accession
stringlengths 6
10
| name
stringlengths 8
11
| Full Name
stringlengths 2
102
⌀ | taxon
stringclasses 1
value | sequence
stringlengths 48
2.3k
| function
stringlengths 15
1.34k
| AlphaFoldDB
stringlengths 6
10
|
|---|---|---|---|---|---|---|
O75607
|
NPM3_HUMAN
|
Nucleoplasmin-3
|
Homo
|
<M><A><A><G><T><A><A><A><L><A><F><L><S><Q><E><S><R><T><R><A><G><G><V><G><G><L><R><V><P><A><P><V><T><M><D><S><F><F><F><G><C><E><L><S><G><H><T><R><S><F><T><F><K><V><E><E><E><D><D><A><E><H><V><L><A><L><T><M><L><C><L><T><E><G><A><K><D><E><C><N><V><V><E><V><V><A><R><N><H><D><H><Q><E><I><A><V><P><V><A><N><L><K><L><S><C><Q><P><M><L><S><L><D><D><F><Q><L><Q><P><P><V><T><F><R><L><K><S><G><S><G><P><V><R><I><T><G><R><H><Q><I><V><T><M><S><N><D><V><S><E><E><E><S><E><E><E><E><E><D><S><D><E><E><E><V><E><L><C><P><I><L><P><A><K><K><Q><G><G><R><P>
|
Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning . Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM . Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM .<BOP>
|
O75607
|
O43272
|
PROD_HUMAN
|
p53-induced gene 6 protein
|
Homo
|
<M><A><L><R><R><A><L><P><A><L><R><P><C><I><P><R><F><V><Q><L><S><T><A><P><A><S><R><E><Q><P><A><A><G><P><A><A><V><P><G><G><G><S><A><T><A><V><R><P><P><V><P><A><V><D><F><G><N><A><Q><E><A><Y><R><S><R><R><T><W><E><L><A><R><S><L><L><V><L><R><L><C><A><W><P><A><L><L><A><R><H><E><Q><L><L><Y><V><S><R><K><L><L><G><Q><R><L><F><N><K><L><M><K><M><T><F><Y><G><H><F><V><A><G><E><D><Q><E><S><I><Q><P><L><L><R><H><Y><R><A><F><G><V><S><A><I><L><D><Y><G><V><E><E><D><L><S><P><E><E><A><E><H><K><E><M><E><S><C><T><S><A><A><E><R><D><G><S><G><T><N><K><R><D><K><Q><Y><Q><A><H><R><A><F><G><D><R><R><N><G><V><I><S><A><R><T><Y><F><Y><A><N><E><A><K><C><D><S><H><M><E><T><F><L><R><C><I><E><A><S><G><R><V><S><D><D><G><F><I><A><I><K><L><T><A><L><G><R><P><Q><F><L><L><Q><F><S><E><V><L><A><K><W><R><C><F><F><H><Q><M><A><V><E><Q><G><Q><A><G><L><A><A><M><D><T><K><L><E><V><A><V><L><Q><E><S><V><A><K><L><G><I><A><S><R><A><E><I><E><D><W><F><T><A><E><T><L><G><V><S><G><T><M><D><L><L><D><W><S><S><L><I><D><S><R><T><K><L><S><K><H><L><V><V><P><N><A><Q><T><G><Q><L><E><P><L><L><S><R><F><T><E><E><E><E><L><Q><M><T><R><M><L><Q><R><M><D><V><L><A><K><K><A><T><E><M><G><V><R><L><M><V><D><A><E><Q><T><Y><F><Q><P><A><I><S><R><L><T><L><E><M><Q><R><K><F><N><V><E><K><P><L><I><F><N><T><Y><Q><C><Y><L><K><D><A><Y><D><N><V><T><L><D><V><E><L><A><R><R><E><G><W><C><F><G><A><K><L><V><R><G><A><Y><L><A><Q><E><R><A><R><A><A><E><I><G><Y><E><D><P><I><N><P><T><Y><E><A><T><N><A><M><Y><H><R><C><L><D><Y><V><L><E><E><L><K><H><N><A><K><A><K><V><M><V><A><S><H><N><E><D><T><V><R><F><A><L><R><R><M><E><E><L><G><L><H><P><A><D><H><Q><V><Y><F><G><Q><L><L><G><M><C><D><Q><I><S><F><P><L><G><Q><A><G><Y><P><V><Y><K><Y><V><P><Y><G><P><V><M><E><V><L><P><Y><L><S><R><R><A><L><E><N><S><S><L><M><K><G><T><H><R><E><R><Q><L><L><W><L><E><L><L><R><R><L><R><T><G><N><L><F><H><R><P><A>
|
Converts proline to delta-1-pyrroline-5-carboxylate.<BOP>
|
O43272
|
O43719
|
HTSF1_HUMAN
|
HIV Tat-specific factor 1
|
Homo
|
<M><S><G><T><N><L><D><G><N><D><E><F><D><E><Q><L><R><M><Q><E><L><Y><G><D><G><K><D><G><D><T><Q><T><D><A><G><G><E><P><D><S><L><G><Q><Q><P><T><D><T><P><Y><E><W><D><L><D><K><K><A><W><F><P><K><I><T><E><D><F><I><A><T><Y><Q><A><N><Y><G><F><S><N><D><G><A><S><S><S><T><A><N><V><E><D><V><H><A><R><T><A><E><E><P><P><Q><E><K><A><P><E><P><T><D><A><R><K><K><G><E><K><R><K><A><E><S><G><W><F><H><V><E><E><D><R><N><T><N><V><Y><V><S><G><L><P><P><D><I><T><V><D><E><F><I><Q><L><M><S><K><F><G><I><I><M><R><D><P><Q><T><E><E><F><K><V><K><L><Y><K><D><N><Q><G><N><L><K><G><D><G><L><C><C><Y><L><K><R><E><S><V><E><L><A><L><K><L><L><D><E><D><E><I><R><G><Y><K><L><H><V><E><V><A><K><F><Q><L><K><G><E><Y><D><A><S><K><K><K><K><K><C><K><D><Y><K><K><K><L><S><M><Q><Q><K><Q><L><D><W><R><P><E><R><R><A><G><P><S><R><M><R><H><E><R><V><V><I><I><K><N><M><F><H><P><M><D><F><E><D><D><P><L><V><L><N><E><I><R><E><D><L><R><V><E><C><S><K><F><G><Q><I><R><K><L><L><L><F><D><R><H><P><D><G><V><A><S><V><S><F><R><D><P><E><E><A><D><Y><C><I><Q><T><L><D><G><R><W><F><G><G><R><Q><I><T><A><Q><A><W><D><G><T><T><D><Y><Q><V><E><E><T><S><R><E><R><E><E><R><L><R><G><W><E><A><F><L><N><A><P><E><A><N><R><G><L><R><R><S><D><S><V><S><A><S><E><R><A><G><P><S><R><A><R><H><F><S><E><H><P><S><T><S><K><M><N><A><Q><E><T><A><T><G><M><A><F><E><E><P><I><D><E><K><K><F><E><K><T><E><D><G><G><E><F><E><E><G><A><S><E><N><N><A><K><E><S><S><P><E><K><E><A><E><E><G><C><P><E><K><E><S><E><E><G><C><P><K><R><G><F><E><G><S><C><S><Q><K><E><S><E><E><G><N><P><V><R><G><S><E><E><D><S><P><K><K><E><S><K><K><K><T><L><K><N><D><C><E><E><N><G><L><A><K><E><S><E><D><D><L><N><K><E><S><E><E><E><V><G><P><T><K><E><S><E><E><D><D><S><E><K><E><S><D><E><D><C><S><E><K><Q><S><E><D><G><S><E><R><E><F><E><E><N><G><L><E><K><D><L><D><E><E><G><S><E><K><E><L><H><E><N><V><L><D><K><E><L><E><E><N><D><S><E><N><S><E><F><E><D><D><G><S><E><K><V><L><D><E><E><G><S><E><R><E><F><D><E><D><S><D><E><K><E><E><E><E><D><T><Y><E><K><V><F><D><D><E><S><D><E><K><E><D><E><E><Y><A><D><E><K><G><L><E><A><A><D><K><K><A><E><E><G><D><A><D><E><K><L><F><E><E><S><D><D><K><E><D><E><D><A><D><G><K><E><V><E><D><A><D><E><K><L><F><E><D><D><D><S><N><E><K><L><F><D><E><E><E><D><S><S><E><K><L><F><D><D><S><D><E><R><G><T><L><G><G><F><G><S><V><E><E><G><P><L><S><T><G><S><S><F><I><L><S><S><D><D><D><D><D><D><I>
|
Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.<BOP>
|
O43719
|
Q8IUF8
|
RIOX2_HUMAN
|
Ribosomal oxygenase MINA
|
Homo
|
<M><P><K><K><A><K><P><T><G><S><G><K><E><E><G><P><A><P><C><K><Q><M><K><L><E><A><A><G><G><P><S><A><L><N><F><D><S><P><S><S><L><F><E><S><L><I><S><P><I><K><T><E><T><F><F><K><E><F><W><E><Q><K><P><L><L><I><Q><R><D><D><P><A><L><A><T><Y><Y><G><S><L><F><K><L><T><D><L><K><S><L><C><S><R><G><M><Y><Y><G><R><D><V><N><V><C><R><C><V><N><G><K><K><K><V><L><N><K><D><G><K><A><H><F><L><Q><L><R><K><D><F><D><Q><K><R><A><T><I><Q><F><H><Q><P><Q><R><F><K><D><E><L><W><R><I><Q><E><K><L><E><C><Y><F><G><S><L><V><G><S><N><V><Y><I><T><P><A><G><S><Q><G><L><P><P><H><Y><D><D><V><E><V><F><I><L><Q><L><E><G><E><K><H><W><R><L><Y><H><P><T><V><P><L><A><R><E><Y><S><V><E><A><E><E><R><I><G><R><P><V><H><E><F><M><L><K><P><G><D><L><L><Y><F><P><R><G><T><I><H><Q><A><D><T><P><A><G><L><A><H><S><T><H><V><T><I><S><T><Y><Q><N><N><S><W><G><D><F><L><L><D><T><I><S><G><L><V><F><D><T><A><K><E><D><V><E><L><R><T><G><I><P><R><Q><L><L><L><Q><V><E><S><T><T><V><A><T><R><R><L><S><G><F><L><R><T><L><A><D><R><L><E><G><T><K><E><L><L><S><S><D><M><K><K><D><F><I><M><H><R><L><P><P><Y><S><A><G><D><G><A><E><L><S><T><P><G><G><K><L><P><R><L><D><S><V><V><R><L><Q><F><K><D><H><I><V><L><T><V><L><P><D><Q><D><Q><S><D><E><A><Q><E><K><M><V><Y><I><Y><H><S><L><K><N><S><R><E><T><H><M><M><G><N><E><E><E><T><E><F><H><G><L><R><F><P><L><S><H><L><D><A><L><K><Q><I><W><N><S><P><A><I><S><V><K><D><L><K><L><T><T><D><E><E><K><E><S><L><V><L><S><L><W><T><E><C><L><I><Q><V><V>
|
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.<BOP>
|
Q8IUF8
|
Q96N19
|
G137A_HUMAN
|
Transmembrane 7 superfamily member 1-like 1 protein
|
Homo
|
<M><E><S><N><L><S><G><L><V><P><A><A><G><L><V><P><A><L><P><P><A><V><T><L><G><L><T><A><A><Y><T><T><L><Y><A><L><L><F><F><S><V><Y><A><Q><L><W><L><V><L><L><Y><G><H><K><R><L><S><Y><Q><T><V><F><L><A><L><C><L><L><W><A><A><L><R><T><T><L><F><S><F><Y><F><R><D><T><P><R><A><N><R><L><G><P><L><P><F><W><L><L><Y><C><C><P><V><C><L><Q><F><F><T><L><T><L><M><N><L><Y><F><A><Q><V><V><F><K><A><K><V><K><R><R><P><E><M><S><R><G><L><L><A><V><R><G><A><F><V><G><A><S><L><L><F><L><L><V><N><V><L><C><A><V><L><S><H><R><R><R><A><Q><P><W><A><L><L><L><V><R><V><L><V><S><D><S><L><F><V><I><C><A><L><S><L><A><A><C><L><C><L><V><A><R><R><A><P><S><T><S><I><Y><L><E><A><K><G><T><S><V><C><Q><A><A><A><M><G><G><A><M><V><L><L><Y><A><S><R><A><C><Y><N><L><T><A><L><A><L><A><P><Q><S><R><L><D><T><F><D><Y><D><W><Y><N><V><S><D><Q><A><D><L><V><N><D><L><G><N><K><G><Y><L><V><F><G><L><I><L><F><V><W><E><L><L><P><T><T><L><L><V><G><F><F><R><V><H><R><P><P><Q><D><L><S><T><S><H><I><L><N><G><Q><V><F><A><S><R><S><Y><F><F><D><R><A><G><H><C><E><D><E><G><C><S><W><E><H><S><R><G><E><S><T><R><C><Q><D><Q><A><A><T><T><T><V><S><T><P><P><H><R><R><D><P><P><P><S><P><T><E><Y><P><G><P><S><P><P><H><P><R><P><L><C><Q><V><C><L><P><L><L><A><Q><D><P><G><G><R><G><Y><P><L><L><W><P><A><P><C><C><S><C><H><S><E><L><V><P><S><P>
|
May activate Wnt/beta-catenin signaling to modulate epithelial cell function.<BOP>
|
Q96N19
|
Q96G04
|
EF2KT_HUMAN
|
eEF2-lysine methyltransferase
|
Homo
|
<M><A><P><E><E><N><A><G><T><E><L><L><L><Q><S><F><E><R><R><F><L><A><A><R><T><L><R><S><F><P><W><Q><S><L><E><A><K><L><R><D><S><S><D><S><E><L><L><R><D><I><L><H><K><T><V><K><H><P><V><C><V><K><H><P><P><S><V><K><Y><A><R><C><F><L><S><E><L><I><K><K><H><E><A><V><H><T><E><P><L><D><E><L><Y><E><A><L><A><E><T><L><M><A><K><E><S><T><Q><G><H><R><S><Y><L><L><P><S><G><G><S><V><T><L><S><E><S><T><A><I><I><S><Y><G><T><T><G><L><V><T><W><D><A><A><L><Y><L><A><E><W><A><I><E><N><P><A><V><F><T><N><R><T><V><L><E><L><G><S><G><A><G><L><T><G><L><A><I><C><K><M><C><R><P><R><A><Y><I><F><S><D><C><H><S><R><V><L><E><Q><L><R><G><N><V><L><L><N><G><L><S><L><E><A><D><I><T><A><K><L><D><S><P><R><V><T><V><A><Q><L><D><W><D><V><A><T><V><H><Q><L><S><A><F><Q><P><D><V><V><I><A><A><D><V><L><Y><C><P><E><A><I><M><S><L><V><G><V><L><R><R><L><A><A><C><R><E><H><Q><R><A><P><E><V><Y><V><A><F><T><V><R><N><P><E><T><C><Q><L><F><T><T><E><L><G><R><A><G><I><R><W><E><V><E><P><R><H><E><Q><K><L><F><P><Y><E><E><H><L><E><M><A><M><L><N><L><T><L>
|
Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.<BOP>
|
Q96G04
|
P63130
|
GAK7_HUMAN
|
HERV-K_1q22 provirus ancestral Gag polyprotein
|
Homo
|
<M><G><Q><T><K><S><K><I><K><S><K><Y><A><S><Y><L><S><F><I><K><I><L><L><K><R><G><G><V><K><V><S><T><K><N><L><I><K><L><F><Q><I><I><E><Q><F><C><P><W><F><P><E><Q><G><T><L><D><L><K><D><W><K><R><I><G><K><E><L><K><Q><A><G><R><K><G><N><I><I><P><L><T><V><W><N><D><W><A><I><I><K><A><A><L><E><P><F><Q><T><E><K><D><S><V><S><V><S><D><A><L><G><S><C><I><I><D><C><N><E><N><T><R><K><K><S><Q><K><E><T><E><G><L><H><C><E><Y><V><A><E><P><V><M><A><Q><S><T><Q><N><V><D><Y><N><Q><L><Q><E><V><I><Y><P><E><T><L><K><L><E><G><K><G><P><E><L><V><G><P><S><E><S><K><P><R><G><T><S><H><L><P><A><G><Q><V><P><V><T><L><Q><P><Q><K><Q><V><K><E><N><K><T><Q><P><P><V><A><Y><Q><Y><W><P><P><A><E><L><Q><Y><R><P><P><P><E><S><Q><Y><G><Y><P><G><M><P><P><A><P><Q><G><R><A><P><Y><P><Q><P><P><T><R><R><L><N><P><T><A><P><P><S><R><Q><G><S><E><L><H><E><I><I><D><K><S><R><K><E><G><D><T><E><A><W><Q><F><P><V><T><L><E><P><M><P><P><G><E><G><A><Q><E><G><E><P><P><T><V><E><A><R><Y><K><S><F><S><I><K><M><L><K><D><M><K><E><G><V><K><Q><Y><G><P><N><S><P><Y><M><R><T><L><L><D><S><I><A><H><G><H><R><L><I><P><Y><D><W><E><I><L><A><K><S><S><L><S><P><S><Q><F><L><Q><F><K><T><W><W><I><D><G><V><Q><E><Q><V><R><R><N><R><A><A><N><P><P><V><N><I><D><A><D><Q><L><L><G><I><G><Q><N><W><S><T><I><S><Q><Q><A><L><M><Q><N><E><A><I><E><Q><V><R><A><I><C><L><R><A><W><E><K><I><Q><D><P><G><S><T><C><P><S><F><N><T><V><R><Q><G><S><K><E><P><Y><P><D><F><V><A><R><L><Q><D><V><A><Q><K><S><I><A><D><E><K><A><R><K><V><I><V><E><L><M><A><Y><E><N><A><N><P><E><C><Q><S><A><I><K><P><L><K><G><K><V><P><A><G><S><D><V><I><S><E><Y><V><K><A><C><D><G><I><G><G><A><M><H><K><A><M><L><M><A><Q><A><I><T><G><V><V><L><G><G><Q><V><R><T><F><G><G><K><C><Y><N><C><G><Q><I><G><H><L><K><K><N><C><P><V><L><N><K><Q><N><I><T><I><Q><A><T><T><T><G><R><E><P><P><D><L><C><P><R><C><K><K><G><K><H><W><A><S><Q><C><R><S><K><F><D><K><N><G><Q><P><L><S><G><N><E><Q><R><G><Q><P><Q><A><P><Q><Q><T><G><A><F><P><I><Q><P><F><V><P><Q><G><F><Q><E><Q><Q><P><P><L><S><Q><V><F><Q><G><I><S><Q><L><P><Q><Y><N><N><C><P><P><P><Q><A><A><V><Q><Q>
|
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.<BOP>
|
P63130
|
Q12797
|
ASPH_HUMAN
|
Peptide-aspartate beta-dioxygenase
|
Homo
|
<M><A><Q><R><K><N><A><K><S><S><G><N><S><S><S><S><G><S><G><S><G><S><T><S><A><G><S><S><S><P><G><A><R><R><E><T><K><H><G><G><H><K><N><G><R><K><G><G><L><S><G><T><S><F><F><T><W><F><M><V><I><A><L><L><G><V><W><T><S><V><A><V><V><W><F><D><L><V><D><Y><E><E><V><L><G><K><L><G><I><Y><D><A><D><G><D><G><D><F><D><V><D><D><A><K><V><L><L><G><L><K><E><R><S><T><S><E><P><A><V><P><P><E><E><A><E><P><H><T><E><P><E><E><Q><V><P><V><E><A><E><P><Q><N><I><E><D><E><A><K><E><Q><I><Q><S><L><L><H><E><M><V><H><A><E><H><V><E><G><E><D><L><Q><Q><E><D><G><P><T><G><E><P><Q><Q><E><D><D><E><F><L><M><A><T><D><V><D><D><R><F><E><T><L><E><P><E><V><S><H><E><E><T><E><H><S><Y><H><V><E><E><T><V><S><Q><D><C><N><Q><D><M><E><E><M><M><S><E><Q><E><N><P><D><S><S><E><P><V><V><E><D><E><R><L><H><H><D><T><D><D><V><T><Y><Q><V><Y><E><E><Q><A><V><Y><E><P><L><E><N><E><G><I><E><I><T><E><V><T><A><P><P><E><D><N><P><V><E><D><S><Q><V><I><V><E><E><V><S><I><F><P><V><E><E><Q><Q><E><V><P><P><E><T><N><R><K><T><D><D><P><E><Q><K><A><K><V><K><K><K><K><P><K><L><L><N><K><F><D><K><T><I><K><A><E><L><D><A><A><E><K><L><R><K><R><G><K><I><E><E><A><V><N><A><F><K><E><L><V><R><K><Y><P><Q><S><P><R><A><R><Y><G><K><A><Q><C><E><D><D><L><A><E><K><R><R><S><N><E><V><L><R><G><A><I><E><T><Y><Q><E><V><A><S><L><P><D><V><P><A><D><L><L><K><L><S><L><K><R><R><S><D><R><Q><Q><F><L><G><H><M><R><G><S><L><L><T><L><Q><R><L><V><Q><L><F><P><N><D><T><S><L><K><N><D><L><G><V><G><Y><L><L><I><G><D><N><D><N><A><K><K><V><Y><E><E><V><L><S><V><T><P><N><D><G><F><A><K><V><H><Y><G><F><I><L><K><A><Q><N><K><I><A><E><S><I><P><Y><L><K><E><G><I><E><S><G><D><P><G><T><D><D><G><R><F><Y><F><H><L><G><D><A><M><Q><R><V><G><N><K><E><A><Y><K><W><Y><E><L><G><H><K><R><G><H><F><A><S><V><W><Q><R><S><L><Y><N><V><N><G><L><K><A><Q><P><W><W><T><P><K><E><T><G><Y><T><E><L><V><K><S><L><E><R><N><W><K><L><I><R><D><E><G><L><A><V><M><D><K><A><K><G><L><F><L><P><E><D><E><N><L><R><E><K><G><D><W><S><Q><F><T><L><W><Q><Q><G><R><R><N><E><N><A><C><K><G><A><P><K><T><C><T><L><L><E><K><F><P><E><T><T><G><C><R><R><G><Q><I><K><Y><S><I><M><H><P><G><T><H><V><W><P><H><T><G><P><T><N><C><R><L><R><M><H><L><G><L><V><I><P><K><E><G><C><K><I><R><C><A><N><E><T><K><T><W><E><E><G><K><V><L><I><F><D><D><S><F><E><H><E><V><W><Q><D><A><S><S><F><R><L><I><F><I><V><D><V><W><H><P><E><L><T><P><Q><Q><R><R><S><L><P><A><I>
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Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells.<BOP>
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Q12797
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A0A1B0GUS4
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UB2L5_HUMAN
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Ubiquitin-protein ligase L5
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Homo
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<M><A><A><S><R><R><L><M><K><E><L><E><E><I><R><K><C><G><M><E><N><F><R><N><I><Q><V><D><E><A><N><L><L><T><W><Q><G><L><I><V><P><D><N><P><P><Y><N><K><G><A><F><R><I><E><I><N><F><P><A><E><Y><P><F><K><P><P><R><I><T><F><K><T><K><I><Y><H><P><N><I><D><E><K><G><Q><V><C><L><P><V><I><S><A><E><N><W><K><P><A><T><K><T><D><Q><V><I><Q><S><L><I><A><L><V><N><D><P><Q><P><E><H><P><L><R><A><D><L><A><E><E><Y><S><N><D><R><K><K><F><C><K><N><A><E><E><F><T><K><K><Y><G><E><K><R><P><V><D>
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Catalyzes the covalent attachment of ubiquitin to other proteins.<BOP>
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A0A1B0GUS4
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Q96DR5
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BPIA2_HUMAN
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Short palate, lung and nasal epithelium carcinoma-associated protein 2
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Homo
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<M><L><Q><L><W><K><L><V><L><L><C><G><V><L><T><G><T><S><E><S><L><L><D><N><L><G><N><D><L><S><N><V><V><D><K><L><E><P><V><L><H><E><G><L><E><T><V><D><N><T><L><K><G><I><L><E><K><L><K><V><D><L><G><V><L><Q><K><S><S><A><W><Q><L><A><K><Q><K><A><Q><E><A><E><K><L><L><N><N><V><I><S><K><L><L><P><T><N><T><D><I><F><G><L><K><I><S><N><S><L><I><L><D><V><K><A><E><P><I><D><D><G><K><G><L><N><L><S><F><P><V><T><A><N><V><T><V><A><G><P><I><I><G><Q><I><I><N><L><K><A><S><L><D><L><L><T><A><V><T><I><E><T><D><P><Q><T><H><Q><P><V><A><V><L><G><E><C><A><S><D><P><T><S><I><S><L><S><L><L><D><K><H><S><Q><I><I><N><K><F><V><N><S><V><I><N><T><L><K><S><T><V><S><S><L><L><Q><K><E><I><C><P><L><I><R><I><F><I><H><S><L><D><V><N><V><I><Q><Q><V><V><D><N><P><Q><H><K><T><Q><L><Q><T><L><I>
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Has strong antibacterial activity against P. aeruginosa.<BOP>
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Q96DR5
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A0A286YFG1
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SCGR8_HUMAN
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Keratin-associated protein 28-8
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Homo
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<M><G><C><C><G><C><G><G><C><G><G><G><C><G><G><C><S><G><G><C><G><G><G><C><G><G><G><C><G><G><G><G><C><G><G><G><C><G><S><C><T><T><C><R><C><Y><R><V><G><C><C><S><S><C><C><P><C><C><R><G><C><C><G><G><C><C><S><T><P><V><I><C><C><C><R><R><T><C><S><S><C><G><C><G><Y><G><K><G><C><C><Q><Q><K><G><C><C><Q><Q><K><C><C><C><Q><K><Q><C><C><C>
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In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
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A0A286YFG1
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Q9UPY8
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MARE3_HUMAN
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RP3
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Homo
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<M><A><V><N><V><Y><S><T><S><V><T><S><E><N><L><S><R><H><D><M><L><A><W><V><N><D><S><L><H><L><N><Y><T><K><I><E><Q><L><C><S><G><A><A><Y><C><Q><F><M><D><M><L><F><P><G><C><V><H><L><R><K><V><K><F><Q><A><K><L><E><H><E><Y><I><H><N><F><K><V><L><Q><A><A><F><K><K><M><G><V><D><K><I><I><P><V><E><K><L><V><K><G><K><F><Q><D><N><F><E><F><I><Q><W><F><K><K><F><F><D><A><N><Y><D><G><K><D><Y><N><P><L><L><A><R><Q><G><Q><D><V><A><P><P><P><N><P><G><D><Q><I><F><N><K><S><K><K><L><I><G><T><A><V><P><Q><R><T><S><P><T><G><P><K><N><M><Q><T><S><G><R><L><S><N><V><A><P><P><C><I><L><R><K><N><P><P><S><A><R><N><G><G><H><E><T><D><A><Q><I><L><E><L><N><Q><Q><L><V><D><L><K><L><T><V><D><G><L><E><K><E><R><D><F><Y><F><S><K><L><R><D><I><E><L><I><C><Q><E><H><E><S><E><N><S><P><V><I><S><G><I><I><G><I><L><Y><A><T><E><E><G><F><A><P><P><E><D><D><E><I><E><E><H><Q><Q><E><D><Q><D><E><Y>
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Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton . Promotes microtubule growth . May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes . Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement . Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules .<BOP>
