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A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.
|
[
{
"ade": "ischaemic cerebrovascular accident",
"drug": "streptokinase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.",
"role": "user"
},
{
"content": "[{'ade': 'ischaemic cerebrovascular accident', 'drug': 'streptokinase'}]",
"role": "assistant"
}
] |
We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.
|
[
{
"ade": "hepatitis",
"drug": "riluzole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.",
"role": "user"
},
{
"content": "[{'ade': 'hepatitis', 'drug': 'riluzole'}]",
"role": "assistant"
}
] |
In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.
|
[
{
"ade": "decrease in serum Na+",
"drug": "lorcainide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.",
"role": "user"
},
{
"content": "[{'ade': 'decrease in serum Na+', 'drug': 'lorcainide'}]",
"role": "assistant"
}
] |
A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.
|
[
{
"ade": "manic episode",
"drug": "fluoxetine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.",
"role": "user"
},
{
"content": "[{'ade': 'manic episode', 'drug': 'fluoxetine'}]",
"role": "assistant"
}
] |
Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.
|
[
{
"ade": "bilateral pulmonary infiltrates",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.",
"role": "user"
},
{
"content": "[{'ade': 'bilateral pulmonary infiltrates', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.
|
[
{
"ade": "cranial polyneuropathy",
"drug": "vincristine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.",
"role": "user"
},
{
"content": "[{'ade': 'cranial polyneuropathy', 'drug': 'vincristine'}]",
"role": "assistant"
}
] |
RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.
|
[
{
"ade": "weight loss",
"drug": "leflunomide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.",
"role": "user"
},
{
"content": "[{'ade': 'weight loss', 'drug': 'leflunomide'}]",
"role": "assistant"
}
] |
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.
|
[
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
Renal injury due to anastrozole has not been published in the English literature.
|
[
{
"ade": "Renal injury",
"drug": "anastrozole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Renal injury due to anastrozole has not been published in the English literature.",
"role": "user"
},
{
"content": "[{'ade': 'Renal injury', 'drug': 'anastrozole'}]",
"role": "assistant"
}
] |
Pulmonary toxicity with mefloquine.
|
[
{
"ade": "Pulmonary toxicity",
"drug": "mefloquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Pulmonary toxicity with mefloquine.",
"role": "user"
},
{
"content": "[{'ade': 'Pulmonary toxicity', 'drug': 'mefloquine'}]",
"role": "assistant"
}
] |
A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.
|
[
{
"ade": "acute chest pain",
"drug": "ritodrine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.",
"role": "user"
},
{
"content": "[{'ade': 'acute chest pain', 'drug': 'ritodrine'}]",
"role": "assistant"
}
] |
Recurrent hyponatremia associated with citalopram and mirtazapine.
|
[
{
"ade": "Recurrent hyponatremia",
"drug": "mirtazapine"
},
{
"ade": "Recurrent hyponatremia",
"drug": "citalopram"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Recurrent hyponatremia associated with citalopram and mirtazapine.",
"role": "user"
},
{
"content": "[{'ade': 'Recurrent hyponatremia', 'drug': 'mirtazapine'}, {'ade': 'Recurrent hyponatremia', 'drug': 'citalopram'}]",
"role": "assistant"
}
] |
This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.
|
[
{
"ade": "hepatitis",
"drug": "artesunate"
},
{
"ade": "hepatitis",
"drug": "amodiaquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.",
"role": "user"
},
{
"content": "[{'ade': 'hepatitis', 'drug': 'artesunate'}, {'ade': 'hepatitis', 'drug': 'amodiaquine'}]",
"role": "assistant"
}
] |
This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.
|
[
{
"ade": "acute lung injury",
"drug": "mefloquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'acute lung injury', 'drug': 'mefloquine'}]",
"role": "assistant"
}
] |
CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.
|
[
{
"ade": "dermatologic and ocular 5-FU toxicities",
"drug": "5-FU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.",
"role": "user"
},
{
"content": "[{'ade': 'dermatologic and ocular 5-FU toxicities', 'drug': '5-FU'}]",
"role": "assistant"
}
] |
In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.
|
[
{
"ade": "spasm",
"drug": "ergonovine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.",
"role": "user"
},
{
"content": "[{'ade': 'spasm', 'drug': 'ergonovine'}]",
"role": "assistant"
}
] |
A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.
