategic
| 7research_infrastructure
|
gen_56961da9cea6e8da1e853b876ea7b829
|
Digitizing Israeli Ephemera
|
Arcadia Fundation
|
National Library of Israel
|
360G-ArcadiaFund-3193
|
To collect, digitize and preserve printed ephemera from the early history of modern Israel and make them available for free online.
|
Archives and manuscripts / Strategic
| 7research_infrastructure
|
gen_cdc463339857edfc4ee667c4895324ef
|
Institute for Archival Research
|
Arcadia Fundation
|
Wende Museum
|
360G-ArcadiaFund-4981
|
Towards construction costs for the Wende Museum's international centre for digitization and conservation of at-risk post-war archives
|
Other / Strategic
| 7research_infrastructure
|
gen_082ef0fd9a470733fe60a80a33fec255
|
Modern Endangered Archives Program
|
Arcadia Fundation
|
The Regents of the University of California, on behalf of its Los Angeles campus, for the UCLA Library
|
360G-ArcadiaFund-4765
|
To continue a grants programme that funds projects to digitize and make accessible at-risk archival materials from the 20th and 21st centuries. The digitized materials are available for free online.
|
Archives and manuscripts / Grant programme
| 7research_infrastructure
|
gen_5ab69d89b6e1383b58a7ba983d36a5be
|
Dead Sea Scrolls online database
|
Arcadia Fundation
|
Israel Antiquities Authority
|
360G-ArcadiaFund-2990
|
To develop resources related to the Dead Sea Scrolls including bibliography, transcriptions of the text, translations and commentaries from experts and make them available for free online.
|
Archives and manuscripts / Strategic
| 7research_infrastructure
|
gen_df6d1a7677f2058588a091f110ef2cef
|
OpenAlex: a free index for the world's research
|
Arcadia Fundation
|
Our Research
|
360G-ArcadiaFund-5147
|
To support the growth, development, and institutional usage of OpenAlex - an open and comprehensive index of scholarly works, authors, and institutions.
|
Discoverability / Strategic
| 7research_infrastructure
|
gen_65df78710c99d2f9a8e4d045cef7fac6
|
Genomics Strategic Core Platform
|
Medical Research Council
|
London School of Hygiene and Tropical Medicine
|
HRCS22_01346
|
Genomics Strategic Core Platform - The move towards high throughput genomics technologies will increase the unit genomics sequencing and data output. The genomics core platform will link the genomics facility with the data science platform (Bioinformatics, HPC, AI) and strengthen current capabilities and work towards becoming a hub for genomics service provider, centre of excellence for establishing SOP and protocols, training in the sub-region. This vision will be pursued vigorously with the aim of establishing a formal sub-regional sequencing service provider that will have visibility for collaboration, joint grant application and revenue earning potential. There is a niche in the sub-region for a provider of this vital service and the ongoing unit-wide programme of accreditation standards will provide relevant experience for the platform to be genomics clinical testing centre and for all its sequencing platforms to achieving the standard required internationally to be certified/accredited service provider. Funding will be sought to support a system for periodic assessment of sample integrity by whole genome amplification (WGA) that allow wider use of stored samples in the unit Biobank, expanding on the system been developed and established for a current project. One key area is developing a platform operated by proactive group continually evolving, seeking out new challenges to solve and new technologies to exploit. And active involvement in knowledge and technology transfer through extension, networks and partnerships experience in training MSc and Post Doc fellows, visitors, and interns. The platform will contribute to the overall Institutional capacity development and will involve improving staff and stakeholder skills, knowledge and experience as well as developing infrastructure, financial resourcefulness, organizational culture, and learning. And thus, strengthening the capacity for influencing policy effectively by working with National Public Health Laboratories, Ministry of Health. We will put in place strategies to attract and retain a new generation of technically qualified staffs and at the same time increase the impact and scale of capacity development for genomics interventions and investment. Secure core-funding for post graduate qualifications and for establishing a R and D and training activities on research areas in the facility. Our status as a World Health Organization Collaborating Centre for New Vaccines Surveillance, Pandemic Preparedness, will open improved opportunities for exchange of information and technical cooperation with other institutions in West Africa, in particular at the international level, and to mobilize additional and important resources from funding partners.