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Q9UPY8
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Q9H5J0
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ZBTB3_HUMAN
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Zinc finger and BTB domain-containing protein 3
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Homo
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<M><L><R><E><F><S><K><W><G><V><E><A><S><P><G><K><A><W><E><R><K><R><S><L><L><R><G><A><V><G><R><Y><R><G><A><T><G><G><D><L><F><W><A><P><F><P><S><W><G><T><M><E><F><P><E><H><S><Q><Q><L><L><Q><S><L><R><E><Q><R><S><Q><G><F><L><C><D><C><T><V><M><V><G><S><T><Q><F><L><A><H><R><A><V><L><A><S><C><S><P><F><F><Q><L><F><Y><K><E><R><E><L><D><K><R><D><L><V><C><I><H><N><E><I><V><T><A><P><A><F><G><L><L><L><D><F><M><Y><A><G><Q><L><T><L><R><G><D><T><P><V><E><D><V><L><A><A><A><S><Y><L><H><M><N><D><I><V><K><V><C><K><R><R><L><Q><A><R><A><L><A><E><A><D><S><T><K><K><E><E><E><T><N><S><Q><L><P><S><L><E><F><L><S><S><T><S><R><G><T><Q><P><S><L><A><S><A><E><T><S><G><H><W><G><K><G><E><W><K><G><S><A><A><P><S><P><T><V><R><P><P><D><E><P><P><M><S><S><G><A><D><T><T><Q><P><G><M><E><V><D><A><P><H><L><R><A><P><H><P><P><V><A><D><V><S><L><A><S><P><S><S><S><T><E><T><I><P><T><N><Y><F><S><S><G><I><S><A><V><S><L><E><P><L><P><S><L><D><V><G><P><E><S><L><R><V><V><E><P><K><D><P><G><G><P><L><Q><G><F><Y><P><P><A><S><A><P><T><S><A><P><A><P><V><S><A><P><V><P><S><Q><A><P><A><P><A><E><A><E><L><V><Q><V><K><V><E><A><I><V><I><S><D><E><E><T><D><V><S><D><E><Q><P><Q><G><P><E><R><A><F><P><S><G><G><A><V><Y><G><A><Q><P><S><Q><P><E><A><F><E><D><P><G><A><A><G><L><E><E><V><G><P><S><D><H><F><L><P><T><D><P><H><L><P><Y><H><L><L><P><G><A><G><Q><Y><H><R><G><L><V><T><S><P><L><P><A><P><A><S><L><H><E><P><L><Y><L><S><S><E><Y><E><A><A><P><G><S><F><G><V><F><T><E><D><V><P><T><C><K><T><C><G><K><T><F><S><C><S><Y><T><L><R><R><H><A><T><V><H><T><R><E><R><P><Y><E><C><R><Y><C><L><R><S><Y><T><Q><S><G><D><L><Y><R><H><I><R><K><A><H><N><E><D><L><A><K><R><S><K><P><D><P><E><V><G><P><L><L><G><V><Q><P><L><P><G><S><P><T><A><D><R><Q><S><S><S><G><G><G><P><P><K><D><F><V><L><A><P><K><T><N><I>
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May be involved in transcriptional regulation.<BOP>
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Q9H5J0
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P32243
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OTX2_HUMAN
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Orthodenticle homolog 2
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Homo
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<M><M><S><Y><L><K><Q><P><P><Y><A><V><N><G><L><S><L><T><T><S><G><M><D><L><L><H><P><S><V><G><Y><P><A><T><P><R><K><Q><R><R><E><R><T><T><F><T><R><A><Q><L><D><V><L><E><A><L><F><A><K><T><R><Y><P><D><I><F><M><R><E><E><V><A><L><K><I><N><L><P><E><S><R><V><Q><V><W><F><K><N><R><R><A><K><C><R><Q><Q><Q><Q><Q><Q><Q><N><G><G><Q><N><K><V><R><P><A><K><K><K><T><S><P><A><R><E><V><S><S><E><S><G><T><S><G><Q><F><T><P><P><S><S><T><S><V><P><T><I><A><S><S><S><A><P><V><S><I><W><S><P><A><S><I><S><P><L><S><D><P><L><S><T><S><S><S><C><M><Q><R><S><Y><P><M><T><Y><T><Q><A><S><G><Y><S><Q><G><Y><A><G><S><T><S><Y><F><G><G><M><D><C><G><S><Y><L><T><P><M><H><H><Q><L><P><G><P><G><A><T><L><S><P><M><G><T><N><A><V><T><S><H><L><N><Q><S><P><A><S><L><S><T><Q><G><Y><G><A><S><S><L><G><F><N><S><T><T><D><C><L><D><Y><K><D><Q><T><A><S><W><K><L><N><F><N><A><D><C><L><D><Y><K><D><Q><T><S><S><W><K><F><Q><V><L>
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Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.<BOP>
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P32243
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P60606
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CTXN1_HUMAN
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Cortexin-1
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Homo
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<M><S><A><T><W><T><L><S><P><E><P><L><P><P><S><T><G><P><P><V><G><A><G><L><D><A><E><Q><R><T><V><F><A><F><V><L><C><L><L><V><V><L><V><L><L><M><V><R><C><V><R><I><L><L><D><P><Y><S><R><M><P><A><S><S><W><T><D><H><K><E><A><L><E><R><G><Q><F><D><Y><A><L><V>
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May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.<BOP>
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P60606
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Q96DZ5
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CLIP3_HUMAN
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Cytoplasmic linker protein 170-related 59 kDa protein
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Homo
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<M><T><K><T><D><P><A><P><M><A><P><P><P><R><G><E><E><E><E><E><E><E><E><D><E><P><V><P><E><A><P><S><P><T><Q><E><R><R><Q><K><P><V><V><H><P><S><A><P><A><P><L><P><K><D><Y><A><F><T><F><F><D><P><N><D><P><A><C><Q><E><I><L><F><D><P><Q><T><T><I><P><E><L><F><A><I><V><R><Q><W><V><P><Q><V><Q><H><K><I><D><V><I><G><N><E><I><L><R><R><G><C><H><V><N><D><R><D><G><L><T><D><M><T><L><L><H><Y><A><C><K><A><G><A><H><G><V><G><D><P><A><A><A><V><R><L><S><Q><Q><L><L><A><L><G><A><D><V><T><L><R><S><R><W><T><N><M><N><A><L><H><Y><A><A><Y><F><D><V><P><D><L><V><R><V><L><L><K><G><A><R><P><R><V><V><N><S><T><C><S><D><F><N><H><G><S><A><L><H><I><A><A><S><S><L><C><L><G><A><A><K><C><L><L><E><H><G><A><N><P><A><L><R><N><R><K><G><Q><V><P><A><E><V><V><P><D><P><M><D><M><S><L><D><K><A><E><A><A><L><V><A><K><E><L><R><T><L><L><E><E><A><V><P><L><S><C><A><L><P><K><V><T><L><P><N><Y><D><N><V><P><G><N><L><M><L><S><A><L><G><L><R><L><G><D><R><V><L><L><D><G><Q><K><T><G><T><L><R><F><C><G><T><T><E><F><A><S><G><Q><W><V><G><V><E><L><D><E><P><E><G><K><N><D><G><S><V><G><G><V><R><Y><F><I><C><P><P><K><Q><G><L><F><A><S><V><S><K><I><S><K><A><V><D><A><P><P><S><S><V><T><S><T><P><R><T><P><R><M><D><F><S><R><V><T><G><K><G><R><R><E><H><K><G><K><K><K><T><P><S><S><P><S><L><G><S><L><Q><Q><R><D><G><A><K><A><E><V><G><D><Q><V><L><V><A><G><Q><K><Q><G><I><V><R><F><Y><G><K><T><D><F><A><P><G><Y><W><Y><G><I><E><L><D><Q><P><T><G><K><H><D><G><S><V><F><G><V><R><Y><F><T><C><P><P><R><H><G><V><F><A><P><A><S><R><I><Q><R><I><G><G><S><T><D><S><P><G><D><S><V><G><A><K><K><V><H><Q><V><T><M><T><Q><P><K><R><T><F><T><T><V><R><T><P><K><D><I><A><S><E><N><S><I><S><R><L><L><F><C><C><W><F><P><W><M><L><R><A><E><M><Q><S>
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Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.<BOP>
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Q96DZ5
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Q9UGJ1
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GCP4_HUMAN
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Gamma-ring complex protein 76 kDa
|
Homo
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<M><I><H><E><L><L><L><A><L><S><G><Y><P><G><S><I><F><T><W><N><K><R><S><G><L><Q><V><S><Q><D><F><P><F><L><H><P><S><E><T><S><V><L><N><R><L><C><R><L><G><T><D><Y><I><R><F><T><E><F><I><E><Q><Y><T><G><H><V><Q><Q><Q><D><H><H><P><S><Q><Q><G><Q><G><G><L><H><G><I><Y><L><R><A><F><C><T><G><L><D><S><V><L><Q><P><Y><R><Q><A><L><L><D><L><E><Q><E><F><L><G><D><P><H><L><S><I><S><H><V><N><Y><F><L><D><Q><F><Q><L><L><F><P><S><V><M><V><V><V><E><Q><I><K><S><Q><K><I><H><G><C><Q><I><L><E><T><V><Y><K><H><S><C><G><G><L><P><P><V><R><S><A><L><E><K><I><L><A><V><C><H><G><V><M><Y><K><Q><L><S><A><W><M><L><H><G><L><L><L><D><Q><H><E><E><F><F><I><K><Q><G><P><S><S><G><N><V><S><A><Q><P><E><E><D><E><E><D><L><G><I><G><G><L><T><G><K><Q><L><R><E><L><Q><D><L><R><L><I><E><E><E><N><M><L><A><P><S><L><K><Q><F><S><L><R><V><E><I><L><P><S><Y><I><P><V><R><V><A><E><K><I><L><F><V><G><E><S><V><Q><M><F><E><N><Q><N><V><N><L><T><R><K><G><S><I><L><K><N><Q><E><D><T><F><A><A><E><L><H><R><L><K><Q><Q><P><L><F><S><L><V><D><F><E><Q><V><V><D><R><I><R><S><T><V><A><E><H><L><W><K><L><M><V><E><E><S><D><L><L><G><Q><L><K><I><I><K><D><F><Y><L><L><G><R><G><E><L><F><Q><A><F><I><D><T><A><Q><H><M><L><K><T><P><P><T><A><V><T><E><H><D><V><N><V><A><F><Q><Q><S><A><H><K><V><L><L><D><D><D><N><L><L><P><L><L><H><L><T><I><E><Y><H><G><K><E><H><K><A><D><A><T><Q><A><R><E><G><P><S><R><E><T><S><P><R><E><A><P><A><S><G><W><A><A><L><G><L><S><Y><K><V><Q><W><P><L><H><I><L><F><T><P><A><V><L><E><K><Y><N><V><V><F><K><Y><L><L><S><V><R><R><V><Q><A><E><L><Q><H><C><W><A><L><Q><M><Q><R><K><H><L><K><S><N><Q><T><D><A><I><K><W><R><L><R><N><H><M><A><F><L><V><D><N><L><Q><Y><Y><L><Q><V><D><V><L><E><S><Q><F><S><Q><L><L><H><Q><I><N><S><T><R><D><F><E><S><I><R><L><A><H><D><H><F><L><S><N><L><L><A><Q><S><F><I><L><L><K><P><V><F><H><C><L><N><E><I><L><D><L><C><H><S><F><C><S><L><V><S><Q><N><L><G><P><L><D><E><R><G><A><A><Q><L><S><I><L><V><K><G><F><S><R><Q><S><S><L><L><F><K><I><L><S><S><V><R><N><H><Q><I><N><S><D><L><A><Q><L><L><L><R><L><D><Y><N><K><Y><Y><T><Q><A><G><G><T><L><G><S><F><G><M>
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Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.<BOP>
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Q9UGJ1
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Q969M3
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YIPF5_HUMAN
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YPT-interacting protein 1 A
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Homo
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<M><S><G><F><E><N><L><N><T><D><F><Y><Q><T><S><Y><S><I><D><D><Q><S><Q><Q><S><Y><D><Y><G><G><S><G><G><P><Y><S><K><Q><Y><A><G><Y><D><Y><S><Q><Q><G><R><F><V><P><P><D><M><M><Q><P><Q><Q><P><Y><T><G><Q><I><Y><Q><P><T><Q><A><Y><T><P><A><S><P><Q><P><F><Y><G><N><N><F><E><D><E><P><P><L><L><E><E><L><G><I><N><F><D><H><I><W><Q><K><T><L><T><V><L><H><P><L><K><V><A><D><G><S><I><M><N><E><T><D><L><A><G><P><M><V><F><C><L><A><F><G><A><T><L><L><L><A><G><K><I><Q><F><G><Y><V><Y><G><I><S><A><I><G><C><L><G><M><F><C><L><L><N><L><M><S><M><T><G><V><S><F><G><C><V><A><S><V><L><G><Y><C><L><L><P><M><I><L><L><S><S><F><A><V><I><F><S><L><Q><G><M><V><G><I><I><L><T><A><G><I><I><G><W><C><S><F><S><A><S><K><I><F><I><S><A><L><A><M><E><G><Q><Q><L><L><V><A><Y><P><C><A><L><L><Y><G><V><F><A><L><I><S><V><F>
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Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi .<BOP>
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Q969M3
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Q8WXH2
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JPH3_HUMAN
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Trinucleotide repeat-containing gene 22 protein
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Homo
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<M><S><S><G><G><R><F><N><F><D><D><G><G><S><Y><C><G><G><W><E><D><G><K><A><H><G><H><G><V><C><T><G><P><K><G><Q><G><E><Y><T><G><S><W><S><H><G><F><E><V><L><G><V><Y><T><W><P><S><G><N><T><Y><Q><G><T><W><A><Q><G><K><R><H><G><I><G><L><E><S><K><G><K><W><V><Y><K><G><E><W><T><H><G><F><K><G><R><Y><G><V><R><E><C><A><G><N><G><A><K><Y><E><G><T><W><S><N><G><L><Q><D><G><Y><G><T><E><T><Y><S><D><G><G><T><Y><Q><G><Q><W><V><G><G><M><R><Q><G><Y><G><V><R><Q><S><V><P><Y><G><M><A><A><V><I><R><S><P><L><R><T><S><I><N><S><L><R><S><E><H><T><N><G><T><A><L><H><P><D><A><S><P><A><V><A><G><S><P><A><V><S><R><G><G><F><V><L><V><A><H><S><D><S><E><I><L><K><S><K><K><K><G><L><F><R><R><S><L><L><S><G><L><K><L><R><K><S><E><S><K><S><S><L><A><S><Q><R><S><K><Q><S><S><F><R><S><E><A><G><M><S><T><V><S><S><T><A><S><D><I><H><S><T><I><S><L><G><E><A><E><A><E><L><A><V><I><E><D><D><I><D><A><T><T><T><E><T><Y><V><G><E><W><K><N><D><K><R><S><G><F><G><V><S><Q><R><S><D><G><L><K><Y><E><G><E><W><A><S><N><R><R><H><G><Y><G><C><M><T><F><P><D><G><T><K><E><E><G><K><Y><K><Q><N><I><L><V><G><G><K><R><K><N><L><I><P><L><R><A><S><K><I><R><E><K><V><D><R><A><V><E><A><A><E><R><A><A><T><I><A><K><Q><K><A><E><I><A><A><S><R><T><S><H><S><R><A><K><A><E><A><A><L><T><A><A><Q><K><A><Q><E><E><A><R><I><A><R><I><T><A><K><E><F><S><P><S><F><Q><H><R><E><N><G><L><E><Y><Q><R><P><K><R><Q><T><S><C><D><D><I><E><V><L><S><T><G><T><P><L><Q><Q><E><S><P><E><L><Y><R><K><G><T><T><P><S><D><L><T><P><D><D><S><P><L><Q><S><F><P><T><S><P><A><A><T><P><P><P><A><P><A><A><R><N><K><V><A><H><F><S><R><Q><V><S><V><D><E><E><R><G><G><D><I><Q><M><L><L><E><G><R><A><G><D><C><A><R><S><S><W><G><E><E><Q><A><G><G><S><R><G><V><R><S><G><A><L><R><G><G><L><L><V><D><D><F><R><T><R><G><S><G><R><K><Q><P><G><N><P><K><P><R><E><R><R><T><E><S><P><P><V><F><T><W><T><S><H><H><R><A><S><N><H><S><P><G><G><S><R><L><L><E><L><Q><E><E><K><L><S><N><Y><R><M><E><M><K><P><L><L><R><M><E><T><H><P><Q><K><R><R><Y><S><K><G><G><A><C><R><G><L><G><D><D><H><R><P><E><D><R><G><F><G><V><Q><R><L><R><S><K><A><Q><N><K><E><N><F><R><P><A><S><S><A><E><P><A><V><Q><K><L><A><S><L><R><L><G><G><A><E><P><R><L><L><R><W><D><L><T><F><S><P><P><Q><K><S><L><P><V><A><L><E><S><D><E><E><N><G><D><E><L><K><S><S><T><G><S><A><P><I><L><V><V><M><V><I><L><L><N><I><G><V><A><I><L><F><I><N><F><F><I>
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Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.<BOP>
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Q8WXH2
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Q6P9A3
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ZN549_HUMAN
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Zinc finger protein 549
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Homo
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<M><A><E><A><A><L><V><I><T><P><Q><I><P><M><V><T><E><E><F><V><K><P><S><Q><G><H><V><T><F><E><D><I><A><V><Y><F><S><Q><E><E><W><G><L><L><D><E><A><Q><R><C><L><Y><H><D><V><M><L><E><N><F><S><L><M><A><S><V><G><C><L><H><G><I><E><A><E><E><A><P><S><E><Q><T><L><S><A><Q><G><V><S><Q><A><R><T><P><K><L><G><P><S><I><P><N><A><H><S><C><E><M><C><I><L><V><M><K><D><I><L><Y><L><S><E><H><Q><G><T><L><P><W><Q><K><P><Y><T><S><V><A><S><G><K><W><F><S><F><G><S><N><L><Q><Q><H><Q><N><Q><D><S><G><E><K><H><I><R><K><E><E><S><S><A><L><L><L><N><S><C><K><I><P><L><S><D><N><L><F><P><C><K><D><V><E><K><D><F><P><T><I><L><G><L><L><Q><H><Q><T><T><H><S><R><Q><E><Y><A><H><R><S><R><E><T><F><Q><Q><R><R><Y><K><C><E><Q><V><F><N><E><K><V><H><V><T><E><H><Q><R><V><H><T><G><E><K><A><Y><K><R><R><E><Y><G><K><S><L><N><S><K><Y><L><F><V><E><H><Q><R><T><H><N><A><E><K><P><Y><V><C><N><I><C><G><K><S><F><L><H><K><Q><T><L><V><G><H><Q><Q><R><I><H><T><R><E><R><S><Y><V><C><I><E><C><G><K><S><L><S><S><K><Y><S><L><V><E><H><Q><R><T><H><N><G><E><K><P><Y><V><C><N><V><C><G><K><S><F><R><H><K><Q><T><F><V><G><H><Q><Q><R><I><H><T><G><E><R><P><Y><V><C><M><E><C><G><K><S><F><I><H><S><Y><D><R><I><R><H><Q><R><V><H><T><G><E><G><A><Y><Q><C><S><E><C><G><K><S><F><I><Y><K><Q><S><L><L><D><H><H><R><I><H><T><G><E><R><P><Y><E><C><K><E><C><G><K><A><F><I><H><K><K><R><L><L><E><H><Q><R><I><H><T><G><E><K><P><Y><V><C><I><I><C><G><K><S><F><I><R><S><S><D><Y><M><R><H><Q><R><I><H><T><G><E><R><A><Y><E><C><S><D><C><G><K><A><F><I><S><K><Q><T><L><L><K><H><H><K><I><H><T><R><E><R><P><Y><E><C><S><E><C><G><K><G><F><Y><L><E><V><K><L><L><Q><H><Q><R><I><H><T><R><E><Q><L><C><E><C><N><E><C><G><K><V><F><S><H><Q><K><R><L><L><E><H><Q><K><V><H><T><G><E><K><P><C><E><C><S><E><C><G><K><C><F><R><H><R><T><S><L><I><Q><H><Q><K><V><H><S><G><E><R><P><Y><N><C><T><A><C><E><K><A><F><I><Y><K><N><K><L><V><E><H><Q><R><I><H><T><G><E><K><P><Y><E><C><G><K><C><G><K><A><F><N><K><R><Y><S><L><V><R><H><Q><K><V><H><I><T><E><E><P>
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May be involved in transcriptional regulation.<BOP>
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Q6P9A3
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Q6ZN04
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MEX3B_HUMAN
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RING finger protein 195
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Homo
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<M><P><S><S><L><F><A><D><L><E><R><N><G><S><G><G><G><G><G><G><S><S><G><G><G><E><T><L><D><D><Q><R><A><L><Q><L><A><L><D><Q><L><S><L><L><G><L><D><S><D><E><G><A><S><L><Y><D><S><E><P><R><K><K><S><V><N><M><T><E><C><V><P><V><P><S><S><E><H><V><A><E><I><V><G><R><Q><G><C><K><I><K><A><L><R><A><K><T><N><T><Y><I><K><T><P><V><R><G><E><E><P><V><F><V><V><T><G><R><K><E><D><V><A><M><A><R><R><E><I><I><S><A><A><E><H><F><S><M><I><R><A><S><R><N><K><N><T><A><L><N><G><A><V><P><G><P><P><N><L><P><G><Q><T><T><I><Q><V><R><V><P><Y><R><V><V><G><L><V><V><G><P><K><G><A><T><I><K><R><I><Q><Q><Q><T><H><T><Y><I><V><T><P><S><R><D><K><E><P><V><F><E><V><T><G><M><P><E><N><V><D><R><A><R><E><E><I><E><A><H><I><A><L><R><T><G><G><I><I><E><L><T><D><E><N><D><F><H><A><N><G><T><D><V><G><F><D><L><H><H><G><S><G><G><S><G><P><G><S><L><W><S><K><P><T><P><S><I><T><P><T><P><G><R><K><P><F><S><S><Y><R><N><D><S><S><S><S><L><G><S><A><S><T><D><S><Y><F><G><G><G><T><S><S><S><A><A><A><T><Q><R><L><A><D><Y><S><P><P><S><P><A><L><S><F><A><H><N><G><N><N><N><N><N><G><N><G><Y><T><Y><T><A><G><G><E><A><S><V><P><S><P><D><G><C><P><E><L><Q><P><T><F><D><P><A><P><A><P><P><P><G><A><P><L><I><W><A><Q><F><E><R><S><P><G><G><G><P><A><A><P><V><S><S><S><C><S><S><S><A><S><S><S><A><S><S><S><S><V><V><F><P><G><G><G><A><S><A><P><S><N><A><N><L><G><L><L><V><H><R><R><L><H><P><G><T><S><C><P><R><L><S><P><P><L><H><M><A><P><G><A><G><E><H><H><L><A><R><R><V><R><S><D><P><G><G><G><G><L><A><Y><A><A><Y><A><N><G><L><G><A><Q><L><P><G><L><Q><P><S><D><T><S><G><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><G><L><R><R><K><G><S><R><D><C><S><V><C><F><E><S><E><V><I><A><A><L><V><P><C><G><H><N><L><F><C><M><E><C><A><N><R><I><C><E><K><S><E><P><E><C><P><V><C><H><T><A><V><T><Q><A><I><R><I><F><S>
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RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.<BOP>
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Q6ZN04
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Q9BUE6
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ISCA1_HUMAN
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Iron-sulfur assembly protein IscA
|
Homo
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<M><S><A><S><L><V><R><A><T><V><R><A><V><S><K><R><K><L><Q><P><T><R><A><A><L><T><L><T><P><S><A><V><N><K><I><K><Q><L><L><K><D><K><P><E><H><V><G><V><K><V><G><V><R><T><R><G><C><N><G><L><S><Y><T><L><E><Y><T><K><T><K><G><D><S><D><E><E><V><I><Q><D><G><V><R><V><F><I><E><K><K><A><Q><L><T><L><L><G><T><E><M><D><Y><V><E><D><K><L><S><S><E><F><V><F><N><N><P><N><I><K><G><T><C><G><C><G><E><S><F><N><I>
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Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.<BOP>