|
[
{
"ade": "postprandial hyperglycemia",
"drug": "betamethasone valerate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.",
"role": "user"
},
{
"content": "[{'ade': 'postprandial hyperglycemia', 'drug': 'betamethasone valerate'}]",
"role": "assistant"
}
] |
One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.
|
[
{
"ade": "ceroid-like pigment",
"drug": "clofazimine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.",
"role": "user"
},
{
"content": "[{'ade': 'ceroid-like pigment', 'drug': 'clofazimine'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.
|
[
{
"ade": "Hypersensitivity reactions",
"drug": "cyclosporine"
},
{
"ade": "Hypersensitivity reactions",
"drug": "Cremophor EL"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.",
"role": "user"
},
{
"content": "[{'ade': 'Hypersensitivity reactions', 'drug': 'cyclosporine'}, {'ade': 'Hypersensitivity reactions', 'drug': 'Cremophor EL'}]",
"role": "assistant"
}
] |
A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.
|
[
{
"ade": "generalized tonic-clonic seizure",
"drug": "naloxone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.",
"role": "user"
},
{
"content": "[{'ade': 'generalized tonic-clonic seizure', 'drug': 'naloxone'}]",
"role": "assistant"
}
] |
The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.
|
[
{
"ade": "radiation recall reactions",
"drug": "gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.",
"role": "user"
},
{
"content": "[{'ade': 'radiation recall reactions', 'drug': 'gemcitabine'}]",
"role": "assistant"
}
] |
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.
|
[
{
"ade": "Intrahepatic cholestasis",
"drug": "glibenclamide"
},
{
"ade": "cutaneous bullae",
"drug": "glibenclamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.",
"role": "user"
},
{
"content": "[{'ade': 'Intrahepatic cholestasis', 'drug': 'glibenclamide'}, {'ade': 'cutaneous bullae', 'drug': 'glibenclamide'}]",
"role": "assistant"
}
] |
This concerns 2 male patients who experienced incontinence while taking venlafaxine.
|
[
{
"ade": "incontinence",
"drug": "venlafaxine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This concerns 2 male patients who experienced incontinence while taking venlafaxine.",
"role": "user"
},
{
"content": "[{'ade': 'incontinence', 'drug': 'venlafaxine'}]",
"role": "assistant"
}
] |
Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.
|
[
{
"ade": "Total blindness with a transient tonic pupillary response",
"drug": "quinine sulfate"
},
{
"ade": "denervation supersensitivity",
"drug": "quinine sulfate"
},
{
"ade": "abnormal visual-evoked potentials",
"drug": "quinine sulfate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.",
"role": "user"
},
{
"content": "[{'ade': 'Total blindness with a transient tonic pupillary response', 'drug': 'quinine sulfate'}, {'ade': 'denervation supersensitivity', 'drug': 'quinine sulfate'}, {'ade': 'abnormal visual-evoked potentials', 'drug': 'quinine sulfate'}]",
"role": "assistant"
}
] |
Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.
|
[
{
"ade": "Pigmentary disorders",
"drug": "minocycline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.",
"role": "user"
},
{
"content": "[{'ade': 'Pigmentary disorders', 'drug': 'minocycline'}]",
"role": "assistant"
}
] |
Ticlopidine-induced marrow aplasia treated with cyclosporine.
|
[
{
"ade": "marrow aplasia",
"drug": "Ticlopidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ticlopidine-induced marrow aplasia treated with cyclosporine.",
"role": "user"
},
{
"content": "[{'ade': 'marrow aplasia', 'drug': 'Ticlopidine'}]",
"role": "assistant"
}
] |
Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.
|
[
{
"ade": "hypocalcemic tetany",
"drug": "fleet phospho-soda"
},
{
"ade": "hypocalcemic tetany",
"drug": "alendronate sodium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.",
"role": "user"
},
{
"content": "[{'ade': 'hypocalcemic tetany', 'drug': 'fleet phospho-soda'}, {'ade': 'hypocalcemic tetany', 'drug': 'alendronate sodium'}]",
"role": "assistant"
}
] |
Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.