|
2.6 Resources and infrastructure (aetiology) / Unit
| 7research_infrastructure
|
gen_59cd4621431152ba23b329d5aaf43f5b
|
Alzheimer’s Research UK Drug Discovery Institute 2020: University College London
|
Alzheimer's Research UK
|
University College London
|
HRCS22_20352
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_8cfc47d53f53de27fa129decb756d2ff
|
Diamond Capital Award 2021/22 (Diamond FY22/23)
|
Wellcome Trust
|
Diamond Light Source
|
HRCS22_20554
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_95a7ad6f98589d3a3d501006bea29ad3
|
Alzheimer’s Research UK Drug Discovery Institute 2023: Oxford
|
Alzheimer's Research UK
|
University of Oxford
|
HRCS22_20576
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_818cc7c564aa2154c8d986760baf414e
|
ARUK DRI 2021-22 Commitment
|
Alzheimer's Research UK
|
University College London
|
HRCS22_20582
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_e82061dfcd329e9ba6b4f8d3c2749bfc
|
UK Biobank Core Renewal Years 6-10 (Joint funding with UKRI, CRUK, WT and DHSC)
|
British Heart Foundation
|
University of Oxford
|
HRCS22_20733
|
No abstract available for this analysis
|
Infrastructure
| 7research_infrastructure
|
gen_0ffd6981fd94af330e26776c4e45e458
|
Joint Global Health Trials Award - round 7 - June 2017
|
Wellcome Trust
|
Medical Research Council
|
HRCS22_20829
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_e03b26dd8d13f5f18b96a821301eaf3c
|
Global Health Trials Award – Round 8 - June 2018
|
Wellcome Trust
|
Medical Research Council
|
HRCS22_20883
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_9671e93b4e919ae8d45e1052b6ea6456
|
Building research facilities for the future
|
Barts Charity
|
Queen Mary University of London
|
HRCS22_20922
|
Barts and The London School of Medicine and Dentistry at Queen Mary University London (SMD) aims to improve the health and wellbeing of people throughout the UK and beyond through research and teaching excellence. Over the past ten years, the SMD has experienced unparalleled growth in research power and research output quality. Researchers in the key strategic areas of cancer, cardiovascular disease, inflammation and preventive medicine have been extremely successful in winning major new grant funding that has huge potential to deliver major patient benefits through translation of research from bench to bedside and into the wider population. This is a very exciting time for SMD. A new phase of growth is planned, aiming to increase the overall research power by recruiting between 50-100 new talents over the next 3-4 years, helping the School continue to grow in breadth and depth within a very competitive London market. This application, requesting £6,460,200 of funds, aims to enhance SMD?s research facilities by optimizing the existing footprint of the Charterhouse Square Campus through an ambitious project of renovation. The SMD is in the fortunate position of being able to expand within the existing campus, unlike many other London universities. Providing new research laboratories equipped to the latest standard, as well as creating additional and bespoke teaching facilities and office space, this proposal supports the Faculty?s ambition of growth. It will ensure the current and ambitiously expanding research programmes are supported, enabling them to reach their full potential to deliver tangible benefits to patients and the community. Providing optimal space to accommodate existing staff and new talent recruited into SMD, will allow them to flourish scientifically and therefore shape the future of research and setting the School in the optimal position for the next Research Excellence Framework (REF2021). The expanded portfolio of research and training activities will enable delivery in terms of translation into patient benefits, high quality publications and further successful grant applications. The School has engaged with all key stakeholders, feasibility studies have already been carried out and a clear plan has been developed to ensure staff and students are fully supported during the renovations which will result in 21st century, high quality research and teaching facilities.