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Q9BUE6
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P01909
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DQA1_HUMAN
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MHC class II DQA1
|
Homo
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<M><I><L><N><K><A><L><M><L><G><A><L><A><L><T><T><V><M><S><P><C><G><G><E><D><I><V><A><D><H><V><A><S><Y><G><V><N><L><Y><Q><S><Y><G><P><S><G><Q><Y><T><H><E><F><D><G><D><E><Q><F><Y><V><D><L><G><R><K><E><T><V><W><C><L><P><V><L><R><Q><F><R><F><D><P><Q><F><A><L><T><N><I><A><V><L><K><H><N><L><N><S><L><I><K><R><S><N><S><T><A><A><T><N><E><V><P><E><V><T><V><F><S><K><S><P><V><T><L><G><Q><P><N><I><L><I><C><L><V><D><N><I><F><P><P><V><V><N><I><T><W><L><S><N><G><H><S><V><T><E><G><V><S><E><T><S><F><L><S><K><S><D><H><S><F><F><K><I><S><Y><L><T><L><L><P><S><A><E><E><S><Y><D><C><K><V><E><H><W><G><L><D><K><P><L><L><K><H><W><E><P><E><I><P><A><P><M><S><E><L><T><E><T><V><V><C><A><L><G><L><S><V><G><L><V><G><I><V><V><G><T><V><F><I><I><R><G><L><R><S><V><G><A><S><R><H><Q><G><P><L>
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Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To
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P01909
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Q96CQ1
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S2536_HUMAN
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Solute carrier family 25 member 36
|
Homo
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<M><S><Q><R><D><T><L><V><H><L><F><A><G><G><C><G><G><T><V><G><A><I><L><T><C><P><L><E><V><V><K><T><R><L><Q><S><S><S><V><T><L><Y><I><S><E><V><Q><L><N><T><M><A><G><A><S><V><N><R><V><V><S><P><G><P><L><H><C><L><K><V><I><L><E><K><E><G><P><R><S><L><F><R><G><L><G><P><N><L><V><G><V><A><P><S><R><A><I><Y><F><A><A><Y><S><N><C><K><E><K><L><N><D><V><F><D><P><D><S><T><Q><V><H><M><I><S><A><A><M><A><G><F><T><A><I><T><A><T><N><P><I><W><L><I><K><T><R><L><Q><L><D><A><R><N><R><G><E><R><R><M><G><A><F><E><C><V><R><K><V><Y><Q><T><D><G><L><K><G><F><Y><R><G><M><S><A><S><Y><A><G><I><S><E><T><V><I><H><F><V><I><Y><E><S><I><K><Q><K><L><L><E><Y><K><T><A><S><T><M><E><N><D><E><E><S><V><K><E><A><S><D><F><V><G><M><M><L><A><A><A><T><S><K><T><C><A><T><T><I><A><Y><P><H><E><V><V><R><T><R><L><R><E><E><G><T><K><Y><R><S><F><F><Q><T><L><S><L><L><V><Q><E><E><G><Y><G><S><L><Y><R><G><L><T><T><H><L><V><R><Q><I><P><N><T><A><I><M><M><A><T><Y><E><L><V><V><Y><L><L><N><G>
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Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.<BOP>
|
Q96CQ1
|
Q8N5H3
|
LRA25_HUMAN
|
Leucine repeat adapter protein 25
|
Homo
|
<M><N><G><L><P><S><A><E><A><P><G><G><A><G><C><A><L><A><G><L><P><P><L><P><R><G><L><S><G><L><L><N><A><S><G><G><S><W><R><E><L><E><R><V><Y><S><Q><R><S><R><I><H><D><E><L><S><R><A><A><R><A><P><D><G><P><R><H><A><A><G><A><A><N><A><G><P><A><A><G><P><R><R><P><V><N><L><D><S><A><L><A><A><L><R><K><E><M><V><G><L><R><Q><L><D><M><S><L><L><C><Q><L><W><G><L><Y><E><S><I><Q><D><Y><K><H><L><C><Q><D><L><S><F><C><Q><D><L><S><S><S><L><H><S><D><S><S><Y><P><P><D><A><G><L><S><D><D><E><E><P><P><D><A><S><L><P><P><D><P><P><P><L><T><V><P><Q><T><H><N><A><R><D><Q><W><L><Q><D><A><F><H><I><S><L>
|
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.<BOP>
|
Q8N5H3
|
Q6IN84
|
MRM1_HUMAN
|
16S rRNA [Gm1145] 2'-O-methyltransferase
|
Homo
|
<M><A><L><L><S><T><V><R><G><A><T><W><G><R><L><V><T><R><H><F><S><H><A><A><R><H><G><E><R><P><G><G><E><E><L><S><R><L><L><L><D><D><L><V><P><T><S><R><L><E><L><L><F><G><M><T><P><C><L><L><A><L><Q><A><A><R><R><S><V><A><R><L><L><L><Q><A><G><K><A><G><L><Q><G><K><R><A><E><L><L><R><M><A><E><A><R><D><I><P><V><L><R><P><R><R><Q><K><L><D><T><M><C><R><Y><Q><V><H><Q><G><V><C><M><E><V><S><P><L><R><P><R><P><W><R><E><A><G><E><A><S><P><G><D><D><P><Q><Q><L><W><L><V><L><D><G><I><Q><D><P><R><N><F><G><A><V><L><R><S><A><H><F><L><G><V><D><K><V><I><T><S><R><R><N><S><C><P><L><T><P><V><V><S><K><S><S><A><G><A><M><E><V><M><D><V><F><S><T><D><D><L><T><G><F><L><Q><T><K><A><Q><Q><G><W><L><V><A><G><T><V><G><C><P><S><T><E><D><P><Q><S><S><E><I><P><I><M><S><C><L><E><F><L><W><E><R><P><T><L><L><V><L><G><N><E><G><S><G><L><S><Q><E><V><Q><A><S><C><Q><L><L><L><T><I><L><P><R><R><Q><L><P><P><G><L><E><S><L><N><V><S><V><A><A><G><I><L><L><H><S><I><C><S><Q><R><K><G><F><P><T><E><G><E><R><R><Q><L><L><Q><D><P><Q><E><P><S><A><R><S><E><G><L><S><M><A><Q><H><P><G><L><S><S><G><P><E><K><E><R><Q><N><E><G>
|
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.<BOP>
|
Q6IN84
|
P01040
|
CYTA_HUMAN
|
Cystatin-A, N-terminally processed
|
Homo
|
<M><I><P><G><G><L><S><E><A><K><P><A><T><P><E><I><Q><E><I><V><D><K><V><K><P><Q><L><E><E><K><T><N><E><T><Y><G><K><L><E><A><V><Q><Y><K><T><Q><V><V><A><G><T><N><Y><Y><I><K><V><R><A><G><D><N><K><Y><M><H><L><K><V><F><K><S><L><P><G><Q><N><E><D><L><V><L><T><G><Y><Q><V><D><K><N><K><D><D><E><L><T><G><F>
|
This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.<BOP>
|
P01040
|
P35247
|
SFTPD_HUMAN
|
Lung surfactant protein D
|
Homo
|
<M><L><L><F><L><L><S><A><L><V><L><L><T><Q><P><L><G><Y><L><E><A><E><M><K><T><Y><S><H><R><T><M><P><S><A><C><T><L><V><M><C><S><S><V><E><S><G><L><P><G><R><D><G><R><D><G><R><E><G><P><R><G><E><K><G><D><P><G><L><P><G><A><A><G><Q><A><G><M><P><G><Q><A><G><P><V><G><P><K><G><D><N><G><S><V><G><E><P><G><P><K><G><D><T><G><P><S><G><P><P><G><P><P><G><V><P><G><P><A><G><R><E><G><P><L><G><K><Q><G><N><I><G><P><Q><G><K><P><G><P><K><G><E><A><G><P><K><G><E><V><G><A><P><G><M><Q><G><S><A><G><A><R><G><L><A><G><P><K><G><E><R><G><V><P><G><E><R><G><V><P><G><N><T><G><A><A><G><S><A><G><A><M><G><P><Q><G><S><P><G><A><R><G><P><P><G><L><K><G><D><K><G><I><P><G><D><K><G><A><K><G><E><S><G><L><P><D><V><A><S><L><R><Q><Q><V><E><A><L><Q><G><Q><V><Q><H><L><Q><A><A><F><S><Q><Y><K><K><V><E><L><F><P><N><G><Q><S><V><G><E><K><I><F><K><T><A><G><F><V><K><P><F><T><E><A><Q><L><L><C><T><Q><A><G><G><Q><L><A><S><P><R><S><A><A><E><N><A><A><L><Q><Q><L><V><V><A><K><N><E><A><A><F><L><S><M><T><D><S><K><T><E><G><K><F><T><Y><P><T><G><E><S><L><V><Y><S><N><W><A><P><G><E><P><N><D><D><G><G><S><E><D><C><V><E><I><F><T><N><G><K><W><N><D><R><A><C><G><E><K><R><L><V><V><C><E><F>
|
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.<BOP>
|
P35247
|
A6NKD2
|
TSPY2_HUMAN
|
Testis-specific Y-encoded protein Q1
|
Homo
|
<M><R><P><E><G><S><L><T><Y><R><V><P><E><R><L><R><Q><G><S><C><G><V><G><R><A><A><Q><A><L><V><C><A><S><A><K><E><G><T><A><F><R><M><E><A><V><Q><E><G><A><A><G><V><E><S><E><Q><A><A><L><G><E><E><A><V><L><L><L><D><D><I><M><A><E><V><E><V><V><A><E><E><E><G><L><V><E><R><R><E><E><A><Q><R><A><Q><Q><A><V><P><G><P><G><P><M><T><P><E><S><A><L><E><E><L><L><A><V><Q><V><E><L><E><P><V><N><A><Q><A><R><K><A><F><S><R><Q><R><E><K><M><E><R><R><R><K><P><H><L><D><R><R><G><A><V><I><Q><S><V><P><G><F><W><A><N><V><I><A><N><H><P><Q><M><S><A><L><I><T><D><E><D><E><D><M><L><S><Y><M><V><S><L><E><V><E><E><E><K><H><R><V><H><L><C><K><I><M><L><F><F><R><S><N><P><Y><F><Q><N><K><V><I><T><K><E><Y><L><V><N><I><T><E><Y><R><A><S><H><S><T><P><I><E><W><Y><P><D><Y><E><V><E><A><Y><R><R><R><H><H><N><S><S><L><N><F><F><N><W><F><S><D><H><N><F><A><G><S><N><K><I><A><E><I><L><C><K><D><L><W><R><N><P><L><Q><Y><Y><K><R><M><K><P><P><E><E><G><T><E><T><S><G><D><S><Q><L><L><S>
|
May be involved in sperm differentiation and proliferation.<BOP>
|
A6NKD2
|
Q8IUI8
|
CRLF3_HUMAN
|
Type I cytokine receptor-like factor p48
|
Homo
|
<M><R><G><A><M><E><L><E><P><E><L><L><L><Q><E><A><R><E><N><V><E><A><A><Q><S><Y><R><R><E><L><G><H><R><L><E><G><L><R><E><A><R><R><Q><I><K><E><S><A><S><Q><T><R><D><V><L><K><Q><H><F><N><D><L><K><G><T><L><G><K><L><L><D><E><R><L><V><T><L><L><Q><E><V><D><T><I><E><Q><E><T><I><K><P><L><D><D><C><Q><K><L><I><E><H><G><V><N><T><A><E><D><L><V><R><E><G><E><I><A><M><L><G><G><V><G><E><E><N><E><K><L><W><S><F><T><K><K><A><S><H><I><Q><L><D><S><L><P><E><V><P><L><L><V><D><V><P><C><L><S><A><Q><L><D><D><S><I><L><N><I><V><K><D><H><I><F><K><H><G><T><V><A><S><R><P><P><V><Q><I><E><E><L><I><E><K><P><G><G><I><I><V><R><W><C><K><V><D><D><D><F><T><A><Q><D><Y><R><L><Q><F><R><K><C><T><S><N><H><F><E><D><V><Y><V><G><S><E><T><E><F><I><V><L><H><I><D><P><N><V><D><Y><Q><F><R><V><C><A><R><G><D><G><R><Q><E><W><S><P><W><S><V><P><Q><I><G><H><S><T><L><V><P><H><E><W><T><A><G><F><E><G><Y><S><L><S><S><R><R><N><I><A><L><R><N><D><S><E><S><S><G><V><L><Y><S><R><A><P><T><Y><F><C><G><Q><T><L><T><F><R><V><E><T><V><G><Q><P><D><R><R><D><S><I><G><V><C><A><E><K><Q><D><G><Y><D><S><L><Q><R><D><Q><A><V><C><I><S><T><N><G><A><V><F><V><N><G><K><E><M><T><N><Q><L><P><A><V><T><S><G><S><T><V><T><F><D><I><E><A><V><T><L><G><T><T><S><N><N><E><G><G><H><F><K><L><R><V><T><I><S><S><N><N><R><E><V><V><F><D><W><L><L><D><Q><S><C><G><S><L><Y><F><G><C><S><F><F><Y><P><G><W><K><V><L><V><F>
|
May play a role in the negative regulation of cell cycle progression.<BOP>
|
Q8IUI8
|
Q9NPA2
|
MMP25_HUMAN
|
Membrane-type-6 matrix metalloproteinase
|
Homo
|
<M><R><L><R><L><R><L><L><A><L><L><L><L><L><L><A><P><P><A><R><A><P><K><P><S><A><Q><D><V><S><L><G><V><D><W><L><T><R><Y><G><Y><L><P><P><P><H><P><A><Q><A><Q><L><Q><S><P><E><K><L><R><D><A><I><K><V><M><Q><R><F><A><G><L><P><E><T><G><R><M><D><P><G><T><V><A><T><M><R><K><P><R><C><S><L><P><D><V><L><G><V><A><G><L><V><R><R><R><R><R><Y><A><L><S><G><S><V><W><K><K><R><T><L><T><W><R><V><R><S><F><P><Q><S><S><Q><L><S><Q><E><T><V><R><V><L><M><S><Y><A><L><M><A><W><G><M><E><S><G><L><T><F><H><E><V><D><S><P><Q><G><Q><E><P><D><I><L><I><D><F><A><R><A><F><H><Q><D><S><Y><P><F><D><G><L><G><G><T><L><A><H><A><F><F><P><G><E><H><P><I><S><G><D><T><H><F><D><D><E><E><T><W><T><F><G><S><K><D><G><E><G><T><D><L><F><A><V><A><V><H><E><F><G><H><A><L><G><L><G><H><S><S><A><P><N><S><I><M><R><P><F><Y><Q><G><P><V><G><D><P><D><K><Y><R><L><S><Q><D><D><R><D><G><L><Q><Q><L><Y><G><K><A><P><Q><T><P><Y><D><K><P><T><R><K><P><L><A><P><P><P><Q><P><P><A><S><P><T><H><S><P><S><F><P><I><P><D><R><C><E><G><N><F><D><A><I><A><N><I><R><G><E><T><F><F><F><K><G><P><W><F><W><R><L><Q><P><S><G><Q><L><V><S><P><R><P><A><R><L><H><R><F><W><E><G><L><P><A><Q><V><R><V><V><Q><A><A><Y><A><R><H><R><D><G><R><I><L><L><F><S><G><P><Q><F><W><V><F><Q><D><R><Q><L><E><G><G><A><R><P><L><T><E><L><G><L><P><P><G><E><E><V><D><A><V><F><S><W><P><Q><N><G><K><T><Y><L><V><R><G><R><Q><Y><W><R><Y><D><E><A><A><A><R><P><D><P><G><Y><P><R><D><L><S><L><W><E><G><A><P><P><S><P><D><D><V><T><V><S><N><A><G><D><T><Y><F><F><K><G><A><H><Y><W><R><F><P><K><N><S><I><K><T><E><P><D><A><P><Q><P><M><G><P><N><W><L><D><C><P><A><P><S><S><G><P><R><A><P><R><P><P><K><A><T><P><V><S><E><T><C><D><C><Q><C><E><L><N><Q><A><A><G><R><W><P><A><P><I><P><L><L><L><L><P><L><L><V><G><G><V><A><S><R>
|
May activate progelatinase A.<BOP>
|
Q9NPA2
|
Q8WVD5
|
RN141_HUMAN
|
Zinc finger protein 230
|
Homo
|
<M><G><Q><Q><I><S><D><Q><T><Q><L><V><I><N><K><L><P><E><K><V><A><K><H><V><T><L><V><R><E><S><G><S><L><T><Y><E><E><F><L><G><R><V><A><E><L><N><D><V><T><A><K><V><A><S><G><Q><E><K><H><L><L><F><E><V><Q><P><G><S><D><S><S><A><F><W><K><V><V><V><R><V><V><C><T><K><I><N><K><S><S><G><I><V><E><A><S><R><I><M><N><L><Y><Q><F><I><Q><L><Y><K><D><I><T><S><Q><A><A><G><V><L><A><Q><S><S><T><S><E><E><P><D><E><N><S><S><S><V><T><S><C><Q><A><S><L><W><M><G><R><V><K><Q><L><T><D><E><E><E><C><C><I><C><M><D><G><R><A><D><L><I><L><P><C><A><H><S><F><C><Q><K><C><I><D><K><W><S><D><R><H><R><N><C><P><I><C><R><L><Q><M><T><G><A><N><E><S><W><V><V><S><D><A><P><T><E><D><D><M><A><N><Y><I><L><N><M><A><D><E><A><G><Q><P><H><R><P>
|
May be involved in spermatogenesis.<BOP>
|
Q8WVD5
|
Q92837
|
FRAT1_HUMAN
|
Frequently rearranged in advanced T-cell lymphomas 1
|
Homo
|
<M><P><C><R><R><E><E><E><E><E><A><G><E><E><A><E><G><E><E><E><E><E><D><S><F><L><L><L><Q><Q><S><V><A><L><G><S><S><G><E><V><D><R><L><V><A><Q><I><G><E><T><L><Q><L><D><A><A><Q><H><S><P><A><S><P><C><G><P><P><G><A><P><L><R><A><P><G><P><L><A><A><A><V><P><A><D><K><A><R><S><P><A><V><P><L><L><L><P><P><A><L><A><E><T><V><G><P><A><P><P><G><V><L><R><C><A><L><G><D><R><G><R><V><R><G><R><A><A><P><Y><C><V><A><E><L><A><T><G><P><S><A><L><S><P><L><P><P><Q><A><D><L><D><G><P><P><G><A><G><K><Q><G><I><P><Q><P><L><S><G><P><C><R><R><G><W><L><R><G><A><A><A><S><R><R><L><Q><Q><R><R><G><S><Q><P><E><T><R><T><G><D><D><D><P><H><R><L><L><Q><Q><L><V><L><S><G><N><L><I><K><E><A><V><R><R><L><H><S><R><R><L><Q><L><R><A><K><L><P><Q><R><P><L><L><G><P><L><S><A><P><V><H><E><P><P><S><P><R><S><P><R><A><A><C><S><D><P><G><A><S><G><R><A><Q><L><R><T><G><D><G><V><L><V><P><G><S>
|
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.<BOP>
|
Q92837
|
Q9C0F3
|
ZN436_HUMAN
|
Zinc finger protein 436
|
Homo
|
<M><A><A><T><L><L><M><A><G><S><Q><A><P><V><T><F><E><D><M><A><M><Y><L><T><R><E><E><W><R><P><L><D><A><A><Q><R><D><L><Y><R><D><V><M><Q><E><N><Y><G><N><V><V><S><L><D><F><E><I><R><S><E><N><E><V><N><P><K><Q><E><I><S><E><D><V><Q><F><G><T><T><S><E><R><P><A><E><N><A><E><E><N><P><E><S><E><E><G><F><E><S><G><D><R><S><E><R><Q><W><G><D><L><T><A><E><E><W><V><S><Y><P><L><Q><P><V><T><D><L><L><V><H><K><E><V><H><T><G><I><R><Y><H><I><C><S><H><C><G><K><A><F><S><Q><I><S><D><L><N><R><H><Q><K><T><H><T><G><D><R><P><Y><K><C><Y><E><C><G><K><G><F><S><R><S><S><H><L><I><Q><H><Q><R><T><H><T><G><E><R><P><Y><D><C><N><E><C><G><K><S><F><G><R><S><S><H><L><I><Q><H><Q><T><I><H><T><G><E><K><P><H><K><C><N><E><C><G><K><S><F><C><R><L><S><H><L><I><Q><H><Q><R><T><H><S><G><E><K><P><Y><E><C><E><E><C><G><K><S><F><S><R><S><S><H><L><A><Q><H><Q><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><R><G><F><S><E><R><S><D><L><I><K><H><Y><R><V><H><T><G><E><R><P><Y><K><C><D><E><C><G><K><N><F><S><Q><N><S><D><L><V><R><H><R><R><A><H><T><G><E><K><P><Y><H><C><N><E><C><G><E><N><F><S><R><I><S><H><L><V><Q><H><Q><R><T><H><T><G><E><K><P><Y><E><C><N><A><C><G><K><S><F><S><R><S><S><H><L><I><T><H><Q><K><I><H><T><G><E><K><P><Y><E><C><N><E><C><W><R><S><F><G><E><R><S><D><L><I><K><H><Q><R><T><H><T><G><E><K><P><Y><E><C><V><Q><C><G><K><G><F><T><Q><S><S><N><L><I><T><H><Q><R><V><H><T><G><E><K><P><Y><E><C><T><E><C><E><K><S><F><S><R><S><S><A><L><I><K><H><K><R><V><H><T><D>
|
May be a transcriptional repressor.<BOP>
|
Q9C0F3
|
P04211
|
LV743_HUMAN
|
Ig lambda chain V region 4A
|
Homo
|
<M><A><W><T><P><L><F><L><F><L><L><T><C><C><P><G><S><N><S><Q><T><V><V><T><Q><E><P><S><L><T><V><S><P><G><G><T><V><T><L><T><C><A><S><S><T><G><A><V><T><S><G><Y><Y><P><N><W><F><Q><Q><K><P><G><Q><A><P><R><A><L><I><Y><S><T><S><N><K><H><S><W><T><P><A><R><F><S><G><S><L><L><G><G><K><A><A><L><T><L><S><G><V><Q><P><E><D><E><A><E><Y><Y><C><L><L><Y><Y><G><G><A><Q>
|
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
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P04211
|
A6NMU1
|
O52A4_HUMAN
|
Olfactory receptor 52A4
|
Homo
|
<M><A><L><P><I><T><N><G><T><L><F><M><P><F><V><L><T><F><I><G><I><P><G><F><E><S><V><Q><C><W><I><G><I><P><F><C><A><T><Y><V><I><A><L><I><G><N><S><L><L><L><I><I><I><K><S><E><P><S><L><H><E><P><M><Y><I><F><L><A><T><L><G><A><T><D><I><S><L><S><T><S><I><V><P><K><M><L><D><I><F><W><F><H><L><P><E><I><Y><F><D><A><C><L><F><Q><M><W><L><I><H><T><F><Q><G><I><E><S><G><V><L><L><A><M><A><L><D><R><C><V><A><I><C><Y><P><L><R><R><A><I><V><F><T><R><Q><L><V><T><Y><I><V><V><G><V><T><L><R><P><A><I><L><V><I><P><C><L><L><L><I><K><C><H><L><K><L><Y><R><T><K><L><I><Y><H><T><Y><C><E><R><V><A><L><V><K><L><A><T><E><D><V><Y><I><N><K><V><Y><G><I><L><G><A><F><I><V><G><G><L><D><F><I><F><I><T><L><S><Y><I><Q><I><F><I><T><V><F><H><L><P><L><K><E><A><R><L><K><V><F><N><T><C><I><P><H><I><Y><V><F><F><Q><F><Y><L><L><A><F><F><F><I><F><Y><S><Q><I><W><I><L><Y><P><I><I><C><T><Y><H><L><V><Q><S><L><P><T><G><P><T><I><P><Q><P><L><Y><L><W><V><K><D><Q><T><H>
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Odorant receptor.<BOP>
|
A6NMU1
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Q9NX74
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DUS2L_HUMAN
|
tRNA-dihydrouridine synthase 2-like
|
Homo
|
<M><I><L><N><S><L><S><L><C><Y><H><N><K><L><I><L><A><P><M><V><R><V><G><T><L><P><M><R><L><L><A><L><D><Y><G><A><D><I><V><Y><C><E><E><L><I><D><L><K><M><I><Q><C><K><R><V><V><N><E><V><L><S><T><V><D><F><V><A><P><D><D><R><V><V><F><R><T><C><E><R><E><Q><N><R><V><V><F><Q><M><G><T><S><D><A><E><R><A><L><A><V><A><R><L><V><E><N><D><V><A><G><I><D><V><N><M><G><C><P><K><Q><Y><S><T><K><G><G><M><G><A><A><L><L><S><D><P><D><K><I><E><K><I><L><S><T><L><V><K><G><T><R><R><P><V><T><C><K><I><R><I><L><P><S><L><E><D><T><L><S><L><V><K><R><I><E><R><T><G><I><A><A><I><A><V><H><G><R><K><R><E><E><R><P><Q><H><P><V><S><C><E><V><I><K><A><I><A><D><T><L><S><I><P><V><I><A><N><G><G><S><H><D><H><I><Q><Q><Y><S><D><I><E><D><F><R><Q><A><T><A><A><S><S><V><M><V><A><R><A><A><M><W><N><P><S><I><F><L><K><E><G><L><R><P><L><E><E><V><M><Q><K><Y><I><R><Y><A><V><Q><Y><D><N><H><Y><T><N><T><K><Y><C><L><C><Q><M><L><R><E><Q><L><E><S><P><Q><G><R><L><L><H><A><A><Q><S><S><R><E><I><C><E><A><F><G><L><G><A><F><Y><E><E><T><T><Q><E><L><D><A><Q><Q><A><R><L><S><A><K><T><S><E><Q><T><G><E><P><A><E><D><T><S><G><V><I><K><M><A><V><K><F><D><R><R><A><Y><P><A><Q><I><T><P><K><M><C><L><L><E><W><C><R><R><E><K><L><A><Q><P><V><Y><E><T><V><Q><R><P><L><D><R><L><F><S><S><I><V><T><V><A><E><Q><K><Y><Q><S><T><L><W><D><K><S><K><K><L><A><E><Q><A><A><A><I><V><C><L><R><S><Q><G><L><P><E><G><R><L><G><E><E><S><P><S><L><H><K><R><K><R><E><A><P><D><Q><D><P><G><G><P><R><A><Q><E><L><A><Q><P><G><D><L><C><K><K><P><F><V><A><L><G><S><G><E><E><S><P><L><E><G><W>
|
Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs . Negatively regulates the activation of EIF2AK2/PKR .<BOP>
|
Q9NX74
|
Q96N28
|
PLD3A_HUMAN
|
Protein slowmo homolog 1
|
Homo
|
<M><K><I><W><S><S><E><H><V><F><G><H><P><W><D><T><V><I><Q><A><A><M><R><K><Y><P><N><P><M><N><P><S><V><L><G><V><D><V><L><Q><R><R><V><D><G><R><G><R><L><H><S><L><R><L><L><S><T><E><W><G><L><P><S><L><V><R><A><I><L><G><T><S><R><T><L><T><Y><I><R><E><H><S><V><V><D><P><V><E><K><K><M><E><L><C><S><T><N><I><T><L><T><N><L><V><S><V><N><E><R><L><V><Y><T><P><H><P><E><N><P><E><M><T><V><L><T><Q><E><A><I><I><T><V><K><G><I><S><L><G><S><Y><L><E><S><L><M><A><N><T><I><S><S><N><A><K><K><G><W><A><A><I><E><W><I><I><E><H><S><E><S><A><V><S>
|
In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.<BOP>
|
Q96N28
|
Q8IYT1
|
GAR4_HUMAN
|
Golgi-associated Rab2B interactor-like 4
|
Homo
|