|
[
{
"ade": "Cryptococcus neoformans fatal sepsis",
"drug": "alemtuzumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.",
"role": "user"
},
{
"content": "[{'ade': 'Cryptococcus neoformans fatal sepsis', 'drug': 'alemtuzumab'}]",
"role": "assistant"
}
] |
Cough induced by quinapril with resolution after changing to fosinopril.
|
[
{
"ade": "Cough",
"drug": "quinapril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cough induced by quinapril with resolution after changing to fosinopril.",
"role": "user"
},
{
"content": "[{'ade': 'Cough', 'drug': 'quinapril'}]",
"role": "assistant"
}
] |
Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.
|
[
{
"ade": "catatonia",
"drug": "disulfiram"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.",
"role": "user"
},
{
"content": "[{'ade': 'catatonia', 'drug': 'disulfiram'}]",
"role": "assistant"
}
] |
Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.
|
[
{
"ade": "Fracture of the femoral neck",
"drug": "PSL"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.",
"role": "user"
},
{
"content": "[{'ade': 'Fracture of the femoral neck', 'drug': 'PSL'}]",
"role": "assistant"
}
] |
Visual loss after a single small dose of vincristine has never been reported.
|
[
{
"ade": "Visual loss",
"drug": "vincristine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Visual loss after a single small dose of vincristine has never been reported.",
"role": "user"
},
{
"content": "[{'ade': 'Visual loss', 'drug': 'vincristine'}]",
"role": "assistant"
}
] |
Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.
|
[
{
"ade": "cranial nerve areflexia",
"drug": "CBZ"
},
{
"ade": "cortical hyperexcitability",
"drug": "CBZ"
},
{
"ade": "profound burst-suppression EEG pattern",
"drug": "CBZ"
},
{
"ade": "reversible encephalopathy",
"drug": "CBZ"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.",
"role": "user"
},
{
"content": "[{'ade': 'cranial nerve areflexia', 'drug': 'CBZ'}, {'ade': 'cortical hyperexcitability', 'drug': 'CBZ'}, {'ade': 'profound burst-suppression EEG pattern', 'drug': 'CBZ'}, {'ade': 'reversible encephalopathy', 'drug': 'CBZ'}]",
"role": "assistant"
}
] |
When measured, the serum lithium level had increased 4-fold during acyclovir therapy.
|
[
{
"ade": "serum lithium level had increased",
"drug": "acyclovir"
},
{
"ade": "serum lithium level had increased",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: When measured, the serum lithium level had increased 4-fold during acyclovir therapy.",
"role": "user"
},
{
"content": "[{'ade': 'serum lithium level had increased', 'drug': 'acyclovir'}, {'ade': 'serum lithium level had increased', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Ezetimibe-induced acute pancreatitis.
|
[
{
"ade": "acute pancreatitis",
"drug": "Ezetimibe"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ezetimibe-induced acute pancreatitis.",
"role": "user"
},
{
"content": "[{'ade': 'acute pancreatitis', 'drug': 'Ezetimibe'}]",
"role": "assistant"
}
] |
The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.
|
[
{
"ade": "ulcer",
"drug": "ATRA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.",
"role": "user"
},
{
"content": "[{'ade': 'ulcer', 'drug': 'ATRA'}]",
"role": "assistant"
}
] |
Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.
|
[
{
"ade": "pulmonary toxicity",
"drug": "fludarabine"
},
{
"ade": "Multiple pulmonary nodules",
"drug": "fludarabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary toxicity', 'drug': 'fludarabine'}, {'ade': 'Multiple pulmonary nodules', 'drug': 'fludarabine'}]",
"role": "assistant"
}
] |
Fulminant hepatic failure associated with bicalutamide.
|
[
{
"ade": "Fulminant hepatic failure",
"drug": "bicalutamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fulminant hepatic failure associated with bicalutamide.",
"role": "user"
},
{
"content": "[{'ade': 'Fulminant hepatic failure', 'drug': 'bicalutamide'}]",
"role": "assistant"
}
] |
These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.
|
[
{
"ade": "TRAb/TBII without thyroid-stimulating activity",
"drug": "amiodarone"
},
{
"ade": "thyroiditis",
"drug": "amiodarone"
},
{
"ade": "destructive thyroiditis",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.",
"role": "user"
},
{
"content": "[{'ade': 'TRAb/TBII without thyroid-stimulating activity', 'drug': 'amiodarone'}, {'ade': 'thyroiditis', 'drug': 'amiodarone'}, {'ade': 'destructive thyroiditis', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.