|
Infrastructure
| 7research_infrastructure
|
gen_bdd56fbc8b6f92d1139289884b85a114
|
UK Biobank - Core Renewal
|
Wellcome Trust
|
UK Biobank
|
HRCS22_20932
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_72e57da7bc10b769f4b088a2ab0fb23f
|
Diamond Operating Award 2021/22 (Diamond FY22/23)
|
Wellcome Trust
|
Diamond Light Source
|
HRCS22_20973
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_410026c8037f9fe2b1dbf27b309b04a8
|
Funding towards Cambridge Heart and Lung Research Institute (HLRI)
|
British Heart Foundation
|
University of Cambridge
|
HRCS22_20975
|
No abstract available for this analysis
|
Infrastructure
| 7research_infrastructure
|
gen_744fe88ffd5f058fa2159a5447043ec2
|
EMBL-EBI expansion: response to the exponential increase in life science data
|
Wellcome Trust
|
EMBL - European Bioinformatics Institute
|
HRCS22_20977
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_2ccbbc05552a5bbd5d86aacccc8383a7
|
Sanger Supplementary Award 2021-2023
|
Wellcome Trust
|
Wellcome Sanger Institute
|
HRCS22_21020
|
No abstract available for this analysis.
|
Infrastructure
| 7research_infrastructure
|
gen_3079d1721a68b7b5870243dfd8ab859f
|
CELL AND GENE THERAPY CATAPULT CORE DELIVERY PROGRAMME
|
Innovate UK
|
Cell Therapy Catapult Limited
|
HRCS22_21305
|
Awaiting Public Project Summary
|
Infrastructure
| 7research_infrastructure
|
gen_3d29d070a1adeb990354a86ff3aa208f
|
GFA in relation to the Acquisition, Development and Operation of the Cell and Gene Therapy Catapult Manufacturing Innovation Centre
|
Innovate UK
|
Cell Therapy Catapult Limited
|
HRCS22_21306
|
Awaiting Public Project Summary
|
Infrastructure
| 7research_infrastructure
|
gen_507ef083efdfa498338f4054d99323a2
|
ISCF Supported whole genome sequencing in cancer trials
|
Innovate UK
|
Genomics England Limited
|
HRCS22_21458
|
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
|
Infrastructure
| 7research_infrastructure
|
gen_20ac58936276c732c9bfebd1f7f8a9c2
|
Medicine Discovery Catapult Core Delivery Programme
|
Innovate UK
|
Medicines Discovery Catapult
|
HRCS22_21613
|
Awaiting Public Project Summary
|
Infrastructure
| 7research_infrastructure
|
gen_bb1d83c00f45be083c49db624cc9cca2
|
A coordinated strategy to scale-up advanced therapies for patient in Manchester
|
Innovate UK
|
The Christie NHS Foundation Trust
|
HRCS22_21929
|
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
|
Infrastructure
| 7research_infrastructure
|
gen_06bef843b48e3f9985a6153ad7a01290
|
The Living Laboratory: driving economic growth in Glasgow through real world implementation of precision medicine
|
Innovate UK
|
University of Glasgow
|
HRCS22_22001
|
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
|
Infrastructure
| 7research_infrastructure
|
gen_91b9f06174be1860f548ef68be629f00
|
Virtual VMIC
|
Innovate UK
|
Vaccine Manufacturing and Innovation Centre UK Limited
|
HRCS22_22046
|
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
|
Infrastructure
| 7research_infrastructure
|
gen_1b1b81371bf6e92f945d4bde38b6bfcc
|
Vaccines Manufacturing and Innovation Centre
|
Innovate UK
|
Vaccines Manufacturing and Innovation Centre UK Ltd
|
HRCS22_22047
|
Awaiting Public Project Summary
|
Infrastructure
| 7research_infrastructure
|
gen_230ec863a32fe0855b27f78c7a0e36b2
|
The Living Laboratory
|
UK Research and Innovation
|
University of Glasgow
|
HRCS22_22417
|
Not available
|
Infrastructure
| 7research_infrastructure
|
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