<M><N><A><D><F><L><L><P><Y><Y><T><A><Q><S><G><S><S><M><S><M><F><N><T><T><M><G><K><L><Q><R><Q><L><Y><K><G><E><Y><D><I><F><K><Y><A><P><I><F><E><S><D><F><I><Q><I><T><K><R><G><E><V><I><D><V><H><N><R><V><R><M><V><T><M><G><I><A><R><T><S><P><I><L><P><L><P><D><V><M><L><L><A><R><P><A><T><G><C><E><E><Y><A><G><H><G><Q><A><T><K><R><K><K><R><K><A><A><K><N><L><E><L><T><R><L><L><P><L><R><F><V><R><I><S><V><Q><D><H><E><K><Q><Q><L><R><L><K><F><A><T><G><R><S><C><Y><L><Q><L><C><P><A><L><D><T><R><D><D><L><F><A><Y><W><E><K><L><I><Y><L><L><R><P><P><M><E><S><N><S><S><T><C><G><I><P><A><E><D><M><M><W><M><P><V><F><Q><E><D><R><R><S><L><G><A><V><N><L><Q><G><K><G><D><Q><D><Q><V><S><I><Q><S><L><H><M><V><S><E><V><C><G><A><T><S><A><A><Y><A><G><G><E><G><L><Q><N><D><F><N><K><P><T><N><V><L><N><A><S><I><P><K><T><S><T><E><L><A><E><E><P><A><T><G><G><I><K><E><A><A><A><A><G><A><A><A><G><A><A><T><G><T><V><A><G><A><L><S><V><A><A><A><N><S><A><P><G><Q><V><S><A><A><I><A><G><A><A><T><I><G><A><G><G><N><K><G><N><M><A><L><A><G><T><A><S><M><A><P><N><S><T><K><V><A><V><A><G><A><A><G><K><S><S><E><H><V><S><S><A><S><M><S><L><S><R><E><G><S><V><S><L><A><I><A><G><V><V><L><T><S><R><T><A><A><E><A><D><M><D><A><A><A><G><P><P><V><S><T><R><Q><S><K><S><S><L><S><G><Q><H><G><R><E><R><T><Q><A><S><A><E><G><C><K><E><G><R><E><R><R><E><K><D><R><A><L><G><R><S><S><H><R><R><R><T><G><E><S><R><H><K><T><R><G><D><K><I><A><Q><K><S><S><S><R><S><S><F><S><H><R><A><N><R><D><D><K><K><E><K><G><C><G><N><P><G><S><S><R><H><R><D><S><H><K><G><V><S><H><T><P><I><S><K><E><S><R><T><S><H><K><S><G><R><S><L><W><T><T><S><S><G><S><S><K><G><L><G><R><V><S><S><F><L><R><N><V><R><A><N><L><T><T><K><V><V><G><T><P><H><G><R><D><V><N><V><M><A><K><M><A><E><R><S><T><N><V><A><I><A><E><T><A><E><G><G><Q><G><L><E><T><V><G><S><M><T><P><D><I><M><E><T><V><T><F><E><A><H>
|
RAB2B effector protein required for the compacted Golgi morphology, probably through interaction with small GTPase RAB2B.<BOP>
|
Q8IYT1
|
Q9BT25
|
HAUS8_HUMAN
|
Sarcoma antigen NY-SAR-48
|
Homo
|
<M><A><D><S><S><G><R><G><A><G><K><P><A><T><G><P><T><N><S><S><S><A><K><K><K><D><K><R><V><Q><G><G><R><V><I><E><S><R><Y><L><Q><Y><E><K><K><T><T><Q><K><A><P><A><G><D><G><S><Q><T><R><G><K><M><S><E><G><G><R><K><S><S><L><L><Q><K><S><K><A><D><S><S><G><V><G><K><G><D><L><Q><S><T><L><L><E><G><H><G><T><A><P><P><D><L><D><L><S><A><I><N><D><K><S><I><V><K><K><T><P><Q><L><A><K><T><I><S><K><K><P><E><S><T><S><F><S><A><P><R><K><K><S><P><D><L><S><E><A><M><E><M><M><E><S><Q><T><L><L><L><T><L><L><S><V><K><M><E><N><N><L><A><E><F><E><R><R><A><E><K><N><L><L><I><M><C><K><E><K><E><K><L><Q><K><K><A><H><E><L><K><R><R><L><L><L><S><Q><R><K><R><E><L><A><D><V><L><D><A><Q><I><E><M><L><S><P><F><E><A><V><A><T><R><F><K><E><Q><Y><R><T><F><A><T><A><L><D><T><T><R><H><E><L><P><V><R><S><I><H><L><E><G><D><G><Q><Q><L><L><D><A><L><Q><H><E><L><V><T><T><Q><R><L><L><G><E><L><D><V><G><D><S><E><E><N><V><Q><V><L><D><L><L><S><E><L><K><D><V><T><A><K><K><D><L><E><L><R><R><S><F><A><Q><V><L><E><L><S><A><E><A><S><K><E><A><A><L><A><N><Q><E><V><W><E><E><T><Q><G><M><A><P><P><S><R><W><Y><F><N><Q><D><S><A><C><R><E><S><G><G><A><P><K><N><T><P><L><S><E><D><D><N><P><G><A><S><S><A><P><A><Q><A><T><F><I><S><P><S><E><D><F><S><S><S><S><Q><A><E><V><P><P><S><L><S><R><S><G><R><D><L><S>
|
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.<BOP>
|
Q9BT25
|
A6NMB1
|
SIG16_HUMAN
|
Siglec-P16
|
Homo
|
<M><L><L><L><P><L><L><L><P><V><L><G><A><G><S><L><N><K><D><P><S><Y><S><L><Q><V><Q><R><Q><V><P><V><P><E><G><L><C><V><I><V><S><C><N><L><S><Y><P><R><D><G><W><D><E><S><T><A><A><Y><G><Y><W><F><K><G><R><T><S><P><K><T><G><A><P><V><A><T><N><N><Q><S><R><E><V><A><M><S><T><R><D><R><F><Q><L><T><G><D><P><G><K><G><S><C><S><L><V><I><R><D><A><Q><R><E><D><E><A><W><Y><F><F><R><V><E><R><G><S><R><V><R><H><S><F><L><S><N><A><F><F><L><K><V><T><A><L><T><Q><K><P><D><V><Y><I><P><E><T><L><E><P><G><Q><P><V><T><V><I><C><V><F><N><W><A><F><K><K><C><P><A><P><S><F><S><W><T><G><A><A><L><S><P><R><R><T><R><P><S><T><S><H><F><S><V><L><S><F><T><P><S><P><Q><D><H><D><T><D><L><T><C><H><V><D><F><S><R><K><G><V><S><A><Q><R><T><V><R><L><R><V><A><S><L><E><L><Q><G><N><V><I><Y><L><E><V><Q><K><G><Q><F><L><R><L><L><C><A><A><D><S><Q><P><P><A><T><L><S><W><V><L><Q><D><R><V><L><S><S><S><H><P><W><G><P><R><T><L><G><L><E><L><P><G><V><K><A><G><D><S><G><R><Y><T><C><R><A><E><N><R><L><G><S><Q><Q><R><A><L><D><L><S><V><Q><Y><P><P><E><N><L><R><V><M><V><S><Q><A><N><R><T><V><L><E><N><L><R><N><G><T><S><L><R><V><L><E><G><Q><S><L><R><L><V><C><V><T><H><S><S><P><P><A><R><L><S><W><T><W><G><E><Q><T><V><G><P><S><Q><P><S><D><P><G><V><L><Q><L><P><R><V><Q><M><E><H><E><G><E><F><T><C><H><A><R><H><P><L><G><S><Q><R><V><S><L><S><F><S><V><H><C><K><S><G><P><M><T><G><V><V><L><V><A><V><G><E><V><A><M><K><I><L><L><L><C><L><C><L><I><L><L><R><V><R><S><C><R><R><K><A><A><R><A><A><L><G><M><E><A><A><D><A><V><T><D>
|
Putative adhesion molecule that mediates sialic-acid dependent binding to cells.<BOP>
|
A6NMB1
|
Q8NG76
|
O2T33_HUMAN
|
Olfactory receptor OR1-56
|
Homo
|
<M><E><M><R><N><T><T><P><D><F><I><L><L><G><L><F><N><H><T><R><A><H><Q><V><L><F><M><M><V><L><S><I><V><L><T><S><L><F><G><N><S><L><M><I><L><L><I><H><W><D><H><R><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><M><D><M><M><L><V><S><T><T><V><P><K><M><A><A><D><Y><L><T><G><S><K><A><I><S><R><A><G><C><G><V><Q><I><F><F><L><P><T><L><G><G><G><E><C><F><L><L><A><A><M><A><Y><D><R><Y><A><A><V><C><H><P><L><R><Y><P><T><L><M><S><W><Q><L><C><L><R><M><T><M><S><C><W><L><L><G><A><A><D><G><L><L><Q><A><V><V><T><L><S><F><P><Y><C><G><A><H><E><I><D><H><F><F><C><E><T><P><V><L><V><R><L><A><C><A><D><T><S><V><F><E><N><A><M><Y><I><C><C><V><L><M><L><L><V><P><F><S><L><I><L><S><S><Y><G><L><I><L><A><A><V><L><H><M><R><S><T><E><A><R><K><K><A><F><A><T><C><S><S><H><V><A><V><V><G><L><F><Y><G><A><A><I><F><T><Y><M><R><P><K><S><H><R><S><T><N><H><D><K><V><V><S><A><F><Y><T><M><F><T><P><L><L><N><P><L><I><Y><S><V><K><N><S><E><V><K><G><A><L><K><R><W><L><G><T><C><V><N><I><K><H><Q><Q><N><E><A><H><R><S><R>
|
Odorant receptor.<BOP>
|
Q8NG76
|
O75154
|
RFIP3_HUMAN
|
MU-MB-17.148
|
Homo
|
<M><A><S><A><P><P><A><S><P><P><G><S><E><P><P><G><P><D><P><E><P><G><G><P><D><G><P><G><A><A><Q><L><A><P><G><P><A><E><L><R><L><G><A><P><V><G><G><P><D><P><Q><S><P><G><L><D><E><P><A><P><G><A><A><A><D><G><G><A><R><W><S><A><G><P><A><P><G><L><E><G><G><P><R><D><P><G><P><S><A><P><P><P><R><S><G><P><R><G><Q><L><A><S><P><D><A><P><G><P><G><P><R><S><E><A><P><L><P><E><L><D><P><L><F><S><W><T><E><E><P><E><E><C><G><P><A><S><C><P><E><S><A><P><F><R><L><Q><G><S><S><S><S><H><R><A><R><G><E><V><D><V><F><S><P><F><P><A><P><T><A><G><E><L><A><L><E><Q><G><P><G><S><P><P><Q><P><S><D><L><S><Q><T><H><P><L><P><S><E><P><V><G><S><Q><E><D><G><P><R><L><R><A><V><F><D><A><L><D><G><D><G><D><G><F><V><R><I><E><D><F><I><Q><F><A><T><V><Y><G><A><E><Q><V><K><D><L><T><K><Y><L><D><P><S><G><L><G><V><I><S><F><E><D><F><Y><Q><G><I><T><A><I><R><N><G><D><P><D><G><Q><C><Y><G><G><V><A><S><A><Q><D><E><E><P><L><A><C><P><D><E><F><D><D><F><V><T><Y><E><A><N><E><V><T><D><S><A><Y><M><G><S><E><S><T><Y><S><E><C><E><T><F><T><D><E><D><T><S><T><L><V><H><P><E><L><Q><P><E><G><D><A><D><S><A><G><G><S><A><V><P><S><E><C><L><D><A><M><E><E><P><D><H><G><A><L><L><L><L><P><G><R><P><H><P><H><G><Q><S><V><I><T><V><I><G><G><E><E><H><F><E><D><Y><G><E><G><S><E><A><E><L><S><P><E><T><L><C><N><G><Q><L><G><C><S><D><P><A><F><L><T><P><S><P><T><K><R><L><S><S><K><K><V><A><R><Y><L><H><Q><S><G><A><L><T><M><E><A><L><E><D><P><S><P><E><L><M><E><G><P><E><E><D><I><A><D><K><V><V><F><L><E><R><R><V><L><E><L><E><K><D><T><A><A><T><G><E><Q><H><S><R><L><R><Q><E><N><L><Q><L><V><H><R><A><N><A><L><E><E><Q><L><K><E><Q><E><L><R><A><C><E><M><V><L><E><E><T><R><R><Q><K><E><L><L><C><K><M><E><R><E><K><S><I><E><I><E><N><L><Q><T><R><L><Q><Q><L><D><E><E><N><S><E><L><R><S><C><T><P><C><L><K><A><N><I><E><R><L><E><E><E><K><Q><K><L><L><D><E><I><E><S><L><T><L><R><L><S><E><E><Q><E><N><K><R><R><M><G><D><R><L><S><H><E><R><H><Q><F><Q><R><D><K><E><A><T><Q><E><L><I><E><D><L><R><K><Q><L><E><H><L><Q><L><L><K><L><E><A><E><Q><R><R><G><R><S><S><S><M><G><L><Q><E><Y><H><S><R><A><R><E><S><E><L><E><Q><E><V><R><R><L><K><Q><D><N><R><N><L><K><E><Q><N><E><E><L><N><G><Q><I><I><T><L><S><I><Q><G><A><K><S><L><F><S><T><A><F><S><E><S><L><A><A><E><I><S><S><V><S><R><D><E><L><M><E><A><I><Q><K><Q><E><E><I><N><F><R><L><Q><D><Y><I><D><R><I><I><V><A><I><M><E><T><N><P><S><I><L><E><V><K>
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Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) .<BOP>
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O75154
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P51685
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CCR8_HUMAN
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TER1
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Homo
|
<M><D><Y><T><L><D><L><S><V><T><T><V><T><D><Y><Y><Y><P><D><I><F><S><S><P><C><D><A><E><L><I><Q><T><N><G><K><L><L><L><A><V><F><Y><C><L><L><F><V><F><S><L><L><G><N><S><L><V><I><L><V><L><V><V><C><K><K><L><R><S><I><T><D><V><Y><L><L><N><L><A><L><S><D><L><L><F><V><F><S><F><P><F><Q><T><Y><Y><L><L><D><Q><W><V><F><G><T><V><M><C><K><V><V><S><G><F><Y><Y><I><G><F><Y><S><S><M><F><F><I><T><L><M><S><V><D><R><Y><L><A><V><V><H><A><V><Y><A><L><K><V><R><T><I><R><M><G><T><T><L><C><L><A><V><W><L><T><A><I><M><A><T><I><P><L><L><V><F><Y><Q><V><A><S><E><D><G><V><L><Q><C><Y><S><F><Y><N><Q><Q><T><L><K><W><K><I><F><T><N><F><K><M><N><I><L><G><L><L><I><P><F><T><I><F><M><F><C><Y><I><K><I><L><H><Q><L><K><R><C><Q><N><H><N><K><T><K><A><I><R><L><V><L><I><V><V><I><A><S><L><L><F><W><V><P><F><N><V><V><L><F><L><T><S><L><H><S><M><H><I><L><D><G><C><S><I><S><Q><Q><L><T><Y><A><T><H><V><T><E><I><I><S><F><T><H><C><C><V><N><P><V><I><Y><A><F><V><G><E><K><F><K><K><H><L><S><E><I><F><Q><K><S><C><S><Q><I><F><N><Y><L><G><R><Q><M><P><R><E><S><C><E><K><S><S><S><C><Q><Q><H><S><S><R><S><S><S><V><D><Y><I><L>
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Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.<BOP>
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P51685
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Q16186
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ADRM1_HUMAN
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Rpn13 homolog
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Homo
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<M><T><T><S><G><A><L><F><P><S><L><V><P><G><S><R><G><A><S><N><K><Y><L><V><E><F><R><A><G><K><M><S><L><K><G><T><T><V><T><P><D><K><R><K><G><L><V><Y><I><Q><Q><T><D><D><S><L><I><H><F><C><W><K><D><R><T><S><G><N><V><E><D><D><L><I><I><F><P><D><D><C><E><F><K><R><V><P><Q><C><P><S><G><R><V><Y><V><L><K><F><K><A><G><S><K><R><L><F><F><W><M><Q><E><P><K><T><D><Q><D><E><E><H><C><R><K><V><N><E><Y><L><N><N><P><P><M><P><G><A><L><G><A><S><G><S><S><G><H><E><L><S><A><L><G><G><E><G><G><L><Q><S><L><L><G><N><M><S><H><S><Q><L><M><Q><L><I><G><P><A><G><L><G><G><L><G><G><L><G><A><L><T><G><P><G><L><A><S><L><L><G><S><S><G><P><P><G><S><S><S><S><S><S><S><R><S><Q><S><A><A><V><T><P><S><S><T><T><S><S><T><R><A><T><P><A><P><S><A><P><A><A><A><S><A><T><S><P><S><P><A><P><S><S><G><N><G><A><S><T><A><A><S><P><T><Q><P><I><Q><L><S><D><L><Q><S><I><L><A><T><M><N><V><P><A><G><P><A><G><G><Q><Q><V><D><L><A><S><V><L><T><P><E><I><M><A><P><I><L><A><N><A><D><V><Q><E><R><L><L><P><Y><L><P><S><G><E><S><L><P><Q><T><A><D><E><I><Q><N><T><L><T><S><P><Q><F><Q><Q><A><L><G><M><F><S><A><A><L><A><S><G><Q><L><G><P><L><M><C><Q><F><G><L><P><A><E><A><V><E><A><A><N><K><G><D><V><E><A><F><A><K><A><M><Q><N><N><A><K><P><E><Q><K><E><G><D><T><K><D><K><K><D><E><E><E><D><M><S><L><D>
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Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins . This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required . Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair . Within the complex, functions as a proteasomal ubiquitin receptor . Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation . UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex .<BOP>
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Q16186
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P58170
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OR1D5_HUMAN
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Olfactory receptor 17-31
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Homo
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<M><D><G><D><N><Q><S><E><N><S><Q><F><L><L><L><G><I><S><E><S><P><E><Q><Q><R><I><L><F><W><M><F><L><S><M><Y><L><V><T><V><L><G><N><V><L><I><I><L><A><I><S><S><D><S><H><L><H><T><P><M><Y><F><F><L><A><N><L><S><F><T><D><L><F><F><V><T><N><T><I><P><K><M><L><V><N><F><Q><S><Q><N><K><A><I><S><Y><A><G><C><L><T><Q><L><Y><F><L><V><S><L><V><T><L><D><N><L><I><L><A><V><M><A><Y><D><R><Y><V><A><T><C><C><P><L><H><Y><V><T><A><M><S><P><G><L><C><V><L><L><L><S><L><C><W><G><L><S><V><L><Y><G><L><L><L><T><F><L><L><T><R><V><T><F><C><G><P><R><E><I><H><Y><L><F><C><D><M><Y><I><L><L><W><L><A><C><S><N><T><H><I><I><H><T><A><L><I><A><T><G><C><F><I><F><L><T><P><L><G><F><M><T><T><S><Y><V><R><I><V><R><T><I><L><Q><M><P><S><A><S><K><K><Y><K><T><F><S><T><C><A><S><H><L><G><V><V><S><L><F><Y><G><T><L><A><M><V><Y><L><Q><P><L><H><T><Y><S><M><K><D><S><V><A><T><V><M><Y><A><V><L><T><P><M><M><N><P><F><I><Y><R><L><R><N><K><D><M><H><G><A><P><G><R><V><L><W><R><P><F><Q><R><P><K>
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Odorant receptor.<BOP>
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P58170
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Q8N4N3
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KLH36_HUMAN
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Kelch-like protein 36
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Homo
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<M><M><E><G><S><R><Q><T><R><V><S><R><P><Y><K><I><S><E><S><S><K><V><Y><R><W><A><D><H><S><S><T><V><L><Q><R><L><N><E><Q><R><L><R><G><L><F><C><D><V><V><L><V><A><D><E><Q><R><V><P><A><H><R><N><L><L><A><V><C><S><D><Y><F><N><S><M><F><T><I><G><M><R><E><A><F><Q><K><E><V><E><L><I><G><A><S><Y><I><G><L><K><A><V><V><D><F><L><Y><G><G><E><L><V><L><D><G><G><N><I><D><Y><V><L><E><T><A><H><L><L><Q><I><W><T><V><V><D><F><C><C><E><Y><L><E><Q><E><V><S><E><D><N><Y><L><Y><L><Q><E><L><A><S><I><Y><S><L><K><R><L><D><A><F><I><D><G><F><I><L><N><H><F><G><T><L><S><F><T><P><D><F><L><Q><N><V><S><M><Q><K><L><C><V><Y><L><S><S><S><E><V><Q><R><E><C><E><H><D><L><L><Q><A><A><L><Q><W><L><T><Q><Q><P><E><R><E><A><H><A><R><Q><V><L><E><N><I><H><F><P><L><I><P><K><N><D><L><L><H><R><V><K><P><A><V><C><S><L><L><P><K><E><A><N><C><E><G><F><I><E><E><A><V><R><Y><H><N><N><L><A><A><Q><P><V><M><Q><T><K><R><T><A><L><R><T><N><Q><E><R><L><L><F><V><G><G><E><V><S><E><R><C><L><E><L><S><D><D><T><C><Y><L><D><A><K><S><E><Q><W><V><K><E><T><P><L><P><A><R><R><S><H><H><C><V><A><V><L><G><G><F><I><F><I><A><G><G><S><F><S><R><D><N><G><G><D><A><A><S><N><L><L><Y><R><Y><D><P><R><C><K><Q><W><I><K><V><A><S><M><N><Q><R><R><V><D><F><Y><L><A><S><I><E><D><M><L><V><A><I><G><G><R><N><E><N><G><A><L><S><S><V><E><T><Y><S><P><K><T><D><S><W><S><Y><V><A><G><L><P><R><F><T><Y><G><H><A><G><T><I><Y><K><D><F><V><Y><I><S><G><G><H><D><Y><Q><I><G><P><Y><R><K><N><L><L><C><Y><D><H><R><T><D><V><W><E><E><R><R><P><M><T><T><A><R><G><W><H><S><M><C><S><L><G><D><S><I><Y><S><I><G><G><S><D><D><N><I><E><S><M><E><R><F><D><V><L><G><V><E><A><Y><S><P><Q><C><N><Q><W><T><R><V><A><P><L><L><H><A><N><S><E><S><G><V><A><V><W><E><G><R><I><Y><I><L><G><G><Y><S><W><E><N><T><A><F><S><K><T><V><Q><V><Y><D><R><E><A><D><K><W><S><R><G><V><D><L><P><K><A><I><A><G><G><S><A><C><V><C><A><L><E><P><R><P><E><D><K><K><K><K><G><K><G><K><R><H><Q><D><R><G><Q>
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Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<BOP>
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Q8N4N3
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Q6P087
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RUSD3_HUMAN
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RNA pseudouridylate synthase domain-containing protein 3
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Homo
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<M><R><A><V><L><A><R><E><M><D><G><R><R><V><L><G><R><F><W><S><G><W><R><R><G><L><G><V><R><P><V><P><E><D><A><G><F><G><T><E><A><R><H><Q><R><Q><P><R><G><S><C><Q><R><S><G><P><L><G><D><Q><P><F><A><G><L><L><P><K><N><L><S><R><E><E><L><V><D><A><L><R><A><A><V><V><D><R><K><G><P><L><V><T><L><N><K><P><Q><G><L><P><V><T><G><K><P><G><E><L><T><L><F><S><V><L><P><E><L><S><Q><S><L><G><L><R><E><Q><E><L><Q><V><V><R><A><S><G><K><E><S><S><G><L><V><L><L><S><S><C><P><Q><T><A><S><R><L><Q><K><Y><F><T><H><A><R><R><A><Q><R><P><T><A><T><Y><C><A><V><T><D><G><I><P><A><A><S><E><G><K><I><Q><A><A><L><K><L><E><H><I><D><G><V><N><L><T><V><P><V><K><A><P><S><R><K><D><I><L><E><G><V><K><K><T><L><S><H><F><R><V><V><A><T><G><S><G><C><A><L><V><Q><L><Q><P><L><T><V><F><S><S><Q><L><Q><V><H><M><V><L><Q><L><C><P><V><L><G><D><H><M><Y><S><A><R><V><G><T><V><L><G><Q><R><F><L><L><P><A><E><N><N><K><P><Q><R><Q><V><L><D><E><A><L><L><R><R><L><H><L><T><P><S><Q><A><A><Q><L><P><L><H><L><H><L><H><R><L><L><L><P><G><T><R><A><R><D><T><P><V><E><L><L><A><P><L><P><P><Y><F><S><R><T><L><Q><C><L><G><L><R><L><Q>
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Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA . As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis .<BOP>
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Q6P087
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Q8NG35
|
D105A_HUMAN
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Defensin, beta 105
|
Homo
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<M><A><L><I><R><K><T><F><Y><F><L><F><A><M><F><F><I><L><V><Q><L><P><S><G><C><Q><A><G><L><D><F><S><Q><P><F><P><S><G><E><F><A><V><C><E><S><C><K><L><G><R><G><K><C><R><K><E><C><L><E><N><E><K><P><D><G><N><C><R><L><N><F><L><C><C><R><Q><R><I>
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Has antibacterial activity.<BOP>
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Q8NG35
|
Q9BYE3
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LCE3D_HUMAN
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Small proline-rich-like epidermal differentiation complex protein 6B
|
Homo
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<M><S><C><Q><Q><N><Q><Q><Q><C><Q><P><P><P><K><C><P><S><P><K><C><P><P><K><S><P><V><Q><C><L><P><P><A><S><S><G><C><A><P><S><S><G><G><C><G><P><S><S><E><G><G><C><F><L><N><H><H><R><R><H><H><R><C><R><R><Q><R><P><N><S><C><D><R><G><S><G><Q><Q><G><G><G><S><G><C><G><H><G><S><G><G><C><C>
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Precursors of the cornified envelope of the stratum corneum.<BOP>
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Q9BYE3
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Q8NHU3
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SMS2_HUMAN
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Sphingomyelin synthase 2
|
Homo