|
[
{
"ade": "lethargy",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.",
"role": "user"
},
{
"content": "[{'ade': 'lethargy', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Spindle coma in benzodiazepine toxicity: case report.
|
[
{
"ade": "Spindle coma",
"drug": "benzodiazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Spindle coma in benzodiazepine toxicity: case report.",
"role": "user"
},
{
"content": "[{'ade': 'Spindle coma', 'drug': 'benzodiazepine'}]",
"role": "assistant"
}
] |
Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.
|
[
{
"ade": "Sudden cardiac death",
"drug": "clozapine"
},
{
"ade": "hypersensitivity myocarditis",
"drug": "clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.",
"role": "user"
},
{
"content": "[{'ade': 'Sudden cardiac death', 'drug': 'clozapine'}, {'ade': 'hypersensitivity myocarditis', 'drug': 'clozapine'}]",
"role": "assistant"
}
] |
PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.
|
[
{
"ade": "anemia",
"drug": "ribavirin"
},
{
"ade": "anemia",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "ribavirin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.",
"role": "user"
},
{
"content": "[{'ade': 'anemia', 'drug': 'ribavirin'}, {'ade': 'anemia', 'drug': 'pegylated interferon alpha-2a'}, {'ade': 'progressive malaise', 'drug': 'pegylated interferon alpha-2a'}, {'ade': 'progressive malaise', 'drug': 'ribavirin'}]",
"role": "assistant"
}
] |
Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.
|
[
{
"ade": "congestive heart failure",
"drug": "recombinant alpha-interferon"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.",
"role": "user"
},
{
"content": "[{'ade': 'congestive heart failure', 'drug': 'recombinant alpha-interferon'}]",
"role": "assistant"
}
] |
However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
},
{
"ade": "Stevens-Johnson syndrome",
"drug": "ofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.",
"role": "user"
},
{
"content": "[{'ade': 'toxic epidermal necrolysis', 'drug': 'ofloxacin'}, {'ade': 'Stevens-Johnson syndrome', 'drug': 'ofloxacin'}]",
"role": "assistant"
}
] |
Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.
|
[
{
"ade": "electrolyte disorders",
"drug": "Foscarnet"
},
{
"ade": "severe hypomagnesemia",
"drug": "Foscarnet"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.",
"role": "user"
},
{
"content": "[{'ade': 'electrolyte disorders', 'drug': 'Foscarnet'}, {'ade': 'severe hypomagnesemia', 'drug': 'Foscarnet'}]",
"role": "assistant"
}
] |
Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.
|
[
{
"ade": "hypotension",
"drug": "valproate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.",
"role": "user"
},
{
"content": "[{'ade': 'hypotension', 'drug': 'valproate'}]",
"role": "assistant"
}
] |
To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.
|
[
{
"ade": "gastric LPD",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.",
"role": "user"
},
{
"content": "[{'ade': 'gastric LPD', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
Ofloxacin: a probable cause of toxic epidermal necrolysis.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "Ofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ofloxacin: a probable cause of toxic epidermal necrolysis.",
"role": "user"
},
{
"content": "[{'ade': 'toxic epidermal necrolysis', 'drug': 'Ofloxacin'}]",
"role": "assistant"
}
] |
Trimethoprim-sulfamethoxazole-induced aseptic meningitis.
|
[
{
"ade": "aseptic meningitis",
"drug": "Trimethoprim-sulfamethoxazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Trimethoprim-sulfamethoxazole-induced aseptic meningitis.",
"role": "user"
},
{
"content": "[{'ade': 'aseptic meningitis', 'drug': 'Trimethoprim-sulfamethoxazole'}]",
"role": "assistant"
}
] |
Hepatotoxicity induced by cyproterone acetate: a report of three cases.
|
[
{
"ade": "Hepatotoxicity",
"drug": "cyproterone acetate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatotoxicity induced by cyproterone acetate: a report of three cases.",
"role": "user"
},
{
"content": "[{'ade': 'Hepatotoxicity', 'drug': 'cyproterone acetate'}]",
"role": "assistant"
}
] |
Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.