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<M><D><I><I><E><T><A><K><L><E><E><H><L><E><N><Q><P><S><D><P><T><N><T><Y><A><R><P><A><E><P><V><E><E><E><N><K><N><G><N><G><K><P><K><S><L><S><S><G><L><R><K><G><T><K><K><Y><P><D><Y><I><Q><I><A><M><P><T><E><S><R><N><K><F><P><L><E><W><W><K><T><G><I><A><F><I><Y><A><V><F><N><L><V><L><T><T><V><M><I><T><V><V><H><E><R><V><P><P><K><E><L><S><P><P><L><P><D><K><F><F><D><Y><I><D><R><V><K><W><A><F><S><V><S><E><I><N><G><I><I><L><V><G><L><W><I><T><Q><W><L><F><L><R><Y><K><S><I><V><G><R><R><F><C><F><I><I><G><T><L><Y><L><Y><R><C><I><T><M><Y><V><T><T><L><P><V><P><G><M><H><F><Q><C><A><P><K><L><N><G><D><S><Q><A><K><V><Q><R><I><L><R><L><I><S><G><G><G><L><S><I><T><G><S><H><I><L><C><G><D><F><L><F><S><G><H><T><V><T><L><T><L><T><Y><L><F><I><K><E><Y><S><P><R><H><F><W><W><Y><H><L><I><C><W><L><L><S><A><A><G><I><I><C><I><L><V><A><H><E><H><Y><T><I><D><V><I><I><A><Y><Y><I><T><T><R><L><F><W><W><Y><H><S><M><A><N><E><K><N><L><K><V><S><S><Q><T><N><F><L><S><R><A><W><W><F><P><I><F><Y><F><F><E><K><N><V><Q><G><S><I><P><C><C><F><S><W><P><L><S><W><P><P><G><C><F><K><S><S><C><K><K><Y><S><R><V><Q><K><I><G><E><D><N><E><K><S><T>
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Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane . Does not use free phosphorylcholine or CDP-choline as donors . Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE) . Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting . To a lesser extent, plays a role in
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Q8NHU3
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Q9HCJ1
|
ANKH_HUMAN
|
Progressive ankylosis protein homolog
|
Homo
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<M><V><K><F><P><A><L><T><H><Y><W><P><L><I><R><F><L><V><P><L><G><I><T><N><I><A><I><D><F><G><E><Q><A><L><N><R><G><I><A><A><V><K><E><D><A><V><E><M><L><A><S><Y><G><L><A><Y><S><L><M><K><F><F><T><G><P><M><S><D><F><K><N><V><G><L><V><F><V><N><S><K><R><D><R><T><K><A><V><L><C><M><V><V><A><G><A><I><A><A><V><F><H><T><L><I><A><Y><S><D><L><G><Y><Y><I><I><N><K><L><H><H><V><D><E><S><V><G><S><K><T><R><R><A><F><L><Y><L><A><A><F><P><F><M><D><A><M><A><W><T><H><A><G><I><L><L><K><H><K><Y><S><F><L><V><G><C><A><S><I><S><D><V><I><A><Q><V><V><F><V><A><I><L><L><H><S><H><L><E><C><R><E><P><L><L><I><P><I><L><S><L><Y><M><G><A><L><V><R><C><T><T><L><C><L><G><Y><Y><K><N><I><H><D><I><I><P><D><R><S><G><P><E><L><G><G><D><A><T><I><R><K><M><L><S><F><W><W><P><L><A><L><I><L><A><T><Q><R><I><S><R><P><I><V><N><L><F><V><S><R><D><L><G><G><S><S><A><A><T><E><A><V><A><I><L><T><A><T><Y><P><V><G><H><M><P><Y><G><W><L><T><E><I><R><A><V><Y><P><A><F><D><K><N><N><P><S><N><K><L><V><S><T><S><N><T><V><T><A><A><H><I><K><K><F><T><F><V><C><M><A><L><S><L><T><L><C><F><V><M><F><W><T><P><N><V><S><E><K><I><L><I><D><I><I><G><V><D><F><A><F><A><E><L><C><V><V><P><L><R><I><F><S><F><F><P><V><P><V><T><V><R><A><H><L><T><G><W><L><M><T><L><K><K><T><F><V><L><A><P><S><S><V><L><R><I><I><V><L><I><A><S><L><V><V><L><P><Y><L><G><V><H><G><A><T><L><G><V><G><S><L><L><A><G><F><V><G><E><S><T><M><V><A><I><A><A><C><Y><V><Y><R><K><Q><K><K><K><M><E><N><E><S><A><T><E><G><E><D><S><A><M><T><D><M><P><P><T><E><E><V><T><D><I><V><E><M><R><E><E><N><E>
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Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.<BOP>
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Q9HCJ1
|
P31997
|
CEAM8_HUMAN
|
Non-specific cross-reacting antigen NCA-95
|
Homo
|
<M><G><P><I><S><A><P><S><C><R><W><R><I><P><W><Q><G><L><L><L><T><A><S><L><F><T><F><W><N><P><P><T><T><A><Q><L><T><I><E><A><V><P><S><N><A><A><E><G><K><E><V><L><L><L><V><H><N><L><P><Q><D><P><R><G><Y><N><W><Y><K><G><E><T><V><D><A><N><R><R><I><I><G><Y><V><I><S><N><Q><Q><I><T><P><G><P><A><Y><S><N><R><E><T><I><Y><P><N><A><S><L><L><M><R><N><V><T><R><N><D><T><G><S><Y><T><L><Q><V><I><K><L><N><L><M><S><E><E><V><T><G><Q><F><S><V><H><P><E><T><P><K><P><S><I><S><S><N><N><S><N><P><V><E><D><K><D><A><V><A><F><T><C><E><P><E><T><Q><N><T><T><Y><L><W><W><V><N><G><Q><S><L><P><V><S><P><R><L><Q><L><S><N><G><N><R><T><L><T><L><L><S><V><T><R><N><D><V><G><P><Y><E><C><E><I><Q><N><P><A><S><A><N><F><S><D><P><V><T><L><N><V><L><Y><G><P><D><A><P><T><I><S><P><S><D><T><Y><Y><H><A><G><V><N><L><N><L><S><C><H><A><A><S><N><P><P><S><Q><Y><S><W><S><V><N><G><T><F><Q><Q><Y><T><Q><K><L><F><I><P><N><I><T><T><K><N><S><G><S><Y><A><C><H><T><T><N><S><A><T><G><R><N><R><T><T><V><R><M><I><T><V><S><D><A><L><V><Q><G><S><S><P><G><L><S><A><R><A><T><V><S><I><M><I><G><V><L><A><R><V><A><L><I>
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Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner . Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 . Heterophilic interaction with CEACAM8 occurs in activated neutrophils .<BOP>
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P31997
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Q9Y2E8
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SL9A8_HUMAN
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Solute carrier family 9 member 8
|
Homo
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<M><G><E><K><M><A><E><E><E><R><F><P><N><T><T><H><E><G><F><N><V><T><L><H><T><T><L><V><V><T><T><K><L><V><L><P><T><P><G><K><P><I><L><P><V><Q><T><G><E><Q><A><Q><Q><E><E><Q><S><S><G><M><T><I><F><F><S><L><L><V><L><A><I><C><I><I><L><V><H><L><L><I><R><Y><R><L><H><F><L><P><E><S><V><A><V><V><S><L><G><I><L><M><G><A><V><I><K><I><I><E><F><K><K><L><A><N><W><K><E><E><E><M><F><R><P><N><M><F><F><L><L><L><L><P><P><I><I><F><E><S><G><Y><S><L><H><K><G><N><F><F><Q><N><I><G><S><I><T><L><F><A><V><F><G><T><A><I><S><A><F><V><V><G><G><G><I><Y><F><L><G><Q><A><D><V><I><S><K><L><N><M><T><D><S><F><A><F><G><S><L><I><S><A><V><D><P><V><A><T><I><A><I><F><N><A><L><H><V><D><P><V><L><N><M><L><V><F><G><E><S><I><L><N><D><A><V><S><I><V><L><T><N><T><A><E><G><L><T><R><K><N><M><S><D><V><S><G><W><Q><T><F><L><Q><A><L><D><Y><F><L><K><M><F><F><G><S><A><A><L><G><T><L><T><G><L><I><S><A><L><V><L><K><H><I><D><L><R><K><T><P><S><L><E><F><G><M><M><I><I><F><A><Y><L><P><Y><G><L><A><E><G><I><S><L><S><G><I><M><A><I><L><F><S><G><I><V><M><S><H><Y><T><H><H><N><L><S><P><V><T><Q><I><L><M><Q><Q><T><L><R><T><V><A><F><L><C><E><T><C><V><F><A><F><L><G><L><S><I><F><S><F><P><H><K><F><E><I><S><F><V><I><W><C><I><V><L><V><L><F><G><R><A><V><N><I><F><P><L><S><Y><L><L><N><F><F><R><D><H><K><I><T><P><K><M><M><F><I><M><W><F><S><G><L><R><G><A><I><P><Y><A><L><S><L><H><L><D><L><E><P><M><E><K><R><Q><L><I><G><T><T><T><I><V><I><V><L><F><T><I><L><L><L><G><G><S><T><M><P><L><I><R><L><M><D><I><E><D><A><K><A><H><R><R><N><K><K><D><V><N><L><S><K><T><E><K><M><G><N><T><V><E><S><E><H><L><S><E><L><T><E><E><E><Y><E><A><H><Y><I><R><R><Q><D><L><K><G><F><V><W><L><D><A><K><Y><L><N><P><F><F><T><R><R><L><T><Q><E><D><L><H><H><G><R><I><Q><M><K><T><L><T><N><K><W><Y><E><E><V><R><Q><G><P><S><G><S><E><D><D><E><Q><E><L><L>
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Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<BOP>
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Q9Y2E8
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Q9UQ07
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MOK_HUMAN
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Renal tumor antigen 1
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Homo
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<M><K><N><Y><K><A><I><G><K><I><G><E><G><T><F><S><E><V><M><K><M><Q><S><L><R><D><G><N><Y><Y><A><C><K><Q><M><K><Q><R><F><E><S><I><E><Q><V><N><N><L><R><E><I><Q><A><L><R><R><L><N><P><H><P><N><I><L><M><L><H><E><V><V><F><D><R><K><S><G><S><L><A><L><I><C><E><L><M><D><M><N><I><Y><E><L><I><R><G><R><R><Y><P><L><S><E><K><K><I><M><H><Y><M><Y><Q><L><C><K><S><L><D><H><I><H><R><N><G><I><F><H><R><D><V><K><P><E><N><I><L><I><K><Q><D><V><L><K><L><G><D><F><G><S><C><R><S><V><Y><S><K><Q><P><Y><T><E><Y><I><S><T><R><W><Y><R><A><P><E><C><L><L><T><D><G><F><Y><T><Y><K><M><D><L><W><S><A><G><C><V><F><Y><E><I><A><S><L><Q><P><L><F><P><G><V><N><E><L><D><Q><I><S><K><I><H><D><V><I><G><T><P><A><Q><K><I><L><T><K><F><K><Q><S><R><A><M><N><F><D><F><P><F><K><K><G><S><G><I><P><L><L><T><T><N><L><S><P><Q><C><L><S><L><L><H><A><M><V><A><Y><D><P><D><E><R><I><A><A><H><Q><A><L><Q><H><P><Y><F><Q><E><Q><R><K><T><E><K><R><A><L><G><S><H><R><K><A><G><F><P><E><H><P><V><A><P><E><P><L><S><N><S><C><Q><I><S><K><E><G><R><K><Q><K><Q><S><L><K><Q><E><E><D><R><P><K><R><R><G><P><A><Y><V><M><E><L><P><K><L><K><L><S><G><V><V><R><L><S><S><Y><S><S><P><T><L><Q><S><V><L><G><S><G><T><N><G><R><V><P><V><L><R><P><L><K><C><I><P><A><S><K><K><T><D><P><Q><K><D><L><K><P><A><P><Q><Q><C><R><L><P><T><I><V><R><K><G><G><R>
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Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.<BOP>
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Q9UQ07
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P07910
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HNRPC_HUMAN
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Heterogeneous nuclear ribonucleoproteins C1/C2
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Homo
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<M><A><S><N><V><T><N><K><T><D><P><R><S><M><N><S><R><V><F><I><G><N><L><N><T><L><V><V><K><K><S><D><V><E><A><I><F><S><K><Y><G><K><I><V><G><C><S><V><H><K><G><F><A><F><V><Q><Y><V><N><E><R><N><A><R><A><A><V><A><G><E><D><G><R><M><I><A><G><Q><V><L><D><I><N><L><A><A><E><P><K><V><N><R><G><K><A><G><V><K><R><S><A><A><E><M><Y><G><S><V><T><E><H><P><S><P><S><P><L><L><S><S><S><F><D><L><D><Y><D><F><Q><R><D><Y><Y><D><R><M><Y><S><Y><P><A><R><V><P><P><P><P><P><I><A><R><A><V><V><P><S><K><R><Q><R><V><S><G><N><T><S><R><R><G><K><S><G><F><N><S><K><S><G><Q><R><G><S><S><K><S><G><K><L><K><G><D><D><L><Q><A><I><K><K><E><L><T><Q><I><K><Q><K><V><D><S><L><L><E><N><L><E><K><I><E><K><E><Q><S><K><Q><A><V><E><M><K><N><D><K><S><E><E><E><Q><S><S><S><S><V><K><K><D><E><T><N><V><K><M><E><S><E><G><G><A><D><D><S><A><E><E><G><D><L><L><D><D><D><D><N><E><D><R><G><D><D><Q><L><E><L><I><K><D><D><E><K><E><A><E><E><G><E><D><D><R><D><S><A><N><G><E><D><D><S>
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Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles . Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides . May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing .<BOP>
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P07910
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Q9ULR3
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PPM1H_HUMAN
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Protein phosphatase 1H
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Homo
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<M><L><T><R><V><K><S><A><V><A><N><F><M><G><G><I><M><A><G><S><S><G><S><E><H><G><G><G><S><C><G><G><S><D><L><P><L><R><F><P><Y><G><R><P><E><F><L><G><L><S><Q><D><E><V><E><C><S><A><D><H><I><A><R><P><I><L><I><L><K><E><T><R><R><L><P><W><A><T><G><Y><A><E><V><I><N><A><G><K><S><T><H><N><E><D><Q><A><S><C><E><V><L><T><V><K><K><K><A><G><A><V><T><S><T><P><N><R><N><S><S><K><R><R><S><S><L><P><N><G><E><G><L><Q><L><K><E><N><S><E><S><E><G><V><S><C><H><Y><W><S><L><F><D><G><H><A><G><S><G><A><A><V><V><A><S><R><L><L><Q><H><H><I><T><E><Q><L><Q><D><I><V><D><I><L><K><N><S><A><V><L><P><P><T><C><L><G><E><E><P><E><N><T><P><A><N><S><R><T><L><T><R><A><A><S><L><R><G><G><V><G><A><P><G><S><P><S><T><P><P><T><R><F><F><T><E><K><K><I><P><H><E><C><L><V><I><G><A><L><E><S><A><F><K><E><M><D><L><Q><I><E><R><E><R><S><S><Y><N><I><S><G><G><C><T><A><L><I><V><I><C><L><L><G><K><L><Y><V><A><N><A><G><D><S><R><A><I><I><I><R><N><G><E><I><I><P><M><S><S><E><F><T><P><E><T><E><R><Q><R><L><Q><Y><L><A><F><M><Q><P><H><L><L><G><N><E><F><T><H><L><E><F><P><R><R><V><Q><R><K><E><L><G><K><K><M><L><Y><R><D><F><N><M><T><G><W><A><Y><K><T><I><E><D><E><D><L><K><F><P><L><I><Y><G><E><G><K><K><A><R><V><M><A><T><I><G><V><T><R><G><L><G><D><H><D><L><K><V><H><D><S><N><I><Y><I><K><P><F><L><S><S><A><P><E><V><R><I><Y><D><L><S><K><Y><D><H><G><S><D><D><V><L><I><L><A><T><D><G><L><W><D><V><L><S><N><E><E><V><A><E><A><I><T><Q><F><L><P><N><C><D><P><D><D><P><H><R><Y><T><L><A><A><Q><D><L><V><M><R><A><R><G><V><L><K><D><R><G><W><R><I><S><N><D><R><L><G><S><G><D><D><I><S><V><Y><V><I><P><L><I><H><G><N><K><L><S>
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Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.<BOP>
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Q9ULR3
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P0CF51
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TRGC1_HUMAN
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T cell receptor gamma constant 1
|
Homo
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<D><K><Q><L><D><A><D><V><S><P><K><P><T><I><F><L><P><S><I><A><E><T><K><L><Q><K><A><G><T><Y><L><C><L><L><E><K><F><F><P><D><V><I><K><I><H><W><Q><E><K><K><S><N><T><I><L><G><S><Q><E><G><N><T><M><K><T><N><D><T><Y><M><K><F><S><W><L><T><V><P><E><K><S><L><D><K><E><H><R><C><I><V><R><H><E><N><N><K><N><G><V><D><Q><E><I><I><F><P><P><I><K><T><D><V><I><T><M><D><P><K><D><N><C><S><K><D><A><N><D><T><L><L><L><Q><L><T><N><T><S><A><Y><Y><M><Y><L><L><L><L><L><K><S><V><V><Y><F><A><I><I><T><C><C><L><L><R><R><T><A><F><C><C><N><G><E><K><S>
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Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair . Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells . Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-d
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P0CF51
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Q96M95
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CCD42_HUMAN
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Coiled-coil domain-containing protein 42
|
Homo
|
<M><S><L><G><I><M><E><E><E><D><L><A><E><Y><F><R><L><Q><Y><G><E><R><L><L><Q><M><L><Q><K><L><P><N><V><E><G><A><S><E><S><P><S><I><W><L><L><E><K><K><K><E><T><E><I><M><H><Q><T><M><V><Q><K><K><K><M><F><Q><R><R><M><E><T><L><N><L><R><W><E><E><L><G><V><K><E><A><Q><L><K><A><H><I><Q><K><S><E><Q><F><I><Q><E><N><D><Q><K><R><I><R><A><M><K><K><A><N><K><E><R><E><L><K><C><Q><H><M><Q><E><L><T><K><R><K><Q><E><M><V><A><L><R><L><E><H><Q><R><L><S><A><K><L><K><D><Y><Y><I><F><N><K><Y><L><E><K><V><V><E><N><S><E><F><E><E><I><H><E><V><I><A><R><Y><K><T><L><V><S><M><R><H><D><L><M><Q><S><A><Q><E><G><Q><E><K><I><E><R><A><K><A><R><L><A><R><Y><M><E><E><K><D><D><E><I><L><Q><Q><N><N><E><L><A><R><L><Q><M><R><F><D><R><A><R><S><N><V><I><F><W><E><S><R><W><A><H><I><Q><N><T><A><A><K><K><T><L><L><L><G><T><I><K><M><A><T><L><N><L><F><Q><I><V><S><K><H><L><K><E><V><T><E><V><A><L><E><D><T><H><K><Q><L><D><M><I><Q><Q><F><I><Q><D><R><S><D><I><W><A><E><V><K><K><K><E><Q><Q><R><V><R><I>
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Required for sperm development.<BOP>
|
Q96M95
|
Q9H5I1
|
SUV92_HUMAN
|
Suppressor of variegation 3-9 homolog 2
|
Homo
|
<M><A><A><V><G><A><E><A><R><G><A><W><C><V><P><C><L><V><S><L><D><T><L><Q><E><L><C><R><K><E><K><L><T><C><K><S><I><G><I><T><K><R><N><L><N><N><Y><E><V><E><Y><L><C><D><Y><K><V><V><K><D><M><E><Y><Y><L><V><K><W><K><G><W><P><D><S><T><N><T><W><E><P><L><Q><N><L><K><C><P><L><L><L><Q><Q><F><S><N><D><K><H><N><Y><L><S><Q><V><K><K><G><K><A><I><T><P><K><D><N><N><K><T><L><K><P><A><I><A><E><Y><I><V><K><K><A><K><Q><R><I><A><L><Q><R><W><Q><D><E><L><N><R><R><K><N><H><K><G><M><I><F><V><E><N><T><V><D><L><E><G><P><P><S><D><F><Y><Y><I><N><E><Y><K><P><A><P><G><I><S><L><V><N><E><A><T><F><G><C><S><C><T><D><C><F><F><Q><K><C><C><P><A><E><A><G><V><L><L><A><Y><N><K><N><Q><Q><I><K><I><P><P><G><T><P><I><Y><E><C><N><S><R><C><Q><C><G><P><D><C><P><N><R><I><V><Q><K><G><T><Q><Y><S><L><C><I><F><R><T><S><N><G><R><G><W><G><V><K><T><L><V><K><I><K><R><M><S><F><V><M><E><Y><V><G><E><V><I><T><S><E><E><A><E><R><R><G><Q><F><Y><D><N><K><G><I><T><Y><L><F><D><L><D><Y><E><S><D><E><F><T><V><D><A><A><R><Y><G><N><V><S><H><F><V><N><H><S><C><D><P><N><L><Q><V><F><N><V><F><I><D><N><L><D><T><R><L><P><R><I><A><L><F><S><T><R><T><I><N><A><G><E><E><L><T><F><D><Y><Q><M><K><G><S><G><D><I><S><S><D><S><I><D><H><S><P><A><K><K><R><V><R><T><V><C><K><C><G><A><V><T><C><R><G><Y><L><N>
|
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trim
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Q9H5I1
|
Q629K1
|
TRIQK_HUMAN
|
Triple repetitive-sequence of QXXK/R protein homolog
|
Homo
|
<M><G><R><K><D><A><A><T><I><K><L><P><V><D><Q><Y><R><K><Q><I><G><K><Q><D><Y><K><K><T><K><P><I><L><R><A><T><K><L><K><A><E><A><K><K><T><A><I><G><I><K><E><V><G><L><V><L><A><A><I><L><A><L><L><L><A><F><Y><A><F><F><Y><L><R><L><T><T><D><V><D><P><D><L><D><Q><D><E><D>
|
May play a role in cell growth and maintenance of cell morphology.<BOP>
|
Q629K1
|
Q9H8W5
|
TRI45_HUMAN
|
RING finger protein 99
|
Homo
|
<M><S><E><N><R><K><P><L><L><G><F><V><S><K><L><T><S><G><T><A><L><G><N><S><G><K><T><H><C><P><L><C><L><G><L><F><K><A><P><R><L><L><P><C><L><H><T><V><C><T><T><C><L><E><Q><L><E><P><F><S><V><V><D><I><R><G><G><D><S><D><T><S><S><E><G><S><I><F><Q><E><L><K><P><R><S><L><Q><S><Q><I><G><I><L><C><P><V><C><D><A><Q><V><D><L><P><M><G><G><V><K><A><L><T><I><D><H><L><A><V><N><D><V><M><L><E><S><L><R><G><E><G><Q><G><L><V><C><D><L><C><N><D><R><E><V><E><K><R><C><Q><T><C><K><A><N><L><C><H><F><C><C><Q><A><H><R><R><Q><K><K><T><T><Y><H><T><M><V><D><L><K><D><L><K><G><Y><S><R><I><G><K><P><I><L><C><P><V><H><P><A><E><E><L><R><L><F><C><E><F><C><D><R><P><V><C><Q><D><C><V><V><G><E><H><R><E><H><P><C><D><F><T><S><N><V><I><H><K><H><G><D><S><V><W><E><L><L><K><G><T><Q><P><H><V><E><A><L><E><E><A><L><A><Q><I><H><I><I><N><S><A><L><Q><K><R><V><E><A><V><A><A><D><V><R><T><F><S><E><G><Y><I><K><A><I><E><E><H><R><D><K><L><L><K><Q><L><E><D><I><R><A><Q><K><E><N><S><L><Q><L><Q><K><A><Q><L><E><Q><L><L><A><D><M><R><T><G><V><E><F><T><E><H><L><L><T><S><G><S><D><L><E><I><L><I><T><K><R><V><V><V><E><R><L><R><K><L><N><K><V><Q><Y><S><T><R><P><G><V><N><D><K><I><R><F><C><P><Q><E><K><A><G><Q><C><R><G><Y><E><I><Y><G><T><I><N><T><K><E><V><D><P><A><K><C><V><L><Q><G><E><D><L><H><R><A><R><E><K><Q><T><A><S><F><T><L><L><C><K><D><A><A><G><E><I><M><G><R><G><G><D><N><V><Q><V><A><V><V><P><K><D><K><K><D><S><P><V><R><T><M><V><Q><D><N><K><D><G><T><Y><Y><I><S><Y><T><P><K><E><P><G><V><Y><T><V><W><V><C><I><K><E><Q><H><V><Q><G><S><P><F><T><V><M><V><R><R><K><H><R><P><H><S><G><V><F><H><C><C><T><F><C><S><S><G><G><Q><K><T><A><R><C><A><C><G><G><T><M><P><G><G><Y><L><G><C><G><H><G><H><K><G><H><P><G><H><P><H><W><S><C><C><G><K><F><N><E><K><S><E><C><T><W><T><G><G><Q><S><A><P><R><S><L><L><R><T><V><A><L>
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May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.<BOP>
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Q9H8W5
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Q9NVJ2
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ARL8B_HUMAN
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Novel small G protein indispensable for equal chromosome segregation 1
|
Homo
|
<M><L><A><L><I><S><R><L><L><D><W><F><R><S><L><F><W><K><E><E><M><E><L><T><L><V><G><L><Q><Y><S><G><K><T><T><F><V><N><V><I><A><S><G><Q><F><S><E><D><M><I><P><T><V><G><F><N><M><R><K><V><T><K><G><N><V><T><I><K><I><W><D><I><G><G><Q><P><R><F><R><S><M><W><E><R><Y><C><R><G><V><N><A><I><V><Y><M><I><D><A><A><D><R><E><K><I><E><A><S><R><N><E><L><H><N><L><L><D><K><P><Q><L><Q><G><I><P><V><L><V><L><G><N><K><R><D><L><P><N><A><L><D><E><K><Q><L><I><E><K><M><N><L><S><A><I><Q><D><R><E><I><C><C><Y><S><I><S><C><K><E><K><D><N><I><D><I><T><L><Q><W><L><I><Q><H><S><K><S><R><R><S>
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(Microbial infection) During infection, coronaviruses such as SARS-CoV-2 and the chaperone HSPA5/GRP78 are probably co-released through ARL8B-dependent lysosomal exocytic pathway for unconventional egress.<BOP>
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Q9NVJ2
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P19338
|
NUCL_HUMAN
|
Protein C23
|
Homo
|
<M><V><K><L><A><K><A><G><K><N><Q><G><D><P><K><K><M><A><P><P><P><K><E><V><E><E><D><S><E><D><E><E><M><S><E><D><E><E><D><D><S><S><G><E><E><V><V><I><P><Q><K><K><G><K><K><A><A><A><T><S><A><K><K><V><V><V><S><P><T><K><K><V><A><V><A><T><P><A><K><K><A><A><V><T><P><G><K><K><A><A><A><T><P><A><K><K><T><V><T><P><A><K><A><V><T><T><P><G><K><K><G><A><T><P><G><K><A><L><V><A><T><P><G><K><K><G><A><A><I><P><A><K><G><A><K><N><G><K><N><A><K><K><E><D><S><D><E><E><E><D><D><D><S><E><E><D><E><E><D><D><E><D><E><D><E><D><E><D><E><I><E><P><A><A><M><K><A><A><A><A><A><P><A><S><E><D><E><D><D><E><D><D><E><D><D><E><D><D><D><D><D><E><E><D><D><S><E><E><E><A><M><E><T><T><P><A><K><G><K><K><A><A><K><V><V><P><V><K><A><K><N><V><A><E><D><E><D><E><E><E><D><D><E><D><E><D><D><D><D><D><E><D><D><E><D><D><D><D><E><D><D><E><E><E><E><E><E><E><E><E><E><P><V><K><E><A><P><G><K><R><K><K><E><M><A><K><Q><K><A><A><P><E><A><K><K><Q><K><V><E><G><T><E><P><T><T><A><F><N><L><F><V><G><N><L><N><F><N><K><S><A><P><E><L><K><T><G><I><S><D><V><F><A><K><N><D><L><A><V><V><D><V><R><I><G><M><T><R><K><F><G><Y><V><D><F><E><S><A><E><D><L><E><K><A><L><E><L><T><G><L><K><V><F><G><N><E><I><K><L><E><K><P><K><G><K><D><S><K><K><E><R><D><A><R><T><L><L><A><K><N><L><P><Y><K><V><T><Q><D><E><L><K><E><V><F><E><D><A><A><E><I><R><L><V><S><K><D><G><K><S><K><G><I><A><Y><I><E><F><K><T><E><A><D><A><E><K><T><F><E><E><K><Q><G><T><E><I><D><G><R><S><I><S><L><Y><Y><T><G><E><K><G><Q><N><Q><D><Y><R><G><G><K><N><S><T><W><S><G><E><S><K><T><L><V><L><S><N><L><S><Y><S><A><T><E><E><T><L><Q><E><V><F><E><K><A><T><F><I><K><V><P><Q><N><Q><N><G><K><S><K><G><Y><A><F><I><E><F><A><S><F><E><D><A><K><E><A><L><N><S><C><N><K><R><E><I><E><G><R><A><I><R><L><E><L><Q><G><P><R><G><S><P><N><A><R><S><Q><P><S><K><T><L><F><V><K><G><L><S><E><D><T><T><E><E><T><L><K><E><S><F><D><G><S><V><R><A><R><I><V><T><D><R><E><T><G><S><S><K><G><F><G><F><V><D><F><N><S><E><E><D><A><K><A><A><K><E><A><M><E><D><G><E><I><D><G><N><K><V><T><L><D><W><A><K><P><K><G><E><G><G><F><G><G><R><G><G><G><R><G><G><F><G><G><R><G><G><G><R><G><G><R><G><G><F><G><G><R><G><R><G><G><F><G><G><R><G><G><F><R><G><G><R><G><G><G><G><D><H><K><P><Q><G><K><K><T><K><F><E>
|
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.<BOP>
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P19338
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Q7L266
|
ASGL1_HUMAN
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Isoaspartyl peptidase/L-asparaginase beta chain
|
Homo
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<M><N><P><I><V><V><V><H><G><G><G><A><G><P><I><S><K><D><R><K><E><R><V><H><Q><G><M><V><R><A><A><T><V><G><Y><G><I><L><R><E><G><G><S><A><V><D><A><V><E><G><A><V><V><A><L><E><D><D><P><E><F><N><A><G><C><G><S><V><L><N><T><N><G><E><V><E><M><D><A><S><I><M><D><G><K><D><L><S><A><G><A><V><S><A><V><Q><C><I><A><N><P><I><K><L><A><R><L><V><M><E><K><T><P><H><C><F><L><T><D><Q><G><A><A><Q><F><A><A><A><M><G><V><P><E><I><P><G><E><K><L><V><T><E><R><N><K><K><R><L><E><K><E><K><H><E><K><G><A><Q><K><T><D><C><Q><K><N><L><G><T><V><G><A><V><A><L><D><C><K><G><N><V><A><Y><A><T><S><T><G><G><I><V><N><K><M><V><G><R><V><G><D><S><P><C><L><G><A><G><G><Y><A><D><N><D><I><G><A><V><S><T><T><G><H><G><E><S><I><L><K><V><N><L><A><R><L><T><L><F><H><I><E><Q><G><K><T><V><E><E><A><A><D><L><S><L><G><Y><M><K><S><R><V><K><G><L><G><G><L><I><V><V><S><K><T><G><D><W><V><A><K><W><T><S><T><S><M><P><W><A><A><A><K><D><G><K><L><H><F><G><I><D><P><D><D><T><T><I><T><D><L><P>
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Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.<BOP>
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Q7L266
|
Q8N442
|
GUF1_HUMAN
|
Ribosomal back-translocase
|
Homo
|
<M><W><T><L><V><G><R><G><W><G><C><A><R><A><L><A><P><R><A><T><G><A><A><L><L><V><A><P><G><P><R><S><A><P><T><L><G><A><A><P><E><S><W><A><T><D><R><L><Y><S><S><A><E><F><K><E><K><L><D><M><S><R><F><P><V><E><N><I><R><N><F><S><I><V><A><H><V><D><H><G><K><S><T><L><A><D><R><L><L><E><L><T><G><T><I><D><K><T><K><N><N><K><Q><V><L><D><K><L><Q><V><E><R><E><R><G><I><T><V><K><A><Q><T><A><S><L><F><Y><N><C><E><G><K><Q><Y><L><L><N><L><I><D><T><P><G><H><V><D><F><S><Y><E><V><S><R><S><L><S><A><C><Q><G><V><L><L><V><V><D><A><N><E><G><I><Q><A><Q><T><V><A><N><F><F><L><A><F><E><A><Q><L><S><V><I><P><V><I><N><K><I><D><L><K><N><A><D><P><E><R><V><E><N><Q><I><E><K><V><F><D><I><P><S><D><E><C><I><K><I><S><A><K><L><G><T><N><V><E><S><V><L><Q><A><I><I><E><R><I><P><P><P><K><V><H><R><K><N><P><L><R><A><L><V><F><D><S><T><F><D><Q><Y><R><G><V><I><A><N><V><A><L><F><D><G><V><V><S><K><G><D><K><I><V><S><A><H><T><Q><K><T><Y><E><V><N><E><V><G><V><L><N><P><N><E><Q><P><T><H><K><L><Y><A><G><Q><V><G><Y><L><I><A><G><M><K><D><V><T><E><A><Q><I><G><D><T><L><C><L><H><K><Q><P><V><E><P><L><P><G><F><K><S><A><K><P><M><V><F><A><G><M><Y><P><L><D><Q><S><E><Y><N><N><L><K><S><A><I><E><K><L><T><L><N><D><S><S><V><T><V><H><R><D><S><S><L><A><L><G><A><G><W><R><L><G><F><L><G><L><L><H><M><E><V><F><N><Q><R><L><E><Q><E><Y><N><A><S><V><I><L><T><T><P><T><V><P><Y><K><A><V><L><S><S><S><K><L><I><K><E><H><R><E><K><E><I><T><I><I><N><P><A><Q><F><P><D><K><S><K><V><T><E><Y><L><E><P><V><V><L><G><T><I><I><T><P><D><E><Y><T><G><K><I><M><M><L><C><E><A><R><R><A><V><Q><K><N><M><I><F><I><D><Q><N><R><V><M><L><K><Y><L><F><P><L><N><E><I><V><V><D><F><Y><D><S><L><K><S><L><S><S><G><Y><A><S><F><D><Y><E><D><A><G><Y><Q><T><A><E><L><V><K><M><D><I><L><L><N><G><N><T><V><E><E><L><V><T><V><V><H><K><D><K><A><H><S><I><G><K><A><I><C><E><R><L><K><D><S><L><P><R><Q><L><F><E><I><A><I><Q><A><A><I><G><S><K><I><I><A><R><E><T><V><K><A><Y><R><K><N><V><L><A><K><C><Y><G><G><D><I><T><R><K><M><K><L><L><K><R><Q><A><E><G><K><K><K><L><R><K><I><G><N><V><E><V><P><K><D><A><F><I><K><V><L><K><T><Q><S><S><K>
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Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.<BOP>
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Q8N442
|
P28324
|
ELK4_HUMAN
|
Serum response factor accessory protein 1
|
Homo
|
<M><D><S><A><I><T><L><W><Q><F><L><L><Q><L><L><Q><K><P><Q><N><K><H><M><I><C><W><T><S><N><D><G><Q><F><K><L><L><Q><A><E><E><V><A><R><L><W><G><I><R><K><N><K><P><N><M><N><Y><D><K><L><S><R><A><L><R><Y><Y><Y><V><K><N><I><I><K><K><V><N><G><Q><K><F><V><Y><K><F><V><S><Y><P><E><I><L><N><M><D><P><M><T><V><G><R><I><E><G><D><C><E><S><L><N><F><S><E><V><S><S><S><S><K><D><V><E><N><G><G><K><D><K><P><P><Q><P><G><A><K><T><S><S><R><N><D><Y><I><H><S><G><L><Y><S><S><F><T><L><N><S><L><N><S><S><N><V><K><L><F><K><L><I><K><T><E><N><P><A><E><K><L><A><E><K><K><S><P><Q><E><P><T><P><S><V><I><K><F><V><T><T><P><S><K><K><P><P><V><E><P><V><A><A><T><I><S><I><G><P><S><I><S><P><S><S><E><E><T><I><Q><A><L><E><T><L><V><S><P><K><L><P><S><L><E><A><P><T><S><A><S><N><V><M><T><A><F><A><T><T><P><P><I><S><S><I><P><P><L><Q><E><P><P><R><T><P><S><P><P><L><S><S><H><P><D><I><D><T><D><I><D><S><V><A><S><Q><P><M><E><L><P><E><N><L><S><L><E><P><K><D><Q><D><S><V><L><L><E><K><D><K><V><N><N><S><S><R><S><K><K><P><K><G><L><E><L><A><P><T><L><V><I><T><S><S><D><P><S><P><L><G><I><L><S><P><S><L><P><T><A><S><L><T><P><A><F><F><S><Q><T><P><I><I><L><T><P><S><P><L><L><S><S><I><H><F><W><S><T><L><S><P><V><A><P><L><S><P><A><R><L><Q><G><A><N><T><L><F><Q><F><P><S><V><L><N><S><H><G><P><F><T><L><S><G><L><D><G><P><S><T><P><G><P><F><S><P><D><L><Q><K><T>
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Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.<BOP>
|
P28324
|
Q8NGC2
|
OR4E2_HUMAN
|
Olfactory receptor OR14-42
|
Homo
|
<M><D><S><L><N><Q><T><R><V><T><E><F><V><F><L><G><L><T><D><N><R><V><L><E><M><L><F><F><M><A><F><S><A><I><Y><M><L><T><L><S><G><N><I><L><I><I><I><A><T><V><F><T><P><S><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><I><D><I><C><H><S><S><V><T><V><P><K><M><L><E><G><L><L><L><E><R><K><T><I><S><F><D><N><C><I><T><Q><L><F><F><L><H><L><F><A><C><A><E><I><F><L><L><I><I><V><A><Y><D><R><Y><V><A><I><C><T><P><L><H><Y><P><N><V><M><N><M><R><V><C><I><Q><L><V><F><A><L><W><L><G><G><T><V><H><S><L><G><Q><T><F><L><T><I><R><L><P><Y><C><G><P><N><I><I><D><S><Y><F><C><D><V><P><L><V><I><K><L><A><C><T><D><T><Y><L><T><G><I><L><I><V><T><N><S><G><T><I><S><L><S><C><F><L><A><V><V><T><S><Y><M><V><I><L><V><S><L><R><K><H><S><A><E><G><R><Q><K><A><L><S><T><C><S><A><H><F><M><V><V><A><L><F><F><G><P><C><I><F><I><Y><T><R><P><D><T><S><F><S><I><D><K><V><V><S><V><F><Y><T><V><V><T><P><L><L><N><P><F><I><Y><T><L><R><N><E><E><V><K><S><A><M><K><Q><L><R><Q><R><Q><V><F><F><T><K><S><Y><T>
|
Odorant receptor.<BOP>
|
Q8NGC2
|
Q99795
|
GPA33_HUMAN
|
Glycoprotein A33
|
Homo
|
<M><V><G><K><M><W><P><V><L><W><T><L><C><A><V><R><V><T><V><D><A><I><S><V><E><T><P><Q><D><V><L><R><A><S><Q><G><K><S><V><T><L><P><C><T><Y><H><T><S><T><S><S><R><E><G><L><I><Q><W><D><K><L><L><L><T><H><T><E><R><V><V><I><W><P><F><S><N><K><N><Y><I><H><G><E><L><Y><K><N><R><V><S><I><S><N><N><A><E><Q><S><D><A><S><I><T><I><D><Q><L><T><M><A><D><N><G><T><Y><E><C><S><V><S><L><M><S><D><L><E><G><N><T><K><S><R><V><R><L><L><V><L><V><P><P><S><K><P><E><C><G><I><E><G><E><T><I><I><G><N><N><I><Q><L><T><C><Q><S><K><E><G><S><P><T><P><Q><Y><S><W><K><R><Y><N><I><L><N><Q><E><Q><P><L><A><Q><P><A><S><G><Q><P><V><S><L><K><N><I><S><T><D><T><S><G><Y><Y><I><C><T><S><S><N><E><E><G><T><Q><F><C><N><I><T><V><A><V><R><S><P><S><M><N><V><A><L><Y><V><G><I><A><V><G><V><V><A><A><L><I><I><I><G><I><I><I><Y><C><C><C><C><R><G><K><D><D><N><T><E><D><K><E><D><A><R><P><N><R><E><A><Y><E><E><P><P><E><Q><L><R><E><L><S><R><E><R><E><E><E><D><D><Y><R><Q><E><E><Q><R><S><T><G><R><E><S><P><D><H><L><D><Q>
|
May play a role in cell-cell recognition and signaling.<BOP>
|
Q99795
|
Q9BZE2
|
PUS3_HUMAN
|
tRNA-uridine isomerase 3
|
Homo
|
<M><A><Y><N><D><T><D><R><N><Q><T><E><K><L><L><K><R><V><R><E><L><E><Q><E><V><Q><R><L><K><K><E><Q><A><K><N><K><E><D><S><N><I><R><E><N><S><A><G><A><G><K><T><K><R><A><F><D><F><S><A><H><G><R><R><H><V><A><L><R><I><A><Y><M><G><W><G><Y><Q><G><F><A><S><Q><E><N><T><N><N><T><I><E><E><K><L><F><E><A><L><T><K><T><R><L><V><E><S><R><Q><T><S><N><Y><H><R><C><G><R><T><D><K><G><V><S><A><F><G><Q><V><I><S><L><D><L><R><S><Q><F><P><R><G><R><D><S><E><D><F><N><V><K><E><E><A><N><A><A><A><E><E><I><R><Y><T><H><I><L><N><R><V><L><P><P><D><I><R><I><L><A><W><A><P><V><E><P><S><F><S><A><R><F><S><C><L><E><R><T><Y><R><Y><F><F><P><R><A><D><L><D><I><V><T><M><D><Y><A><A><Q><K><Y><V><G><T><H><D><F><R><N><L><C><K><M><D><V><A><N><G><V><I><N><F><Q><R><T><I><L><S><A><Q><V><Q><L><V><G><Q><S><P><G><E><G><R><W><Q><E><P><F><Q><L><C><Q><F><E><V><T><G><Q><A><F><L><Y><H><Q><V><R><C><M><M><A><I><L><F><L><I><G><Q><G><M><E><K><P><E><I><I><D><E><L><L><N><I><E><K><N><P><Q><K><P><Q><Y><S><M><A><V><E><F><P><L><V><L><Y><D><C><K><F><E><N><V><K><W><I><Y><D><Q><E><A><Q><E><F><N><I><T><H><L><Q><Q><L><W><A><N><H><A><V><K><T><H><M><L><Y><S><M><L><Q><G><L><D><T><V><P><V><P><C><G><I><G><P><K><M><D><G><M><T><E><W><G><N><V><K><P><S><V><I><K><Q><T><S><A><F><V><E><G><V><K><M><R><T><Y><K><P><L><M><D><R><P><K><C><Q><G><L><E><S><R><I><Q><H><F><V><R><R><G><R><I><E><H><P><H><L><F><H><E><E><E><T><K><A><K><R><D><C><N><D><T><L><E><E><E><N><T><N><L><E><T><P><T><K><R><V><C><V><D><T><E><I><K><S><I><I>
|
Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs.<BOP>
|
Q9BZE2
|
A6NJ46
|
NKX63_HUMAN
|
Homeobox protein Nkx-6.3
|
Homo
|
<M><E><S><N><L><Q><G><T><F><L><L><N><N><T><P><L><A><Q><F><P><E><M><K><A><P><V><C><Q><Y><S><V><Q><N><S><F><Y><K><L><S><P><P><G><L><G><P><Q><L><A><A><G><T><P><H><G><I><T><D><I><L><S><R><P><V><A><A><P><N><N><S><L><L><S><G><Y><P><H><V><A><G><F><G><G><L><S><S><Q><G><V><Y><Y><S><P><Q><V><G><N><F><S><K><A><G><N><E><Y><P><T><R><T><R><N><C><W><A><D><T><G><Q><D><W><R><G><G><R><Q><C><S><N><T><P><D><P><L><S><D><S><I><H><K><K><K><H><T><R><P><T><F><T><G><H><Q><I><F><A><L><E><K><T><F><E><Q><T><K><Y><L><A><G><P><E><R><A><R><L><A><Y><S><L><G><M><T><E><S><Q><V><K><V><W><F><Q><N><R><R><T><K><W><R><K><K><S><A><L><E><P><S><S><S><T><P><R><A><P><G><G><A><G><A><G><A><G><G><D><R><A><P><S><E><N><E><D><D><E><Y><N><K><P><L><D><P><D><S><D><D><E><K><I><R><L><L><L><R><K><H><R><A><A><F><S><V><L><S><L><G><A><H><S><V>
|
Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.<BOP>
|
A6NJ46
|
Q8NGP8
|
OR5M1_HUMAN
|
Olfactory receptor OR11-208
|
Homo
|
<M><F><S><P><N><H><T><I><V><T><E><F><I><L><L><G><L><T><D><D><P><V><L><E><K><I><L><F><G><V><F><L><A><I><Y><L><I><T><L><A><G><N><L><C><M><I><L><L><I><R><T><N><S><H><L><Q><T><P><M><Y><F><F><L><G><H><L><S><F><V><D><I><C><Y><S><S><N><V><T><P><N><M><L><H><N><F><L><S><E><Q><K><T><I><S><Y><A><G><C><F><T><Q><C><L><L><F><I><A><L><V><I><T><E><F><Y><I><L><A><S><M><A><L><D><R><Y><V><A><I><C><S><P><L><H><Y><S><S><R><M><S><K><N><I><C><V><C><L><V><T><I><P><Y><M><Y><G><F><L><S><G><F><S><Q><S><L><L><T><F><H><L><S><F><C><G><S><L><E><I><N><H><F><Y><C><A><D><P><P><L><I><M><L><A><C><S><D><T><R><V><K><K><M><A><M><F><V><V><A><G><F><N><L><S><S><S><L><F><I><I><L><L><S><Y><L><F><I><F><A><A><I><F><R><I><R><S><A><E><G><R><H><K><A><F><S><T><C><A><S><H><L><T><I><V><T><L><F><Y><G><T><L><F><C><M><Y><V><R><P><P><S><E><K><S><V><E><E><S><K><I><T><A><V><F><Y><T><F><L><S><P><M><L><N><P><L><I><Y><S><L><R><N><T><D><V><I><L><A><M><Q><Q><M><I><R><G><K><S><F><H><K><I><A><V>
|
Odorant receptor.<BOP>
|
Q8NGP8
|
Q15363
|
TMED2_HUMAN
|
p24 family protein beta-1
|
Homo
|
<M><V><T><L><A><E><L><L><V><L><L><A><A><L><L><A><T><V><S><G><Y><F><V><S><I><D><A><H><A><E><E><C><F><F><E><R><V><T><S><G><T><K><M><G><L><I><F><E><V><A><E><G><G><F><L><D><I><D><V><E><I><T><G><P><D><N><K><G><I><Y><K><G><D><R><E><S><S><G><K><Y><T><F><A><A><H><M><D><G><T><Y><K><F><C><F><S><N><R><M><S><T><M><T><P><K><I><V><M><F><T><I><D><I><G><E><A><P><K><G><Q><D><M><E><T><E><A><H><Q><N><K><L><E><E><M><I><N><E><L><A><V><A><M><T><A><V><K><H><E><Q><E><Y><M><E><V><R><E><R><I><H><R><A><I><N><D><N><T><N><S><R><V><V><L><W><S><F><F><E><A><L><V><L><V><A><M><T><L><G><Q><I><Y><Y><L><K><R><F><F><E><V><R><R><V><V>
|
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization
|
Q15363
|
P25929
|
NPY1R_HUMAN
|
Neuropeptide Y receptor type 1
|
Homo
|
<M><N><S><T><L><F><S><Q><V><E><N><H><S><V><H><S><N><F><S><E><K><N><A><Q><L><L><A><F><E><N><D><D><C><H><L><P><L><A><M><I><F><T><L><A><L><A><Y><G><A><V><I><I><L><G><V><S><G><N><L><A><L><I><I><I><I><L><K><Q><K><E><M><R><N><V><T><N><I><L><I><V><N><L><S><F><S><D><L><L><V><A><I><M><C><L><P><F><T><F><V><Y><T><L><M><D><H><W><V><F><G><E><A><M><C><K><L><N><P><F><V><Q><C><V><S><I><T><V><S><I><F><S><L><V><L><I><A><V><E><R><H><Q><L><I><I><N><P><R><G><W><R><P><N><N><R><H><A><Y><V><G><I><A><V><I><W><V><L><A><V><A><S><S><L><P><F><L><I><Y><Q><V><M><T><D><E><P><F><Q><N><V><T><L><D><A><Y><K><D><K><Y><V><C><F><D><Q><F><P><S><D><S><H><R><L><S><Y><T><T><L><L><L><V><L><Q><Y><F><G><P><L><C><F><I><F><I><C><Y><F><K><I><Y><I><R><L><K><R><R><N><N><M><M><D><K><M><R><D><N><K><Y><R><S><S><E><T><K><R><I><N><I><M><L><L><S><I><V><V><A><F><A><V><C><W><L><P><L><T><I><F><N><T><V><F><D><W><N><H><Q><I><I><A><T><C><N><H><N><L><L><F><L><L><C><H><L><T><A><M><I><S><T><C><V><N><P><I><F><Y><G><F><L><N><K><N><F><Q><R><D><L><Q><F><F><F><N><F><C><D><F><R><S><R><D><D><D><Y><E><T><I><A><M><S><T><M><H><T><D><V><S><K><T><S><L><K><Q><A><S><P><V><A><F><K><K><I><N><N><N><D><D><N><E><K><I>
|
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.<BOP>
|
P25929
|
Q5SQN1
|
SNP47_HUMAN
|
Synaptosomal-associated 47 kDa protein
|
Homo
|
<M><R><A><A><R><R><G><L><H><C><A><G><A><E><R><P><R><R><R><G><R><L><W><D><S><S><G><V><P><Q><R><Q><K><R><P><G><P><W><R><T><Q><T><Q><E><Q><M><S><R><D><V><C><I><H><T><W><P><C><T><Y><Y><L><E><P><K><R><R><W><V><T><G><Q><L><S><L><T><S><L><S><L><R><F><M><T><D><S><T><G><E><I><L><V><S><F><P><L><S><S><I><V><E><I><K><K><E><A><S><H><F><I><F><S><S><I><T><I><L><E><K><G><H><A><K><H><W><F><S><S><L><R><P><S><R><N><V><V><F><S><I><I><E><H><F><W><R><E><L><L><L><S><Q><P><G><A><V><A><D><A><S><V><P><R><T><R><G><E><E><L><T><G><L><M><A><G><S><Q><K><R><L><E><D><T><A><R><V><L><H><H><Q><G><Q><Q><L><D><S><V><M><R><G><L><D><K><M><E><S><D><L><E><V><A><D><R><L><L><T><E><L><E><S><P><A><W><W><P><F><S><S><K><L><W><K><T><P><P><E><T><K><P><R><E><D><V><S><M><T><S><C><E><P><F><G><K><E><G><I><L><I><K><I><P><A><V><I><S><H><R><T><E><S><H><V><K><P><G><R><L><T><V><L><V><S><G><L><E><I><H><D><S><S><S><L><L><M><H><R><F><E><R><E><D><V><D><D><I><K><V><H><S><P><Y><E><I><S><I><R><Q><R><F><I><G><K><P><D><M><A><Y><R><L><I><S><A><K><M><P><E><V><I><P><I><L><E><V><Q><F><S><K><K><M><E><L><L><E><D><A><L><V><L><R><S><A><R><T><S><S><P><A><E><K><S><C><S><V><W><H><A><A><S><G><L><M><G><R><T><L><H><R><E><P><P><A><G><D><Q><E><G><T><A><L><H><L><Q><T><S><L><P><A><L><S><E><A><D><T><Q><E><L><T><Q><I><L><R><R><M><K><G><L><A><L><E><A><E><S><E><L><E><R><Q><D><E><A><L><D><G><V><A><A><A><V><D><R><A><T><L><T><I><D><K><H><N><R><R><M><K><R><L><T>
|
Plays a role in intracellular membrane fusion.<BOP>
|
Q5SQN1
|
Q96EX3
|
DC2I2_HUMAN
|
WD repeat-containing protein 34
|
Homo
|
<M><A><T><R><A><Q><P><G><P><L><S><Q><A><G><S><A><G><V><A><A><L><A><T><V><G><V><A><S><G><P><G><P><G><R><P><G><P><L><Q><D><E><T><L><G><V><A><S><V><P><S><Q><W><R><A><V><Q><G><I><R><W><E><T><K><S><C><Q><T><A><S><I><A><T><A><S><A><S><A><Q><A><R><N><H><V><D><A><Q><V><Q><T><E><A><P><V><P><V><S><V><Q><P><P><S><Q><Y><D><I><P><R><L><A><A><F><L><R><R><V><E><A><M><V><I><R><E><L><N><K><N><W><Q><S><H><A><F><D><G><F><E><V><N><W><T><E><Q><Q><Q><M><V><S><C><L><Y><T><L><G><Y><P><P><A><Q><A><Q><G><L><H><V><T><S><I><S><W><N><S><T><G><S><V><V><A><C><A><Y><G><R><L><D><H><G><D><W><S><T><L><K><S><F><V><C><A><W><N><L><D><R><R><D><L><R><P><Q><Q><P><S><A><V><V><E><V><P><S><A><V><L><C><L><A><F><H><P><T><Q><P><S><H><V><A><G><G><L><Y><S><G><E><V><L><V><W><D><L><S><R><L><E><D><P><L><L><W><R><T><G><L><T><D><D><T><H><T><D><P><V><S><Q><V><V><W><L><P><E><P><G><H><S><H><R><F><Q><V><L><S><V><A><T><D><G><K><V><L><L><W><Q><G><I><G><V><G><Q><L><Q><L><T><E><G><F><A><L><V><M><Q><Q><L><P><R><S><T><K><L><K><K><H><P><R><G><E><T><E><V><G><A><T><A><V><A><F><S><S><F><D><P><R><L><F><I><L><G><T><E><G><G><F><P><L><K><C><S><L><A><A><G><E><A><A><L><T><R><M><P><S><S><V><P><L><R><A><P><A><Q><F><T><F><S><P><H><G><G><P><I><Y><S><V><S><C><S><P><F><H><R><N><L><F><L><S><A><G><T><D><G><H><V><H><L><Y><S><M><L><Q><A><P><P><L><T><S><L><Q><L><S><L><K><Y><L><F><A><V><R><W><S><P><V><R><P><L><V><F><A><A><A><S><G><K><G><D><V><Q><L><F><D><L><Q><K><S><S><Q><K><P><T><V><L><I><K><Q><T><Q><D><E><S><P><V><Y><C><L><E><F><N><S><Q><Q><T><Q><L><L><A><A><G><D><A><Q><G><T><V><K><V><W><Q><L><S><T><E><F><T><E><Q><G><P><R><E><A><E><D><L><D><C><L><A><A><E><V><A><A>