|
[
{
"ade": "Prolongation of the QT interval",
"drug": "halofantrine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.",
"role": "user"
},
{
"content": "[{'ade': 'Prolongation of the QT interval', 'drug': 'halofantrine'}]",
"role": "assistant"
}
] |
We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.
|
[
{
"ade": "skin toxicity",
"drug": "aminoglutethimide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.",
"role": "user"
},
{
"content": "[{'ade': 'skin toxicity', 'drug': 'aminoglutethimide'}]",
"role": "assistant"
}
] |
Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.
|
[
{
"ade": "Acute myocardial ischemia",
"drug": "epinephrine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.",
"role": "user"
},
{
"content": "[{'ade': 'Acute myocardial ischemia', 'drug': 'epinephrine'}]",
"role": "assistant"
}
] |
After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.
|
[
{
"ade": "anaphylaxis",
"drug": "cisplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.",
"role": "user"
},
{
"content": "[{'ade': 'anaphylaxis', 'drug': 'cisplatin'}]",
"role": "assistant"
}
] |
A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.
|
[
{
"ade": "generalized rigidity",
"drug": "olanzapine"
},
{
"ade": "leukocytosis",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "lithium"
},
{
"ade": "leukocytosis",
"drug": "lithium"
},
{
"ade": "increased serum transaminase and creatine kinase",
"drug": "lithium"
},
{
"ade": "increased serum transaminase and creatine kinase",
"drug": "olanzapine"
},
{
"ade": "generalized rigidity",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",
"role": "user"
},
{
"content": "[{'ade': 'generalized rigidity', 'drug': 'olanzapine'}, {'ade': 'leukocytosis', 'drug': 'olanzapine'}, {'ade': 'fever', 'drug': 'olanzapine'}, {'ade': 'fever', 'drug': 'lithium'}, {'ade': 'leukocytosis', 'drug': 'lithium'}, {'ade': 'increased serum transaminase and creatine kinase', 'drug': 'lithium'}, {'ade': 'increased serum transaminase and creatine kinase', 'drug': 'olanzapine'}, {'ade': 'generalized rigidity', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.
|
[
{
"ade": "exacerbation of a preexisting maladaptive behavior",
"drug": "phenobarbital"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.",
"role": "user"
},
{
"content": "[{'ade': 'exacerbation of a preexisting maladaptive behavior', 'drug': 'phenobarbital'}]",
"role": "assistant"
}
] |
Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.
|
[
{
"ade": "Cardiac arrest",
"drug": "esmolol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.",
"role": "user"
},
{
"content": "[{'ade': 'Cardiac arrest', 'drug': 'esmolol'}]",
"role": "assistant"
}
] |
Interference with the cortisol axis by the microtubule antagonist, CPH82.
|
[
{
"ade": "Interference with the cortisol axis",
"drug": "CPH82"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Interference with the cortisol axis by the microtubule antagonist, CPH82.",
"role": "user"
},
{
"content": "[{'ade': 'Interference with the cortisol axis', 'drug': 'CPH82'}]",
"role": "assistant"
}
] |
A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.
|
[
{
"ade": "sarcoma",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.",
"role": "user"
},
{
"content": "[{'ade': 'sarcoma', 'drug': 'cyclophosphamide'}]",
"role": "assistant"
}
] |
Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.
|
[
{
"ade": "blood levels in the toxic range",
"drug": "phenytoin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.",
"role": "user"
},
{
"content": "[{'ade': 'blood levels in the toxic range', 'drug': 'phenytoin'}]",
"role": "assistant"
}
] |
CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.
|
[
{
"ade": "ischemic skin complications",
"drug": "vasopressin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.",
"role": "user"
},
{
"content": "[{'ade': 'ischemic skin complications', 'drug': 'vasopressin'}]",
"role": "assistant"
}
] |
Transient global amnesia after clioquinol: five personal observations from outside Japan.
|
[
{
"ade": "Transient global amnesia",
"drug": "clioquinol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Transient global amnesia after clioquinol: five personal observations from outside Japan.",
"role": "user"
},
{
"content": "[{'ade': 'Transient global amnesia', 'drug': 'clioquinol'}]",
"role": "assistant"
}
] |
Withdrawal of Depakote resulted in resolution of the effusion.