|
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.<BOP>
|
Q96EX3
|
Q7L5N1
|
CSN6_HUMAN
|
Vpr-interacting protein
|
Homo
|
<M><A><A><A><A><A><A><A><A><A><T><N><G><T><G><G><S><S><G><M><E><V><D><A><A><V><V><P><S><V><M><A><C><G><V><T><G><S><V><S><V><A><L><H><P><L><V><I><L><N><I><S><D><H><W><I><R><M><R><S><Q><E><G><R><P><V><Q><V><I><G><A><L><I><G><K><Q><E><G><R><N><I><E><V><M><N><S><F><E><L><L><S><H><T><V><E><E><K><I><I><I><D><K><E><Y><Y><Y><T><K><E><E><Q><F><K><Q><V><F><K><E><L><E><F><L><G><W><Y><T><T><G><G><P><P><D><P><S><D><I><H><V><H><K><Q><V><C><E><I><I><E><S><P><L><F><L><K><L><N><P><M><T><K><H><T><D><L><P><V><S><V><F><E><S><V><I><D><I><I><N><G><E><A><T><M><L><F><A><E><L><T><Y><T><L><A><T><E><E><A><E><R><I><G><V><D><H><V><A><R><M><T><A><T><G><S><G><E><N><S><T><V><A><E><H><L><I><A><Q><H><S><A><I><K><M><L><H><S><R><V><K><L><I><L><E><Y><V><K><A><S><E><A><G><E><V><P><F><N><H><E><I><L><R><E><A><Y><A><L><C><H><C><L><P><V><L><S><T><D><K><F><K><T><D><F><Y><D><Q><C><N><D><V><G><L><M><A><Y><L><G><T><I><T><K><T><C><N><T><M><N><Q><F><V><N><K><F><N><V><L><Y><D><R><Q><G><I><G><R><R><M><R><G><L><F><F>
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Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets.<BOP>
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Q7L5N1
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A6NJ69
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IGIP_HUMAN
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IgA-inducing protein homolog
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Homo
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<M><C><S><Y><Y><H><M><K><K><R><S><V><S><G><C><N><I><T><I><F><A><V><M><F><S><H><L><S><A><G><K><S><P><C><G><N><Q><A><N><V><L><C><I><S><R><L><E><F><V><Q><Y><Q><S>
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Enhances IgA secretion from B-cells stimulated via CD40.<BOP>
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A6NJ69
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P49748
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ACADV_HUMAN
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Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
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Homo
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<M><Q><A><A><R><M><A><A><S><L><G><R><Q><L><L><R><L><G><G><G><S><S><R><L><T><A><L><L><G><Q><P><R><P><G><P><A><R><R><P><Y><A><G><G><A><A><Q><L><A><L><D><K><S><D><S><H><P><S><D><A><L><T><R><K><K><P><A><K><A><E><S><K><S><F><A><V><G><M><F><K><G><Q><L><T><T><D><Q><V><F><P><Y><P><S><V><L><N><E><E><Q><T><Q><F><L><K><E><L><V><E><P><V><S><R><F><F><E><E><V><N><D><P><A><K><N><D><A><L><E><M><V><E><E><T><T><W><Q><G><L><K><E><L><G><A><F><G><L><Q><V><P><S><E><L><G><G><V><G><L><C><N><T><Q><Y><A><R><L><V><E><I><V><G><M><H><D><L><G><V><G><I><T><L><G><A><H><Q><S><I><G><F><K><G><I><L><L><F><G><T><K><A><Q><K><E><K><Y><L><P><K><L><A><S><G><E><T><V><A><A><F><C><L><T><E><P><S><S><G><S><D><A><A><S><I><R><T><S><A><V><P><S><P><C><G><K><Y><Y><T><L><N><G><S><K><L><W><I><S><N><G><G><L><A><D><I><F><T><V><F><A><K><T><P><V><T><D><P><A><T><G><A><V><K><E><K><I><T><A><F><V><V><E><R><G><F><G><G><I><T><H><G><P><P><E><K><K><M><G><I><K><A><S><N><T><A><E><V><F><F><D><G><V><R><V><P><S><E><N><V><L><G><E><V><G><S><G><F><K><V><A><M><H><I><L><N><N><G><R><F><G><M><A><A><A><L><A><G><T><M><R><G><I><I><A><K><A><V><D><H><A><T><N><R><T><Q><F><G><E><K><I><H><N><F><G><L><I><Q><E><K><L><A><R><M><V><M><L><Q><Y><V><T><E><S><M><A><Y><M><V><S><A><N><M><D><Q><G><A><T><D><F><Q><I><E><A><A><I><S><K><I><F><G><S><E><A><A><W><K><V><T><D><E><C><I><Q><I><M><G><G><M><G><F><M><K><E><P><G><V><E><R><V><L><R><D><L><R><I><F><R><I><F><E><G><T><N><D><I><L><R><L><F><V><A><L><Q><G><C><M><D><K><G><K><E><L><S><G><L><G><S><A><L><K><N><P><F><G><N><A><G><L><L><L><G><E><A><G><K><Q><L><R><R><R><A><G><L><G><S><G><L><S><L><S><G><L><V><H><P><E><L><S><R><S><G><E><L><A><V><R><A><L><E><Q><F><A><T><V><V><E><A><K><L><I><K><H><K><K><G><I><V><N><E><Q><F><L><L><Q><R><L><A><D><G><A><I><D><L><Y><A><M><V><V><V><L><S><R><A><S><R><S><L><S><E><G><H><P><T><A><Q><H><E><K><M><L><C><D><T><W><C><I><E><A><A><A><R><I><R><E><G><M><A><A><L><Q><S><D><P><W><Q><Q><E><L><Y><R><N><F><K><S><I><S><K><A><L><V><E><R><G><G><V><V><T><S><N><P><L><G><F>
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Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats . The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA . Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains .<BOP>
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P49748
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P0CJ75
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HMN8_HUMAN
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MT-RNR2-like protein 8
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Homo
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<M><A><P><R><G><F><S><C><L><L><L><S><T><S><E><I><D><L><P><V><K><R><R><A>
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Plays a role as a neuroprotective and antiapoptotic factor.<BOP>
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P0CJ75
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Q9H7S9
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ZN703_HUMAN
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Zinc finger elbow-related proline domain protein 1
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Homo
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<M><S><D><S><P><A><G><S><N><P><R><T><P><E><S><S><G><S><G><S><G><G><G><G><K><R><P><A><V><P><A><A><V><S><L><L><P><P><A><D><P><L><R><Q><A><N><R><L><P><I><R><V><L><K><M><L><S><A><H><T><G><H><L><L><H><P><E><Y><L><Q><P><L><S><S><T><P><V><S><P><I><E><L><D><A><K><K><S><P><L><A><L><L><A><Q><T><C><S><Q><I><G><K><P><D><P><P><P><S><S><K><L><N><S><V><A><A><A><A><N><G><L><G><A><E><K><D><P><G><R><S><A><P><G><A><A><S><A><A><A><A><L><K><Q><L><G><D><S><P><A><E><D><K><S><S><F><K><P><Y><S><K><G><S><G><G><G><D><S><R><K><D><S><G><S><S><S><V><S><S><T><S><S><S><S><S><S><S><P><G><D><K><A><G><F><R><V><P><S><A><A><C><P><P><F><P><P><H><G><A><P><V><S><A><S><S><S><S><S><S><P><G><G><S><R><G><G><S><P><H><H><S><D><C><K><N><G><G><G><V><G><G><G><E><L><D><K><K><D><Q><E><P><K><P><S><P><E><P><A><A><V><S><R><G><G><G><G><E><P><G><A><H><G><G><A><E><S><G><A><S><G><R><K><S><E><P><P><S><A><L><V><G><A><G><H><V><A><P><V><S><P><Y><K><P><G><H><S><V><F><P><L><P><P><S><S><I><G><Y><H><G><S><I><V><G><A><Y><A><G><Y><P><S><Q><F><V><P><G><L><D><P><S><K><S><G><L><V><G><G><Q><L><S><G><G><L><G><L><P><P><G><K><P><P><S><S><S><P><L><T><G><A><S><P><P><S><F><L><Q><G><L><C><R><D><P><Y><C><L><G><G><Y><H><G><A><S><H><L><G><G><S><S><C><S><T><C><S><A><H><D><P><A><G><P><S><L><K><A><G><G><Y><P><L><V><Y><P><G><H><P><L><Q><P><A><A><L><S><S><S><A><A><Q><A><A><L><P><G><H><P><L><Y><T><Y><G><F><M><L><Q><N><E><P><L><P><H><S><C><N><W><V><A><A><S><G><P><C><D><K><R><F><A><T><S><E><E><L><L><S><H><L><R><T><H><T><A><L><P><G><A><E><K><L><L><A><A><Y><P><G><A><S><G><L><G><S><A><A><A><A><A><A><A><A><A><S><C><H><L><H><L><P><P><P><A><A><P><G><S><P><G><S><L><S><L><R><N><P><H><T><L><G><L><S><R><Y><H><P><Y><G><K><S><H><L><S><T><A><G><G><L><A><V><P><S><L><P><T><A><G><P><Y><Y><S><P><Y><A><L><Y><G><Q><R><L><A><S><A><S><A><L><G><Y><Q>
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Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.<BOP>
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Q9H7S9
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P36383
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CXG1_HUMAN
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Gap junction alpha-7 protein
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Homo
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<M><S><W><S><F><L><T><R><L><L><E><E><I><H><N><H><S><T><F><V><G><K><I><W><L><T><V><L><I><V><F><R><I><V><L><T><A><V><G><G><E><S><I><Y><Y><D><E><Q><S><K><F><V><C><N><T><E><Q><P><G><C><E><N><V><C><Y><D><A><F><A><P><L><S><H><V><R><F><W><V><F><Q><I><I><L><V><A><T><P><S><V><M><Y><L><G><Y><A><I><H><K><I><A><K><M><E><H><G><E><A><D><K><K><A><A><R><S><K><P><Y><A><M><R><W><K><Q><H><R><A><L><E><E><T><E><E><D><N><E><E><D><P><M><M><Y><P><E><M><E><L><E><S><D><K><E><N><K><E><Q><S><Q><P><K><P><K><H><D><G><R><R><R><I><R><E><D><G><L><M><K><I><Y><V><L><Q><L><L><A><R><T><V><F><E><V><G><F><L><I><G><Q><Y><F><L><Y><G><F><Q><V><H><P><F><Y><V><C><S><R><L><P><C><P><H><K><I><D><C><F><I><S><R><P><T><E><K><T><I><F><L><L><I><M><Y><G><V><T><G><L><C><L><L><L><N><I><W><E><M><L><H><L><G><F><G><T><I><R><D><S><L><N><S><K><R><R><E><L><E><D><P><G><A><Y><N><Y><P><F><T><W><N><T><P><S><A><P><P><G><Y><N><I><A><V><K><P><D><Q><I><Q><Y><T><E><L><S><N><A><K><I><A><Y><K><Q><N><K><A><N><T><A><Q><E><Q><Q><Y><G><S><H><E><E><N><L><P><A><D><L><E><A><L><Q><R><E><I><R><M><A><Q><E><R><L><D><L><A><V><Q><A><Y><S><H><Q><N><N><P><H><G><P><R><E><K><K><A><K><V><G><S><K><A><G><S><N><K><S><T><A><S><S><K><S><G><D><G><K><T><S><V><W><I>
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One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.<BOP>
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P36383
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Q96EM0
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T3HPD_HUMAN
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Trans-L-3-hydroxyproline dehydratase
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Homo
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<M><E><S><A><L><A><V><P><R><L><P><P><H><D><P><G><T><P><V><L><S><V><V><D><M><H><T><G><G><E><P><L><R><I><V><L><A><G><C><P><E><V><S><G><P><T><L><L><A><K><R><R><Y><M><R><Q><H><L><D><H><V><R><R><R><L><M><F><E><P><R><G><H><R><D><M><Y><G><A><V><L><V><P><S><E><L><P><D><A><H><L><G><V><L><F><L><H><N><E><G><Y><S><S><M><C><G><H><A><V><L><A><L><G><R><F><A><L><D><F><G><L><V><P><A><P><P><A><G><T><R><E><A><R><V><N><I><H><C><P><C><G><L><V><T><A><F><V><A><C><E><D><G><R><S><H><G><P><V><R><F><H><S><V><P><A><F><V><L><A><T><D><L><M><V><D><V><P><G><H><G><K><V><M><V><D><I><A><Y><G><G><A><F><Y><A><F><V><T><A><E><K><L><G><L><D><I><C><S><A><K><T><R><D><L><V><D><A><A><S><A><V><T><E><A><V><K><A><Q><F><K><I><N><H><P><D><S><E><D><L><A><F><L><Y><G><T><I><L><T><D><G><K><D><A><Y><T><K><E><P><T><T><N><I><C><V><F><A><D><E><Q><V><D><R><S><P><T><G><S><G><V><T><A><R><I><A><L><Q><Y><H><K><G><L><L><E><L><N><Q><M><R><A><F><K><S><S><A><T><G><S><V><F><T><G><K><A><V><R><E><A><K><C><G><D><F><K><A><V><I><V><E><V><S><G><Q><A><H><Y><T><G><T><A><S><F><I><I><E><D><D><D><P><L><R><D><G><F><L><L><K>
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Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.<BOP>
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Q96EM0
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Q96FG2
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ELMD3_HUMAN
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RNA-binding protein 29
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Homo
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<M><N><E><K><S><C><S><F><H><S><K><E><E><L><R><D><G><Q><G><E><R><L><S><A><G><Y><S><P><S><Y><D><K><D><K><S><V><L><A><F><R><G><I><P><I><S><E><L><K><N><H><G><I><L><Q><A><L><T><T><E><A><Y><E><W><E><P><R><V><V><S><T><E><V><V><R><A><Q><E><E><W><E><A><V><D><T><I><Q><P><E><T><G><S><Q><A><S><S><E><Q><P><G><Q><L><I><S><F><S><E><A><L><Q><H><F><Q><T><V><D><L><S><P><F><K><K><R><I><Q><P><T><I><R><R><T><G><L><A><A><L><R><H><Y><L><F><G><P><P><K><L><H><Q><R><L><R><E><E><R><D><L><V><L><T><I><A><Q><C><G><L><D><S><Q><D><P><V><H><G><R><V><L><Q><T><I><Y><K><K><L><T><G><S><K><F><D><C><A><L><H><G><N><H><W><E><D><L><G><F><Q><G><A><N><P><A><T><D><L><R><G><A><G><F><L><A><L><L><H><L><L><Y><L><V><M><D><S><K><T><L><P><M><A><Q><E><I><F><R><L><S><R><H><H><I><Q><Q><F><P><F><C><L><M><S><V><N><I><T><H><I><A><I><Q><A><L><R><E><E><C><L><S><R><E><C><N><R><Q><Q><K><V><I><P><V><V><N><S><F><Y><A><A><T><F><L><H><L><A><H><V><W><R><T><Q><R><K><T><I><S><D><S><G><F><V><L><K><E><L><E><V><L><A><K><K><S><P><R><R><L><L><K><T><L><E><L><Y><L><A><R><V><S><K><G><Q><A><S><L><L><G><A><Q><K><C><Y><G><P><E><A><P><P><F><K><D><L><T><F><T><G><E><S><D><L><Q><S><H><S><S><E><G><V><W><L><I>
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Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity.<BOP>
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Q96FG2
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Q9UJ71
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CLC4K_HUMAN
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Langerin
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Homo
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<M><T><V><E><K><E><A><P><D><A><H><F><T><V><D><K><Q><N><I><S><L><W><P><R><E><P><P><P><K><S><G><P><S><L><V><P><G><K><T><P><T><V><R><A><A><L><I><C><L><T><L><V><L><V><A><S><V><L><L><Q><A><V><L><Y><P><R><F><M><G><T><I><S><D><V><K><T><N><V><Q><L><L><K><G><R><V><D><N><I><S><T><L><D><S><E><I><K><K><N><S><D><G><M><E><A><A><G><V><Q><I><Q><M><V><N><E><S><L><G><Y><V><R><S><Q><F><L><K><L><K><T><S><V><E><K><A><N><A><Q><I><Q><I><L><T><R><S><W><E><E><V><S><T><L><N><A><Q><I><P><E><L><K><S><D><L><E><K><A><S><A><L><N><T><K><I><R><A><L><Q><G><S><L><E><N><M><S><K><L><L><K><R><Q><N><D><I><L><Q><V><V><S><Q><G><W><K><Y><F><K><G><N><F><Y><Y><F><S><L><I><P><K><T><W><Y><S><A><E><Q><F><C><V><S><R><N><S><H><L><T><S><V><T><S><E><S><E><Q><E><F><L><Y><K><T><A><G><G><L><I><Y><W><I><G><L><T><K><A><G><M><E><G><D><W><S><W><V><D><D><T><P><F><N><K><V><Q><S><V><R><F><W><I><P><G><E><P><N><N><A><G><N><N><E><H><C><G><N><I><K><A><P><S><L><Q><A><W><N><D><A><P><C><D><K><T><F><L><F><I><C><K><R><P><Y><V><P><S><E><P>
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Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<BOP>
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Q9UJ71
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P48169
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GBRA4_HUMAN
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GABA(A) receptor subunit alpha-4
|
Homo
|
<M><V><S><A><K><K><V><P><A><I><A><L><S><A><G><V><S><F><A><L><L><R><F><L><C><L><A><V><C><L><N><E><S><P><G><Q><N><Q><K><E><E><K><L><C><T><E><N><F><T><R><I><L><D><S><L><L><D><G><Y><D><N><R><L><R><P><G><F><G><G><P><V><T><E><V><K><T><D><I><Y><V><T><S><F><G><P><V><S><D><V><E><M><E><Y><T><M><D><V><F><F><R><Q><T><W><I><D><K><R><L><K><Y><D><G><P><I><E><I><L><R><L><N><N><M><M><V><T><K><V><W><T><P><D><T><F><F><R><N><G><K><K><S><V><S><H><N><M><T><A><P><N><K><L><F><R><I><M><R><N><G><T><I><L><Y><T><M><R><L><T><I><S><A><E><C><P><M><R><L><V><D><F><P><M><D><G><H><A><C><P><L><K><F><G><S><Y><A><Y><P><K><S><E><M><I><Y><T><W><T><K><G><P><E><K><S><V><E><V><P><K><E><S><S><S><L><V><Q><Y><D><L><I><G><Q><T><V><S><S><E><T><I><K><S><I><T><G><E><Y><I><V><M><T><V><Y><F><H><L><R><R><K><M><G><Y><F><M><I><Q><T><Y><I><P><C><I><M><T><V><I><L><S><Q><V><S><F><W><I><N><K><E><S><V><P><A><R><T><V><F><G><I><T><T><V><L><T><M><T><T><L><S><I><S><A><R><H><S><L><P><K><V><S><Y><A><T><A><M><D><W><F><I><A><V><C><F><A><F><V><F><S><A><L><I><E><F><A><A><V><N><Y><F><T><N><I><Q><M><E><K><A><K><R><K><T><S><K><P><P><Q><E><V><P><A><A><P><V><Q><R><E><K><H><P><E><A><P><L><Q><N><T><N><A><N><L><N><M><R><K><R><T><N><A><L><V><H><S><E><S><D><V><G><N><R><T><E><V><G><N><H><S><S><K><S><S><T><V><V><Q><E><S><S><K><G><T><P><R><S><Y><L><A><S><S><P><N><P><F><S><R><A><N><A><A><E><T><I><S><A><A><R><A><L><P><S><A><S><P><T><S><I><R><T><G><Y><M><P><R><K><A><S><V><G><S><A><S><T><R><H><V><F><G><S><R><L><Q><R><I><K><T><T><V><N><T><I><G><A><T><G><K><L><S><A><T><P><P><P><S><A><P><P><P><S><G><S><G><T><S><K><I><D><K><Y><A><R><I><L><F><P><V><T><F><G><A><F><N><M><V><Y><W><V><V><Y><L><S><K><D><T><M><E><K><S><E><S><L><M>
|
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.<BOP>
|
P48169
|
Q9GZV3
|
SC5A7_HUMAN
|
Solute carrier family 5 member 7
|
Homo
|
<M><A><F><H><V><E><G><L><I><A><I><I><V><F><Y><L><L><I><L><L><V><G><I><W><A><A><W><R><T><K><N><S><G><S><A><E><E><R><S><E><A><I><I><V><G><G><R><D><I><G><L><L><V><G><G><F><T><M><T><A><T><W><V><G><G><G><Y><I><N><G><T><A><E><A><V><Y><V><P><G><Y><G><L><A><W><A><Q><A><P><I><G><Y><S><L><S><L><I><L><G><G><L><F><F><A><K><P><M><R><S><K><G><Y><V><T><M><L><D><P><F><Q><Q><I><Y><G><K><R><M><G><G><L><L><F><I><P><A><L><M><G><E><M><F><W><A><A><A><I><F><S><A><L><G><A><T><I><S><V><I><I><D><V><D><M><H><I><S><V><I><I><S><A><L><I><A><T><L><Y><T><L><V><G><G><L><Y><S><V><A><Y><T><D><V><V><Q><L><F><C><I><F><V><G><L><W><I><S><V><P><F><A><L><S><H><P><A><V><A><D><I><G><F><T><A><V><H><A><K><Y><Q><K><P><W><L><G><T><V><D><S><S><E><V><Y><S><W><L><D><S><F><L><L><L><M><L><G><G><I><P><W><Q><A><Y><F><Q><R><V><L><S><S><S><S><A><T><Y><A><Q><V><L><S><F><L><A><A><F><G><C><L><V><M><A><I><P><A><I><L><I><G><A><I><G><A><S><T><D><W><N><Q><T><A><Y><G><L><P><D><P><K><T><T><E><E><A><D><M><I><L><P><I><V><L><Q><Y><L><C><P><V><Y><I><S><F><F><G><L><G><A><V><S><A><A><V><M><S><S><A><D><S><S><I><L><S><A><S><S><M><F><A><R><N><I><Y><Q><L><S><F><R><Q><N><A><S><D><K><E><I><V><W><V><M><R><I><T><V><F><V><F><G><A><S><A><T><A><M><A><L><L><T><K><T><V><Y><G><L><W><Y><L><S><S><D><L><V><Y><I><V><I><F><P><Q><L><L><C><V><L><F><V><K><G><T><N><T><Y><G><A><V><A><G><Y><V><S><G><L><F><L><R><I><T><G><G><E><P><Y><L><Y><L><Q><P><L><I><F><Y><P><G><Y><Y><P><D><D><N><G><I><Y><N><Q><K><F><P><F><K><T><L><A><M><V><T><S><F><L><T><N><I><C><I><S><Y><L><A><K><Y><L><F><E><S><G><T><L><P><P><K><L><D><V><F><D><A><V><V><A><R><H><S><E><E><N><M><D><K><T><I><L><V><K><N><E><N><I><K><L><D><E><L><A><L><V><K><P><R><Q><S><M><T><L><S><S><T><F><T><N><K><E><A><F><L><D><V><D><S><S><P><E><G><S><G><T><E><D><N><L><Q>
|
Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent.<BOP>
|
Q9GZV3
|
Q92561
|
PHYIP_HUMAN
|
Phytanoyl-CoA hydroxylase-associated protein 1
|
Homo
|