|
[
{
"ade": "effusion",
"drug": "Depakote"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Withdrawal of Depakote resulted in resolution of the effusion.",
"role": "user"
},
{
"content": "[{'ade': 'effusion', 'drug': 'Depakote'}]",
"role": "assistant"
}
] |
Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.
|
[
{
"ade": "fibrotic lesions",
"drug": "cyclophosphamide"
},
{
"ade": "fibrotic lesions",
"drug": "bleomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.",
"role": "user"
},
{
"content": "[{'ade': 'fibrotic lesions', 'drug': 'cyclophosphamide'}, {'ade': 'fibrotic lesions', 'drug': 'bleomycin'}]",
"role": "assistant"
}
] |
We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.
|
[
{
"ade": "hyperkalemia",
"drug": "aliskiren"
},
{
"ade": "acute renal failure",
"drug": "aliskiren"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.",
"role": "user"
},
{
"content": "[{'ade': 'hyperkalemia', 'drug': 'aliskiren'}, {'ade': 'acute renal failure', 'drug': 'aliskiren'}]",
"role": "assistant"
}
] |
We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.
|
[
{
"ade": "hypernatraemia",
"drug": "Kayexalate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.",
"role": "user"
},
{
"content": "[{'ade': 'hypernatraemia', 'drug': 'Kayexalate'}]",
"role": "assistant"
}
] |
The mechanism of RTA induced by FK506 has not yet been clearly elucidated.
|
[
{
"ade": "RTA",
"drug": "FK506"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The mechanism of RTA induced by FK506 has not yet been clearly elucidated.",
"role": "user"
},
{
"content": "[{'ade': 'RTA', 'drug': 'FK506'}]",
"role": "assistant"
}
] |
We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.
|
[
{
"ade": "SJS",
"drug": "nevirapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.",
"role": "user"
},
{
"content": "[{'ade': 'SJS', 'drug': 'nevirapine'}]",
"role": "assistant"
}
] |
Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.
|
[
{
"ade": "Osteonecrosis",
"drug": "dexamethasone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.",
"role": "user"
},
{
"content": "[{'ade': 'Osteonecrosis', 'drug': 'dexamethasone'}]",
"role": "assistant"
}
] |
Adenosine-induced ventricular fibrillation.
|
[
{
"ade": "ventricular fibrillation",
"drug": "Adenosine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Adenosine-induced ventricular fibrillation.",
"role": "user"
},
{
"content": "[{'ade': 'ventricular fibrillation', 'drug': 'Adenosine'}]",
"role": "assistant"
}
] |
The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.
|
[
{
"ade": "severe thrombocytopoaenia",
"drug": "quinine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.",
"role": "user"
},
{
"content": "[{'ade': 'severe thrombocytopoaenia', 'drug': 'quinine'}]",
"role": "assistant"
}
] |
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.
|
[
{
"ade": "demyelinating peripheral neuropathy",
"drug": "cytosine arabinoside"
},
{
"ade": "Horner's syndrome",
"drug": "cytosine arabinoside"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.",
"role": "user"
},
{
"content": "[{'ade': 'demyelinating peripheral neuropathy', 'drug': 'cytosine arabinoside'}, {'ade': \"Horner's syndrome\", 'drug': 'cytosine arabinoside'}]",
"role": "assistant"
}
] |
Carbamazepine-induced hyperammonemia.
|
[
{
"ade": "hyperammonemia",
"drug": "Carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Carbamazepine-induced hyperammonemia.",
"role": "user"
},
{
"content": "[{'ade': 'hyperammonemia', 'drug': 'Carbamazepine'}]",
"role": "assistant"
}
] |
Corneal endothelial deposits associated with rifabutin use.
|
[
{
"ade": "Corneal endothelial deposits",
"drug": "rifabutin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Corneal endothelial deposits associated with rifabutin use.",
"role": "user"
},
{
"content": "[{'ade': 'Corneal endothelial deposits', 'drug': 'rifabutin'}]",
"role": "assistant"
}
] |
CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.",
"role": "user"
},
{
"content": "[{'ade': 'toxic epidermal necrolysis', 'drug': 'ofloxacin'}]",
"role": "assistant"
}
] |
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.
|
[
{
"ade": "severe hepatotoxicity",
"drug": "benzarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.",
"role": "user"
},
{
"content": "[{'ade': 'severe hepatotoxicity', 'drug': 'benzarone'}]",
"role": "assistant"
}
] |
The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.
|
[
{
"ade": "hypercortisolism",
"drug": "CPH82"
},
{
"ade": "suppression of the endogeneous production of ACTH and cortisol",
"drug": "CPH82"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.",
"role": "user"
},
{
"content": "[{'ade': 'hypercortisolism', 'drug': 'CPH82'}, {'ade': 'suppression of the endogeneous production of ACTH and cortisol', 'drug': 'CPH82'}]",
"role": "assistant"
}
] |
Severe acidosis from acetazolamide in a diabetic patient.
|
[
{
"ade": "Severe acidosis",
"drug": "acetazolamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe acidosis from acetazolamide in a diabetic patient.",
"role": "user"
},
{
"content": "[{'ade': 'Severe acidosis', 'drug': 'acetazolamide'}]",
"role": "assistant"
}
] |
Rupture of a cerebral aneurysm associated with nifedipine treatment.
|
[
{
"ade": "Rupture of a cerebral aneurysm",
"drug": "nifedipine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Rupture of a cerebral aneurysm associated with nifedipine treatment.",
"role": "user"
},
{
"content": "[{'ade': 'Rupture of a cerebral aneurysm', 'drug': 'nifedipine'}]",
"role": "assistant"
}
] |
CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.
|
[
{
"ade": "delay corneal wound healing",
"drug": "colchicine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.",
"role": "user"
},
{
"content": "[{'ade': 'delay corneal wound healing', 'drug': 'colchicine'}]",
"role": "assistant"
}
] |
We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.
|
[
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "mizoribin"
},
{
"ade": "SIADH",
"drug": "mizoribin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.",
"role": "user"
},
{
"content": "[{'ade': 'syndrome of inappropriate secretion of antidiuretic hormone', 'drug': 'mizoribin'}, {'ade': 'SIADH', 'drug': 'mizoribin'}]",
"role": "assistant"
}
] |
Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.
|
[
{
"ade": "methanol poisoning",
"drug": "methanol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.",
"role": "user"
},
{
"content": "[{'ade': 'methanol poisoning', 'drug': 'methanol'}]",
"role": "assistant"
}
] |
We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.
|
[
{
"ade": "prolonged QT",
"drug": "methadone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'prolonged QT', 'drug': 'methadone'}]",
"role": "assistant"
}
] |
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.
|
[
{
"ade": "morbidity",
"drug": "hyperbaric oxygen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.",
"role": "user"
},
{
"content": "[{'ade': 'morbidity', 'drug': 'hyperbaric oxygen'}]",
"role": "assistant"
}
] |
We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.
|
[
{
"ade": "diphasic dyskinesias",
"drug": "levo-dopa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.",
"role": "user"
},
{
"content": "[{'ade': 'diphasic dyskinesias', 'drug': 'levo-dopa'}]",
"role": "assistant"
}
] |
BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.
|
[
{
"ade": "hemolytic-uremic syndrome",
"drug": "gemcitabine"
},
{
"ade": "HUS",
"drug": "Gemcitabine"
},
{
"ade": "HUS",
"drug": "gemcitabine"
},
{
"ade": "renal toxicity",
"drug": "Gemcitabine"
},
{
"ade": "hemolytic-uremic syndrome",
"drug": "Gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.",
"role": "user"
},
{
"content": "[{'ade': 'hemolytic-uremic syndrome', 'drug': 'gemcitabine'}, {'ade': 'HUS', 'drug': 'Gemcitabine'}, {'ade': 'HUS', 'drug': 'gemcitabine'}, {'ade': 'renal toxicity', 'drug': 'Gemcitabine'}, {'ade': 'hemolytic-uremic syndrome', 'drug': 'Gemcitabine'}]",
"role": "assistant"
}
] |
A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.
|
[
{
"ade": "bromide intoxication",
"drug": "pyridostigmine bromide"
},
{
"ade": "postoperative psychosis",
"drug": "pyridostigmine bromide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.",
"role": "user"
},
{
"content": "[{'ade': 'bromide intoxication', 'drug': 'pyridostigmine bromide'}, {'ade': 'postoperative psychosis', 'drug': 'pyridostigmine bromide'}]",
"role": "assistant"
}
] |
Capecitabine-induced headache responding to diltiazem.