<M><E><L><L><S><T><P><H><S><I><E><I><N><N><I><T><C><D><S><F><R><I><S><W><A><M><E><D><S><D><L><E><R><V><T><H><Y><F><I><D><L><N><K><K><E><N><K><N><S><N><K><F><K><H><R><D><V><P><T><K><L><V><A><K><A><V><P><L><P><M><T><V><R><G><H><W><F><L><S><P><R><T><E><Y><S><V><A><V><Q><T><A><V><K><Q><S><D><G><E><Y><L><V><S><G><W><S><E><T><V><E><F><C><T><G><D><Y><A><K><E><H><L><A><Q><L><Q><E><K><A><E><Q><I><A><G><R><M><L><R><F><S><V><F><Y><R><N><H><H><K><E><Y><F><Q><H><A><R><T><H><C><G><N><M><L><Q><P><Y><L><K><D><N><S><G><S><H><G><S><P><T><S><G><M><L><H><G><V><F><F><S><C><N><T><E><F><N><T><G><Q><P><P><Q><D><S><P><Y><G><R><W><R><F><Q><I><P><A><Q><R><L><F><N><P><S><T><N><L><Y><F><A><D><F><Y><C><M><Y><T><A><Y><H><Y><A><I><L><V><L><A><P><K><G><S><L><G><D><R><F><C><R><D><R><L><P><L><L><D><I><A><C><N><K><F><L><T><C><S><V><E><D><G><E><L><V><F><R><H><A><Q><D><L><I><L><E><I><I><Y><T><E><P><V><D><L><S><L><G><T><L><G><E><I><S><G><H><Q><L><M><S><L><S><T><A><D><A><K><K><D><P><S><C><K><T><C><N><I><S><V><G><R>
|
Its interaction with PHYH suggests a role in the development of the central system.<BOP>
|
Q92561
|
O76064
|
RNF8_HUMAN
|
RING-type E3 ubiquitin transferase RNF8
|
Homo
|
<M><G><E><P><G><F><F><V><T><G><D><R><A><G><G><R><S><W><C><L><R><R><V><G><M><S><A><G><W><L><L><L><E><D><G><C><E><V><T><V><G><R><G><F><G><V><T><Y><Q><L><V><S><K><I><C><P><L><M><I><S><R><N><H><C><V><L><K><Q><N><P><E><G><Q><W><T><I><M><D><N><K><S><L><N><G><V><W><L><N><R><A><R><L><E><P><L><R><V><Y><S><I><H><Q><G><D><Y><I><Q><L><G><V><P><L><E><N><K><E><N><A><E><Y><E><Y><E><V><T><E><E><D><W><E><T><I><Y><P><C><L><S><P><K><N><D><Q><M><I><E><K><N><K><E><L><R><T><K><R><K><F><S><L><D><E><L><A><G><P><G><A><E><G><P><S><N><L><K><S><K><I><N><K><V><S><C><E><S><G><Q><P><V><K><S><Q><G><K><G><E><V><A><S><T><P><S><D><N><L><D><P><K><L><T><A><L><E><P><S><K><T><T><G><A><P><I><Y><P><G><F><P><K><V><T><E><V><H><H><E><Q><K><A><S><N><S><S><A><S><Q><R><S><L><Q><M><F><K><V><T><M><S><R><I><L><R><L><K><I><Q><M><Q><E><K><H><E><A><V><M><N><V><K><K><Q><T><Q><K><G><N><S><K><K><V><V><Q><M><E><Q><E><L><Q><D><L><Q><S><Q><L><C><A><E><Q><A><Q><Q><Q><A><R><V><E><Q><L><E><K><T><F><Q><E><E><E><Q><H><L><Q><G><L><E><I><A><Q><G><E><K><D><L><K><Q><Q><L><A><Q><A><L><Q><E><H><W><A><L><M><E><E><L><N><R><S><K><K><D><F><E><A><I><I><Q><A><K><N><K><E><L><E><Q><T><K><E><E><K><E><K><M><Q><A><Q><K><E><E><V><L><S><H><M><N><D><V><L><E><N><E><L><Q><C><I><I><C><S><E><Y><F><I><E><A><V><T><L><N><C><A><H><S><F><C><S><Y><C><I><N><E><W><M><K><R><K><I><E><C><P><I><C><R><K><D><I><K><S><K><T><Y><S><L><V><L><D><N><C><I><N><K><M><V><N><N><L><S><S><E><V><K><E><R><R><I><V><L><I><R><E><R><K><A><K><R><L><F>
|
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and
|
O76064
|
Q96EY5
|
MB12A_HUMAN
|
Protein FAM125A
|
Homo
|
<M><D><P><V><P><G><T><D><S><A><P><L><A><G><L><A><W><S><S><A><S><A><P><P><P><R><G><F><S><A><I><S><C><T><V><E><G><A><P><A><S><F><G><K><S><F><A><Q><K><S><G><Y><F><L><C><L><S><S><L><G><S><L><E><N><P><Q><E><N><V><V><A><D><I><Q><I><V><V><D><K><S><P><L><P><L><G><F><S><P><V><C><D><P><M><D><S><K><A><S><V><S><K><K><K><R><M><C><V><K><L><L><P><L><G><A><T><D><T><A><V><F><D><V><R><L><S><G><K><T><K><T><V><P><G><Y><L><R><I><G><D><M><G><G><F><A><I><W><C><K><K><A><K><A><P><R><P><V><P><K><P><R><G><L><S><R><D><M><Q><G><L><S><L><D><A><A><S><Q><P><S><K><G><G><L><L><E><R><T><A><S><R><L><G><S><R><A><S><T><L><R><R><N><D><S><I><Y><E><A><S><S><L><Y><G><I><S><A><M><D><G><V><P><F><T><L><H><P><R><F><E><G><K><S><C><S><P><L><A><F><S><A><F><G><D><L><T><I><K><S><L><A><D><I><E><E><E><Y><N><Y><G><F><V><V><E><K><T><A><A><A><R><L><P><P><S><V><S>
|
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.<BOP>
|
Q96EY5
|
Q9UJA2
|
CRLS1_HUMAN
|
Protein GCD10 homolog
|
Homo
|
<M><L><A><L><R><V><A><R><G><S><W><G><A><L><R><G><A><A><W><A><P><G><T><R><P><S><K><R><R><A><C><W><A><L><L><P><P><V><P><C><C><L><G><C><L><A><E><R><W><R><L><R><P><A><A><L><G><L><R><L><P><G><I><G><Q><R><N><H><C><S><G><A><G><K><A><A><P><R><P><A><A><G><A><G><A><A><A><E><A><P><G><G><Q><W><G><P><A><S><T><P><S><L><Y><E><N><P><W><T><I><P><N><M><L><S><M><T><R><I><G><L><A><P><V><L><G><Y><L><I><I><E><E><D><F><N><I><A><L><G><V><F><A><L><A><G><L><T><D><L><L><D><G><F><I><A><R><N><W><A><N><Q><R><S><A><L><G><S><A><L><D><P><L><A><D><K><I><L><I><S><I><L><Y><V><S><L><T><Y><A><D><L><I><P><V><P><L><T><Y><M><I><I><S><R><D><V><M><L><I><A><A><V><F><Y><V><R><Y><R><T><L><P><T><P><R><T><L><A><K><Y><F><N><P><C><Y><A><T><A><R><L><K><P><T><F><I><S><K><V><N><T><A><V><Q><L><I><L><V><A><A><S><L><A><A><P><V><F><N><Y><A><D><S><I><Y><L><Q><I><L><W><C><F><T><A><F><T><T><A><A><S><A><Y><S><Y><Y><H><Y><G><R><K><T><V><Q><V><I><K><D>
|
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.<BOP>
|
Q9UJA2
|
P11229
|
ACM1_HUMAN
|
Muscarinic acetylcholine receptor M1
|
Homo
|
<M><N><T><S><A><P><P><A><V><S><P><N><I><T><V><L><A><P><G><K><G><P><W><Q><V><A><F><I><G><I><T><T><G><L><L><S><L><A><T><V><T><G><N><L><L><V><L><I><S><F><K><V><N><T><E><L><K><T><V><N><N><Y><F><L><L><S><L><A><C><A><D><L><I><I><G><T><F><S><M><N><L><Y><T><T><Y><L><L><M><G><H><W><A><L><G><T><L><A><C><D><L><W><L><A><L><D><Y><V><A><S><N><A><S><V><M><N><L><L><L><I><S><F><D><R><Y><F><S><V><T><R><P><L><S><Y><R><A><K><R><T><P><R><R><A><A><L><M><I><G><L><A><W><L><V><S><F><V><L><W><A><P><A><I><L><F><W><Q><Y><L><V><G><E><R><T><V><L><A><G><Q><C><Y><I><Q><F><L><S><Q><P><I><I><T><F><G><T><A><M><A><A><F><Y><L><P><V><T><V><M><C><T><L><Y><W><R><I><Y><R><E><T><E><N><R><A><R><E><L><A><A><L><Q><G><S><E><T><P><G><K><G><G><G><S><S><S><S><S><E><R><S><Q><P><G><A><E><G><S><P><E><T><P><P><G><R><C><C><R><C><C><R><A><P><R><L><L><Q><A><Y><S><W><K><E><E><E><E><E><D><E><G><S><M><E><S><L><T><S><S><E><G><E><E><P><G><S><E><V><V><I><K><M><P><M><V><D><P><E><A><Q><A><P><T><K><Q><P><P><R><S><S><P><N><T><V><K><R><P><T><K><K><G><R><D><R><A><G><K><G><Q><K><P><R><G><K><E><Q><L><A><K><R><K><T><F><S><L><V><K><E><K><K><A><A><R><T><L><S><A><I><L><L><A><F><I><L><T><W><T><P><Y><N><I><M><V><L><V><S><T><F><C><K><D><C><V><P><E><T><L><W><E><L><G><Y><W><L><C><Y><V><N><S><T><I><N><P><M><C><Y><A><L><C><N><K><A><F><R><D><T><F><R><L><L><L><L><C><R><W><D><K><R><R><W><R><K><I><P><K><R><P><G><S><V><H><R><T><P><S><R><Q><C>
|
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<BOP>
|
P11229
|
Q9H426
|
RIMS4_HUMAN
|
Rab3-interacting molecule 4
|
Homo
|
<M><E><R><S><Q><S><R><L><S><L><S><A><S><F><E><A><L><A><I><Y><F><P><C><M><N><S><F><D><D><E><D><A><G><D><S><R><R><L><K><G><A><I><Q><R><S><T><E><T><G><L><A><V><E><M><P><S><R><T><L><R><Q><A><S><H><E><S><I><E><D><S><M><N><S><Y><G><S><E><G><N><L><N><Y><G><G><V><C><L><A><S><D><A><Q><F><S><D><F><L><G><S><M><G><P><A><Q><F><V><G><R><Q><T><L><A><T><T><P><M><G><D><V><E><I><G><L><Q><E><R><N><G><Q><L><E><V><D><I><I><Q><A><R><G><L><T><A><K><P><G><S><K><T><L><P><A><A><Y><I><K><A><Y><L><L><E><N><G><I><C><I><A><K><K><K><T><K><V><A><R><K><S><L><D><P><L><Y><N><Q><V><L><L><F><P><E><S><P><Q><G><K><V><L><Q><V><I><V><W><G><N><Y><G><R><M><E><R><K><Q><F><M><G><V><A><R><V><L><L><E><E><L><D><L><T><T><L><A><V><G><W><Y><K><L><F><P><T><S><S><M><V><D><P><A><T><G><P><L><L><R><Q><A><S><Q><L><S><L><E><S><T><V><G><P><C><G><E><R><S>
|
Regulates synaptic membrane exocytosis.<BOP>
|
Q9H426
|
Q8N6T0
|
TO6BL_HUMAN
|
Type 2 DNA topoisomerase VI subunit B-like
|
Homo
|
<M><E><G><T><A><V><A><V><F><E><I><L><R><F><L><I><I><H><W><K><C><D><I><D><V><S><K><G><A><L><L><E><G><Q><L><V><I><S><I><E><G><L><N><S><K><H><Q><A><N><A><L><H><C><V><T><T><V><A><S><A><G><S><L><F><G><G><M><V><L><K><K><F><L><K><E><I><Q><S><I><L><P><G><I><S><A><K><L><T><W><T><S><E><E><G><S><Y><S><Q><D><M><T><G><V><T><P><F><Q><M><I><F><E><V><D><E><K><P><R><T><L><M><T><D><C><L><V><I><K><H><F><L><R><K><I><I><M><V><H><P><K><V><R><F><H><F><S><V><K><V><N><G><I><L><S><T><E><I><F><G><V><E><N><E><P><T><L><N><L><G><N><G><I><A><L><L><V><D><S><Q><H><Y><V><R><P><N><F><G><T><I><E><S><H><C><S><R><I><H><P><V><L><G><H><P><V><M><L><F><I><P><E><D><V><A><G><M><D><L><L><G><E><L><I><L><T><P><A><A><A><L><C><P><S><P><K><V><S><S><N><Q><L><N><R><I><S><S><V><S><I><F><L><Y><G><P><L><G><L><P><L><I><L><S><T><W><E><Q><P><M><T><T><F><F><K><D><T><S><S><L><V><D><W><K><K><Y><H><L><C><M><I><P><N><L><D><L><N><L><D><R><D><L><V><L><P><D><V><S><Y><Q><V><E><S><S><E><E><D><Q><S><Q><T><M><D><P><Q><G><Q><T><L><L><L><F><L><F><V><D><F><H><S><A><F><P><V><Q><Q><M><E><I><W><G><V><Y><T><L><L><T><T><H><L><N><A><I><L><V><E><S><H><S><V><V><Q><G><S><I><Q><F><T><V><D><K><V><L><E><Q><H><H><Q><A><A><K><A><Q><Q><K><L><Q><A><S><L><S><V><A><V><N><S><I><M><S><I><L><T><G><S><T><R><S><S><F><R><K><M><C><L><Q><T><L><Q><A><A><D><T><Q><E><F><R><T><K><L><H><K><V><F><R><E><I><T><Q><H><Q><F><L><H><H><C><S><C><E><V><K><Q><Q><L><T><L><E><K><K><D><S><A><Q><G><T><E><D><A><P><D><N><S><S><L><E><L><L><A><D><T><S><G><Q><A><E><N><K><R><L><K><R><G><S><P><R><I><E><E><M><R><A><L><R><S><A><R><A><P><S><P><S><E><A><A><P><R><R><P><E><A><T><A><A><P><L><T><P><R><G><R><E><H><R><E><A><H><G><R><A><L><A><P><G><R><A><S><L><G><S><R><L><E><D><V><L><W><L><Q><E><V><S><N><L><S><E><W><L><S><P><S><P><G><P>
|
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.<BOP>
|
Q8N6T0
|
Q96GD0
|
PLPP_HUMAN
|
Pyridoxal phosphate phosphatase
|
Homo
|
<M><A><R><C><E><R><L><R><G><A><A><L><R><D><V><L><G><R><A><Q><G><V><L><F><D><C><D><G><V><L><W><N><G><E><R><A><V><P><G><A><P><E><L><L><E><R><L><A><R><A><G><K><A><A><L><F><V><S><N><N><S><R><R><A><R><P><E><L><A><L><R><F><A><R><L><G><F><G><G><L><R><A><E><Q><L><F><S><S><A><L><C><A><A><R><L><L><R><Q><R><L><P><G><P><P><D><A><P><G><A><V><F><V><L><G><G><E><G><L><R><A><E><L><R><A><A><G><L><R><L><A><G><D><P><S><A><G><D><G><A><A><P><R><V><R><A><V><L><V><G><Y><D><E><H><F><S><F><A><K><L><R><E><A><C><A><H><L><R><D><P><E><C><L><L><V><A><T><D><R><D><P><W><H><P><L><S><D><G><S><R><T><P><G><T><G><S><L><A><A><A><V><E><T><A><S><G><R><Q><A><L><V><V><G><K><P><S><P><Y><M><F><E><C><I><T><E><N><F><S><I><D><P><A><R><T><L><M><V><G><D><R><L><E><T><D><I><L><F><G><H><R><C><G><M><T><T><V><L><T><L><T><G><V><S><R><L><E><E><A><Q><A><Y><L><A><A><G><Q><H><D><L><V><P><H><Y><Y><V><E><S><I><A><D><L><T><E><G><L><E><D>
|
Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism . Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine .<BOP>
|
Q96GD0
|
Q8NFY9
|
KBTB8_HUMAN
|
T-cell activation kelch repeat protein
|
Homo
|
<M><A><A><S><A><D><L><S><K><S><S><P><T><P><N><G><I><P><S><S><D><P><A><S><D><A><M><D><P><F><H><A><C><S><I><L><K><Q><L><K><T><M><Y><D><E><G><Q><L><T><D><I><V><V><E><V><D><H><G><K><T><F><S><C><H><R><N><V><L><A><A><I><S><P><Y><F><R><S><M><F><T><S><G><L><T><E><S><T><Q><K><E><V><R><I><V><G><V><E><A><E><S><M><D><L><V><L><N><Y><A><Y><T><S><R><V><I><L><T><E><A><N><V><Q><A><L><F><T><A><A><S><I><F><Q><I><P><S><I><Q><D><Q><C><A><K><Y><M><I><S><H><L><D><P><Q><N><S><I><G><V><F><I><F><A><D><H><Y><G><H><Q><E><L><G><D><R><S><K><E><Y><I><R><K><K><F><L><C><V><T><K><E><Q><E><F><L><Q><L><T><K><D><Q><L><I><S><I><L><D><S><D><D><L><N><V><D><R><E><E><H><V><Y><E><S><I><I><R><W><F><E><H><E><Q><N><E><R><E><V><H><L><P><E><I><F><A><K><C><I><R><F><P><L><M><E><D><T><F><I><E><K><I><P><P><Q><F><A><Q><A><I><A><K><S><C><V><E><K><G><P><S><N><T><N><G><C><T><Q><R><L><G><M><T><A><S><E><M><I><I><C><F><D><A><A><H><K><H><S><G><K><K><Q><T><V><P><C><L><D><I><V><T><G><R><V><F><K><L><C><K><P><P><N><D><L><R><E><V><G><I><L><V><S><P><D><N><D><I><Y><I><A><G><G><Y><R><P><S><S><S><E><V><S><I><D><H><K><A><E><N><D><F><W><M><Y><D><H><S><T><N><R><W><L><S><K><P><S><L><L><R><A><R><I><G><C><K><L><V><Y><C><C><G><K><M><Y><A><I><G><G><R><V><Y><E><G><D><G><R><N><S><L><K><S><V><E><C><Y><D><S><R><E><N><C><W><T><T><V><C><A><M><P><V><A><M><E><F><H><N><A><V><E><Y><K><E><K><I><Y><V><L><Q><G><E><F><F><L><F><Y><E><P><Q><K><D><Y><W><G><F><L><T><P><M><T><V><P><R><I><Q><G><L><A><A><V><Y><K><D><S><I><Y><Y><I><A><G><T><C><G><N><H><Q><R><M><F><T><V><E><A><Y><D><I><E><L><N><K><W><T><R><K><K><D><F><P><C><D><Q><S><I><N><P><Y><L><K><L><V><L><F><Q><N><K><L><H><L><F><V><R><A><T><Q><V><T><V><E><E><H><V><F><R><T><S><R><K><N><S><L><Y><Q><Y><D><D><I><A><D><Q><W><M><K><V><Y><E><T><P><D><R><L><W><D><L><G><R><H><F><E><C><A><V><A><K><L><Y><P><Q><C><L><Q><K><V><L>
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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification . The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification .<BOP>
|
Q8NFY9
|
Q96LW1
|
Z354B_HUMAN
|
Zinc finger protein 354B
|
Homo
|
<M><A><A><G><Q><R><E><A><R><P><Q><V><S><L><T><F><E><D><V><A><V><L><F><T><W><D><E><W><R><K><L><A><P><S><Q><R><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><G><L><S><F><T><K><P><K><V><I><S><L><L><Q><Q><G><E><D><P><W><E><V><E><K><D><S><S><G><V><S><S><L><G><C><K><S><T><P><K><M><T><K><S><T><Q><T><Q><D><S><F><Q><E><Q><I><R><K><R><L><K><R><D><E><P><W><N><F><I><S><E><R><S><C><I><Y><E><E><K><L><K><K><Q><Q><D><K><N><E><N><L><Q><I><I><S><V><A><H><T><K><I><L><T><V><D><R><S><H><K><N><V><E><F><G><Q><N><F><Y><L><K><S><V><F><I><K><Q><Q><R><F><A><K><E><K><T><P><S><K><C><E><I><Q><R><N><S><F><K><Q><N><S><N><L><L><N><Q><S><K><I><K><T><A><E><K><R><Y><K><C><S><T><C><E><K><A><F><I><H><N><S><S><L><R><K><H><Q><K><N><H><T><G><E><K><L><F><K><C><K><E><C><L><K><A><F><S><Q><S><S><A><L><I><Q><H><Q><R><T><H><T><G><E><K><P><Y><I><C><K><E><C><G><K><A><F><S><H><S><A><S><L><C><K><H><L><R><T><H><T><V><E><K><C><Y><R><C><K><E><C><G><K><S><F><S><R><R><S><G><L><F><I><H><Q><K><I><H><A><Q><E><N><P><H><K><Y><N><P><G><R><K><A><S><S><Y><S><T><S><L><S><G><S><Q><K><I><H><L><R><K><K><S><Y><L><C><N><E><C><G><N><T><F><K><S><S><S><S><L><R><Y><H><Q><R><I><H><T><G><E><K><P><F><K><C><S><E><C><G><R><A><F><S><Q><S><A><S><L><I><Q><H><E><R><I><H><T><G><E><K><P><Y><R><C><N><E><C><G><K><G><F><T><S><I><S><R><L><N><R><H><R><I><I><H><T><G><E><K><L><Y><N><C><N><E><C><G><K><A><L><S><S><H><S><T><L><I><I><H><E><R><I><H><T><G><E><K><P><C><K><C><K><V><C><G><K><A><F><R><Q><S><S><A><L><I><Q><H><Q><R><M><H><T><G><E><R><P><Y><K><C><N><E><C><D><K><T><F><R><C><N><S><S><L><S><N><H><Q><R><I><H><T><G><E><K><P><Y><R><C><L><E><C><G><M><S><F><G><Q><S><A><A><L><I><Q><H><Q><R><I><H><T><G><E><K><P><F><K><C><N><T><C><G><K><T><F><R><Q><S><S><S><L><I><A><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><A><C><G><K><L><F><S><Q><R><S><S><L><T><N><H><Y><K><I><H><I><E><E><D><S><L><K><A><D><L><H><V>
|
May be involved in transcriptional regulation.<BOP>
|
Q96LW1
|
Q9HCJ3
|
RAVR2_HUMAN
|
Protein raver-2
|
Homo
|
<M><A><A><A><A><G><D><G><G><G><E><G><G><A><G><L><G><S><A><A><G><L><G><P><G><P><G><L><R><G><Q><G><P><S><A><E><A><H><E><G><A><P><D><P><M><P><A><A><L><H><P><E><E><V><A><A><R><L><Q><R><M><Q><R><E><L><S><N><R><R><K><I><L><V><K><N><L><P><Q><D><S><N><C><Q><E><V><H><D><L><L><K><D><Y><D><L><K><Y><C><Y><V><D><R><N><K><R><T><A><F><V><T><L><L><N><G><E><Q><A><Q><N><A><I><Q><M><F><H><Q><Y><S><F><R><G><K><D><L><I><V><Q><L><Q><P><T><D><A><L><L><C><I><T><N><V><P><I><S><F><T><S><E><E><F><E><E><L><V><R><A><Y><G><N><I><E><R><C><F><L><V><Y><S><E><V><T><G><H><S><K><G><Y><G><F><V><E><Y><M><K><K><D><F><A><A><K><A><R><L><E><L><L><G><R><Q><L><G><A><S><A><L><F><A><Q><W><M><D><V><N><L><L><A><S><E><L><I><H><S><K><C><L><C><I><D><K><L><P><S><D><Y><R><D><S><E><E><L><L><Q><I><F><S><S><V><H><K><P><V><F><C><Q><L><A><Q><D><E><G><S><Y><V><G><G><F><A><V><V><E><Y><S><T><A><E><Q><A><E><E><V><Q><Q><A><A><D><G><M><T><I><K><G><S><K><V><Q><V><S><F><C><A><P><G><A><P><G><R><S><T><L><A><A><L><I><A><A><Q><R><V><M><H><S><N><Q><K><G><L><L><P><E><P><N><P><V><Q><I><M><K><S><L><N><N><P><A><M><L><Q><V><L><L><Q><P><Q><L><C><G><R><A><V><K><P><A><V><L><G><T><P><H><S><L><P><H><L><M><N><P><S><I><S><P><A><F><L><H><L><N><K><A><H><Q><S><S><V><M><G><N><T><S><N><L><F><L><Q><N><L><S><H><I><P><L><A><Q><Q><Q><L><M><K><F><E><N><I><H><T><N><N><K><P><G><L><L><G><E><P><P><A><V><V><L><Q><T><A><L><G><I><G><S><V><L><P><L><K><K><E><L><G><H><H><H><G><E><A><H><K><T><S><S><L><I><P><T><Q><T><T><I><T><A><G><M><G><M><L><P><F><F><P><N><Q><H><I><A><G><Q><A><G><P><G><H><S><N><T><Q><E><K><Q><P><A><T><V><G><M><A><E><G><N><F><S><G><S><Q><P><Y><L><Q><S><F><P><N><L><A><A><G><S><L><L><V><G><H><H><K><Q><Q><Q><S><Q><P><K><G><T><E><I><S><S><G><A><A><S><K><N><Q><T><S><L><L><G><E><P><P><K><E><I><R><L><S><K><N><P><Y><L><N><L><A><S><V><L><P><S><V><C><L><S><S><P><A><S><K><T><T><L><H><K><T><G><I><A><S><S><I><L><D><A><I><S><Q><G><S><E><S><Q><H><A><L><E><K><C><I><A><Y><S><P><P><F><G><D><Y><A><Q><V><S><S><L><R><N><E><K><R><G><S><S><Y><L><I><S><A><P><E><G><G><S><V><E><C><V><D><Q><H><S><Q><G><T><G><A><Y><Y><M><E><T><Y><L><K><K><K><R><V><Y>
|
May bind single-stranded nucleic acids.<BOP>
|
Q9HCJ3
|
A0AVF1
|
IFT56_HUMAN
|
Tetratricopeptide repeat protein 26
|
Homo
|
<M><M><L><S><R><A><K><P><A><V><G><R><G><V><Q><H><T><D><K><R><K><K><K><G><R><K><I><P><K><L><E><E><L><L><S><K><R><D><F><T><G><A><I><T><L><L><E><F><K><R><H><V><G><E><E><E><E><D><T><N><L><W><I><G><Y><C><A><F><H><L><G><D><Y><K><R><A><L><E><E><Y><E><N><A><T><K><E><E><N><C><N><S><E><V><W><V><N><L><A><C><T><Y><F><F><L><G><M><Y><K><Q><A><E><A><A><G><F><K><A><S><K><S><R><L><Q><N><R><L><L><F><H><L><A><H><K><F><N><D><E><K><K><L><M><S><F><H><Q><N><L><Q><D><V><T><E><D><Q><L><S><L><A><S><I><H><Y><M><R><S><H><Y><Q><E><A><I><D><I><Y><K><R><I><L><L><D><N><R><E><Y><L><A><L><N><V><Y><V><A><L><C><Y><Y><K><L><D><Y><Y><D><V><S><Q><E><V><L><A><V><Y><L><Q><Q><I><P><D><S><T><I><A><L><N><L><K><A><C><N><H><F><R><L><Y><N><G><R><A><A><E><A><E><L><K><S><L><M><D><N><A><S><S><S><F><E><F><A><K><E><L><I><R><H><N><L><V><V><F><R><G><G><E><G><A><L><Q><V><L><P><P><L><V><D><V><I><P><E><A><R><L><N><L><V><I><Y><Y><L><R><Q><D><D><V><Q><E><A><Y><N><L><I><K><D><L><E><P><T><T><P><Q><E><Y><I><L><K><G><V><V><N><A><A><L><G><Q><E><M><G><S><R><D><H><M><K><I><A><Q><Q><F><F><Q><L><V><G><G><S><A><S><E><C><D><T><I><P><G><R><Q><C><M><A><S><C><F><F><L><L><K><Q><F><D><D><V><L><I><Y><L><N><S><F><K><S><Y><F><Y><N><D><D><I><F><N><F><N><Y><A><Q><A><K><A><A><T><G><N><T><S><E><G><E><E><A><F><L><L><I><Q><S><E><K><M><K><N><D><Y><I><Y><L><S><W><L><A><R><C><Y><I><M><N><K><K><P><R><L><A><W><E><L><Y><L><K><M><E><T><S><G><E><S><F><S><L><L><Q><L><I><A><N><D><C><Y><K><M><G><Q><F><Y><Y><S><A><K><A><F><D><V><L><E><R><L><D><P><N><P><E><Y><W><E><G><K><R><G><A><C><V><G><I><F><Q><M><I><I><A><G><R><E><P><K><E><T><L><R><E><V><L><H><L><L><R><S><T><G><N><T><Q><V><E><Y><M><I><R><I><M><K><K><W><A><K><E><N><R><V><S><I>
|
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.<BOP>
|
A0AVF1
|
Q8WVJ2
|
NUDC2_HUMAN
|
NudC domain-containing protein 2
|
Homo
|
<M><S><A><P><F><E><E><R><S><G><V><V><P><C><G><T><P><W><G><Q><W><Y><Q><T><L><E><E><V><F><I><E><V><Q><V><P><P><G><T><R><A><Q><D><I><Q><C><G><L><Q><S><R><H><V><A><L><S><V><G><G><R><E><I><L><K><G><K><L><F><D><S><T><I><A><D><E><G><T><W><T><L><E><D><R><K><M><V><R><I><V><L><T><K><T><K><R><D><A><A><N><C><W><T><S><L><L><E><S><E><Y><A><A><D><P><W><V><Q><D><Q><M><Q><R><K><L><T><L><E><R><F><Q><K><E><N><P><G><F><D><F><S><G><A><E><I><S><G><N><Y><T><K><G><G><P><D><F><S><N><L><E><K>
|
May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.<BOP>
|
Q8WVJ2
|
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