|
[
{
"ade": "headache",
"drug": "Capecitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Capecitabine-induced headache responding to diltiazem.",
"role": "user"
},
{
"content": "[{'ade': 'headache', 'drug': 'Capecitabine'}]",
"role": "assistant"
}
] |
Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).
|
[
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "Treosulfan"
},
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "dihydroxybusulfan"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).",
"role": "user"
},
{
"content": "[{'ade': 'Acute non-lymphocytic leukemia', 'drug': 'Treosulfan'}, {'ade': 'Acute non-lymphocytic leukemia', 'drug': 'dihydroxybusulfan'}]",
"role": "assistant"
}
] |
Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.
|
[
{
"ade": "serotonin syndrome",
"drug": "citalopram"
},
{
"ade": "serotonin syndrome",
"drug": "fentanyl"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.",
"role": "user"
},
{
"content": "[{'ade': 'serotonin syndrome', 'drug': 'citalopram'}, {'ade': 'serotonin syndrome', 'drug': 'fentanyl'}]",
"role": "assistant"
}
] |
The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.
|
[
{
"ade": "hypotension",
"drug": "verapamil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.",
"role": "user"
},
{
"content": "[{'ade': 'hypotension', 'drug': 'verapamil'}]",
"role": "assistant"
}
] |
Acute acoustic nerve palsy associated with vincristine therapy.
|
[
{
"ade": "Acute acoustic nerve palsy",
"drug": "vincristine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute acoustic nerve palsy associated with vincristine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Acute acoustic nerve palsy', 'drug': 'vincristine'}]",
"role": "assistant"
}
] |
Disopyramide (Norpace)-induced hypoglycemia.
|
[
{
"ade": "hypoglycemia",
"drug": "Disopyramide"
},
{
"ade": "hypoglycemia",
"drug": "Norpace"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Disopyramide (Norpace)-induced hypoglycemia.",
"role": "user"
},
{
"content": "[{'ade': 'hypoglycemia', 'drug': 'Disopyramide'}, {'ade': 'hypoglycemia', 'drug': 'Norpace'}]",
"role": "assistant"
}
] |
We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.
|
[
{
"ade": "local cutaneous reactions",
"drug": "pegylated interferon alfa-2b"
},
{
"ade": "local cutaneous reactions",
"drug": "ribavirin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.",
"role": "user"
},
{
"content": "[{'ade': 'local cutaneous reactions', 'drug': 'pegylated interferon alfa-2b'}, {'ade': 'local cutaneous reactions', 'drug': 'ribavirin'}]",
"role": "assistant"
}
] |
Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.
|
[
{
"ade": "multifocal leukoencephalopathy",
"drug": "Capecitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.",
"role": "user"
},
{
"content": "[{'ade': 'multifocal leukoencephalopathy', 'drug': 'Capecitabine'}]",
"role": "assistant"
}
] |
This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.
|
[
{
"ade": "dysphagia",
"drug": "haloperidol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.",
"role": "user"
},
{
"content": "[{'ade': 'dysphagia', 'drug': 'haloperidol'}]",
"role": "assistant"
}
] |
The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.
|
[
{
"ade": "dystonia",
"drug": "carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.",
"role": "user"
},
{
"content": "[{'ade': 'dystonia', 'drug': 'carbamazepine'}]",
"role": "assistant"
}
] |
One patient had severe temporary weakness after an ampicillin sodium challenge.
|
[
{
"ade": "severe temporary weakness",
"drug": "ampicillin sodium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: One patient had severe temporary weakness after an ampicillin sodium challenge.",
"role": "user"
},
{
"content": "[{'ade': 'severe temporary weakness', 'drug': 'ampicillin sodium'}]",
"role": "assistant"
}
] |
Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.
|
[
{
"ade": "hypertrophic obstructive cardiomyopathy",
"drug": "dexamethasone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.",
"role": "user"
},
{
"content": "[{'ade': 'hypertrophic obstructive cardiomyopathy', 'drug': 'dexamethasone'}]",
"role": "assistant"
}
] |
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